Safety Data Sheet...110. N butyl lithium 360 111. N N DiMethyl Formamide 363 112. N-butanol 366 113....

PART 3

MATERIAL SAFETY DATA SHEETS

DRAFT ENVIRONMENTAL IMPACT ASSESSMENT REPORT

PROPOSED PROJECT FOR MANUFACTURING OF

SYNTHETIC ORGANIC CHEMICALS (PHARMACEUTICAL BULK DRUGS & INTERMEDIATES)

[CAPACITY: 43.20 TPM]

[SCHEDULE 5(f) - CATEGORY A]

SURVEY NO: 424, 431, VILLAGE: GANPATPURA

TAL.: KARJAN, DIST.: VADODARA, STATE: GUJARAT

[TOR LETTER NO.: IA-J-11011/5/2019-IA-II(I) Dated 04/02/2019]

[STUDY PERIOD: FEBRUARY 2019 – APRIL 2019]

PREPARED BY:

(QCI-NABET ACCREDITED EIA CONSULTANT)

CERTIFICATE NO.: NABET/EIA/1619/SA 053

3RD FLOOR, AKASHGANGA COMPLEX, B/S. SUVIDHA SHOPPING CENTRE, NR. PARIMAL UNDERPASS, PALDI, AHMEDABAD-380 007, GUJARAT

TELEFAX: (079) 2665 0878; E-MAIL: [email protected]

MAY, 2019

Doc. No.: EEC/A-221/18-19/EIA-48/Rev. 01

Livmore Life Sciences Pvt. Ltd., Karjan-Vadodara

Environmental Impact Assessment Report Proposed Project for Manufacturing of Synthetic Organic Chemicals

Material Safety Data Sheets

SR. NO. NAME OF CHEMICALS PAGE NO.

1. (2,4,5-Trifluoro-phenyl)acetic acid 1

2. [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one 4

3. 1-(3-Chlorophenyl)-piperazine 8

4. 1,3-Dicyclohexyl carbodiamide 11

5. 2 - Phenyl Ethyl Isocynate 14

6. 2 Amino-2-Methyl 1 Propanol 18

7. 2-(chloro Methyl)4 Methyl Quinozoline 21

8. 2, 4-Di-Tert-Butyl-5-Nitrophenyl Methyl Carbonate 24

9. 2,2,4-trichloroacetophenone 26

10. 2-Amino-4-methylpyridine 29

11. 2-Chloro ethoxy ethanol 35

12. 2-Cyano-4-bromomethyl biphenyl 38

13. 3-(4-Hydroxyphenyl) propanoic acid 40

14. 3-(Trifluoro methyl)5,6,7,8-tetra hydro(4,3-a)pyrazinehydrochloride 43

15. 3-Chloro propanol 46

16. 3-Chloro-N,N-dimethyl propyl chloride Hydrochloride 49

17. 3-Ethyl-4-Methyl-3-Pyrroline-2-one 53

18. 4 – Chloro Benz Hydryl Piperzine 56

19. 4 iodoaniline 59

20. 4-(2-chlroethyl)morpholine 62

21. 4,6-Dichloro-2-propylthiopyrimidine-5-amine 65

22. 4-Amino-benzonitrile 68

23. 4-aminomethyl benzoicAcid 72

24. 4-Di methyl amino pyridine 76

25. 4-Nitrobenzene-1-sulfonyl chloride 79

26. 8- Bromo-3-methyl-1H-purine-2,6(3H, 7H)-dione 82

27. Acetic Acid 84

28. Acetic Anhydride 88

29. Acetone 91

30. Acetonitrile 94





31. Activated carbon 97

32. Aloe Emodin 100

33. Aluminium chloride 103

34. Amantadine Hydrochloride 105

35. Ammonia 111

36. Ammonium carbonate 115

37. Ammonium hydroxide 118

38. Amonium chloride 121

39. Benzhydrol 124

40. Benzoic acid 127

41. Benzyl acetone 129

42. Benzylamine 134

43. Bic (2-chloroethyl amine) HCl 136

44. BOC Imino diacetic acid 139

45. Borane Dimethyl sulfide 142

46. Boric acid 146

47. Bromine 149

48. Calcium chloride 152

49. Carbenzyloxy-L-Valine (CBZ-L-Valine) 155

50. Carbonyl diimidazole 158

51. celite 161

52. Chloro acetyl chloride 163

53. Chloro sulfonic acid 166

54. Chlorobenzene 169

55. Chloroform 171

56. Coper iodide 174

57. Cyclohexane 177

58. Cyclopropyl amine 180

59. Di Methyl Amine 182

60. Dichloroethane 188

61. Dicyclo hexyl Carbodimide 192





62. Diethanolamine 195

63. Diisopropyl ether 201

64. Dimethyl acetamide 204

65. Dimethyl Formamide 207

66. Dimethyl sulfoxide 210

67. Disopropyl ethylamine 213

68. Epichlorohydrine 216

69. Ethanol 219

70. Ethyl 3-(pyridin-2ylamino)propanoate 222

71. Ethyl Acetate Hydrochloride (15%) 225

72. Ethyl acetate 230

73. Ethyl Glycol 233

74. Ethyl nicotinate 237

75. Ethyl-2-chloro-2-oxobutanate 241

76. Fumaric Acid 244

77. Gancyclovir 247

78. Glycine methyl ester HCl 249

79. HCL Gas 252

80. Heptane 257

81. Hydrobromic Acid 260

82. Hydrochloric acid 263

83. Hydrogen Peroxide 267

84. Hydrogen 270

85. Hydroxyl amine hydrochloride 275

86. Hyflow 278

87. Imidazole 281

88. IPA HCL 285

89. Iso Propyl Alcohol 287

90. Isobutyl Bromide 290

91. Isobutylamine 294

92. Isopropyl ether (IPE) 298





93. Isopropylamine 305

94. LH-Bromide 309

95. L-Prolinamide 312

96. L-Tartaric acid 317

97. L-Valine methyl ester Hydrochloride 320

98. Meldrums acid 323

99. Meta Xylene 324

100. Methane sulfonic acid 329

101. Methane sulfonyl chloride 331

102. Methanol 334

103. Methyl ethyl ketone 337

104. Methyl iodide 340

105. Methylene Dichloride 343

106. MIBK 345

107. Morphine 350

108. MTBE 353

109. N – Bromo succinamide 357

110. N butyl lithium 360

111. N N DiMethyl Formamide 363

112. N-butanol 366

113. N-Hexane 369

114. n-hexanol 372

115. Nitric acid 375

116. Orotic acid 378

117. Ortho Chloro Nitro Benzene 384

118. Oxcarbazepine (OXC) 386

119. Oxygen 389

120. p -Nitrophenyl chloroformate 395

121. P-Anisidine 399

122. Para formaldehyde 402

123. Pd Carbon 405





124. Pet ether 408

125. Phenyl chlro formate 411

126. Phosphoric Acid 416

127. Phosphrous Pentachloride 419

128. Piperazine 422

129. POCl3 425

130. Poly phosphoric acid 427

131. Potassium carbonate 429

132. potassium dihydrogenphosphate 432

133. Potassium hydroxide 435

134. Potassium iodide 438

135. Potassium t-butoxide 441

136. Propanyl choride 445

137. Propionaldehyde 449

138. P-Toluene Sulfonic Acid 453

139. P-Toluene sulfonyl chloride 456

140. Pyridine 458

141. Pyridinium tribromide 462

142. R(-) Mendelic Acid 466

143. Ruthenium 469

144. S (-)- α- methyl benzyl amine 472

145. Sillica 476

146. Sodium Acetate 479

147. Sodium azide 482

148. Sodium bicarbonate 484

149. Sodium Bisulphite 487

150. Sodium boro Hydride 490

151. Sodium carbonate 493

152. Sodium chloride 496

153. Sodium Hydride 499

154. Sodium Hydroxide 502





155. Sodium Hypo Chlorite 505

156. Sodium iodide 514

157. Sodium metal 517

158. Sodium mono chloro acetate 520

159. Sodium nitrate 522

160. Sodium Nitrite 525

161. Sodium sulfate 528

162. Sodium Sulphite 530

163. Sodium triacetoxyborohydride 533

164. Sulfuric Acid 537

165. Sulfurochloridic acid 541

166. Sulphur 544

167. TBAB 547

168. Tert Butyl Acetoacetate 550

169. Tetrahydrofuran 553

170. Tetramethylethylenediamine 556

171. Theophylline 559

172. Thio phenol 562

173. Thioglycolic acid 566

174. Thionyl chloride 569

175. Thiourea 572

176. Toluene 575

177. Tosylate 577

178. Trans-4-Methylcyclohexyl Isocyanate 580

179. Triethanolamine 583

180. Triethyl amine 586

181. Triethyl Borane Solution 589

182. Trifluoroacetic anhydride 592

183. Tri-n-Butyl Tinchloride 602

184. Triphosgene 606

185. Tripotassium Phosphate 609





186. Urea 612

187. Valeryl Chloride 615

Aldrich - 684155 Page 1 of 7

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 6.0 Revision Date 31.03.2016

Print Date 26.02.2019 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifiers

Product name : 2,4,5-Trifluorophenylacetic acid

Product Number : 684155 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 209995-38-0

1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Chemical Pvt Limited

Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA

1.4 Emergency telephone number

Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Serious eye damage (Category 1), H318 Specific target organ toxicity - single exposure (Category 3), H335

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H315 Causes skin irritation. H318 Causes serious eye damage. H335 May cause respiratory irritation.


Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards - none SECTION 3: Composition/information on ingredients 3.1 Substances

Formula : C8H5F3O2 Molecular weight : 190.12 g/mol CAS-No. : 209995-38-0 Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration

2,4,5-Trifluorophenylacetic acid CAS-No.

209995-38-0

Skin Irrit. 2; Eye Dam. 1; STOT SE 3; H315, H318, H335


5.4 Further information No data available

SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

SECTION 7: Handling and storage 7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection 8.1 Control parameters 8.2 Exposure controls

Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators


and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.

SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties

a) Appearance Form: solid b) Odour No data available c) Odour Threshold No data available d) pH No data available e) Melting point/freezing

point Melting point/range: 121 - 125 °C

f) Initial boiling point and boiling range

No data available

g) Flash point No data available h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower

flammability or explosive limits

No data available

k) Vapour pressure No data available l) Vapour density No data available m) Relative density No data available n) Water solubility No data available o) Partition coefficient: n-

octanol/water log Pow: 1.851

p) Auto-ignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity 10.1 Reactivity

No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

2


10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Hydrogen fluoride Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information 11.1 Information on toxicological effects

Acute toxicity No data available2,4,5-Trifluorophenylacetic acid

Skin corrosion/irritation Serious eye damage/eye irritation No data available(2,4,5-Trifluorophenylacetic acid)

Respiratory or skin sensitisation No data available(2,4,5-Trifluorophenylacetic acid)

Germ cell mutagenicity No data available(2,4,5-Trifluorophenylacetic acid)

Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity No data available(2,4,5-Trifluorophenylacetic acid)

Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.(2,4,5-Trifluorophenylacetic acid)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(2,4,5-Trifluorophenylacetic acid)

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2,4,5-Trifluorophenylacetic acid)

SECTION 12: Ecological information 12.1 Toxicity

No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(2,4,5-Trifluorophenylacetic acid)


12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations 13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.

Contaminated packaging Dispose of as unused product.

SECTION 14: Transport information 14.1 UN number

ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3. H315 Causes skin irritation. H318 Causes serious eye damage. H335 May cause respiratory irritation.

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

3







Product name : 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one

Product Number : 736821 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 6969-71-7








Classification according to Regulation (EC) No 1272/2008 Skin irritation (Category 2), H315 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), H335



Signal word Warning Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.

4


Precautionary statement(s) P261 Avoid breathing dust. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards - none SECTION 3: Composition/information on ingredients 3.1 Substances

Synonyms : 3-Hydroxytriazolo[4,3-a]pyridine s-Triazolo[4,3-a]pyridin-3-ol

Formula : C6H5N3O Molecular weight : 135,12 g/mol CAS-No. : 6969-71-7 EC-No. : 230-191-8 Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration

1,2,4-triazolo[4,3-a]pyridin-3(2H)-one CAS-No.

EC-No.

6969-71-7 230-191-8

Skin Irrit. 2; Eye Irrit. 2; STOT SE 3; H315, H319, H335


Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.


a) Appearance Form: solid b) Odour No data available c) Odour Threshold No data available d) pH No data available e) Melting point/freezing

point Melting point/range: 230 - 235 °C


No data available

g) Flash point No data available h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower


No data available

k) Vapour pressure No data available l) Vapour density No data available m) Relative density No data available n) Water solubility No data available o) Partition coefficient: n-

octanol/water log Pow: 0,448


No data available


No data available




No data available




10.4 Conditions to avoid No data available

10.5 Incompatible materials Strong oxidizing agents, Strong bases

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) In the event of fire: see section 5


Acute toxicity No data available

Skin corrosion/irritation No data available

Serious eye damage/eye irritation No data available

Respiratory or skin sensitisation No data available

Germ cell mutagenicity Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as


Reproductive toxicity Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.


Aspiration hazard No data available

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.


No data available



6


12.4 Mobility in soil No data available(1,2,4-triazolo[4,3-a]pyridin-3(2H)-one)

12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Other adverse effects No data available


Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.



ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -






Full text of H-Statements referred to under sections 2 and 3. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.



7

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1-(3-Chlorophenyl) piperazine (hydrochloride)SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 as amended by (EC) No. 1272/2008

139491.1 Product Code:

Section 1. Identification of the Substance/Mixture and of the Company/Undertaking

1-(3-Chlorophenyl) piperazine (hydrochloride) Product Name:

Cayman Chemical CompanyCompany Name:1180 E. Ellsworth Rd.Ann Arbor, MI 48108

CHEMTREC Within USA and Canada:Emergency Contact: +1 (800)424-9300CHEMTREC Outside USA and Canada: +1 (703)527-3887

Cayman Chemical CompanyInformation: +1 (734)971-3335

For research use only, not for human or veterinary use.Relevant identified uses:

www.caymanchem.comWeb site address:

1-(3-chlorophenyl)-piperazine, monohydrochloride; mCPP; meta-Chlorophenylpiperazine;

Synonyms:

1.3 Details of the Supplier of the Safety Data Sheet:

1.2 Relevant identified uses of the substance or mixture and uses advised against:

1.4 Emergency telephone number:

Section 2. Hazards Identification

Acute Toxicity: Oral, Category 3Skin Corrosion/Irritation, Category 2Serious Eye Damage/Eye Irritation, Category 2Target Organ Systemic Toxicity (single exposure), Category 3

2.1 Classification of the Substance or Mixture:2.1.1 Classification according to Regulation (EC) No 1272/2008 [CLP]:

2.1.2 Classification according to Directive 1999/45/EC:T: ToxicRisk Phrases: R25, R36/37/38For full text of R- phrases: see SECTION 15.

H301: Toxic if swallowed.H315: Causes skin irritation.H319: Causes serious eye irritation.H335: May cause respiratory irritation.

GHS Hazard Phrases:

2.2 Label Elements:2.2.1 Labeling according to Regulation (EC) No 1272/2008 [CLP]:

DangerGHS Signal Word:

P264: Wash {hands} thoroughly after handling.P280: Wear {protective gloves/protective clothing/eye protection/face protection}.P362+364: Take off contaminated clothing and wash it before reuse.P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.

GHS Precaution Phrases:

P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.P330: Rinse mouth.P302+352: IF ON SKIN: Wash with plenty of soap and water.

GHS Response Phrases:

Multi-region format

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P332+313: If skin irritation occurs, get medical advice/attention.P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, ifpresent and easy to do. Continue rinsing.P337+313: If eye irritation persists, get medical advice/attention.P309+311: Call a POISON CENTER or doctor/physician if exposed or you feel unwell.P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Please refer to Section 7 for Storage and Section 13 for Disposal information.GHS Storage and Disposal Phrases:

T

2.2.2 Labeling according to Directive 1999/45/EC:

2.3 Causes skin irritation.Causes serious eye irritation.Material may be irritating to the mucous membranes and upper respiratory tract.May be harmful by inhalation or skin absorption.May cause respiratory irritation.Toxic if swallowed.To the best of our knowledge, the toxicological properties have not been thoroughlyinvestigated.

Adverse Human HealthEffects and Symptoms:

CAS # /RTECS #

Hazardous Components (Chemical Name)/REACH Registration No.

Section 3. Composition/Information on IngredientsConcentration EC No./

EC Index No.Risk Phrases/GHS Classification

13078-15-4TL2833500

1-(3-Chlorophenyl)piperazinium chloride 100.0 % 235-976-9NA

T; R25-36/37/38Acute Tox.(O) 3: H301Skin Corr. 2: H315Eye Damage 2: H319TOST (SE) 3: H335 H336

4.2

Section 4. First Aid MeasuresDescription of First AidMeasures:

Exposure may cause: headache, nausea, disorientation, weakness, and convulsions.Important Symptomsand Effects, BothAcute and Delayed:

Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Have eyesexamined and tested by medical personnel.

In Case of EyeContact:

Immediately wash skin with soap and plenty of water for at least 15 minutes. Removecontaminated clothing. Get medical attention if symptoms occur. Wash clothing beforereuse.

In Case of SkinContact:

Wash out mouth with water provided person is conscious. Never give anything by mouthto an unconscious person. Get medical attention. Do NOT induce vomiting unlessdirected to do so by medical personnel.

In Case of Ingestion:

Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trainedpersonnel. Get immediate medical attention.

In Case of Inhalation:

4.1

Multi-region format

8

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5.1

5.2

Section 5. Fire Fighting Measures

Flash Pt: No data.

As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSHapproved or equivalent), and full protective gear to prevent contact with skin and eyes.

Fire FightingInstructions:

Autoignition Pt: No data.Explosive Limits: LEL: No data. UEL: No data.

Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray.Use water spray to cool fire-exposed containers.

Suitable ExtinguishingMedia:

A solid water stream may be inefficient.UnsuitableExtinguishing Media:

No data available.Flammable Propertiesand Hazards:

5.3

6.3

6.1

6.2

Section 6. Accidental Release Measures

Contain spill and collect, as appropriate.Transfer to a chemical waste container for disposal in accordance with local regulations.

Methods and MaterialFor Containment andCleaning Up:

Avoid raising and breathing dust, and provide adequate ventilation.As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, orrespirator, and appropriate personal protection (rubber boots, safety goggles, and heavyrubber gloves).

Protective Precautions,Protective Equipmentand EmergencyProcedures:

Take steps to avoid release into the environment, if safe to do so.EnvironmentalPrecautions:

7.1

7.2

Section 7. Handling and StorageAvoid breathing dust/fume/gas/mist/vapours/spray.Avoid prolonged or repeated exposure.

Precautions To BeTaken in Handling:

Keep container tightly closed.Store in accordance with information listed on the product insert.

Precautions To BeTaken in Storing:

Section 8. Exposure Controls/Personal Protection

Britain EH40 France VLCAS # Partial Chemical Name Europe

8.1 Exposure Parameters:

No data. No data. 13078-15-4 1-(3-Chlorophenyl)piperaziniumchloride

No data.

OSHA TWA ACGIH TWACAS # Partial Chemical Name Other Limits

No data. No data. 13078-15-4 1-(3-Chlorophenyl)piperaziniumchloride

No data.

8.2.1

NIOSH approved respirator, as conditions warrant.Respiratory Equipment(Specify Type):

Safety glassesEye Protection:Compatible chemical-resistant glovesProtective Gloves:Lab coatOther Protective

Clothing:

Use process enclosures, local exhaust ventilation, or other engineering controls tocontrol airborne levels below recommended exposure limits.

Engineering Controls(Ventilation etc.):

8.2 Exposure Controls:

8.2.2 Personal protection equipment:

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12/05/2013Revision:

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Do not take internally.Facilities storing or utilizing this material should be equipped with an eyewash and asafety shower.Wash thoroughly after handling.

Work/Hygienic/Maintenance Practices:

Section 9. Physical and Chemical Properties

Physical States: [ ] Gas [ ] Liquid [ X ] Solid

Melting Point: No data.Boiling Point: No data.Flash Pt: No data.

Explosive Limits: LEL: No data. UEL: No data.Vapor Pressure (vs. Air ormm Hg):

No data.

Vapor Density (vs. Air = 1): No data.

Evaporation Rate: No data.

A crystalline solidAppearance and Odor:

9.1 Information on Basic Physical and Chemical Properties

Specific Gravity (Water = 1): No data.Solubility in Water: No data.

~10 mg/ml in PBS (pH 7.2); ~10 mg/ml in DMSO;Solubility Notes:Autoignition Pt: No data.

Percent Volatile: No data.9.2 Other Information

Molecular Formula & Weight: C10H13ClN2 • HCl 233.1

10.410.5

10.6

10.110.210.3

Section 10. Stability and Reactivity

No data available.Conditions To Avoid:

Unstable [ ] Stable [ X ]Stability:

No data available.Incompatibility -Materials To Avoid:

No data available.HazardousDecomposition OrByproducts:

Will occur [ ] Will not occur [ X ]Polymerization:Stable if stored in accordance with information listed on the product insert.Stability Note(s):

No data available.Reactivity:

Multi-region format

9

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11.1

Section 11. Toxicological InformationThe toxicological effects of this product have not been thoroughly studied.1-(3-Chlorophenyl) piperazine (hydrochloride) - Toxicity Data: Oral TDLO (woman): 500μg/kg; Oral LD50 (rat): 142 mg/kg; Intraperitoneal TDLO (rat): 3 mg/kg;

Information onToxicological Effects:

Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presentedhere. See actual entry in RTECS for complete information.1-(3-Chlorophenyl) piperazine (hydrochloride) RTECS Number: TL2833500

Chronic ToxicologicalEffects:

NTP? No IARC Monographs? No OSHA Regulated? NoCarcinogenicity:

12.1 Avoid release into the environment.Runoff from fire control or dilution water may cause pollution.

Toxicity:

Section 12. Ecological Information

13.1 Dispose in accordance with local, state, and federal regulations.Waste DisposalMethod:

Section 13. Disposal Considerations

Section 14. Transport Information

Not dangerous goods.DOT Proper Shipping Name:DOT Hazard Class:UN/NA Number:

14.1 LAND TRANSPORT (US DOT):

Not dangerous goods.ADR/RID Shipping Name:14.1 LAND TRANSPORT (European ADR/RID):

UN Number:Hazard Class:

Not dangerous goods.ICAO/IATA Shipping Name:14.3 AIR TRANSPORT (ICAO/IATA):

Transport in accordance with local, state, and federal regulations.Additional TransportInformation:

CAS # Hazardous Components (Chemical Name)

Section 15. Regulatory Information

S. 302 (EHS) S. 304 RQ S. 313 (TRI)EPA SARA (Superfund Amendments and Reauthorization Act of 1986) Lists

13078-15-4 1-(3-Chlorophenyl)piperazinium chloride No No No

CAS # Hazardous Components (Chemical Name) Other US EPA or State Lists 13078-15-4 1-(3-Chlorophenyl)piperazinium chloride CAA HAP,ODC: No; CWA NPDES: No; TSCA: No; CA

PROP.65: No

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TEuropean Community Risk and Safety Phrases:

European Community Hazard Symbol codes:

Toxic if swallowed.R25Irritating to eyes, respiratory system and skin.R36/37/38Do not breathe dust.S22Avoid contact with skin and eyes.S24/25Wear suitable protective clothing, gloves and eye/face protection.S36/37/39

This SDS was prepared in accordance with Regulation (EC) No.1272/2008 andEuropean Directive 67/548/EEC as amended.

Regulatory InformationStatement:

Section 16. Other Information

No data available.Additional Information AboutThis Product:

DISCLAIMER: This information is believed to be accurate and represents the bestinformation currently available to us. However, we make no warranty of merchantabilityor any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations todetermine the suitability of the information for their particular purposes.

N.A.=Not available, N.P.=Not applicable, N.D.=Not determined, N.E.=Not established,N.R.=Not required

Company Policy orDisclaimer:

12/05/2013Revision Date:

Multi-region format

10

N,N'-Dicyclohexylcarbodiimide

1,3-Dicyclohexylcarbodiimide;Bis(cyclohexyl)carbodiimide;Cyclohexaamine, N,N'-methanetetraylbis-;Dicyclohexylcarbodiimide;N,N'-Methanetetrayl biscyclohexanamine

Carbodiimide, dicyclohexyl-

C13H22N2

Not available.

FF2160000

538-75-0

D2122

Not available.

SPECTRUM LABORATORY PRODUCTS INC.14422 S. SAN PEDRO STREETGARDENA, CA 90248

CALL (310) 516-8000

SPECTRUM LABORATORY PRODUCTS INC.14422 S. SAN PEDRO STREETGARDENA, CA 90248

13 0

Material Safety Data SheetNFPA HMIS Personal Protective Equipment

Section 1. Chemical Product and Company Identification

Common Name/Trade Name

CatalogNumber(s).

CAS#

RTECS

CI#

Manufacturer

Synonym

Chemical Name

Chemical Family

IN CASE OF EMERGENCYCHEMTREC (24hr) 800-424-9300

Chemical Formula

Supplier

See Section 15.

Commercial Name(s) DCC; DCCD; DCCI

TSCA T SCA 8 (b ) i nven t o ry:N,N'-Dicyclohexylcarbodiimide

3

1

0

Health Hazard

Fire Hazard

Reactivity

Page Number: 1

N,N'-Dicyclohexylcarbodiimide: ORAL (LD50): Acute: 400 mg/kg [Rat (RTECS)]. >800 mg/kg [Mouse]. 1110 mg/kg [Rat (Merck)]. DERMAL (LD50): Acute: 71 mg/kg [Rabbit (Merck)]. DUST (LC50): Acute: 159 mg/m3 6 hours [Rat].

1) {N,N'-}Dicyclohexylcarbodiimide 538-75-0 100

Toxicological Dataon Ingredients

Name

Section 2.Composition and Information on Ingredients

Exposure Limits

TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3) % by WeightCAS #

Continued on Next Page

N,N'-Dicyclohexylcarbodiimide Page Number: 2

Very hazardous in case of skin contact (irritant, permeator), of eye contact (irritant). Hazardous in case of ingestion, ofinhalation. Slightly hazardous in case of skin contact (sensitizer). Severe over-exposure can result in death.Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized byitching, scaling, reddening, or, occasionally, blistering.

Slightly hazardous in case of skin contact (sensitizer).CARCINOGENIC EFFECTS: Not available.MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available.Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in oneor many human organs.

Section 3. Hazards Identification

Potential Acute HealthEffects

Potential Chronic HealthEffects

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tightclothing such as a collar, tie, belt or waistband.

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least15 minutes. Get medical attention immediately.

In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminatedclothing and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoesbefore reuse. Get medical attention immediately.

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediatemedical attention.

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Getmedical attention immediately.

Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband.If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation.WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaledmaterial is toxic, infectious or corrosive. Seek immediate medical attention.

Not available.

Section 4. First Aid Measures

Eye Contact

Skin Contact

Serious Skin Contact

Inhalation

Serious Inhalation

Ingestion

Serious Ingestion

Not available.

May be combustible at high temperature.

These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

CLOSED CUP: >110°C (230°F).

Not available.

SMALL FIRE: Use DRY chemical powder.LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Slightly flammable to flammable in presence of open flames and sparks, of heat.

Not available.

Risks of explosion of the product in presence of mechanical impact: Not available.Risks of explosion of the product in presence of static discharge: Not available.

Not available.

Section 5. Fire and Explosion Data

Flammability of the Product

Auto-Ignition Temperature

Flash Points

Flammable Limits

Products of Combustion

Fire Hazards in Presence ofVarious Substances

Explosion Hazards inPresence of VariousSubstances

Fire Fighting Mediaand Instructions

Special Remarks onFire Hazards

Special Remarks onExplosion Hazards


11


Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Poisonous solid.Stop leak if without risk. If the product is in its solid form: Use a shovel to put the material into a convenient wastedisposal container. If the product is in its liquid form: Do not get water inside container. Absorb with an inertmaterial and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use waterspray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignitionsources. Call for assistance on disposal.

Section 6. Accidental Release Measures

Small Spill

Large Spill

Keep container tightly closed. Keep container in a cool, well-ventilated area.

Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do notingest. Do not breathe dust. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seekmedical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away fromincompatibles such as oxidizing agents.

Section 7. Handling and Storage

Precautions

Storage

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels belowrecommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure toairborne contaminants below the exposure limit.

Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used toavoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFOREhandling this product.

Not available.

Section 8. Exposure Controls/Personal Protection

Engineering Controls

Personal Protection

Personal Protection in Caseof a Large Spill

Exposure Limits

153.89°C (309°F) @ 11mmHg

Solid. (Low melting point solid)

Not available.

Not applicable.

33°C (91.4°F) - 36 C.

1.325 (Water = 1)

Not available.

Not applicable.

Not available.

Not available.

Not available.

Insoluble in cold water, hot water.

Not available.

Not available.

206.33 g/mole

Not available.

Not available.

Colorless. White.

Section 9. Physical and Chemical Properties

Physical state andappearance

Odor

Taste

Color

Molecular Weight

pH (1% soln/water)

Boiling Point

Melting Point

Critical Temperature

Specific Gravity

Vapor Pressure

Vapor Density

Volatility

Odor Threshold

Water/Oil Dist. Coeff.

Ionicity (in Water)

Dispersion Properties

Solubility



The product is stable.

Non-corrosive in presence of glass.

Reactive with oxidizing agents.

Not available.

Not available.

Not available.

Excess heat, incompatible materials

Section 10. Stability and Reactivity Data

Stability

Instability Temperature

Conditions of Instability

Incompatibility with varioussubstances

Corrosivity

Special Remarks onReactivity

Special Remarks onCorrosivity

Polymerization Will not occur.

Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.

Acute oral toxicity (LD50): 400 mg/kg [Rat (RTECS)].Acute dermal toxicity (LD50): 71 mg/kg [Rabbit (Merck)].Acute toxicity of the dust (LC50): 159 mg/m3 6 hours [Rat].

Very hazardous in case of skin contact (irritant, permeator).Hazardous in case of skin contact (sensitizer), of ingestion, of inhalation.

Not available.

Lethal Dose/Conc 50% Kill:LD50 [Guinea Pig] - Route: Skin; Dose: 10 mL/kg

Acute Potential Health Effects:Skin: Causes severe irritation. It can be absorbed through the skin. Toxic if absorbed through the skin.Eyes: Causes severe irritation.Inhalation: Harmful if inhaled. Causes respiratory tract irritation and lacrimation. Symptoms may include nausea,vomiting, headache, coughing, wheezing, laryngitis, shortness of breath, inflammation, edema and chemicalpneumonitis.Ingestion: Harmful if swallowed. Causes digestive/gastrointestinal tract irritation (irritation of the mouth, pharynx,esophagus and gastrointestingal tract), nausea, hypermotility, diarrhea. It may also affect hair, behavior/nervoussystem (muscle weakness, headache, convulsions), respiration (dyspnea, cyanosis),.Chronic Potential Health Effects:Skin: Prolonged or repeated skin contact may cause sensitization, an allergic reaction.Chronic Potential Health Effects:Skin: Prolonged or repeated skin contact may cause skin sensitization, an allergic reaction.

Not available.

Section 11. Toxicological Information

Routes of Entry

Toxicity to Animals

Chronic Effects on Humans

Other Toxic Effects onHumans

Special Remarks onToxicity to Animals

Special Remarks onChronic Effects on Humans

Special Remarks on otherToxic Effects on Humans

Not available.

Not available.

Possibly hazardous short term degradation products are not likely. However, long term degradation products mayarise.

The products of degradation are less toxic than the product itself.

Section 12. Ecological Information

Ecotoxicity

BOD5 and COD

Products of Biodegradation

Toxicity of the Productsof Biodegradation


12


Not available.Special Remarks on theProducts of Biodegradation

Section 13. Disposal Considerations

Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental controlregulations.

DOT Classification CLASS 6.1: Poisonous material.

Not available.

UNNA: 2811 : Toxic Solid, organic, n.o.s. (N,N'-Dicyclohexylcarbodiimide) PG: II

Section 14. Transport Information

Identification

DOT (Pictograms)

Special Provisions forTransport

OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.208-704-1).Canada: Listed on Canadian Domestic Substance List (DSL).China: Listed on National Inventory.Japan: Listed on National Inventory (ENCS).Korea: Listed on National Inventory (KECI).Philippines: Listed on National Inventory (PICCS).Australia: Listed on AICS.

01

3

3

1

0

E

CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).CLASS D-2B: Material causing other toxic effects (TOXIC).

R22- Harmful if swallowed.R24- Toxic in contact with skin.R41- Risk of serious damage to eyes.R43- May cause sensitization by skincontact.

Section 15. Other Regulatory Information and Pictograms

Other Regulations

Other Classifications WHMIS (Canada)

DSCL (EEC)

HMIS (U.S.A.) Health Hazard

Fire Hazard

Reactivity

National Fire ProtectionAssociation (U.S.A.)

Personal Protection

Health

Flammability

Reactivity

Specific hazard

Federal and StateRegulations

TSCA 8(b) inventory: N,N'-Dicyclohexylcarbodiimide

CaliforniaProposition 65Warnings

California prop. 65: This product contains the following ingredients for which the State of California has found tocause cancer which would require a warning under the statute: No products were found.California prop. 65: This product contains the following ingredients for which the State of California has found tocause birth defects which would require a warning under the statute: No products were found.

S24- Avoid contact with skin.S26- In case of contact with eyes, rinseimmediately with plenty of water and seekmedical advice.S37/39- Wear suitable gloves and eye/faceprotection.S45- In case of accident or if you feel unwell,seek medical advice immediately (show thelabel where possible).



6

WHMIS (Canada)(Pictograms)

DSCL (Europe)(Pictograms)

TDG (Canada)(Pictograms)

ADR (Europe)(Pictograms)

Protective Equipment

Dust respirator. Be sure to use anapproved/certified respirator or equivalent.Wear appropriate respirator when ventilationis inadequate.

Lab coat.

Splash goggles.

Gloves.

Not available.

Not available.

CALL (310) 516-8000

Notice to Reader

Verified by Sonia Owen.

Printed 11/10/2008.

Validated by Sonia Owen on 10/30/2008.

Other SpecialConsiderations

References

Section 16. Other Information

MSDS Code 5125D


13


All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials,deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actualconditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.






Product name : Phenethyl isocyanate

Product Number : 456179 Brand : Aldrich Index-No. : 615-024-00-2 REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 1943-82-4








Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 3), H331 Skin corrosion (Category 1A), H314 Respiratory sensitisation (Category 1), H334 Skin sensitisation (Category 1), H317 Chronic aquatic toxicity (Category 2), H411



Signal word Danger Hazard statement(s) H302 Harmful if swallowed.

14


H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H331 Toxic if inhaled. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H411 Toxic to aquatic life with long lasting effects. Precautionary statement(s) P261 Avoid breathing vapours. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face

protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Lachrymator.

SECTION 3: Composition/information on ingredients 3.1 Substances

Formula : C9H9NO Molecular weight : 147.17 g/mol CAS-No. : 1943-82-4 EC-No. : 413-080-0 Index-No. : 615-024-00-2 Hazardous ingredients according to Regulation (EC) No 1272/2008 Component Classification Concentration

2-Phenylethylisocyanate CAS-No.

EC-No. Index-No.

1943-82-4 413-080-0 615-024-00-2

Acute Tox. 4; Acute Tox. 3; Skin Corr. 1A; Resp. Sens. 1; Skin Sens. 1; Aquatic Chronic 2; H302, H331, H314, H334, H317, H411


Personal protective equipment Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Splash contact Material: Nitrile rubber Minimum layer thickness: 0.4 mm Break through time: 30 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.


a) Appearance Form: liquid Colour: colourless

b) Odour No data available c) Odour Threshold No data available d) pH No data available e) Melting point/freezing

point No data available


210 °C - lit.

g) Flash point 100 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower No data available



k) Vapour pressure No data available l) Vapour density No data available m) Relative density 1.063 g/cm3 at 25 °C n) Water solubility No data available o) Partition coefficient: n-

octanol/water log Pow: 2.583log Pow: 5


No data available


No data available




No data available



10.4 Conditions to avoid Avoid moisture.

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx) Other decomposition products - No data available In the event of fire: see section 5


Acute toxicity No data available2-Phenylethylisocyanate

Skin corrosion/irritation No data available(2-Phenylethylisocyanate)

Serious eye damage/eye irritation No data available(2-Phenylethylisocyanate)

Respiratory or skin sensitisation No data available(2-Phenylethylisocyanate)

Germ cell mutagenicity No data available(2-Phenylethylisocyanate)

16


Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as


Reproductive toxicity No data available(2-Phenylethylisocyanate)

Specific target organ toxicity - single exposure No data available(2-Phenylethylisocyanate)


Aspiration hazard No data available(2-Phenylethylisocyanate)

Additional Information RTECS: Not available burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2-Phenylethylisocyanate)


No data available



12.4 Mobility in soil No data available(2-Phenylethylisocyanate)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects Toxic to aquatic life with long lasting effects.


Product Offer surplus and non-recyclable solutions to a licensed disposal company.



ADR/RID: 2206 IMDG: 2206 IATA: 2206

14.2 UN proper shipping name ADR/RID: ISOCYANATES, TOXIC, N.O.S. (2-Phenylethylisocyanate) IMDG: ISOCYANATES, TOXIC, N.O.S. (2-Phenylethylisocyanate) IATA: Isocyanates, toxic, n.o.s. (2-Phenylethylisocyanate)


14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packaging group ADR/RID: III IMDG: III IATA: III






Full text of H-Statements referred to under sections 2 and 3. H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage. H317 May cause an allergic skin reaction. H331 Toxic if inhaled. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H411 Toxic to aquatic life with long lasting effects.


17

p. 1

2 2 0

He a lt h

Fire

Re a c t iv it yPe rs o n a lPro t e c t io n

2

2

0

Material Safety Data Sheet2-Amino-2-methyl-1-propanol MSDS

Section 1: Chemical Product and Company Identification

Product Name: 2-Amino-2-methyl-1-propanol

Catalog Codes: SLA4639

CAS#: 124-68-5

RTECS: UA5950000

TSCA: TSCA 8(b) inventory: 2-Amino-2-methyl-1-propanol

CI#: Not applicable.

Synonym: Amino alcohol

Chemical Name: Isobutanolamine

Chemical Formula: CH3C(CH3)NH2CH2OH

Contact Information:Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396US Sales: 1-800-901-7247International Sales: 1-281-441-4400Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on IngredientsComposition:

Name CAS # % byWeight

{2-}Amino-2-methyl-1-propanol 124-68-5 100

Toxicological Data on Ingredients: 2-Amino-2-methyl-1-propanol: ORAL (LD50): Acute: 2900 mg/kg [Rat]. 2150 mg/kg[Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skincontact (permeator). Slightly hazardous in case of skin contact (sensitizer). Corrosive to skin and eyes on contact. Liquid orspray mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin contactmay produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract, characterized by coughing,choking, or shortness of breath. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammationis characterized by itching, scaling, reddening, or, occasionally, blistering.Potential Chronic Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case ofskin contact (permeator). Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: ClassifiedA2 (Suspected for human.) by ACGIH. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: ClassifiedSUSPECTED for human. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to lungs, the nervous system,

p. 2

mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeatedor prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolongedexposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. Repeated orprolonged inhalation of vapors may lead to chronic respiratory irritation.

Section 4: First Aid Measures

Eye Contact:Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Get medical attention immediately. Finish by rinsing thoroughly with running water to avoid apossible infection.

Skin Contact:In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothingand shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly cleanshoes before reuse. Get medical attention immediately.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Combustible.

Auto-Ignition Temperature: Not available.

Flash Points: CLOSED CUP: 67°C (152.6°F).

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances:Highly flammable in presence of open flames and sparks, of oxidizing materials, of reducing materials. Slightly flammable toflammable in presence of heat, of combustible materials.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.

Fire Fighting Media and Instructions:SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: Store under nitrogen.

Special Remarks on Explosion Hazards: Not available.

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p. 3

Section 6: Accidental Release Measures

Small Spill:Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. Ifnecessary: Neutralize the residue with a dilute solution of acetic acid.

Large Spill:Combustible material. Corrosive liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Ifthe product is in its solid form: Use a shovel to put the material into a convenient waste disposal container. If the product isin its liquid form: Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Absorbwith an inert material and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use waterspray curtain to divert vapor drift. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistanceon disposal. Neutralize the residue with a dilute solution of acetic acid.

Section 7: Handling and Storage

Precautions:Keep locked up.. Keep container dry. Keep away from heat. Keep away from sources of ignition. Ground all equipmentcontaining material. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water to this product. In case ofinsufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show thecontainer or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducingagents, metals, acids.

Storage:Keep container in a cool, well-ventilated area. Keep container tightly closed and sealed until ready for use. Avoid all possiblesources of ignition (spark or flame).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respectivethreshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.

Personal Protection:Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Boots.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Liquid. (Liquid.)

Odor: Amine like. (Slight.)

Taste: Not available.

Molecular Weight: 89.14 g/mole

Color: Colorless.

pH (1% soln/water): 11 [Basic.]

Boiling Point: 165°C (329°F)

p. 4

Melting Point: 24°C (75.2°F)

Critical Temperature: Not available.

Specific Gravity: 0.94 (Water = 1)

Vapor Pressure: 0.1 kPa (@ 20°C)

Vapor Density: 3 (Air = 1)

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, methanol, diethyl ether.

Solubility:Easily soluble in hot water, methanol, diethyl ether. Soluble in cold water. Very slightly soluble in n-octanol.

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Not available.

Incompatibility with various substances:Highly reactive with oxidizing agents, reducing agents, acids. Reactive with metals. Slightly reactive to reactive with organicmaterials.

Corrosivity: Corrosive in presence of steel, of aluminum, of zinc, of copper.

Special Remarks on Reactivity: Absorbs CO2 from air.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 2150 mg/kg [Mouse].

Chronic Effects on Humans:CARCINOGENIC EFFECTS: Classified A2 (Suspected for human.) by ACGIH. TERATOGENIC EFFECTS: ClassifiedSUSPECTED for human. Causes damage to the following organs: lungs, the nervous system, mucous membranes.

Other Toxic Effects on Humans:Very hazardous in case of skin contact (irritant), of ingestion, of inhalation. Hazardous in case of skin contact (permeator).Slightly hazardous in case of skin contact (sensitizer).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

19

p. 5

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The products of degradation are more toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: Class 8: Corrosive material

Identification: : Not available. UNNA: 0000 PG: III

Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:Pennsylvania RTK: 2-Amino-2-methyl-1-propanol Massachusetts RTK: 2-Amino-2-methyl-1-propanol TSCA 8(b) inventory: 2-Amino-2-methyl-1-propanol

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada):CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F). CLASS D-2A: Material causingother toxic effects (VERY TOXIC). CLASS E: Corrosive liquid.

DSCL (EEC):R38- Irritating to skin. R41- Risk of serious damage to eyes. R45- May cause cancer. R61- May cause harm to the unbornchild.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 2

Reactivity: 0

Personal Protection:

National Fire Protection Association (U.S.A.):

Health: 2

Flammability: 2

Reactivity: 0

Specific hazard:

Protective Equipment:

p. 6

Gloves. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Face shield.

Section 16: Other Information

References:-The Sigma-Aldrich Library of Chemical Safety Data, Edition II. -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed.,New York N.Y., Van Nostrand Reinold, 1987. -Manufacturer's Material Safety Data Sheet.

Other Special Considerations: Not available.

Created: 10/09/2005 03:42 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

20

1: Identification of substance / mixture

Substance1. Product IdentifierProduct Name

Product Code

CAS Number

Other Names

IUPAC

MFCD Number

EC/EINECS

REACH Number

2-(Chloromethyl)-4-methylquinazoline

092815

109113-72-6

MFCD09807547

2. Relevant identified uses of the substance or mixture and uses advised againstResearch and Development

3. Details of the supplier of the safety data sheet

Fluorochem Ltd

Unit 14,Graphite WayHadfieldDerbyshireSK13 1QH

UK

4. Emergency telephone number+44(0)7855 268577 -

Telephone:Fax:

Email:

+44(0)1457 860111+44(0)1457 892799

[email protected]

2. Hazards Identification

1. Classification of the substance or mixture

2. Label elements

Hazard Statements

Precautionary Phrases

3. Other HazardsAdditional precautionary phrases are located throughout the safety data sheet

3. Composition / Information on Ingredients

2. Mixtures

1. Substances2-(Chloromethyl)-4-methylquinazoline Assay:100% CAS Number :109113-72-6

H314 Skin Corr. 1B R34, R23/34/35

H314 Causes severe skin burns and eye damage.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P301 + P330 + P331

IF SWALLOWED: rinse mouth. Do NOT induce vomiting.

P303 + P361 + P353

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.

P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305 + P351 + P338

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P501 Dispose of contents/container to local regulations

Signal Word Danger

No Resource File

Not Relevant

Page 1 of 6Safety data sheet created using SDSOnline Creation Tool www.hanksolutions.co.uk

Safety Data Sheet Revision: 3.00Modified: 2015-07-21According to Regulation (EC) No. 1272/2008Language : English

7.Handling and Storage

1. Personnal PrecautionsEnsure there is sufficient ventilation of the area.Wash hands immediately after contamination.P264: Wash hands thoroughly after handling.

P363: Wash contaminated clothing before reuse.Protection against explosions and fires

Safe Handling

4. First Aid Measures

1. Description of first aid measures

Skin Contact P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.

Eye Contact P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Ingestion P301 + P330 + P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting.P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.Inhalation

2. Most important symptoms and effectsSevere burns may occur.

3. Indication of any immediate medical attentionNo additional measures required

1. Extinguishing MediaCarbon dioxide.Dry chemical powder.sand

Do not use water.Unsuitable

Suitable

2. Special Hazards arising from the substance or mixture

Corrosive.

3. Advice for Fire FightersWear self-contained breathing apparatus.Wear protective clothing to prevent contact with skin and eyes.

6. Accidental Release Measures

1. Personnal Precautions

Refer to section 8 of SDS for personal protection details.

Do not discharge into drains or rivers.

2. Environmental Precautions

Mix with sand or vermiculite.Transfer to a closable, labelled salvage container for disposal by an appropriate method.

3. Methods & Materials

No Special Measures Required

4. Preventing the occurence of secondary hazards.

5. Firefighting measures



21

no further information availableOther advice

Maintaining Integrity

Storage Controls

Managing Storage Risks

2. Conditions for safe storage, including any incompatibilitiesStore in cool, well ventilated area.Keep container tightly closed.Avoid contact with water or humidity.

No special requirements

Store away from oxidising agentsKeep in tightly closed container in cool area away from direct sunlight or heat sources.

General protective and hydgiene measures

P280: Wear protective gloves/protective clothing/eye protection/face protection.

Engineering measures Ensure there is sufficient ventilation of the area.

Eye / Face Protection Safety Glasses with side-shields.

Hand protection Appropriate impermeable gloves.

Respiratory protection P260: Do not breathe dust/fume/gas/mist/vapours/spray.Use breathing protection with high concentrations

Other personal protection advice

no data

Skin protection Handle with appropriate gloves.Gloves must be inspected prior to use.Use proper glove removal technique to avoid skin contact with this product.Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practice.Wash and dry hands.Protective clothing.

2. Exposure Controls

The end use(s) have not been fully determined. The substance is supplied for Research and Development purposes by professionals only.

3. Specific End Uses

9. Physical and Chemical Properties

1. Physical and Chemical Properties

Appearance Very pale yellow to reddish yellow powder

Odour No Data Available

Odour threshold No Data Available

PH No Data Available

Melting point / Freezing point 63°C

Initial boiling point and boiling range No Data Available

Flash point No Data Available

Evaporation rate No Data Available

Flammability(solid,gas) No Data Available

Upper/lower flammability or explosive limits No Data Available

Vapour pressure No Data Available

Vapour density No Data Available

Relative density No Data Available

Solubility(ies): No Data Available

Partition coefficient: n-octanol/water No Data Available

8. Exposure Controls/Personal Protection

1. Control ParametersNo Data Available



2. Other InformationNo additional information available

no unusual reactivity

1. Reactivity

10. Stability and Reactivity

2. StabilityStable under normal conditions.

3. Possibility of Hazardous Reactionsno hazardous reactions known

4.Conditions to AvoidMoist Air.

In combustion emits toxic fumes.In combustion emits toxic fumes o

Safety Data Sheet...110. N butyl lithium 360 111. N N DiMethyl Formamide 363 112. N-butanol 366 113....

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Transcript of Safety Data Sheet...110. N butyl lithium 360 111. N N DiMethyl Formamide 363 112. N-butanol 366 113....