Adhesion

-2 -1 0 1 2

pilS cassettePilO

MafBPilXPilEOpaPilM

MspaPilNPilTPilQAppTfp

PilDPilC1PilC2

OpcPilPPilF

TNF-IL-8

Log2 Ratio

S7.1

Energy metabolism

-2 -1 0 1 2cytochrome c

putative cytochrometriosephosphate isomerase

acetate kinasealcohol dehydrogenase zinc-containing

Prolin deshydrogenasenuoD NADH dehydrogenase subunit D

NADH dehydrogenase I chain Falcohol dehydrogenase zinc-containing

isocitrate dehydrogenase NADP-dependent monomeric typeacnB bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase

sucD succinyl-CoA synthetase subunit alphayojH malate:quinone oxidoreductase

gltA type II citrate synthaseputative phosphate acetyltransferase Pta

transaldolasesuccinyl-CoA synthetase subunit beta

glycine cleavage system aminomethyltransferase (protein T)cytochrome c5

fumarate hydrataseglucose-6-phosphate isomerase

NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseNa(+)-translocating NADH-quinone reductase subunit E

succinate semialdehyde dehydrogenasecarbon starvation protein A

D-amino acid dehydrogenase small subunitsuccinate dehydrogenase iron-sulfur subunit

NADH dehydrogenase subunit LL-lactate dehydrogenase

phosphogluconate dehydrataseputative 4-hydroxyphenylacetate 3-hydroxylase small subunit

NADH dehydrogenase subunit Gglycine cleavage system protein H

phosphoglyceromutasealcohol dehydrogenase

Na(+)-translocating NADH-quinone reductase subunit AprpB 2-methylisocitrate lyase

TNF-IL-8

Log2 ratio

S7.2

Transport and binding proteins

-4 -2 0 2sulfate ABC transporter periplasmic sulfate-binding protein

ABC transporterouter membrane lipoprotein

ABC transporterbfrB bacterioferritin B

ABC transporteriron(III) ABC transporter

hypothetical proteinporB major outer membrane protein PIB

tbp2 transferrin-binding protein BpotA-1 spermidine/putrescine ABC transporter

fbpA iron(III) ABC transporterfarB fatty acid efflux system protein

Na+/H+ antiporterTonB-dependent receptor

ctrB capsule polysaccharide export inner-membrane proteinlbpB lactoferrin-binding protein

amino acid ABC transportertbp1 transferrin-binding protein 1

mtrD multiple transferable resistance system protein MtrDhmbR hemoglobin receptor

putative sodium/alanine symporterputative phosphate permease

putative ABC transporter ATP-binding proteinputative sugar transporter

mtrE multidrug efflux pump channel proteinspermidine/putrescine ABC transporter

mtrC membrane fusion proteinmgtE magnesium transporter

potD-1 spermidine/putrescine ABC transporterexbD biopolymer transport protein

amino acid ABC transporterputative bicyclomycin resistance protein

glucose/galactose transporterspermidine/putrescine ABC transporter

ctrD capsule polysaccharide export ATP-binding protein CtrDlbpA lactoferrin-binding protein Aserine/threonine transporter SstT

putative ammonium transporter AmtBsodium/glutamate symport carrier protein

ABC transporterABC transporter

multidrug efflux proteinABC transporter

TonB proteinexbB biopolymer transport protein

citrate transporterouter membrane lipoprotein carrier protein

ABC transporter family proteinfatty acid efflux system protein

ABC transporteriron(III) ABC transporter

TNFa

IL-8

Log2 Ratio

S7.3

Cell envelope

-3 -2 -1 0 1 2 3polysialic acid capsule biosynthesis protein SiaD

pilS cassettepenicillin-binding protein

coaD phosphopantetheine adenylyltransferaseH.8 outer membrane protein

large pilS cassettelipB capsule polysaccharide modification proteinlipA capsule polysaccharide modification protein

pilO proteinpilS cassettepilS cassette

lipoproteinrfaD ADP-L-glycero-D-mannoheptose-6-epimerase

synX polysialic acid capsule biosynthesis protein SynXmembrane-bound lytic murein transglycosylase D

outer membrane lipoproteinputative type IV pilus assembly protein PilZ

pilin PilEpilS cassette

yidC putative inner membrane protein translocase component YidCkdsA 2-dehydro-3-deoxyphosphooctonate aldolase

putative outer membrane protein OmpHpan1 major anaerobically induced outer membrane protein

lgtF beta-1outer membrane protein Omp85class 5 outer membrane protein

amiC N-acetylmuramoyl-L-alanine amidaseUDP-glucose 4-epimerase

peroxiredoxin 2 family protein/glutaredoxinputative outer membrane protein P1

penA penicillin-binding protein 2fimB fimbrial assembly protein

lgtE lacto-N-neotetraose biosynthesis glycosyl transferase LgtEputative cell-binding factor

mpl-1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligasemtrC membrane fusion protein

undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferasetype IV pilus assembly protein

outer membrane lipoprotein LolBputative rare lipoprotein B

ponA penicillin-binding protein 1pseudo

murA UDP-N-acetylglucosamine 1-carboxyvinyltransferasemurB UDP-N-acetylenolpyruvoylglucosamine reductase

kdtA 3-deoxy-D-manno-octulosonic-acid transferaseADP-heptose:LPS heptosyltransferase II

lpxB lipid-A-disaccharide synthase

TNF-

IL-8

log2 ratio

S7.4

Bacterial Survival

-3 -2 -1 0 1 2 3

SiaDLipBLipA

SynXfHbpSiaB

RfbB-2AniaA

MiplpxC PorACtrBSiaCCtrA

SodCCtrD

kdtA 3-deoxy-D-manno-octulosonic-acid transferaselpxB lipid-A-disaccharide synthase

TNF-

IL-8

Log2 ratio

S7.5

Regulatory function

-2 -1 0 1 2

MarR family transcriptional regulator

mtrA AraC-family transcriptional regulator

ArsR family transcriptional regulator

transcriptional regulator UmuD/LexA family

hfq host factor-I

relA GTP pyrophosphokinase

DNA-binding response regulator

MarR family transcriptional regulator

ntrX nitrogen assimilation regulatory protein NtrX

GntR family transcriptional regulator

putative nitrogen regulation protein NtrY

fur ferric uptake regulation protein TNF-

IL-8

Log2 ratio

S7.6

Amino acid Synthesis

-2 -1 0 1 2

hisB imidazoleglycerol-phosphate dehydratase

leuD isopropylmalate isomerase small subunit

aspC aromatic amino acid aminotransferase

argG argininosuccinate synthase

leuC isopropylmalate isomerase large subunit

lysC aspartate kinase

gdhA glutamate dehydrogenase

metB cystathionine gamma-synthase

ilvC ketol-acid reductoisomerase

cysK cysteine synthase

serC phosphoserine aminotransferase

hisG ATP phosphoribosyltransferase catalytic subunit

dapF diaminopimelate epimerase

argB acetylglutamate kinase

hisA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-

serB phosphoserine phosphatase TNF-

IL-8

Log2 Ratio

S7.7