S O D I U M a n d C H L O R I D E C H A N N E L S 2 :2 :1 aminobutyric acid (GABA)...
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Transcript of S O D I U M a n d C H L O R I D E C H A N N E L S 2 :2 :1 aminobutyric acid (GABA)...
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S O D I U M a n d C H L O R I D E C H A N N E L S
2:2:1
aminobutyric acid (GABA) receptor/channel
i
o10ion ion
ionlog
z
58E
mM3
mM104
Cl
Cl
i
0
mV90~ECl
ligand gated Cl- channel EtOH is an agonist
(CNS depressant)
![Page 2: S O D I U M a n d C H L O R I D E C H A N N E L S 2 :2 :1 aminobutyric acid (GABA) receptor/channel ligand gated Cl - channel EtOH is an agonist.](https://reader035.fdocuments.us/reader035/viewer/2022062315/5697c0141a28abf838ccd118/html5/thumbnails/2.jpg)
M U S C L E
Duchenne muscular dystrophy (DMD)
frame shift mutation no dystrophin is synthesized and DMD, a very severe form of the disease, results
Becker muscular dystrophy (BMD)
If the deletion simply removes certain exons, a shortened protein results that produces BMD, a milder form of the disease
Dystrophin staining
Duchenne Muscular DystrophyNormal Muscle
Western blot of dystrophin from dystrophinopathies
Lane 1: Becker dystrophyLane 2: Becker dystrophyLane 3: NormalLane 4: Duchenne dystrophy
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T H E N E U R O M U S C U L A R J U N C T I O N
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A X O N S - D E S I G N A N D D I S E A S E
myelin increases resistance and decreases capacitance
decreases signal attenuation
node of Ranvier
decreased capacitance means less charge transfer required to change membrane potential and faster APs
d
AC o
CRt
eEE o
am R/R
![Page 5: S O D I U M a n d C H L O R I D E C H A N N E L S 2 :2 :1 aminobutyric acid (GABA) receptor/channel ligand gated Cl - channel EtOH is an agonist.](https://reader035.fdocuments.us/reader035/viewer/2022062315/5697c0141a28abf838ccd118/html5/thumbnails/5.jpg)
A X O N S - D E S I G N A N D D I S E A S E
squid giant axon ~ 1mm and conducts at 20m/sec
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S o d i u m a n d S o d i u m C h a n n e l s
tetrodotoxin
Why don’t the puffer fish die from their
own toxin?
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N E U R O D E G E N E R A T I O N
-sectetase: non-pathologic protein
and secretase: A plaque forming protein
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N E U R O L O G I C A L S U R G E R Y
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T H E N E U R O M U S C U L A R J U N C T I O N
botox structure and mechanism of action
Can antisera help an active infection?
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JACK KEVORKIAN DR. DEATH
“When society reaches the age of enlightenment, then they’ll call me Dr. Life”
Narcotic plus a lethal dose of KCl
Assisted 130 people over 10 years to kill themselves
P o t a s s i u m a n d M e m b r a n e P u m p s
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NERNST EQUILIBRIUM POTENTIAL
i
oion ion
ionln
Fz
TRE
i
o10ion ion
ionlog
z
58E
mM140
mM4
K
K
i
0
mV90EK
IV 100 mg/Kg is a lethal dose
DEATH BY DEPOLARIZATION
P o t a s s i u m a n d M e m b r a n e P u m p s
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T H E A U T O N O M I C N E R V O U S S Y S T E M
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T H E A U T O N O M I C N E R V O U S S Y S T E M