Role of surgery in testicular cancer
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Transcript of Role of surgery in testicular cancer
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ROLE OF SURGERY IN TESTICULAR CANCER
Dr.A.Joseph Stalin
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Testicular cancervs
Squamous cell carcinoma/ Adenocarcinoma
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Biology of Testicular malignancy
• Primordial germ cells
• Over expression of stem cell genes
• Rapidly dividing cells
• Highly responsive to Chemo & Radiotherapy.
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Testicular cancer Vs SCC/Adeno ca
• Radiotherapy dose : 20-30 Gy.
• Chemotherapy dose : Cisplatin -20 mg/m2 Bleomycin -30 units weekly
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Surgery has limited and selective role in management of Testicular
cancer
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Role of Surgery
• 1.Radical High Inguinal Orchidectomy
- PRIMARY TREATMENT of testicular malignancy - STAGING - PROGNOSTICATION - MANAGEMENT PROTOCOL based on surgery.
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PRINCIPLES OF ORCHIDECTOMY
– Early ligation of cord at deep ring level
– Stump should be pushed into retro peritoneum ( future removal with RPLND)
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CHEVASSU MANEUVER
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2. Hemi Scrotectomy with Radical orchidectomy
• In patients who have undergone trans scrotal procedures.
• Risk of Inguinal and pelvic lymphatic spread.
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Chemotherapy should never be started without doing Radical
High Inguinal orchidectomy & Post orchidectomy tumour markers.
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3.RPLND
• In Pure Seminoma , RPLND has NO ROLE except for ,
- Post chemo residual mass (>3 cm) with normal tumour markers and PET positive cases.
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RPLND
• In Non Seminomatous GCT, role can be
- Prophylactic RPLND - Therapeutic RPLND - Post chemo RPLND - Desperate RPLND
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Prophylactic RPLND
• Indication : NSGCT Stage: IA,IB
• Rationale: 30 % of stage I harbour occult mets.
• Advantage: Defnitive patholoigcal nodal staging Disadvantage : Surgical morbidity/over treatment.
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Therapeutic RPLND
• Indication : NSGCTStage II (Low burden, markers negative)
• Advantage: Complete removal of viable GCT, Chemo resistant teratoma.
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Post Chemo - RPLND
-Post Chemo - RPLND is indicated in the setting of normalized
tumor markers with radiographic evidence of a residual
retroperitoneal mass (≥ 1 cm) after induction chemotherapy
• Done at 6 weeks following chemotherapy.
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HISTOLOGY in retroperitoneal specimen
after induction chemotherapy
• Necrosis/fibrosis – 45%
• Teratoma-40%
• Viable GCT-15%
AFTER SECOND LINE CHEMOTHERAPY
• Viable GCT- 50%
• Teratoma - 40%
• Necrosis / Fibrosis -10%
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Role of Chemo after Post Chemo - RPLND
• Two additional cycles of chemotherapy following complete resection
of viable GCT (> 10% of the specimen)after first chemotherapy
remains a common standard of care with a cure rate of 70%
• When necrosis or teratoma is present, no additional chemotherapy
is required
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Why is it important to remove teratoma?
• Teratoma though benign is biologically unpredictable
• Left un-resected, possesses the potential to invade adjacent organs (growing teratoma syndrome)
• Undergo malignant transformation
• Increases the risk of late relapse
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GROWING TERATOMA SYNDROME
• Tumor growth with declining tumor markers
occurring during chemotherapy
• Needs early surgical intervention and
completion of chemotherapy after surgery
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DESPERATION RPLND
• Persistently elevated or increasing tumor markers after
primary induction chemotherapy, failed salvage
chemotherapy
• Completely resectable retroperitoneal masses
• Technically difficult
• 20% to 55% - 5-year survival rate
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ANATOMY
1. Lymphatics of the testis drain into the
retroperitoneal lymphnode chain extending from
T11 to L5,concentrated in the renal hilum
2. Common embryologic origin with kidney
3. Surgical mapping studies by Donohue et al divides
the retro-peritoneum into specific anatomic
regions
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• The sympathetic fibers that mediate
seminal emission originate primarily
from the T12 to L3 thoraco lumbar
spinal cord.
• After leaving the sympathetic trunk,
the fibers converge towards the
midline and form the hypogastric
plexus near the takeoff of the inferior
mesenteric artery (IMA) just above
the aortic bifurcation.
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TYPES OF RPLND
EXTENT OF DISSECTION
Bilateral supra hilar/extended template
Bilateral infra hilar / Standard template
Nerve Sparing Unilateral modified template
Nerve dissecting bilateral template
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Suprahilar
• Supra-hilar metastasis rare in low stage NSGCT
• Reserved for residual hilar or suprahilar masses following chemotherapy
• Higher complication rates
• Chylous ascites
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Complications
• Retrograde Ejaculation• Infertility• Prolonged ileus• Hemorrhage• Ureteral injury• Injury to major viscera
• Mortality <1%
• Lymphocele• Wound infection• Atelectasis• Pulmonary embolism• Bowel obstruction• Wound dehiscence
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Role of surgery
• EXTRA GONADAL Germ cell tumour : Sacro coccyxeal region, mediastinum
• NON GERM CELL TUMOUR : Surgery is the main modality of treatment
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CONCLUSION
• Role of Surgery :
• High Inguinal Orchidectomy is the primary treatment.
• Other surgical options include : Hemi scrotectomy. RPLND Metastectomy/Wide local excision.
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Thank You