Long-Term Metformin Adherence in the Diabetes Prevention ...
Role of Metformin & Glilipiride in Diabetes
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Transcript of Role of Metformin & Glilipiride in Diabetes
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ROLE OF METFORMIN AND GLIMIPIRIDEINDIABETES BY – ABHIJEET KUMAR
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Diabetes Mellitus Metabolic disorder characterized by
chronic or persistant hyperglycemia. Associated with abnormal carbohydrate,
fat and protein metabolism. Major types a) Type 1 DM (IDDM) b) Type 2 DM (NIDDM) c) Gestational Diabetes
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Type 1 DM must be managed by insulin injections.
Type 2 DM may be treated with medications with or without insulin.
Other treatment options Life style modification Diet and Exercise Pharmacological therapy
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Diabetic Complications
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Management of Type-2 DM Oral Hypoglycemic agents : Decreases glucose level by direct
stimulation on insulin secretion.Eg; Sulfonylurea derivatives1st Gen : Tolbutamide, Chlorpropamide.2nd Gen : Glibenclamide, Glipizide,
Gliclazide, Glimepride.
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Anti-hyperglycemic agents :a) Sensitizers- improves insulin sensitivity. Eg; Bigunides - Metformin Glitazones – Rosiglitazone, Pioglitazoneb) Alpha-Glicosidase inhibitor- delaying glucose
absorption. Eg; Acarbose, Voglibose.c) DPP 4 enzyme inhibitor- extend the action of
insulin and supress glucagon release. Eg; Sitagliptin, Saxagliptin.
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Metformin – Glimipiride Market The Rs 4,500 crore anti-diabetic market is
growing annually at 20%, with the glimepiride and metformin combination molecule contributing 1/4th of sales.
Widely-prescribed anti-diabetic drugs (glimepiride plus metformin) clocked sales of Rs 105 crore, in May 2014.
The anti-diabetic sub-class, a combination of glimepiride and metformin, registered a growth of 34.4% in May 2014.
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Top leaders of Glimepiride Amaryl – Sanofi Zoryl – Intas Glimy – Dr.Reddys GP – USV Euglim – Zydus Glimulin – Glenmark Glypride – Sun
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Ordain Presents
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Top leaders of Metformin Glyciphage – Franco Ind Glycomet – USV Obimet – Abbott Riomet – Ranbaxy Gliconorm – Lupin Xmet – Glenmark Cetapin XR – Aventis
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Ordain Presents
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Various Combination available Metformin starting dose is 500mg b.i.d or
850mg o.d with meals and maximum dose is 2550mg per day.
Glimepiride 1mg + Metformin 500mg Glimepiride 2mg + Metformin 500mg Glimepiride 0.5 mg + Metformin 1000mgTriple drug combinations; (Glimepiride 1&2mg + Pioglitazone 15mg
+ Metformin HCl 500mg)
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Top leaders Glycomet GP – USV Gemer – Sun Glimaday – Wokhardt Zoryl M – Intas Gluconorm G – Lupin
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Ordain Presents
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End Note "While metformin is the best drug to treat
diabetes, combination therapy with glimepiride is required in most cases sooner or later. In India, this combination is most commonly-used since it is cheap and effective. Because of unabated diabetes increasing use of this combined therapy is understandable", says Dr Anoop Misra, director of Delhi-based Fortis-CDOC hospital for diabetes.