Role of medication ( drug and intervention ) - Thai Heart of...•Recurrent rheumatic fever...
Transcript of Role of medication ( drug and intervention ) - Thai Heart of...•Recurrent rheumatic fever...
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Valvular heart disease : Role of medication
( drug and intervention )
Pol.Col.Dr.Kasem Ratanasumawong
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Management of valvular heart disease
• Accurate diagnosis and disease severity
• Prevention and treatment of complication
• Monitor and consider timing of surgery ( wait and watch )
• Assess and treatment of comorbidity and associated condition
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Role of medications
• Prevention of complication
• Treatment of complication
• Symptomatic treatment
• General health care
• Treatment of co-existent disease
• Prevention of disease progression : delayed surgical treatment
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Complication of valvular heart disease
• Infective endocarditis
• Recurrent rheumatic fever
• Thromboembolism
• Disease progression -> heart failure
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Case study 1
A 40 year old female patient with severe MS with
Dyspnea on exertion.
BP 110/80 mmHg, HR 120/min, irregular pulse
Echo : Thickened and doming of MV
MVA 0.8cm.2by pressure half time
no LA thrombus What is your management?
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Prevention of endocarditis
2008 focused update ACC/AHA guideline management of valvular heart disease
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Prevention of endocarditis
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Secondary rheumatic prophylaxis
Statement for health professionals, AHA 1995
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Prevention of rheumatic fever
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Risk of thromboembolism in valvular heart disease
• Systemic embolization may occur in 10-
20% of patients with MS
• Risk related to age and present of AF
• AF with MS : highest risk among native
valve
• AF with MR, aortic valve and tricuspid valve : relatively lower risk
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Thai guideline of oral anticoagulant 2010
New oral anticoagulants is not recommended
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Prevention of thromboembolism
• Mitral stenosis
2008 focused update ACC/AHA guideline management of valvular heart disease
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Symptomatic MS
• Mitral stenosis – Loop diuretics
– Beta blocker, rate slowing calcium blocker
– Digoxin
ACE inhibitor or vasodilator : not recommended
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Management of mitral stenosis
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Symptomatic MR
• Mitral regurgitation – Acute or chronic
• Acute setting
– Sodium nitroprusside / Dobutamine
• Chronic setting
– Diuretic, vasodilator, ACE inhibitor , Beta blocker indicate in IHD, LV dysfunction or HT
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Medical treatment in MR
• No indication for vasodilator and ACE inhibitors
in asymptomatic patients with MR and preserved
LV function
• ACE inhibitor and beta blocker indicate in patient
with HT, LV dysfunction from functional or
ischemic MR
• If presence of AF : calcium antagonist, beta
blocker, digoxin or amiodarone and anticoagulant
• IE prophylaxis : no longer recommend
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Symptomatic AR
2008 focused update ACC/AHA guideline management of valvular heart disease
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Evangelista A,et al. N Engl J Med 2005; 353: 1342-1349
Progression to AVR in asymptomatic severe AR
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Symptomatic AS
• Aortic stenosis – Diuretic : relieve pulmonary congestion, over
diuresis -> hypotension
– Vasodilator : use carefully
– Inotropic drug : in cardiogenic shock
– Treatment should be guided by invasive
monitoring in cardiogenic shock with prompt surgery
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Medical treatment in AS
• AS with HT,CAD – Low dose diuretic, beta blocker, ACE
inhibitor,ARB can be used
– Precaution when increase dose
– Nitrates sublingual must be carefully
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Statin in aortic stenosis
Roseboro AB et al, N Engl J Med 2008; 359: 1343-56
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Case study 2
A 80 year old male patient with symptomatic
severe AS
BP 110/80 mmHg, HR 90/min with pulsus parvus
et tardus
What is your management ?
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TAVI
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TAVI
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Take home message (1)
• No specific medical treatment to prevent
progression of native valves disease
• Antithrombotic treatment is essential to
prevent thromboembolism esp. mitral
valve disease
• Rheumatic prophylaxis
• Endocarditis prophylaxis : no longer
recommended
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Take home message (2)
• Concomitant medical treatment of co-
existent disease
• General health care eg. immunization,
daily activity
• Establish schedule of clinical and echo
follow up
• Wait and watch : timing of intervention and surgery