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Role of analgesic in headache

PROBLEM BASED LEARNING (PBL)

PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB

BACHELOR MEDICINE AND SURGERY (MBBS)

UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

Primary differences at a glance:

•

NARCOTIC ANALGESICS(OPIOID ANALGESICS)

• Opioid agonist /Partial agonist/antagonist

• Common Mechanism of Action

–Act on the opioid receptors

–Act on opioid receptors inhibit the

release of excitatory neurotransmitters

decrease synaptic transmission.

–Morphine and heroine

Mechanism of Narcotic Analgesics

Opioid

Attach to opioid receptor

(brain, etc.)

Block the substance P

Reduce perception of

pain

Classification of NSAID

Para-aminophenol

derivatives (paracetamol)

Salicylic acid

derivative (aspirin)

Acetic acid derivatives

(indomethacin)

Fenamic acid derivatives (mefenamic

acid)

Propionic acid

derivative (ibuprofen)

Enolic acid derivatives

(meloxicam)

Non acidic drugs

Mechanism of non narcotic analgesic

Arachidonic acid pathway

Cyclooxygenase (COX)

Prostaglandins, prostacyclin, thromboxane

Pain, fever, inflammation etc

5-lipoxygenase (LOX