Rodent Breeding Colonies Bill Greer Penn State. The most Common Models Colonies maintained by...
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Transcript of Rodent Breeding Colonies Bill Greer Penn State. The most Common Models Colonies maintained by...
![Page 1: Rodent Breeding Colonies Bill Greer Penn State. The most Common Models Colonies maintained by Animal Resources Colonies are maintained by PI’s.](https://reader030.fdocuments.us/reader030/viewer/2022032703/56649f565503460f94c7a041/html5/thumbnails/1.jpg)
Rodent Breeding Colonies
Bill GreerPenn State
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The most Common ModelsThe most Common Models
Colonies maintained by Animal ResourcesColonies maintained by Animal Resources
Colonies are maintained by PI’sColonies are maintained by PI’s
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OK, so What’s the Problem?OK, so What’s the Problem?
Numbers Counting Transferring Strain Maintenance Transgenic animals?
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Problems – Ice Cream!!
![Page 5: Rodent Breeding Colonies Bill Greer Penn State. The most Common Models Colonies maintained by Animal Resources Colonies are maintained by PI’s.](https://reader030.fdocuments.us/reader030/viewer/2022032703/56649f565503460f94c7a041/html5/thumbnails/5.jpg)
How Many to ProduceHow Many to Produce
How may the Animal Resource Program justify numbers?
How may the PI justify numbers? Maintain the strain Research needs
• Loss due to genotype• Can only use one sex (M or F)
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When do you count the animals?When do you count the animals?
At
Birth
Weaning, or
Somewhere in between (e.g., first cage change)
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Transferring from Breeding to Research Transferring from Breeding to Research Protocols?Protocols?
Counting against other protocols
Using it for research/teaching or testing?
When to count Tracking the transfers
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Any Guide Deviations?Any Guide Deviations?
Maybe,
Single housing
Trio Breeding
Delayed cage changes
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Transgenic?Transgenic?
Who’s making them – ARP, the PI, a service unit? IACUC and IBC Protocol
Any problematic phenotypes
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How about if transgenic animals are made offsite
Using PHS funds?
Are you AAALAC accredited; is your collaborator?- Who owns the animals
Need an MOU?
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What did we miss?What did we miss?