Robert A. Johnson, Ph.D. Office Address: Chair of ... · PDF fileUpdated February 14, 2013 1...

Updated February 14, 2013 1 CV of Robert A. Johnson, PhD

Curriculum Vitae

Robert A. Johnson, Ph.D.

Office Address: Chair of Physiology and Pharmacology Lincoln Memorial University DeBusk School of Osteopathic Medicine - DCOM 215

6965 Cumberland Gap Parkway Harrogate, TN 37752 Office Phone: (423) 869-7757 Office Fax: (423) 869-7141 Office E-mail: [email protected] Alternate E-mail: [email protected] Website: www.cvlabs.org Education: 1977 – 1982 B.S. in Psychology Southwest Missouri State University, Springfield, MO Advisor- Frederick Maxwell, PhD 1986 – 1988 M.S. in Pharmacology

University of Missouri-Columbia, MO Advisor- Myron L. Toews, PhD

1988 – 1992 Ph.D. in Physiology

University of Missouri-Columbia, MO Advisor- Ronald H. Freeman, PhD

Post-Doctoral Training:

1991 – 1995 Postdoctoral Fellow Department of Pharmacology New York Medical College, Valhalla NY

Advisor- Alberto Nasjletti, MD Positions Held:

1995 – 1998 Research Assistant Professor Department of Pharmacology New York Medical College, Valhalla NY

Chair- John C. McGiff, MD 1998 Visiting Professor

Department of Physiology Escola Paulista de Medicina, São Paulo, SP Brazil

Chair- Sérgio Luiz Cravo, PhD

1999 – 2004 Assistant Professor of Physiology (tenure track) Department of Physiology Tulane University School of Medicine, New Orleans LA Chair- L. Gabriel Navar, PhD

2004 – 2006 Associate Professor of Physiology with Tenure

Department of Physiology Tulane University, New Orleans LA Chair- L. Gabriel Navar, PhD


2006 – 2011 Associate Professor of Surgery with Tenure

Department of Surgery, Division of Trauma and Emergency Surgery University of Texas Health Sciences Center - San Antonio TX Division Chief and Interim Chair- Ronald M. Stewart, MD 2007 - 2011 Associate Professor of Physiology with Tenure Department of Physiology University of Texas Health Sciences Center - San Antonio TX

Interim Chair- John Johnson, PhD

2011 - 2012 Associate Professor of Physiology and Pharmacology Dept of Physiology and Pharmacology Lincoln Memorial University- Debusk College of Osteopathic Medicine Harrogate, TN 37752 Chair: Stan Kunigelis, PhD

2012 - present Chair of Physiology and Pharmacology Associate Professor of Physiology and Pharmacology Lincoln Memorial University- Debusk College of Osteopathic Medicine Harrogate, TN 37752 Dean: Clarence Colle, PhD

Certifications/Licensure: Not applicable Honors and Awards:

1981 Missouri Psychological Association Undergraduate Research Competition, First Prize

1990 Graduate School Outstanding Graduate Teaching Assistant Award (Department f

Physiology-School of Medicine), University of Missouri

1992 Graduate School Superior Graduate Student Award (Department of Physiology-School of Medicine), University of Missouri

1992 Proctor and Gamble Award for Meritorious Research (Fluid and Electrolyte Homeostasis)-American Physiological Society

2004 Tulane Medical Student Owl Club’s “Claritin Award” for clear and concise lectures

2005 American Physiological Society Featured Press Release “Inhibition of carbon

monoxide may stem bleeding in soft tissue injury” (Forbes) 2011 DeBusk School of Osteopathic Medicine – oms-2 Basic Science Professor of the

Year 2011-2012 Professional Memberships Including Leadership Positions:

1990 - present Member of the American Physiological Society - Cardiovascular Section (primary), Renal Section (secondary). Neural (tertiary)

1999 – 2010 Professional member and Fellow of the American Heart Association

2000 – 2007 Member of the Microcirculation Society

2003 – 2006 Professional Member of the American Diabetes Association


2004 – 2011 Member of the Shock Society

2005 – 2007 Member of the National Lipid Association

2007 Elected as Executive Director of the Consortium for Integrative Cardiovascular Research

Courses Taught, Primary Instructor:

1992 Laboratory Instructor for Elements of Physiology Course, Department of Physiology, School of Medicine, University of Missouri – Columbia

1996 Instructor for Environmental Pathology, Department of Pathology, New York Medical College, Valhalla, NY

1996 Instructor for Graduate Pharmacology, Department of Pharmacology New York Medical College, Valhalla, NY

1996 – 1997 Instructor for Medical Pharmacology, Department of Pharmacology, New York Medical College, Valhalla, NY

1997 Instructor for Toxicology, Department of Pharmacology, New York Medical College, Valhalla, NY

1997 Instructor for Neural Pharmacology, Department of Pharmacology, New York Medical College, Valhalla, NY

1993 – 1997 Instructor for Fundamentals of Animal Research, Department of Comparative Medicine, New York Medical College and Veterinary Technology Mercy College

1999 – 2006 Instructor for Medical Physiology Course, Department of Physiology Tulane University Medical School, New Orleans, LA

1999 – 2005 Instructor for Undergraduate Biomedical Engineering Course, Departments of Physiology/Biomedical Engineering, Tulane University

1999 – 2005 Instructor for Experimental Physiology, Dept. of Physiology, Tulane University

2006 – 2011 Instructor for Foundations in Biological Science, Graduate School of Biomedical Sciences, University of Texas Health Science Center at San Antonio, TX

2006 – 2011 Lecturer and Reviewer/Advisor, Research Resident Presentation Series, Department of Surgery, School of Medicine, University of Texas Health Science Center at San Antonio, TX

2006 – 2011 Lecturer and Reviewer/Advisor, Trauma Research Presentation Series, Division of Trauma and Emergency Surgery, Dept. of Surgery, School of Medicine, University of Texas Health Science Center at San Antonio, TX

2011 – present Lecturer for 1st year medical students (OSM-I) (Physiology and Pharmacology) at

DeBusk School of Osteopathic Medicine, Harrogate TN 2011 - present Lecturer for 2nd year medical students (OSM-II) (Physiology and Pharmacology)

at DeBusk School of Osteopathic Medicine, Harrogate TN 2011 - present Lecturer for Physician Assistant Program (Physiology and Pharmacology) at

DeBusk School of Osteopathic Medicine, Harrogate TN


Courses Taught, Supporting/Secondary Faculty:

1979 – 1981 Laboratory Assistant for Learning Theories Course, Department of Psychology, Southwest Missouri State University

1988 Teaching Assistant for Veterinary Biochemistry Course, Department of Veterinary

Biomedical Sciences, University of Missouri - Columbia

1988 – 1989 Graduate Teaching Assistant for Elements of Physiology Course, Department of Physiology, School of Medicine, University of Missouri – Columbia

1992 Teaching Assistant for Medical Physiology, Department of Physiology, School of Medicine, University of Missouri – Columbia

Course Administration or Director:

2000 Course Director for Graduate Student Workshop, Department of Physiology, Tulane University School of Medicine

2004 – 2005 Course Director for Graduate Integrative Cardiovascular Physiology Course, Department of Physiology, Tulane University School of Medicine

2005 – 2006 Acting Course Director for Medical Physiology Course, Department of Physiology, Tulane University School of Medicine temporarily located at Baylor College of Medicine, Houston, TX (post Hurricane Katrina)

Continuing Education Courses / Seminars / Workshops Taught:

1998 Invited Keynote Lecture: The heme-heme oxygenase-carbon monoxide system: Endogenously-formed carbon monoxide as a modulator of cardiovascular functions. Invitation by FeSBE 98 (Federation of the Brazilian Societies of Experimental Biology) for keynote lecture titled: “Carbon Monoxide: From toxin to endogenous modulator of cardiovascular functions”, Caxambu, MG, Brazil

1998 Invited Course: Chemistry and biochemistry of the heme-heme oxygenase-

carbon monoxide system. -Invitation by the Brazilian Society of Physiology taught at the FeSBE 98 conference, Caxambu, MG, Brazil.

1998 Invited Course: Renal, hormonal and cardiovascular actions of exogenous and

endogenous carbon monoxide -Invitation by the Brazilian Society of Physiology taught at the FeSBE 98 conferenc, Caxambu, MG, Brazil.

1998 Invited Course: Exogenous and endogenous carbon monoxide in central

nervous system functions-Invitation by the Brazilian Society of Physiology taught at the FeSBE 98 conference, Caxambu, MG, Brazil

2001 Symposium Speaker: Endogenously-formed carbon monoxide can promote

endothelium-dependent vasoconstriction, apparently by inhibiting nitric oxide synthase at the Winter Eicosanoid Conference, Baltimore, MD

2002 Symposium Organizer and Chair: Endocrine, Paracrine and Novel Signaling

Messengers in the Regulation of Cardiovascular Functions at the International Society of Pathophysiology meeting in Budapest, Hungary

2002 Symposium Speaker: The Impact of Endogenously-Formed Carbon Monoxide on

Endothelial Function, at the International Society of Pathophysiology meeting in Budapest, Hungary


2004 Symposium Speaker: Endogenous carbon monoxide as a mediator of endothelial dysfunction, at Experimental Biology 2004, Washington DC

2004 Symposium Speaker: Hemorrhagic Shock Promotes Heme Oxygenase-mediated

Endothelial Dysfunction in Rat Arterioles, Advances in Resuscitation Science, American Heart Association National Meeting, New Orleans, LA

2009 – 2011 Lecturer, Continuing Education Course, Department of Laboratory Animal

Resources, University of Texas Health Science Center San Antonio, TX

2010 – 2011 Chair and Lecturer, Institutional Animal Care and Use Committee Continuing Education for Members, Institutional Animal Care Programs, Office of Vice President of Research, University of Texas Health Science Center at San Antonio, TX

2011 – present Chair and Lecturer, Institutional Animal Care and Use Committee Continuing

Education for Members, Office of Vice President of Research, Lincoln Memorial University

Clinical Site Teaching, College and Settings: Not applicable Guest Speaker or Lecturer:

2000 Putative vascular interactions between the endogenous carbon monoxide and nitric oxide systems, at Physiology Seminars, Department of Physiology, Tulane University

2005 Carbon Monoxide and Regulation of Vascular Functions at Physiology Seminars,

Department of Medical Pharmacology and Physiology, University of Missouri - Columbia

2006 Blockade of Carbon Monoxide in the Treatment of Soft Tissue Trauma at Surgery

Grand Rounds, Department of Surgery, University of Texas Health Science Center at San Antonio

2007 Endogenously-formed carbon monoxide in trauma at Pharmacology Seminar,

Department of Pharmacology, University of Texas Health Science Center at San Antonio

2010 Heme oxygenase system and cardiovascular function, at Voelcker Academy

Summer 2010, University of Texas Health Science Center at San Antonio 2010 Endogenously-formed Carbon Monoxide as a Therapeutic Target in Trauma at

Physiology Seminars, Midwestern University, Glendale, AZ 2010 Short term regulation of heart rate and cardiac output, at Medical Physiology

Course, Arizona College of Osteopathic Medicine (AZCOM), Midwestern University, Glendale, AZ

2012 Endogenously-formed Carbon Monoxide and Bleeding in Trauma Patients: From

Bench to Bedside, AT Still, Kirksville MO

Research Performed:

1980 – 1982 Behavioral testing in rodents, undergraduate research in psychology Advisor- Frederick Maxwell, PhD


1986 – 1988 Trans-membrane signaling, first to identify crosstalk between any second messenger systems (adenylate cyclase and protein kinase C), master’s research in pharmacology, Advisor- Myron L. Toews, PhD

1986 – 1992 Integrative cardiovascular and renal physiology, first to identify the effects of

systemic nitric oxide synthase blockade on renal function and plasma rennin activity, PhD research in physiology, Advisor – Ronald H. Freeman, PhD

1991 – 1995 Cardiovascular and renal pharmacology, study the systemic effects of P450-

derived eicosanoids and thromboxane receptor antagonism, post-doctoral research in pharmacology, Advisor – Alberto Nasjletti, MD

1995 – 2004 Integrative cardiovascular and renal physiology and pathophysiology during

hypertension, first to identify the systemic hemodynamic effects of heme oxygenase products and the dual role of heme-derived carbon monoxide in vascular regulation, independent research supported by AHA and NIH

2004 – 2011 Pathophysiology of hemorrhage and circulatory collapse, first to identify the role

of heme oxygenase system in cardiovascular regulation during hemorrhagic shock and circulatory collapse, independent research supported by NIH/DOD

2008 – present Systemic effects of abdominal blood, first to identify that abdominal blood drives

systemic carbon monoxide production that affects coagulation and platelet aggregation, translational (basic science and parallel clinical) independent research project supported by USAMRMC/DOD. Also was first to clinically measure whole body carbon monoxide excretion in adults.

Extramural research collaborations:

1) Prevention and treatment of surgical site infections (Corneille) – University of Texas Health

Science Center - San Antonio

2) Effect of Botox on vascular responsiveness (Bastos) – University of Texas Health Science Center - San Antonio

3) Effect of gastric by-pass on diabetic markers (Lopez) – University of Texas Health Science Center - San Antonio

4) Effect of Hemoperitoneum on Patient Stability (Stewart) – University of Texas Health Science Center - San Antonio

5) Wound Tensile Strength (Myers) – University of Texas Health Science Center - San Antonio

6) Models of TRALI (Johnson, Stewart, Myers) – University of Texas Health Science Center - San Antonio

7) CNS Regulation of Respiratory Functions, University of the Incarnate Word (Gottlieb)

8) Cardiovascular Studies, UTHSCSA Core Cardiovascular Research Group (Toney)

9) Small Animal Surgical Techniques, Surgical Department of Lab Animal Resources (Elliott, Chen)

10) Implant Development, M.D. Anderson Cancer Center, Office of Technology, Houston (Dennis)

11) Materials Analysis, Cook Medical

12) Carbon Monoxide and Cellular Functions, University of Missouri – Columbia, Department of Medical Pharmacology and Physiology (Durante)

13) Artificial Organ Systems, University of California Los Angeles, Dept. of Molecular, Cell and Developmental Biology (Arispe)


14) Inert Gas Advanced Quantification, Stanford University, Department of Pediatrics (Vreman)

15) CNS Regulation of Respiratory Functions, University of the Incarnate Word (Gottlieb)

Research Funding Awards:

Agency and ID Role Title / Principal Investigator Dates of Support

Total Amount

Castel-Krob Fund Principal Investigator

Hemodynamic roles for heme oxygenase products / RA Johnson

04/15/96 – 04/14/97

$7,500

American Heart Association, NY State Affiliate Beginning Grant-in-Aid #970128

Principal Investigator

Hemodynamic roles for carbon monoxide / RA Johnson

07/01/97 – 06/30/99 (voluntary termination 03/01/98)

$35,000

FAPESP 97/10415-9

Visiting Professor

Visiting professor support / E Colombari

02/15/98 – 02/14/99

$31,200

FAPESP Consultant CNS in cardiovascular control: Different levels, different integrations / O Ubriaco Lopes

10/01/98 – 10/01/02

$1,636,500

National Institutes of Health R01 HL64577


Hemodynamic roles for carbon monoxide

06/01/99 – 06/01/04

$661,224

American Heart Association, Southeast Affiliate Postdoctoral Fellowship 0020335B

Phantom Sponsor

Role of a heme-heme oxygenase-carbon monoxide system in the regulation of vascular tone in isolated arterial vessels / FK Johnson

07/01/02 – 06/30/04

$60,000

American Heart Association, Southeast Affiliate Medical Student Fellowship

Phantom author and Mentor

Health Sciences Fellowships / L. Gabriel Navar

07/01/02 – 06/30/04

$21,600

Louisiana Board of Regents Health Excellence Fund

Co-Investigator

Center for Hypertension / L. Gabriel Navar

01/01/02 – 05/31/06

$8,200,000

American Heart Association Southeast Affiliate Medical Student Fellowship

Phantom author and Co-Investigator

Health Sciences Fellowships / L. Gabriel Navar

07/01/04 – 06/30/06

$21,600

American Physiological Society Summer Undergraduate Fellowship

Sponsor Summer Undergraduate Fellowship / D.S. Adnan Majid

06/01/04 – 08/30/05

$2,500

National Institutes of Health R01 HL76187


Heme oxygenase and hemorrhagic circulatory collapse / RA Johnson

03/01/04 – 05/31/10

$1,188,000

National Institutes of Health F32 Ruth L. Krischten National Service Award 5F32HL076001

Co-Mentor Carbon monoxide and AngII dependent hypertension / KE Jackson

08/01/04 – 07/31/07

$134,000

Witten B. Russ Department of

Co-Investigator

Evaluation of the effects of Clostridium botulinum toxin type A on

06/01/07 – 05/31/08

$15,000


Surgery Developmental Research Grant, UTHSCSA

mammary artery vessel rings / R Bastos

Witten B. Russ Department of Surgery Developmental Research Grant, UTHSCSA

Co-Investigator

The efficacy of biodegradable antibiotic polymers for prophylaxis in contaminated wounds / MG Corneille

07/01/07 – 06/30/09

$25,000

Semp Russ Foundation of the San Antonio Area Foundation, Research Grant

Co-Investigator

Development of an experimental animal model to investigate the role of arginase in blood transfusion induced acute lung injury / FK Johnson

07/01/08-11/30/09

$33,260

National Institutes of Health Loan Repayment Program

Principal Investigator and Research Supervisor

Hemoperitoneum and endogenous carbon monoxide in the non-operative management of trauma patients/ RA Johnson

07/01/08 – 06/30/10

$70,000

American Association for the Surgery of Trauma Fellowship

Co-Investigator

Novel methods of prevention and treatment of surgical site infections / MG Corneille

07/01/08 – 06/30/10

$50,000

American Heart Association, South Central Affiliate Beginning Grant-in-Aid 0865241F

Consultant A novel rat model of transfusion-related acute lung injury (TRALI) to study pathogenic contributions of RBC arginase / FK Johnson

07/01/08 – 12/31/10 (no cost extension)

$140,000

USAMRC, DOD W81XWH-07-1-0717

Co-Principal Investigator

Effects of hemoperitoneum-derived carbon monoxide on post-traumatic stability / RM Stewart, RA Johnson

04/01/09 – 03/31/11

$467,692

National Institutes of Health 5G11HD052388 Subcontract

Subcontract Principal Investigator

Salvinorin A: Central Effects on Cardiovascular and Renal Function / RA Johnson

06/01/09 – 05/31/10

$5,000

National Institutes of Health 1SC2HL104639-01A1

Co-Investigator

Central Kappa Opioid Neural Regulation of Cardiovascular and Renal Function / HB Gottlieb

03/08/10 – 02/28/13

$111,591

National Institutes of Health 5R01HL059976

Consultant Carbon monoxide and vascular cell function

01/01/11 – 12/31/13

$1,338,001


Research Students and Trainees Supervised:

1989 – 1991 Maryam Naemi, Honors Research in Biology, Recipient of a 1990 Howard Hughes Undergraduate Research Internship, Department of Physiology, University of Missouri – Columbia

1993 Jennifer Wahls, Undergraduate Biology Major with University of Binghamton, Dept. of Pharmacology, New York Medical College, Valhalla, NY

1994 – 1995 Katie DeSeyn, Veterinary Technology Student with Mercy College Dept. of Pharmacology, New York Medical College, Valhalla, NY

1995 -1996 Keri Callis, Veterinary Technology Student with Mercy College Dept. of Pharmacology, New York Medical College, Valhalla, NY

1993 – 1996 Manuel Lavesa, Graduate Student with Dept. of Pharmacology, New York Medical College, Valhalla, NY

1995 – 1997 Matthew J. Scholer, MD/PhD student with Dept. of Pharmacology, New York Medical College, Valhalla, NY

1996 – 1997 Fruzsina Kozma, Medical Student of Semmelweis University (Budapest, Hungary) on Research Externship at Dept. of Pharmacology, New York Medical College, Valhalla, NY

1998 Claudia Soares Silva, Nursing student, Department of Physiology, Escola Paulista de Medicina São Paulo

1998 Vilaria Almeida, Nursing student, Department of Physiology, Escola Paulista de Medicina São Paulo

1999 – 2000 Kay Coco, Honors Research in Biology, Recipient of a 1999 Howard Hughes Undergraduate Research Internship, Department of Physiology, Tulane University

2000 – 2002 Federico Teran, Technician and Medical Student, Department of Physiology,

Tulane University

2000 Chris Nguyen, Tulane Medical Student, Summer Research Fellowship, Department of Physiology, Tulane University

2001 Jason Rozeski, Tulane Medical Student, Summer Research Fellowship,

Department of Physiology, Tulane University 2001 Steven Hale, Tulane Medical Student, Summer Research Fellowship,

Department of Physiology, Tulane University 2001 – 2002 Hop Van Vu, MD, Postdoctoral Fellow, Department of Physiology, Tulane

University 2002 – 2003 E. Patrick Farley, Tulane Medical Student, Summer Research Fellowship,

Department of Physiology, Tulane University 2003 Rudy M. Ortiz, PhD, Postdoctoral Fellow, Department of Physiology, Tulane

University 2003 – 2006 Keith E. Jackson, PhD, Postdoctoral Fellow, Department of Physiology, Tulane

University


2003 – 2005 Scott D. Appleton, PhD, Postdoctoral Fellow, Department of Physiology, Tulane

University 2003 – 2004 Miguel Graciano, PhD, Postdoctoral Fellow, Department of Physiology, Tulane

University 2004 – 2005 D. S. Adnan Majid (Stanford University), American Physiological Society Summer

Undergraduate Research Fellow, Department of Physiology, Tulane University 2004 – 2005 Blake K. Stevenson, Tulane Medical Student, Summer Research Fellowship,

Department of Physiology, Tulane University 2004 – 2005 Robert R. Newsom, III, Tulane Medical Student, Summer Research Fellowship,

Department of Physiology, Tulane University 2005 – 2006 Mary M. McCarty, Tulane Undergraduate Student, Summer Research

Fellowship, Department of Physiology, Tulane University 2007 – 2008 Helmut Gottlieb, PhD, Postdoctoral Fellow, Department of Surgery, University of

Texas Health Science Center at San Antonio 2007 Kayla M. McGloin, UTHSCSA Medical Student, Medical Student Summer

Research Fellowship, Department of Surgery, University of Texas Health Science Center at San Antonio

2007 – 2009 Peter P. Lopez, MD, Assistant Professor, Masters Student in Masters in Clinical

Science Investigation Program, Department of Surgery, University of Texas Health Science Center at San Antonio

2007 – 2009 Renata Bastos, MD, Assistant Professor, Department of Surgery, University of

Texas Health Science Center at San Antonio 2007 Gabriel E. Burkhardt, MD, Surgical Resident, Department of Surgery, University

of Texas Health Science Center at San Antonio 2007 – 2010 Susannah E. Nicholson, MD, Surgical Research Resident, National Institutes of

Health Loan Repayment Program recipient, Department of Surgery, University of Texas Health Science Center at San Antonio

2009 – 2010 Brittany M. Irle, Highschool Student, Summer Research Fellowship, Department

of Surgery, University of Texas Health Science Center at San Antonio 2010 – 2011 Sarah L. Crandall, UTHSCSA Medical Student, Medical Student Summer

Research Fellowship, Medical Student Research Day poster competition 2nd prize, Department of Surgery, University of Texas Health Science Center at San Antonio


Publications, Peer Reviewed:

1. Johnson RA, Toews ML: Protein kinase-C Activators Sensitize Cyclic AMP accumulation by intact 1321N1 human astrocytoma cells. Mol Pharmacol, 1990; 37:296-303

2. Johnson RA, Arneson-Rotert LM, Hoffman JM, Toews ML: Serum-induced sensitization of cyclic AMP accumulation in 1321N1 human astrocytoma cells. Mol Pharmacol, 1991; 39:399-406

3. Villarreal D, Freeman RH, Johnson RA: Renal effects of ANF (95-126), a new atrial peptide analogue, in dogs with experimental heart failure. Am J Hypertens 1991; 4:508-515

4. Villarreal D, Freeman RH, Johnson RA: Captopril enhances renal responsiveness to ANF in dogs with compensated high-output heart failure. Am J Physiol 262 (Regulatory Integrative Comp Physiol 31) 1992; R509-R516

5. Johnson RA, Freeman RH: Pressure natriuresis in rats during blockade of the L-arginine/nitric oxide pathway. Hypertension 1992, 19:333-338

6. Johnson RA, Freeman RH: Sustained hypertension in the rat induced by chronic blockade of nitric oxide synthesis. Am J Hypertens 1992; 5:919-922

7. Villarreal D, Freeman RH, Johnson RA: Neurohumoral modulators and sodium balance in experimental heart failure. Am J Physiol 264 (Heart Circ Physiol 33) 1993; H1187-H1197

8. Villarreal D, Freeman RH, Johnson RA, Simmons JC: Effects of renal denervation on postprandial sodium excretion in experimental heart failure. Am J Physiol 266 (Regulatory Integrative Comp Physiol 35) 1994; R1599-R1604

9. Johnson RA, Freeman RH: Renin release in rats during blockade of nitric oxide synthesis. Am J Physiol 266 (Regulatory Integrative Comp Physiol 35) 1994; R1723-R1729

10. Johnson RA, Lavesa M, Askari B, Abraham NG, Nasjletti A: A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor role in rats. Hypertension 1995; 25:166-169

11. Johnson RA, Belmonte A, Fan N Y-T, Lavesa M, Nasjletti A, Stier CT: Effect of Ifetroban, a thromboxane-A2 receptor antagonist, in stroke-prone spontaneously hypertensive rats Clin Exper Hypertens 1996; 18:171-188

12. Johnson RA, Lavesa M, DeSeyn K, Scholer MJ, Nasjletti A: Heme oxygenase substrates lower blood pressure in hypertensive rats. Am J Physiol 1996; 271:H1132-H1138

13. Kozma F, Johnson RA, Nasjletti A: Role of carbon monoxide in heme-induced vasodilation. Eur J Pharmacol 1997; 323: R1-R2

14. Johnson RA, Colombari E, Colombari DSA, Lavesa M, Talman WT, Nasjletti A: Role of endogenous carbon monoxide in central regulation of arterial pressure. Hypertension 1997; 30:962-967

15. Johnson RA, Kozma F, Colombari E. Invited Review: Carbon monoxide: From toxin to endogenous modulator of cardiovascular functions. Braz J Med Biol Res 1999; 32:1-14

16. Kozma F, Johnson RA, Zhang F, Yu C, Tong X, Nasjletti A: Contribution of endogenous carbon monoxide of diameter in resistance vessels. Am J Physiol 1999; 276:R1087-R1094

17. Leffler CW, Nasjletti A, Yu C, Johnson RA, Fedinec AL, Walker N: Carbon monoxide and cerebral microvascular tone in newborn pigs. Am J Physiol 1999; 276:H1641-H1646


18. Silva CCS, Almeida VA, Haibara AS, Johnson RA, Colombari E: Role of carbon monoxide in L-glutamate-induced cardiovascular responses in nucleus tractus solitarius of conscious rats. Brain Res 1999; 824:147-152

19. Johnson RA, Johnson FK. The effects of carbon monoxide as a neurotransmitter. Current Opinion in Neurology 2000; 13:709-713

20. Leffler CW, Nasjletti A, Johnson RA, Fedinec AL: Contributions of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets. Am J Physiol Heart Circ Physiol. 2001; 280:H1490-H1495

21. Johnson FK, Teran FJ, Prieto-Carrasquero M, Johnson RA. Vascular effects of an inhibitor of heme oxygenase are enhanced in the absence of nitric oxide. Am J Hypertens 2002; 15:1074-1080

22. Johnson FK, Durante W, Peyton KJ, Johnson RA. Heme oxygenase inhibitor restores arteriolar nitric oxide function in Dahl rats Hypertension 2003; 41:149-155

23. Johnson FK, Johnson RA. Carbon monoxide promotes endothelium-dependent constriction of isolated gracilis muscle arterioles. Am J Physiol Regul Integr Comp Physiol 2003; 285:R536-R541

24. Johnson RA, Teran FJ, Durante W, Peyton KJ, Johnson FK. Enhanced heme oxygenase-mediated coronary vasodilation in Dahl salt-sensitive hypertension. Am J Hypertens 2004; 17:25-30

25. Johnson FK, Durante W, Peyton KJ, Johnson RA. Heme oxygenase-mediated endothelial dysfunction in DOCA-salt, but not in spontaneously hypertensive rat arterioles. Am J Physiol Heart Circ Physiol 2004; 286:H1681-H1687

26. Teran FJ, Johnson RA, Stevenson BK, Peyton KJ, Jackson KE, Appleton SD, Durante W, Johnson FK. Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol 2005; 288:R615-R622

27. Johnson FK, Johnson RA, Peyton KJ, Durante W. Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension. Am J Physiol Regul Integr Comp Physiol 2005; 288:R1057-R1062

28. Johnson FK, Johnson RA, Durante W. Aldosterone promotes endothelial dysfunction via prostacyclin independent of hypertension. Hypertension 2005; 46: 29-30

29. Durante W, Johnson FK, Johnson RA. Heme oxygenase-1 as a therapeutic target in atherosclerosis. Drug Discovery Today: Therapeutic Strategies 2005; 2:201-206

30. Johnson FK, Johnson RA, Durante W, Jackson KE, Stevenson BK, Peyton KJ. Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction. Am J Physiol Regul Integr Comp Physiol 2006; 290: R601-R608

31. Durante W, Johnson FK, Johnson RA. Role of carbon monoxide in cardiovascular function. J Cellular Molecular Medicine 2006; 10:672-686

32. Joshi MS, Furguson TB, Johnson FK, Johnson RA, Parthasarathy S, Lancaster JR. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells Proc Natl Acad Sci USA 2007; 104:9982-9987

33. Leszl-Ishiguro M, Horvath B, Johnson RA, Johnson FK, Lenzser G, Herman P, Horvath EM, Benyo Z. Influence of the heme oxygenase pathway on cerebrocortical blood flow. Neuro Report 2007; 18:1193-1197


34. Durante W, Johnson FK, Johnson RA. Invited review. Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol 2007; 34: 906-911

35. Johnson RA, Johnson FK. Heme oxygenase derived endogenous carbon monoxide impairs flow-induced dilation in resistance vessels. Shock 2008; 29:526-530

36. Lopez PP, Nicholson SE, Burkhardt GE, Johnson RA, Johnson FK. Development of a sleeve gastrectomy weight-loss model in obese Zucker rats. J Surg Res 2009; 157: 243-250

37. Wei Y, Liu XM, Peyton KJ, Wang H, Johnson FK, Johnson RA, Durante W. Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival. Am J Physiol Cell Physiol 2009; 297: C907-C915

38. Johnson RA, Durante W, Craig T, Peyton KJ, Myers JG, Stewart RM, Johnson FK. Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock. J Trauma 2010; 69: 384-391

39. Nicholson SE, Johnson RA, Craig T, Myers JG, Durante W, Stewart RM, Johnson FK. Transfusion-related acute lung injury (TRALI) in a rat model of trauma-hemorrhage. J Trauma 2011; 70: 466-471

40. Nicholson SE, Johnson FK, Durante W, Stewart RM, Johnson RA. Effects of heme oxygenase activity on wound strength. J Surgical Res (under revision)

41. Johnson RA, Stewart RM, DeRosa M, Johnson FK, Crandall S, Durante W. Hemoperitoneum drives carbon monoxide formation and decreases platelet aggregation in trauma patients. Shock (submitted)

Publications, Non-Peer Reviewed: None Books and Book Chapters:

Johnson RA, Johnson FK. The heme-heme oxygenase-carbon monoxide system and hypertension. in Carbon Monoxide and Cardiovascular Functions Edited by R. Wang, CRC Press LLC, 2002, pp. 149-163.

Publications, Abstracts:

1. Toews ML, Johnson RA: Activation of protein kinase C leads to sensitization of cyclic AMP accumulation in intact 1321N1 human astrocytoma cells. FASEB J 1988; 2:A1065

2. Toews ML, Johnson RA: Serum induces sensitization of cAMP accumulation in intact 1321N1 human astrocytoma cells. FASEB J 1990; 4:A1120

3. Villarreal D, Freeman RH, Johnson RA: Natriuretic response to synthetic atrial natriuretic factor (ANF) in dogs with heart failure pretreated with chronic Captopril. FASEB J 1990, 4:A695

4. Freeman RH, Villarreal D, Johnson RA: Renal actions of urodilatin, a putative member of the atrial natriuretic factor family of peptides. FASEB J 1990; 4:A696

5. Villarreal D, Freeman RH, Johnson RA: Renal effects of urodilatin in dogs with heart failure. FASEB J 1991; 5:A1020

6. Johnson RA, Freeman RH: Blockade of endothelium-derived nitric oxide (EDNO) synthesis with L-arginine analogues suppresses renin release and increases both arterial pressure and sodium excretion in rats. FASEB J 1991; 5:A657

7. Freeman RH, Johnson RA: Blockade of endothelium-derived nitric oxide production suppresses renin release and increases both arterial pressure and sodium excretion in rats. Am J Hypertens 1991; 4:68A


8. Villarreal D, Freeman RH, Johnson RA: Neural and hormonal modulation of the renal responses to atrial natriuretic factor in experimental heart failure. Circulation 84 (supp II):1991; II-107

9. Johnson RA, Freeman RH: Pressure natriuresis in rats during blockade of endothelium-derived nitric oxide production. Clin Res 1991; 39:749A

10. Villarreal D, Freeman RH, Johnson RA: Neural and hormonal modulation of the renal responses to atrial natriuretic factor in experimental heart failure. Clin Res 1991; 39:693A

11. Johnson RA, Freeman RH: Blockade of endothelium-derived nitric oxide (EDNO) production inhibits renin release independent of the resulting changes in renal perfusion pressure in rats. JASN 1991; 2:507

12. Johnson RA, Freeman RH: Sustained hypertension in the rat by chronic blockade of nitric oxide synthase. FASEB J 1992; 6:A1469

13. Freeman RH, Johnson RA: Blockade of nitric oxide synthesis directly inhibits renin release in the rat. FASEB J 1992; 6:A1809

14. Villarreal D, Freeman RH, Johnson RA: Renal interactions of atrial natriuretic factor, renal nerves and mineralocorticoid in experimental heart failure. FASEB J 1992; 6:A1233

15. Johnson RA, Askari B, Abraham NG, Nasjletti A: Inhibition of heme oxygenase increases blood pressure in the rat. FASEB J 1994; 8:A43

16. Johnson RA, Nasjletti A: Hemodynamic effects of heme-oxygenase inhibition. Hypertension 1994; 24:379

17. Johnson RA, Lavesa M, DeSeyn K, Nasjletti A: Heme oxygenase substrates lower blood pressure in the SHR. FASEB J 1995; 9:A928

18. Johnson RA, Lavesa M, DeSeyn K, Nasjletti A: Heme oxygenase substrates lower blood pressure in the SHR and during DOCA-salt hypertension. Hypertension 1995, 26:555

19. Johnson RA, Lavesa M, Scholer MJ, Nasjletti A: Preferential vasodepressive actions of heme oxygenase substrates and carbon monoxide in hypertensive rats. FASEB J 1996; 10:3668.

20. Scholer MJ, Johnson RA, Nasjletti A: Carbon monoxide mediates the coronary vasodilator effect of heme in isolated rat hearts. FASEB J 1996; 10:1968

21. Johnson RA, Colombari E, Lavesa M, Colombari DSA, Talman WT, Nasjletti A: Carbon monoxide acts on NTS to lower blood pressure. Hypertension 1996; 28:16

22. Kozma F, Johnson RA, Nasjletti A: Heme-derived carbon monoxide - A novel vasodilator. Hypertension 1997; 29:887

23. Kozma F, Scholer MJ, Johnson RA, Nasjletti A: Vasodilatory function of the heme-heme oxygenase-carbon monoxide system. Microcirculation 1997; 4:158

24. Kozma F, Ligeti L, Monos E, Colombari E, Johnson RA: Heme-derived CO: Endogenous regulator of nitric oxide synthase? Pathophysiology 1998; 5 (S1):245

25. Kozma F, Johnson RA, Tong X, Nasjletti A: Role of carbon monoxide in the regulation of basal tone in resistance vessels. Hypertension 1998; 32: 599 Abs. 60

26. Johnson RA, Nasjletti A: Hemodynamic determinant of the hemodynamic antihypertensive effect of heme-L-lysinate in spontaneously hypertensive rats. Hypertension 1998; 32: 610 Abs. P45

27. Colombari E, Silva CCS, Almeida VA, Haibara AS, Johnson RA: Microinjections of heme oxygenase inhibitors into the NTS attenuate L-glutamate-induced responses in awake Wistar rats. Hypertension 1998; 32: 613 Abs.P66

28. Johnson FK, Teran FJ, Coco KC, Johnson RA: L-NAME, but not phenylephrine enhances the effects of endogenous carbon monoxide on vascular tone in vivo and in vitro. Hypertension 2000; 36:678

29. Johnson FK, Teran FJ, Coco KC, Johnson RA: Vascular effects of endogenous carbon monoxide are enhanced in the absence of endothelium-derived nitric oxide. Acta Haematologica 2000; 103(Suppl 1):72 (Abstract 287)

30. Johnson FK, Teran FJ, Navar LG, Johnson RA: Carbon monoxide promotes endothelium-dependent constriction of gracilis arterioles. FASEB J 2001; 15 (Abstract 42.7)


31. Johnson FK, Teran FJ, Navar LG, Johnson RA: Endogenusly-formed carbon monoxide promotes endothelium-dependent constriction of gracilis arterioles. FASEB J 2001; 15:A773. (Abstract 635.14)

32. Johnson RA, Nguyen CV, Teran FJ, Johnson FK: Carbon monoxide decreases contractility of the paced Langendorff-perfused heart. FASEB J 2001; 15:A1139. (Abstract 891.19)

33. Johnson FK, Teran FJ, Durante W, Johnson RA: An inhibitor of endogenous carbon monoxide production restores arteriolar nitric oxide synthase function in hypertensive Dahl rats. Hypertension 2001; 38: 474. (Abstract 12)

34. Teran FJ, Johnson FK, Durante W, Johnson RA: Heme oxygenase-mediated cardioprotection in hypertensive Dahl salt sensitive rats. Hypertension 2001; 38: 531. (Abstract P227)

35. Johnson FK, Johnson RA: Carbon monoxide promotes dilation of arterioles during nitric oxide clamp. J Investig Med 2002; 50:137A (Abstract 719)

36. Vu HV, Johnson FK, Johnson RA: Heme oxygenase inhibitor promotes vasoconstriction independent of Rho-kinase. J Investig Med 2002; 50:138A (Abstract 721)

37. Rozeski JE, Johnson FK, Johnson RA: Endogenous carbon monoxide chronically contributes to water/sodium homeostasis. J Investig Med 2002; 50:133A (Abstract 699)

38. Hale SS, Johnson FK, Johnson RA: Endogenous carbon monoxide interacts with nitric oxide and acutely promotes water/sodium excretion. J Investig Med 2002; 50:149A (Abstract 784)

39. Wilson AR, Johnson FK, Johnson RA: Intraperitoneal heme and carbon monoxide increase carboxyhemoglobin levels in the anesthetized rat. J Investig Med 2002; 50:137A (Abstract 720)

40. Johnson FK, Johnson RA: L-arginine protects against carbon monoxide-induced vasoconstriction. FASEB J 2002; 16:A851. (Abstract 643.16)

41. Johnson FK, Vu HV, Johnson RA: Endogenous carbon monoxide dilates arterioles during nitric oxide clamp. FASEB J 2002; 16:A128. (Abstract 134.22)

42. Vu HV, Johnson FK, Johnson RA: Heme oxygenase inhibitor induced vasoconstriction is modulated by Ca++ channels. FASEB J 2002; 16:A852. (Abstract 643.23)

43. Vu HV, Johnson FK, Johnson RA: Endogenous carbon monoxide promotes vasodilation independent of Rho-kinase. FASEB J 2002; 16:A128. (Abstract 134.23)

44. Hale SS, Johnson FK, Johnson RA: An inhibitor of endogenously-formed carbon monoxide acutely decreases water/sodium excretion in L-NAME treated rats. FASEB J 2002; 16:A840. (Abstract 640.17)

45. Rozeski JE, Johnson FK, Johnson RA: Endogenous carbon monoxide chronically contributes to water and sodium homeostasis in rats. FASEB J 2002; 16:A840. (Abstract 640.17)

46. Wilson AR, Johnson FK, Johnson RA: Heme and delta aminolevulinic acid increase carboxyhemoglobin levels in the anesthetized rat. FASEB J 2002;16:A851. (Abstract 643.15)

47. Johnson FK, Durante W, Wilson AR, Johnson RA. Endogenous carbon monoxide (CO) contributes to arteriolar nitric oxide (NO) dysfunction in hypertensive Dahl rats. Acta Physiol Hung 2002; 89:111. (Abstract D2PS041#18P)

48. Johnson RA, Johnson FK, Vu HV. Endogenously-formed carbon monoxide (CO) exerts both vasodilatory and vasoconstrictor influences on vascular tone. Acta Physiol Hung 2002; 89:103. (Abstract D2AS041#02S)

49. Johnson FK, Durante W, Johnson RA. An inhibitor of endogenous carbon monoxide production restores arteriolar nitric oxide function in DOCA-salt hypertensive rats. Hypertension 2002; 40:381. (Abstract 12)

50. Farley EP, Johnson FK, Johnson RA. Delta-aminolevulinic acid enhances carbon monoxide formation and acutely promotes water/sodium excretion. J Investig Med 2003; 51:S295. (Abstract 221)

51. Johnson FK, Durante W, Peyton KJ, Johnson RA. Heme oxygenase-1 does not promote endothelial dysfunction in spontaneously hypertensive rats. FASEB J 2003; 17:A1250. (Abstract 808.12)


52. Johnson RA, Farley EP, Johnson FK. Delta-aminolevulinic acid enhances endogenous carbon monoxide formation and acutely promotes water/sodium excretion. FASEB J 2003; 17:A1250. (Abstract 808.11)

53. Johnson RA, Johnson FK. Carbon monoxide-induced vascular effects are not mediated by superoxide. FASEB J 2003; 17:A142-A143. (Abstract 102.25)

54. Appleton SD, Johnson RA, Johnson FK. A heme oxygenase inhibitor restores endothelial vasodilator function in obese Zucker rats. J Investig Med 2004; 52:S265. (Abstract 48)

55. Teran FJ, Johnson RA, Appleton SD, Durante W, Peyton KJ, Johnson FK. Heme oxygenase-mediated endothelial dysfunction develops gradually in hypertensive Dahl rats. J Investig Med 2004; 52:S307. (Abstract 279)

56. Jackson KE, Moehlen MW, Johnson FK, Navar LG, Johnson RA. Carbon monoxide acutely alters water/sodium excretion in L-NAME treated rats. J Investig Med 2004; 52:S300. (Abstract 244)

57. Teran FJ, Johnson RA, Appleton SD, Durante W, Peyton KJ, Johnson FK. Gradual development of heme oxygenase-mediated arteriolar endothelial dysfunction in hypertensive Dahl rats. FASEB J 2004; 18:A272. (Abstract 201.2)

58. Appleton SD, Johnson RA, Durante W, Peyton KJ, Johnson FK. Salt-induced hypertension is associated with endothelial dysfunction and cardiac enlargement in obese Zucker rats. FASEB J 2004; 18:A301. (Abstract 209.1)

59. Appleton SD, Johnson RA, Johnson FK. A heme oxygenase inhibitor restores endothelial vasodilator function in obese Zucker rats. FASEB J 2004; 18:A622. (Abstract 430.13)

60. Johnson FK, Johnson RA, Peyton KJ, Durante W. Arginase inhibition improves arteriolar endothelial function in hypertensive Dahl rats. FASEB J 2004; 18:A301. (Abstract 209.2)

61. Johnson RA, Durante W, Peyton KJ, Johnson FK. Inhibition of endogenous carbon monoxide production restores flow-induced dilation in hypertensive Dahl rats. FASEB J 2004; 18:A275. (Abstract 201.18)

62. Johnson RA, Johnson FK. Endogenous carbon monoxide impairs flow-induced dilation in isolated skeletal muscle arterioles. FASEB J 2004; 18:A251. (Abstract 196.19)

63. Jackson KE, Moehlen MW, Johnson FK, Navar LG, Johnson RA. Endogenous carbon monoxide alters water/sodium excretion independent of renal hemodynamics. FASEB J 2004; 18:A1039. (Abstract 680.26)

64. Johnson FK, Jackson KE, Teran FJ, Durante W, Peyton KJ, Ortiz RM, Johnson RA. Spironolactone prevents cardiovascular/renal failure and endothelial dysfunction in hypertensive Dahl rats. FASEB J 2004; 18:A302. (Abstract 209.4)

65. Johnson FK, Durante W, Peyton KJ, Johnson RA. Endogenous carbon monoxide abolishes flow-induced dilation in hypertensive Dahl arterioles in an L-arginine sensitive manner. Hypertension 2004; 44:541-542. (Abstract P137)

66. Johnson RA, Ortiz RM, Appleton SD, Jackson KE, Navar LG, Johnson FK. AngII induces adrenal heme oxygenase-1 to promote feedback inhibition of aldosterone synthesis. Hypertension 2004; 44:515. (Abstract 86)

67. Johnson RA, Appleton SD, Johnson FK, Majid DSA. Hemorrhagic shock promotes heme oxygenase-mediated endothelial dysfunction in rat arterioles. Circulation 2004; 110:III-1098. (Abstract)

68. Stevenson BK, Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. Heme-derived carbon monoxide promotes endothelial dysfunction and hypertension in obese Zucker rats. J Investig Med 2005; 53:S264. (Abstract 62)

69. Jackson KE, Durante W, Peyton KJ, Johnson RA, Johnson FK. L-arginine restores coronary endothelial function in obese Zucker rats. J Investig Med 2005; 53:S265. (Abstract 65)

70. Newsom RR, Appleton SD, Johnson FK, Johnson RA. Neural endogenous carbon monoxide lowers blood pressure via suppression of peripheral sympathetic neurons. J Investig Med 2005; 53:S267. (Abstract 76)


71. Stevenson BK, Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. Endogenous carbon monoxide promotes endothelial dysfunction in obese Zucker rats. FASEB J 2005; 19:A1237 (Abstract 687.16)

72. Jackson KE, Durante W, Peyton KJ, Johnson RA, Johnson FK. Coronary endothelial function in obese Zucker rats is restored by L-arginine. FASEB J 2005; 19:A634 (Abstract 364.17)

73. Johnson RA, Peyton KJ, Durante W, Johnson FK. Increased endogenous carbon monoxide formation promotes hypertension in obese Zucker rats. FASEB J 2005; 19:A635 (Abstract 364.20)

74. Majid A, Appleton SD, Johnson FK, Johnson RA. Hemorrhagic loss induces heme oxygenase-mediated endothelial dysfunction in rat arterioles. FASEB J 2005; 19:A1224 (Abstract 685.14)

75. Appleton SD, Majid A, Johnson RA. Hemorrhagic loss can increase heme oxygenase1 expression in the absence of inflammation. FASEB J 2005; 19:A1224 (Abstract 685.17)

76. Johnson RA, Newsom RR III, Johnson FK. Neural endogenous carbon monoxide lowers blood pressure via suppression of peripheral sympathetic neurons. FASEB J 19:A604, 2005 (Abstract 355.12)

77. Johnson FK, Stevenson BK, Jackson KE, Peyton KJ, Durante W, Johnson RA. Endogenous carbon monoxide promotes endothelial dysfunction and hypertension in obese Zucker rats. Diabetes 2005; 54 (Suppl 1): A435 (Abstract 1813-P)

78. Durante W, Johnson FK, Johnson RA, Peyton KJ. Arginase induces endothelial dysfunction and hypertension in obese Zucker rats. Diabetes 2005; 54 (Suppl 1): A51 (Abstract 206-OR)

79. Johnson RA, Appleton SD, Johnson FK. Heme oxygenase-derived carbon monoxide decreases cardiac contractility and promotes post hemorrhagic circulatory collapse. Shock 23 Suppl 3, 2005. (Abstract 2)

80. Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. Endogenous carbon monoxide production is increased and contributes to hypertension in Dahl salt-sensitive rats on high-salt diets. Hypertension 2005; 46:862 (Abstract P175)

81. Johnson FK, Jackson KE, Peyton KJ, Durante W, Johnson RA. Endogenous carbon monoxide production is increased and contributes to hypertension and endothelial dysfunction in obese Zucker rats. Hypertension 2005; 46:863 (Abstract P176)

82. Johnson FK, Jackson KE, Lin CS, Peyton KJ, Durante W, Johnson RA. PPARα agonist protects from salt-mediated increase in endogenous carbon monoxide production and blood pressure in Dahl salt-sensitive rats. FASEB J 2006; 20:A306. (Abstract 211.5)

83. Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. High-salt diet increases endogenous carbon monoxide production to promote hypertension in Dahl salt-sensitive rats. FASEB J 2006; 20:A306 (Abstract 211.6)

84. Durante W, Johnson FK, Johnson RA, Liu X-M, Ensenat D, Peyton KJ. Hyperglycemia stimulates vascular arginase activity. FASEB J 2006; 20:A727 (Abstract 465.5)

85. Durante W, Johnson FK, Johnson RA, Peyton KJ. Metabolic syndrome promotes endothelial dysfunction and hypertension via the induction of arginase. FASEB J 2006; 20:A1393 (Abstract 905.8)

86. Johnson FK, Johnson RA, Durante W, Stevenson BK, Peyton KJ. Metabolic syndrome elevates heme oxygenase-derived carbon monoxide formation to promote hypertension via endothelial dysfunction. FASEB J 2006; 20:A1392 (Abstract 905.7)

87. McCarty ME, Johnson FK, Lin CS, Durante W, Johnson RA. Inhibitors of endogenously-formed carbon monoxide arrest bleeding and confer protection in a model of severe hepatic injury. FASEB J 2006; 20:A1384 (Abstract 903.16)

88. Joshi MS, Ferguson B, Johnson FK, Johnson RA, Parthasarathy S, Lancester JR. Nitric Oxide 2006; 14: 47 (Abstract P094)

89. Johnson FK, Johnson RA, Sankaranarayanan K, Peyton KJ, Durante W. Endogenous carbon monoxide production is increased and promotes arteriolar endothelial dysfunction in streptozotocin-treated diabetic rats. Diabetes 2006; 55: A33 (Abstract 140-OR)


90. Durante W, Johnson FK, Johnson RA, Sankaranarayanan K, Peyton KJ. Arginase induces endothelial dysfunction in streptozotocin-treated diabetic rats. Diabetes 2006; 55: A33 (Abstract 137-OR)

91. Johnson RA, McCarty M, Johnson FK, Lin CS, Durante W. Inhibitors of endogenously-formed carbon monoxide arrest bleeding and maintain blood pressure in a model of severe hepatic injury. Shock 2006 (Abstract P91)

92. Johnson FK, Durante W, Johnson RA. PPARα, but not PPARγ, agonist protects against salt-mediated increases in endogenous carbon monoxide production and blood pressure in Dahl salt-sensitive rats. Hypertension 2006; 48: e69 (Abstract P123)

93. Durante W, Johnson FK, Peyton KJ, Sankaranarayanan K, Johnson RA. Hyperhomocysteinemia stimulates endogenous carbon monoxide production to promote endothelial dysfunction in rats. Hypertension 2006; 48: e93 (Abstract P252)

94. Johnson FK, Durante W, Stewart RM, Johnson RA. Arginase contributes to arteriolar endothelial dysfunction following hemorrhage. FASEB J 2007; 21: A1404 (Abstract 967.6)

95. Johnson RA, Johnson FK. Dietary zinc can generate Zn-protoporphyrin, reduce endogenous formation of CO and stem bleeding in soft tissue injury. FASEB J 2007; 21: A1279 (Abstract 914.6)

96. Johnson RA, Johnson FK. Blood loss induces heme oxygenase-mediated carbon monoxide formation to promote endothelial dysfunction in rat arterioles. FASEB J 2007; 21: A1280 (Abstract 914.8)

97. Johnson FK, Durante W, Stewart RM, Johnson RA. Arginase contributes to hemorrhage-induced arteriolar endothelial dysfunction. Shock 2007; 27 (Suppl 1):77 (Abstract P166)

98. Johnson RA, Johnson FK. Boosting dietary zinc inhibits endogenous carbon monoxide formation and stems bleeding. Shock 2007; 27 (Suppl 1):68 (Abstract P137)

99. Durante W, Johnson FK, Johnson RA, Azam MA, Peyton KJ. Arginase promotes endothelial dysfunction and hypertension in obesity. Circulation 2007; 116: 173. (Abstract)

100. Johnson RA, McGloin KE, Johnson FK, Nicholson SE, Stewart RM. Chronic heme promotes sustained elevations of CO excretion, anorexia, attenuated physical activity and circulatory collapse in rats. FASEB J 2008; (Abstract 1227.10)

101. Lopez PP, Nicholson SE, Burkhardt GE, Johnson RA, Johnson FK. Development of a sleeve gastrectomy weight-loss model in obese Zucker rats. FASEB J, 2008. (Abstract 1226.11)

102. Nicholson SE, Stewart RM, Johnson FK, Johnson RA. Heme derived iron reduces wound thickness. J Am Coll Surg 2008; 207: S60, 2008. (Abstract)

103. Liu XM, Wei Y, Peyton KJ, Wang H, Johnson FK, Johnson RA, Durante W. Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival. FASEB J, 2009. (EB abstract)

104. Johnson RA, Craig T, Johnson FK. Hemorrhagic shock increases vascular smooth muscle tone preferentially at low pressures via heme oxygenase activity. Shock 2009; 31:14-15

105. Nicholson SE, Johnson RA, Craig T, Durante W, Stewart RM, Johnson FK. Post-Hemorrhage Transfusion of Aged Packed Red Blood Cells Promotes Lung Injury in Rats. Shock 2009; 31:53-54

106. Johnson FK, Nicholson SE, Johnson RA, Craig TA, Myers JG, Durante W, Stewart RM. Transfusion-related acute lung injury (TRALI) in a rat trauma-hemorrhage model. Shock 2010; 33:71 (P238)

107. Nicholson SE, Johnson RA, Craig T, Johnson FK, Myers JG, Stewart RM. Hemoperitoneum elevates carbon monoxide excretion. Shock 2010; 33:34-35 (Abstract P117)

108. Johnson RA, Craig T, Johnson FK, Myers JG. Carbon monoxide is the heme oxygenase product that increases vascular smooth muscle tone preferentially at low pressures after hemorrhagic shock. Shock 2010; 33:47 (Abstract P158)

109. Johnson FK, Durante W, Johnson RA, Craig T, Myers JG, Stewart RM. Increased plasma arginase activity contributes to acute lung injury (ALI) following resuscitation with stored packed


red blood cells (PRBC) in a rat model of trauma/hemorrhage. FASEB J 2011 (Abstract 642.3 accepted to EB2011)

110. Johnson RA, Crandall SL, Irle BM, Craig T, Johnson FK, Stewart RM. Hemoperitoneum: Abdominal Blood, Endogenous Carbon Monoxide and Hemostasis. FASEB J 2011 (Abstract 642.4 accepted to EB2011)

111. Johnson RA, Stewart RM, Meyers JG, Johnson FK. Hemoperitoneum drives carbon monoxide formation and decreases platelet aggregation in trauma patients. Shock 2011 (Submitted)

112. Johnson RA, Johnson FK, Durante W, Stewart RM. Hemoperitonium Increases Carbon Monoxide and Reduces Platelet Aggregation in Trauma Patients. FASEB J 2012; 26:1132.6

113. Johnson FK, Durante W, Johnson RA, Stewart RM. Plasma arginase promotes acute lung injury (ALI) in a rat model of trauma/hemorrhage and resuscitation. FASEB J 2012; 26:1132.5

Publications, Letters to Editors: None Professional Presentations:

1. Toews ML, Johnson RA: Activation of protein kinase C leads to sensitization of cyclic AMP accumulation in intact 1321N1 human astrocytoma cells. FASEB J 1988; 2:A1065

2. Toews ML, Johnson RA: Serum induces sensitization of cAMP accumulation in intact 1321N1 human astrocytoma cells. FASEB J 1990; 4:A1120

3. Villarreal D, Freeman RH, Johnson RA: Natriuretic response to synthetic atrial natriuretic factor (ANF) in dogs with heart failure pretreated with chronic Captopril. FASEB J 1990, 4:A695

4. Freeman RH, Villarreal D, Johnson RA: Renal actions of urodilatin, a putative member of the atrial natriuretic factor family of peptides. FASEB J 1990; 4:A696

5. Villarreal D, Freeman RH, Johnson RA: Renal effects of urodilatin in dogs with heart failure. FASEB J 1991; 5:A1020

6. Johnson RA, Freeman RH: Blockade of endothelium-derived nitric oxide (EDNO) synthesis with L-arginine analogues suppresses renin release and increases both arterial pressure and sodium excretion in rats. FASEB J 1991; 5:A657

7. Freeman RH, Johnson RA: Blockade of endothelium-derived nitric oxide production suppresses renin release and increases both arterial pressure and sodium excretion in rats. Am J Hypertens 1991; 4:68A

8. Villarreal D, Freeman RH, Johnson RA: Neural and hormonal modulation of the renal responses to atrial natriuretic factor in experimental heart failure. Circulation 84 (supp II):1991; II-107

9. Johnson RA, Freeman RH: Pressure natriuresis in rats during blockade of endothelium-derived nitric oxide production. Clin Res 1991; 39:749A

10. Villarreal D, Freeman RH, Johnson RA: Neural and hormonal modulation of the renal responses to atrial natriuretic factor in experimental heart failure. Clin Res 1991; 39:693A

11. Johnson RA, Freeman RH: Blockade of endothelium-derived nitric oxide (EDNO) production inhibits renin release independent of the resulting changes in renal perfusion pressure in rats. JASN 1991; 2:507

12. Johnson RA, Freeman RH: Sustained hypertension in the rat by chronic blockade of nitric oxide synthase. FASEB J 1992; 6:A1469

13. Freeman RH, Johnson RA: Blockade of nitric oxide synthesis directly inhibits renin release in the rat. FASEB J 1992; 6:A1809

14. Villarreal D, Freeman RH, Johnson RA: Renal interactions of atrial natriuretic factor, renal nerves and mineralocorticoid in experimental heart failure. FASEB J 1992; 6:A1233

15. Johnson RA, Askari B, Abraham NG, Nasjletti A: Inhibition of heme oxygenase increases blood pressure in the rat. FASEB J 1994; 8:A43


16. Johnson RA, Nasjletti A: Hemodynamic effects of heme-oxygenase inhibition. Hypertension 1994; 24:379

17. Johnson RA, Lavesa M, DeSeyn K, Nasjletti A: Heme oxygenase substrates lower blood pressure in the SHR. FASEB J 1995; 9:A928

18. Johnson RA, Lavesa M, DeSeyn K, Nasjletti A: Heme oxygenase substrates lower blood pressure in the SHR and during DOCA-salt hypertension. Hypertension 1995, 26:555

19. Johnson RA, Lavesa M, Scholer MJ, Nasjletti A: Preferential vasodepressive actions of heme oxygenase substrates and carbon monoxide in hypertensive rats. FASEB J 1996; 10:3668.

20. Scholer MJ, Johnson RA, Nasjletti A: Carbon monoxide mediates the coronary vasodilator effect of heme in isolated rat hearts. FASEB J 1996; 10:1968

21. Johnson RA, Colombari E, Lavesa M, Colombari DSA, Talman WT, Nasjletti A: Carbon monoxide acts on NTS to lower blood pressure. Hypertension 1996; 28:16

22. Kozma F, Johnson RA, Nasjletti A: Heme-derived carbon monoxide - A novel vasodilator. Hypertension 1997; 29:887

23. Kozma F, Scholer MJ, Johnson RA, Nasjletti A: Vasodilatory function of the heme-heme oxygenase-carbon monoxide system. Microcirculation 1997; 4:158

24. Haibara AB, Silva CCS, Almeida VA, Johnson RA, Colombari E: Microinjection of heme oxygenase inhibitor (ZnDPBG) into the nucleus tractus solitarii (NTS) blocked the baroreflex and cardiovascular responses induced by L-glutamate in conscious rats. Abstracts of Society for Neuroscience 1997; 23 (Part 1):148

25. Kozma F, Ligeti L, Monos E, Colombari E, Johnson RA: Heme-derived CO: Endogenous regulator of nitric oxide synthase? Pathophysiology 1998; 5 (S1):245

26. Silva CCS, Almeida VA, Landulpho CDA Johnson RA, Colambari E: Efeito do Cromo Mesoporfirina (CrMP) sobre as respostas cardiovasculares induzidas pela microinjeção de L-glutamato (L-Glu) no NTS de ratos não anestesiados (trans: Effect of Chromium Mesoporphyrin on the cardiovascular responses induced by microinjections of L-glutamate into the NTS of unanesthetized rats). Abstracts of XIII Reunion of FeSBE, 1998; p. 257 (abstract 02.072)

27. Johnson RA, Kozma F, Colombari E: Heme-derived CO:Endothelium/sGC-independent vasodilation and endothelium/sGC-dependent vasoconstriction. Abstracts of XIII Reunion of FeSBE, 1998; p. 261 (abstract 05.049)

28. Kozma F, Johnson RA, Tong X, Nasjletti A: Role of carbon monoxide in the regulation of basal tone in resistance vessels. Hypertension 1998; 32: 599 Abs. 60

29. Johnson RA, Nasjletti A: Hemodynamic determinant of the hemodynamic antihypertensive effect of heme-L-lysinate in spontaneously hypertensive rats. Hypertension 1998; 32: 610 Abs. P45

30. Colombari E, Silva CCS, Almeida VA, Haibara AS, Johnson RA: Microinjections of heme oxygenase inhibitors into the NTS attenuate L-glutamate-induced responses in awake Wistar rats. Hypertension 1998; 32: 613 Abs.P66

31. Johnson FK, Teran FJ, Coco KC, Johnson RA: L-NAME, but not phenylephrine enhances the effects of endogenous carbon monoxide on vascular tone in vivo and in vitro. Hypertension 2000; 36:678

32. Johnson FK, Coco K, Teran F, Johnson RA: Unique interaction between the carbon monoxide and nitric oxide systems on vascular tone. Addendum to EB 2000 (presented at the Experimental Biology 2000 meeting)

33. Johnson FK, Teran FJ, Coco KC, Johnson RA: Vascular effects of endogenous carbon monoxide are enhanced in the absence of endothelium-derived nitric oxide. Acta Haematologica 2000; 103(Suppl 1):72 (Abstract 287)

34. Johnson FK, Teran FJ, Navar LG, Johnson RA: Carbon monoxide promotes endothelium-dependent constriction of gracilis arterioles. FASEB J 2001; 15 (Abstract 42.7)

35. Johnson FK, Teran FJ, Navar LG, Johnson RA: Endogenusly-formed carbon monoxide promotes endothelium-dependent constriction of gracilis arterioles. FASEB J 2001; 15:A773. (Abstract 635.14)


36. Johnson RA, Nguyen CV, Teran FJ, Johnson FK: Carbon monoxide decreases contractility of the paced Langendorff-perfused heart. FASEB J 2001; 15:A1139. (Abstract 891.19)

37. Teran FJ, Johnson FK, Johnson RA: Endogenously-formed carbon monoxide and nitric oxide interact to affect coronary blood flow and cardiac contractility. EB2001 Late-Breaking Abstracts 2001: page 6. (Abstract LB13)

38. Horváth B, Hrabák A, Johnson RA, Sándor P, Benyó Z: Heme oxygenase blockade increases nitric oxide synthase activity without changing blood or vascular resistance in the hypothalamus of rats. (XXth International Symposium on Cerebral Blood Flow and Metabolism, June 9-13, 2001, Taipei Japan)

39. Johnson FK, Teran FJ, Durante W, Johnson RA: An inhibitor of endogenous carbon monoxide production restores arteriolar nitric oxide synthase function in hypertensive Dahl rats. Hypertension 2001; 38: 474. (Abstract 12)

40. Teran FJ, Johnson FK, Durante W, Johnson RA: Heme oxygenase-mediated cardioprotection in hypertensive Dahl salt sensitive rats. Hypertension 2001; 38: 531. (Abstract P227)

41. Johnson FK, Johnson RA: Carbon monoxide promotes dilation of arterioles during nitric oxide clamp. J Investig Med 2002; 50:137A (Abstract 719)

42. Vu HV, Johnson FK, Johnson RA: Heme oxygenase inhibitor promotes vasoconstriction independent of Rho-kinase. J Investig Med 2002; 50:138A (Abstract 721)

43. Rozeski JE, Johnson FK, Johnson RA: Endogenous carbon monoxide chronically contributes to water/sodium homeostasis. J Investig Med 2002; 50:133A (Abstract 699)

44. Hale SS, Johnson FK, Johnson RA: Endogenous carbon monoxide interacts with nitric oxide and acutely promotes water/sodium excretion. J Investig Med 2002; 50:149A (Abstract 784)

45. Wilson AR, Johnson FK, Johnson RA: Intraperitoneal heme and carbon monoxide increase carboxyhemoglobin levels in the anesthetized rat. J Investig Med 2002; 50:137A (Abstract 720)

46. Johnson FK, Johnson RA: L-arginine protects against carbon monoxide-induced vasoconstriction. FASEB J 2002; 16:A851. (Abstract 643.16)

47. Johnson FK, Vu HV, Johnson RA: Endogenous carbon monoxide dilates arterioles during nitric oxide clamp. FASEB J 2002; 16:A128. (Abstract 134.22)

48. Vu HV, Johnson FK, Johnson RA: Heme oxygenase inhibitor induced vasoconstriction is modulated by Ca++ channels. FASEB J 2002; 16:A852. (Abstract 643.23)

49. Vu HV, Johnson FK, Johnson RA: Endogenous carbon monoxide promotes vasodilation independent of Rho-kinase. FASEB J 2002; 16:A128. (Abstract 134.23)

50. Hale SS, Johnson FK, Johnson RA: An inhibitor of endogenously-formed carbon monoxide acutely decreases water/sodium excretion in L-NAME treated rats. FASEB J 2002; 16:A840. (Abstract 640.17)

51. Rozeski JE, Johnson FK, Johnson RA: Endogenous carbon monoxide chronically contributes to water and sodium homeostasis in rats. FASEB J 2002; 16:A840. (Abstract 640.17)

52. Wilson AR, Johnson FK, Johnson RA: Heme and delta aminolevulinic acid increase carboxyhemoglobin levels in the anesthetized rat. FASEB J 2002;16:A851. (Abstract 643.15)

53. Johnson FK, Durante W, Wilson AR, Johnson RA. Endogenous carbon monoxide (CO) contributes to arteriolar nitric oxide (NO) dysfunction in hypertensive Dahl rats. Acta Physiol Hung 2002; 89:111. (Abstract D2PS041#18P)

54. Johnson RA, Johnson FK, Vu HV. Endogenously-formed carbon monoxide (CO) exerts both vasodilatory and vasoconstrictor influences on vascular tone. Acta Physiol Hung 2002; 89:103. (Abstract D2AS041#02S)

55. Johnson FK, Durante W, Johnson RA. An inhibitor of endogenous carbon monoxide production restores arteriolar nitric oxide function in DOCA-salt hypertensive rats. Hypertension 2002; 40:381. (Abstract 12)

56. Farley EP, Johnson FK, Johnson RA. Delta-aminolevulinic acid enhances carbon monoxide formation and acutely promotes water/sodium excretion. J Investig Med 2003; 51:S295. (Abstract 221)


57. Johnson FK, Durante W, Peyton KJ, Johnson RA. Heme oxygenase-1 does not promote endothelial dysfunction in spontaneously hypertensive rats. FASEB J 2003; 17:A1250. (Abstract 808.12)

58. Johnson RA, Farley EP, Johnson FK. Delta-aminolevulinic acid enhances endogenous carbon monoxide formation and acutely promotes water/sodium excretion. FASEB J 2003; 17:A1250. (Abstract 808.11)

59. Johnson RA, Johnson FK. Carbon monoxide-induced vascular effects are not mediated by superoxide. FASEB J 2003; 17:A142-A143. (Abstract 102.25)

60. Johnson FK, Durante W, Peyton KJ, Johnson RA. Spontaneously hypertensive rats do not display heme oxygenase-1-mediated endothelial dysfunction. IASH Abstracts 2003

61. Johnson RA, Johnson FK. Carbon monoxide-induced vascular effects are tempol insensitive. IASH Abstracts 2003

62. Ortiz RM, Johnson FK, Durante W, Navar LG, Johnson RA. A heme oxygenase inhibitor increases AII-stimulated plasma aldosterone. APS Conference: Aldosterone and ENaC: From genetics to physiology, 2003

63. Appleton SD, Johnson RA, Johnson FK. A heme oxygenase inhibitor restores endothelial vasodilator function in obese Zucker rats. J Investig Med 2004; 52:S265. (Abstract 48)

64. Teran FJ, Johnson RA, Appleton SD, Durante W, Peyton KJ, Johnson FK. Heme oxygenase-mediated endothelial dysfunction develops gradually in hypertensive Dahl rats. J Investig Med 2004; 52:S307. (Abstract 279)

65. Jackson KE, Moehlen MW, Johnson FK, Navar LG, Johnson RA. Carbon monoxide acutely alters water/sodium excretion in L-NAME treated rats. J Investig Med 2004; 52:S300. (Abstract 244)

66. Teran FJ, Johnson RA, Appleton SD, Durante W, Peyton KJ, Johnson FK. Gradual development of heme oxygenase-mediated arteriolar endothelial dysfunction in hypertensive Dahl rats. FASEB J 2004; 18:A272. (Abstract 201.2)

67. Appleton SD, Johnson RA, Durante W, Peyton KJ, Johnson FK. Salt-induced hypertension is associated with endothelial dysfunction and cardiac enlargement in obese Zucker rats. FASEB J 2004; 18:A301. (Abstract 209.1)

68. Appleton SD, Johnson RA, Johnson FK. A heme oxygenase inhibitor restores endothelial vasodilator function in obese Zucker rats. FASEB J 2004; 18:A622. (Abstract 430.13)

69. Johnson FK, Johnson RA, Peyton KJ, Durante W. Arginase inhibition improves arteriolar endothelial function in hypertensive Dahl rats. FASEB J 2004; 18:A301. (Abstract 209.2)

70. Johnson RA, Durante W, Peyton KJ, Johnson FK. Inhibition of endogenous carbon monoxide production restores flow-induced dilation in hypertensive Dahl rats. FASEB J 2004; 18:A275. (Abstract 201.18)

71. Johnson RA, Johnson FK. Endogenous carbon monoxide impairs flow-induced dilation in isolated skeletal muscle arterioles. FASEB J 2004; 18:A251. (Abstract 196.19)

72. Jackson KE, Moehlen MW, Johnson FK, Navar LG, Johnson RA. Endogenous carbon monoxide alters water/sodium excretion independent of renal hemodynamics. FASEB J 2004; 18:A1039. (Abstract 680.26)

73. Johnson FK, Jackson KE, Teran FJ, Durante W, Peyton KJ, Ortiz RM, Johnson RA. Spironolactone prevents cardiovascular/renal failure and endothelial dysfunction in hypertensive Dahl rats. FASEB J 2004; 18:A302. (Abstract 209.4)

74. Johnson FK, Durante W, Peyton KJ, Johnson RA. Endogenous carbon monoxide abolishes flow-induced dilation in hypertensive Dahl arterioles in an L-arginine sensitive manner. Hypertension 2004; 44:541-542. (Abstract P137)

75. Johnson RA, Ortiz RM, Appleton SD, Jackson KE, Navar LG, Johnson FK. AngII induces adrenal heme oxygenase-1 to promote feedback inhibition of aldosterone synthesis. Hypertension 2004; 44:515. (Abstract 86)


76. Johnson RA, Appleton SD, Johnson FK, Majid DSA. Hemorrhagic shock promotes heme oxygenase-mediated endothelial dysfunction in rat arterioles. Circulation 2004; 110:III-1098. (Abstract)

77. Stevenson BK, Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. Heme-derived carbon monoxide promotes endothelial dysfunction and hypertension in obese Zucker rats. J Investig Med 2005; 53:S264. (Abstract 62)

78. Jackson KE, Durante W, Peyton KJ, Johnson RA, Johnson FK. L-arginine restores coronary endothelial function in obese Zucker rats. J Investig Med 2005; 53:S265. (Abstract 65)

79. Newsom RR, Appleton SD, Johnson FK, Johnson RA. Neural endogenous carbon monoxide lowers blood pressure via suppression of peripheral sympathetic neurons. J Investig Med 2005; 53:S267. (Abstract 76)

80. Stevenson BK, Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. Endogenous carbon monoxide promotes endothelial dysfunction in obese Zucker rats. FASEB J 2005; 19:A1237 (Abstract 687.16)

81. Jackson KE, Durante W, Peyton KJ, Johnson RA, Johnson FK. Coronary endothelial function in obese Zucker rats is restored by L-arginine. FASEB J 2005; 19:A634 (Abstract 364.17)

82. Johnson RA, Peyton KJ, Durante W, Johnson FK. Increased endogenous carbon monoxide formation promotes hypertension in obese Zucker rats. FASEB J 2005; 19:A635 (Abstract 364.20)

83. Majid A, Appleton SD, Johnson FK, Johnson RA. Hemorrhagic loss induces heme oxygenase-mediated endothelial dysfunction in rat arterioles. FASEB J 2005; 19:A1224 (Abstract 685.14)

84. Appleton SD, Majid A, Johnson RA. Hemorrhagic loss can increase heme oxygenase1 expression in the absence of inflammation. FASEB J 2005; 19:A1224 (Abstract 685.17)

85. Johnson RA, Newsom RR III, Johnson FK. Neural endogenous carbon monoxide lowers blood pressure via suppression of peripheral sympathetic neurons. FASEB J 19:A604, 2005 (Abstract 355.12)

86. Durante W, Liu XM, Ensenat D, Johnson RA, Johnson FK, Peyton KJ. Glucose stimulates arginase activity in cultured vascular cells. Addendum to EB 2005 (presented at the Experimental Biology 2005 meeting)

87. Johnson FK, Stevenson BK, Jackson KE, Peyton KJ, Durante W, Johnson RA. Endogenous carbon monoxide promotes endothelial dysfunction and hypertension in obese Zucker rats. Diabetes 2005; 54 (Suppl 1): A435 (Abstract 1813-P)

88. Durante W, Johnson FK, Johnson RA, Peyton KJ. Arginase induces endothelial dysfunction and hypertension in obese Zucker rats. Diabetes 2005; 54 (Suppl 1): A51 (Abstract 206-OR)

89. Johnson RA, Appleton SD, Johnson FK. Heme oxygenase-derived carbon monoxide decreases cardiac contractility and promotes post hemorrhagic circulatory collapse. Shock 23 Suppl 3, 2005. (Abstract 2)

90. Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. Endogenous carbon monoxide production is increased and contributes to hypertension in Dahl salt-sensitive rats on high-salt diets. Hypertension 2005; 46:862 (Abstract P175)

91. Johnson FK, Jackson KE, Peyton KJ, Durante W, Johnson RA. Endogenous carbon monoxide production is increased and contributes to hypertension and endothelial dysfunction in obese Zucker rats. Hypertension 2005; 46:863 (Abstract P176)

92. Johnson FK, Johnson RA, Durante W, Jackson KE, Stevenson BK, Peyton KJ. Obesity increases HO-derived CO formation to promote hypertension and endothelial dysfunction. International Heme Oxygenase Conference 2005

93. Johnson RA, Johnson FK, Jackson KE. Endogenous CO inhibits NOS, impairs flow-induced dilation and can enhance pressor responsiveness. International Heme Oxygenase Conference 2005

94. Johnson RA, Majid DSA, Appleton SD, Johnson FK, Jackson KE, McCarty ME, Lin CS. Heme-L-lysinate increases CO formation and acutely promotes hemorrhagic circulatory collapse. International Heme Oxygenase Conference 2005


95. Johnson FK, Jackson KE, Lin CS, Peyton KJ, Durante W, Johnson RA. PPARα agonist protects from salt-mediated increase in endogenous carbon monoxide production and blood pressure in Dahl salt-sensitive rats. FASEB J 2006; 20:A306. (Abstract 211.5)

96. Johnson RA, Jackson KE, Peyton KJ, Durante W, Johnson FK. High-salt diet increases endogenous carbon monoxide production to promote hypertension in Dahl salt-sensitive rats. FASEB J 2006; 20:A306 (Abstract 211.6)

97. Durante W, Johnson FK, Johnson RA, Liu X-M, Ensenat D, Peyton KJ. Hyperglycemia stimulates vascular arginase activity. FASEB J 2006; 20:A727 (Abstract 465.5)

98. Durante W, Johnson FK, Johnson RA, Peyton KJ. Metabolic syndrome promotes endothelial dysfunction and hypertension via the induction of arginase. FASEB J 2006; 20:A1393 (Abstract 905.8)

99. Johnson FK, Johnson RA, Durante W, Stevenson BK, Peyton KJ. Metabolic syndrome elevates heme oxygenase-derived carbon monoxide formation to promote hypertension via endothelial dysfunction. FASEB J 2006; 20:A1392 (Abstract 905.7)

100. McCarty ME, Johnson FK, Lin CS, Durante W, Johnson RA. Inhibitors of endogenously-formed carbon monoxide arrest bleeding and confer protection in a model of severe hepatic injury. FASEB J 2006; 20:A1384 (Abstract 903.16)

101. Joshi MS, Ferguson B, Johnson FK, Johnson RA, Parthasarathy S, Lancester JR. Nitric Oxide 2006; 14: 47 (Abstract P094)

102. Johnson FK, Johnson RA, Sankaranarayanan K, Peyton KJ, Durante W. Endogenous carbon monoxide production is increased and promotes arteriolar endothelial dysfunction in streptozotocin-treated diabetic rats. Diabetes 2006; 55: A33 (Abstract 140-OR)

103. Durante W, Johnson FK, Johnson RA, Sankaranarayanan K, Peyton KJ. Arginase induces endothelial dysfunction in streptozotocin-treated diabetic rats. Diabetes 2006; 55: A33 (Abstract 137-OR)

104. Johnson RA, McCarty M, Johnson FK, Lin CS, Durante W. Inhibitors of endogenously-formed carbon monoxide arrest bleeding and maintain blood pressure in a model of severe hepatic injury. Shock 2006 (Abstract P91)

105. Johnson FK, Durante W, Johnson RA. PPARα, but not PPARγ, agonist protects against salt-mediated increases in endogenous carbon monoxide production and blood pressure in Dahl salt-sensitive rats. Hypertension 2006; 48: e69 (Abstract P123)

106. Durante W, Johnson FK, Peyton KJ, Sankaranarayanan K, Johnson RA. Hyperhomocysteinemia stimulates endogenous carbon monoxide production to promote endothelial dysfunction in rats. Hypertension 2006; 48: e93 (Abstract P252)

107. Johnson FK, Durante W, Stewart RM, Johnson RA. Arginase contributes to arteriolar endothelial dysfunction following hemorrhage. FASEB J 2007; 21: A1404 (Abstract 967.6)

108. Johnson RA, Johnson FK. Dietary zinc can generate Zn-protoporphyrin, reduce endogenous formation of CO and stem bleeding in soft tissue injury. FASEB J 2007; 21: A1279 (Abstract 914.6)

109. Johnson RA, Johnson FK. Blood loss induces heme oxygenase-mediated carbon monoxide formation to promote endothelial dysfunction in rat arterioles. FASEB J 2007; 21: A1280 (Abstract 914.8)

110. Johnson FK, Durante W, Stewart RM, Johnson RA. Arginase contributes to hemorrhage-induced arteriolar endothelial dysfunction. Shock 2007; 27 (Suppl 1):77 (Abstract P166)

111. Johnson RA, Johnson FK. Boosting dietary zinc inhibits endogenous carbon monoxide formation and stems bleeding. Shock 2007; 27 (Suppl 1):68 (Abstract P137)

112. Durante W, Johnson FK, Johnson RA, Azam MA, Peyton KJ. Arginase promotes endothelial dysfunction and hypertension in obesity. Circulation 2007; 116: 173. (Abstract)

113. Johnson RA, McGloin KE, Johnson FK, Nicholson SE, Stewart RM. Chronic heme promotes sustained elevations of CO excretion, anorexia, attenuated physical activity and circulatory collapse in rats. FASEB J 2008; (Abstract 1227.10)


114. Lopez PP, Nicholson SE, Burkhardt GE, Johnson RA, Johnson FK. Development of a sleeve gastrectomy weight-loss model in obese Zucker rats. FASEB J, 2008. (Abstract 1226.11)

115. Nicholson SE, Stewart RM, Johnson FK, Johnson RA. Heme derived iron reduces wound thickness. J Am Coll Surg 2008; 207: S60, 2008. (Abstract)

116. Liu XM, Wei Y, Peyton KJ, Wang H, Johnson FK, Johnson RA, Durante W. Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival. FASEB J, 2009. (EB abstract)

117. Johnson RA, Craig T, Johnson FK. Hemorrhagic shock increases vascular smooth muscle tone preferentially at low pressures via heme oxygenase activity. Shock 2009; 31:14-15

118. Nicholson SE, Johnson RA, Craig T, Durante W, Stewart RM, Johnson FK. Post-Hemorrhage Transfusion of Aged Packed Red Blood Cells Promotes Lung Injury in Rats. Shock 2009; 31:53-54

119. Johnson FK, Nicholson SE, Johnson RA, Craig TA, Myers JG, Durante W, Stewart RM. Transfusion-related acute lung injury (TRALI) in a rat trauma-hemorrhage model. Shock 2010; 33:71 (P238)

120. Nicholson SE, Johnson RA, Craig T, Johnson FK, Myers JG, Stewart RM. Hemoperitoneum elevates carbon monoxide excretion. Shock 2010; 33:34-35 (Abstract P117)

121. Johnson RA, Craig T, Johnson FK, Myers JG. Carbon monoxide is the heme oxygenase product that increases vascular smooth muscle tone preferentially at low pressures after hemorrhagic shock. Shock 2010; 33:47 (Abstract P158)

122. Durante W, Johnson FK, Johnson RA, Azam MA, Shebib AR, Peyton KJ. L-arginine depletion promotes hypertension in obese Zucker rats. International Society of Hypertension. Abstract Book p200, 2010.

123. Johnson FK, Durante W, Johnson RA, Craig T, Myers JG, Stewart RM. Increased plasma arginase activity contributes to acute lung injury (ALI) following resuscitation with stored packed red blood cells (PRBC) in a rat model of trauma/hemorrhage. FASEB J 2011 (Abstract 642.3 accepted to EB2011)

124. Johnson RA, Crandall SL, Irle BM, Craig T, Johnson FK, Stewart RM. Hemoperitoneum: abdominal blood, endogenous carbon monoxide and hemostasis. FASEB J 2011 (Abstract 642.4 EB2011)

125. Crandall S, Irle B, Nicholson SE, Craig T, Stewart RM, Johnson RA. Hemopertioneum: abdominal blood, endogenous carbon monoxide and hemostasis at risk. UTHSCSA Report Spring 2011

126. Johnson RA, Stewart RM, Meyers JG, Johnson FK. Trauma patients with hemoperitoneum display elevated carbon monoxide excretion and impaired platelet aggregation. Shock 35:7 2011

127. Johnson RA, Johnson FK, Durante W, Stewart RM. Hemoperitonium Increases Carbon Monoxide and Reduces Platelet Aggregation in Trauma Patients. FASEB J 2012; 26:1132.6

128. Johnson FK, Durante W, Johnson RA, Stewart RM. Plasma arginase promotes acute lung injury (ALI) in a rat model of trauma/hemorrhage and resuscitation. FASEB J 2012; 26:1132.5

129. Johnson RA. Endogenous carbon monoxide as a therapeutic target for destabilization in trauma. AT Still Medical Sciences Presentation April 30, 2012


Local, State, and National Committees:

2002 – 2004 Library Committee, Department of Physiology, Tulane University

2006 – 2008 Witten B. Russ International Student Travel (WRIST) Fellowship Committee, Department of Surgery, University of Texas Health Science Center at San Antonio

2006 – 2008 Research Committee, Department of Surgery, University of Texas Health

Science Center at San Antonio 2007 – 2010 Institutional Review Board (IRB), voting member, University of Texas Health

Science Center at San Antonio 2007 – 2008 Institutional Animal Care and Use Committee (IACUC), voting member,

University of Texas Health Science Center at San Antonio 2008 – 2010 Institutional Animal Care and Use Committee (IACUC), Vice Chair and voting

member, University of Texas Health Science Center at San Antonio 2010 – 2011 Institutional Animal Care and Use Committee (IACUC), Chair and voting

member, University of Texas Health Science Center at San Antonio

2007 – 2009 Masters of Science in Clinical Investigation Graduate Committee Chair for Peter P. Lopez, MD University of Texas Health Science Center at San Antonio

2007 – 2009 Masters of Science in Clinical Investigation Graduate Committee Chair for

Susannah E. Nicholson, MD University of Texas Health Science Center at San Antonio

2011 – present Institutional Animal Care and Use Committee (IACUC), Chair and voting member, Lincoln Memorial University

Additional Academic and Administrative Duties/Positions:

2000 – 2003 International Advisory Board for the International Society of Pathophysiology meeting

2003 Clinical Science, Editorial Consultant 2004 - 2006 Wellcome Trust Fund - ad hoc reviewer for drug patent development awards

2005 - 2010 American Journal of Physiology - Heart and Circulatory Editorial Board

2005 - present Recent Patent Reviews on Cardiovascular Drug Discovery, Editorial Board

2006 - 2007 Co-editor for Cardiovascular Special Issue in Clinical and Experimental

Pharmacology and Physiology (2007) 2006 - 2009 Foundation of the Georgian National Academy of Science Review Board


Service and Volunteerism:

1996 – 1997 Judge for Graduate Student Research Day, Department of Physiology, New York Medical College

2003 – 2005 Judge for graduate and medical student presentations at the Annual Tulane

Health Research Day, School of Medicine, Tulane University 2007 Judge for the Graduate Student Research Day, Graduate School of Biomedical

Sciences, University of Texas Health Science Center at San Antonio 2007 – 2009 Judge for the Medical Student Research Day, School of Medicine, University of

Texas Health Science Center at San Antonio 2008 Reviewer for Medical Student Summer Research Program proposals, University

of Texas Health Science Center at San Antonio

Robert A. Johnson, Ph.D. Office Address: Chair of ... · PDF fileUpdated February 14, 2013 1...

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