Roadshow Mikrofluidik 2013 Automatized Execution of Multivariate Experiments in Microstructured...
-
Upload
lesley-alexander -
Category
Documents
-
view
237 -
download
0
Transcript of Roadshow Mikrofluidik 2013 Automatized Execution of Multivariate Experiments in Microstructured...
Roadshow Mikrofluidik 2013
Automatized Execution of Multivariate Experiments in Microstructured Reactors
(Automatisierte Durchführung multivariater Experimente in mikrostrukturierten Reaktoren)
Prof. Dr.-Ing. Werner ZangCTO of HiTec Zang GmbH
Automatized execution of multivariate experiments in microstructured reaction plants 2HiTec Zang GmbH
Micro Technology
Motivation for Laboratory Automation
Acceleration of development processes (time-to-market) Advanced reproducibility Increased reliability Increased safety Advanced process control Inline analytics Improvement of quality Cost savings:
Unattended operation (overnight, weekend, ...)
Automated data evaluation
Resource savings: Chemicals Energy
Automatized execution of multivariate experiments in microstructured reaction plants 3HiTec Zang GmbH
Micro Technology
Constraint Resultant claim
Tight deadlines Flexible, modular experimental setup with standardised components and connectors
Rare space Compact technology
High cost pressure Cost effective technique, low engineering costs
For lack of qualified personnel:Adaptation of changing tasks and operation of automation technology by laboratory personnel, as far as compatible with the safety regulations
Easy to use technology for basic functions (like connection of sensors, actuators and standardised components …)
Laboratory Automation
Special conditions for automation in R&D labs
Automatized execution of multivariate experiments in microstructured reaction plants 4HiTec Zang GmbH
Micro Technology
Laboratory Automation
General requirements to Process Control Systems in R&D Very easy handling
High flexibility
Modular construction of hardware and software
PC-based user interface
Low system costs compared toautomation of production
Automatized execution of multivariate experiments in microstructured reaction plants 5HiTec Zang GmbH
Micro Technology
Laboratory Automation
Special hardware requirements for R&D Compact installation direct at the process plant
Flexible, standardised and potential-free interfaces (EMI robust)
Trouble-free interfacing with sensors, actuators and laboratory apparatuses
High precision (20/24 bit resolution, absolute measurement uncertainty <0.1% / <0.01%)
Integrated universal and specialized closed loop process controllers with autotune functionality
Automatized execution of multivariate experiments in microstructured reaction plants 6HiTec Zang GmbH
Micro Technology
Laboratory Automation
Special software requirements for R&D Drag and drop programming of the recipe schedule e.g. according to IEC
unit operation concept
Online configuration and parameterisation during plant operation
Large depth of processing data by using integrated control and analysis programming language
Data export for external programs (.xls, .csv, .txt, …)
Automatized execution of multivariate experiments in microstructured reaction plants 7HiTec Zang GmbH
Micro Technology
Accelerating the development process
Previous methods: Parallelisation of experiments in Batch Reactors Typical Volume 0.1 to 5 Liter
Advantages Proven technology
Simplified scale-up
Disadvantages Relatively large space required
Possibly high safety expenses
Automatized execution of multivariate experiments in microstructured reaction plants 8HiTec Zang GmbH
Micro Technology
Previous methods: Parallelisation of experiments in Synthesis Robots Typical Volume 1 ml to 100 ml
Advantages Proven technology
Highest throughput by massively parallel operation
Disadvantages Restricted in unit operations
Possibly high safety expenses
Very complicated for pressure or vacuum
No simple scale-up
Accelerating the development process
Automatized execution of multivariate experiments in microstructured reaction plants 9HiTec Zang GmbH
Micro Technology
New paradigm in micro reaction plants:Sequencing of experiments in Continuous Reactors instead of parallelisation experiments in batch reactors
Advantages Only one single reaction system needed
Fewer restrictions in terms of pressure and temperature
compatible to continous production
Relatively high throughput
Best reproducibility due to automated operation
Disadvantages Not yet adopted everywhere
Not suitable for all syntheses
Accelerating the development process
Automatized execution of multivariate experiments in microstructured reaction plants 10HiTec Zang GmbH
Micro Technology
Experimental setup
PI flowsheet (example) 2 reaction steps 4 individualy controlled
feeds 5 individually controlled
temperatures
Automatized execution of multivariate experiments in microstructured reaction plants 11HiTec Zang GmbH
Micro Technology
Experimental setup
Fully automated LabBox
TM
process-interface LabVision® software with EasyBatch
TM
AuotSamTM
autosampler
Automatized execution of multivariate experiments in microstructured reaction plants 12HiTec Zang GmbH
Micro Technology
Liquid conveyors Gear pumps Annular gear pumps Syringe pumps
Gravimetric control units Balances Mass flow meters
and controllers
Autosamplers, Liquid handling systems and multi port valves Upstream and downstream
processing
Instrumentation components
Automatized execution of multivariate experiments in microstructured reaction plants 13HiTec Zang GmbH
Micro Technology
Standard sensors and actuators T, p, pH,... / valves, heaters,...
Tempering systems Electrical heaters Constant temperature circulators Fourfold tempering System,
only one chiller required Cryogenic system
down to - 180 ° C
Inline analytical instruments ATR-FTIR, NIR, UV spectr. Liquid phase detector
(organic/anorganic)
Instrumentation components
Automatized execution of multivariate experiments in microstructured reaction plants 14HiTec Zang GmbH
Micro Technology
Automation system hardware
LabManager® (or LabBoxTM) process interface Standardised NAMUR connectors for sensors, actuators, laboratory
equipment and analytic instruments Integrated closed loop controllers and power supplies Extremly compact
(a small box instead of a bulky cabinet)
Automatized execution of multivariate experiments in microstructured reaction plants 15HiTec Zang GmbH
Micro Technology
Automation system interfaces
Analogue inputsand outputs
Automatized execution of multivariate experiments in microstructured reaction plants 16HiTec Zang GmbH
Micro Technology
Automation system interfaces
Analogue inputs
Automatized execution of multivariate experiments in microstructured reaction plants 17HiTec Zang GmbH
Micro Technology
Automation system interfaces
Digital inputs and outputs
Automatized execution of multivariate experiments in microstructured reaction plants 18HiTec Zang GmbH
Micro Technology
Automation system interfaces
Heater drivers and serial interfaces
Automatized execution of multivariate experiments in microstructured reaction plants 19HiTec Zang GmbH
Micro Technology
Interface Example
Automatized execution of multivariate experiments in microstructured reaction plants 20HiTec Zang GmbH
Micro Technology
Automation system software
LabVision® Standard in laboratory automation software Real NAMUR compliant R&D process control system End to end data chain from experiment design
to ELN/LIMS database User-friendly operation
Automatized execution of multivariate experiments in microstructured reaction plants 21HiTec Zang GmbH
Micro Technology
LabVision™ Project Modules
Automation project design via drag and drop
Automatized execution of multivariate experiments in microstructured reaction plants 22HiTec Zang GmbH
Micro Technology
Easy connection of sensors, actuators and laboratory instruments
Automatized execution of multivariate experiments in microstructured reaction plants 23HiTec Zang GmbH
Micro Technology
Application oriented function blocks
Operations (excerpt): Surge doser Batch amount doser Batch rate doser Conti doser Refill device Vacuum controller Temperature
cascade controller
Automatized execution of multivariate experiments in microstructured reaction plants 24HiTec Zang GmbH
Micro Technology
Application oriented function blocks
Example: Gravimetric flow control Balance and pump Autotuning
Automatized execution of multivariate experiments in microstructured reaction plants 25HiTec Zang GmbH
Micro Technology
EasyBatchTM sequential control
Spreadsheet based programming of test procedures
Self-explanatory
Interactive operation and changes during runtime are possible
Automatized execution of multivariate experiments in microstructured reaction plants 26HiTec Zang GmbH
Micro Technology
HiTextTM universal programming language
Control
Online evaluation
Communication Special procedures
for EasyBatchTM
Multitasking
Easy to use
Automatized execution of multivariate experiments in microstructured reaction plants 27HiTec Zang GmbH
Micro Technology
Laboratory Notebook and automatically generated documentation
Functionality Standardised
automated evaluation
Consistent presen-tation of parameters, measured values, analytic data and results
Transfer of data to a LIMS
Export as .pdf file (manipulation-proof)
Export as .rtf file (for post-processing)
WYSIWYG form designer
Automatized execution of multivariate experiments in microstructured reaction plants 28HiTec Zang GmbH
Micro Technology
Event report
Complete report of the course of events
Automatized execution of multivariate experiments in microstructured reaction plants 29HiTec Zang GmbH
Micro Technology
Event report
Complete report of measured data and set points
Automatized execution of multivariate experiments in microstructured reaction plants 30HiTec Zang GmbH
Micro Technology
Laboratory Information Management System
Functionality Planning and organising Administration and documen-
tation of recipe, batch-, educt-, product- and sample-data
Search and retrieval Comparison and analysis of data Coupling devices
Advantages Support of daily laboratory work Increases productivity Error prevention Protects sensitive information Makes knowledge available to the user Prevents information manipulation Easy utilisation of information
Automatized execution of multivariate experiments in microstructured reaction plants 31HiTec Zang GmbH
Micro Technology
SyrDos™ - syringe pump for mixing and continuous operation
All-purpose use Resistant to aggressive media Wetted materials: glass, PTFE,
KEL-F or PPF, opt. ceramics Compact high grade steel casing Syringes from 10µl up to 50 ml Optional pressure up to 90 bar 48.000 steps, max. 10.000 steps/s Optional continuous conveyance Calibration in mg/min and ml/min Interfaces (RS232, RS485, MODBus,
4-20mA, 0-10V) Comfortable DosiMaster™ software
for dosing profiles, dispensing and mixing purposes
Automatized execution of multivariate experiments in microstructured reaction plants 32HiTec Zang GmbH
Micro Technology
AutoSamTM liquid handling system
Applications Sampling of specimens Provision of reactants Quenching, mixing and diluting Liquid/Liquid extraction
Properties and Procedures Sample tubes with diaphragms
are easily processed Bottling under inert gas possible Exchangeable sample tray Separate, large waste vessel Programmable handling methods
Automatized execution of multivariate experiments in microstructured reaction plants 33HiTec Zang GmbH
Micro Technology
GraviDos® - gravimetric controlled dosage
High performance
Low-cost
Compact and robust
Large dosing range
Refilling without dosing interruption
Increased control accuracycompared to balances
Resistant to aggressive media
Easy to clean
Available as platform- or overhead-balance
Optionally stirring and heating
Applicable as massflow and filling quantity meter
Automatized execution of multivariate experiments in microstructured reaction plants 34HiTec Zang GmbH
Micro Technology
Phase detection and separation
Detection of anorganic and organic liquid (and gaseous) phase
Automated separation of anorganic and organic liquid phase
Thermal measuring principle or
Capacitive measuring principle
Automatized execution of multivariate experiments in microstructured reaction plants 35HiTec Zang GmbH
Micro Technology
Customised Solutions
Mixed assembly applications micro-mixers and glas
components Continuous as well as
batch operation
Totally integrated Automation
Unattended operation
Mobile
Automatized execution of multivariate experiments in microstructured reaction plants 36HiTec Zang GmbH
Micro Technology
Fully Automated Execution of
Multivariate Experiments
on the example of
Microstructured Reactors
www.hitec-zang.com
Thanks a lot for your attention!