RNK Virusi Slajdovi Farmaceutska Mikrobiologija Farmacija

7/25/2019 RNK Virusi Slajdovi Farmaceutska Mikrobiologija Farmacija

1/77


2/77

Familija Picornaviridae

*Genus Enterovirus

*Genus Rhinovirus

*Genus Hepatovirus

Genus Cardiovirus

Genus Aphthovirus


3/77

Familija Picornaviridae

(24-30 nm)

60


4/77

(30%),

(70%)

- , ,

8-9 kb, -

, VPg

- VP1 VP3 ,VP4


5/77

(33000; 27000; 23000 6000)

, ,


6/77

(, 1949)

, 1-3

(1-6) 31 (engl. enteric

cytopathogenic human orphan viruses)

(68-71)


7/77

(+)


8/77


9/77


10/77

72,

, ,

,

(, ), ,, ,


11/77

POLIO VIRUS

1949.

1, 2 3

(MORBUS

HEINE MEDIN)


12/77


13/77


14/77


15/77


16/77


17/77

.

UV , .1%


18/77

(

)

(HeLa, VERO)


19/77

:

-

-

- 3-4


20/77

PEYEROVE PLOE

19


21/77

(), CNS

IN VIVO


22/77


23/77

1)

2)

4) 5)


24/77


25/77

. ( )

. , )

. ( )


26/77

:


27/77

:

()

() 18


28/77

COXSACKIE VIRUSI

1948 . COXSACKIE (SAD)

(

)

(23)


29/77

COXSACKIE VIRUSI

(6) :

-

-

-

- , ,,


30/77

COXSACKIE VIRUSIGRUPE A COXSACKIE VIRUSIGRUPE B

HERPANGINA (2-6, 8, 10)

ASEPTINI MENINGITIS

(2, 4, 7, 9, 10)

PLEURODINIJA (1-5)

ASEPTINI MENINGITIS (1-

6)

EGZANTEM (4-6, 9 i 16)

PNEUMONITIS

NOVOROENADI (9 i 16)HEPATITIS (4 i 9)

BOLEST AKA, STOPALA

I USTA

-

OSPA (5)

PERI I MIOKARDITIS (1-5)

HEPATITIS (tip 5)

NEDIFERENCIRANAFEBRILNA STANJA


31/77

1) -

2) ()

3) -

4)


32/77

5) - COXSACKIEVIRUS GRUPE B

6)

7) COXSACKIE -24


33/77

) ( )

) (, )

: , ,,


34/77

- 100

pH< 6,

33

() ,


35/77

ORTHOMYXOVIRIDAE

( ):, , 80-120nm

: , (-) , 6

, ,

: (1%), (73%), (20%), (6%)

:


36/77


37/77


38/77


39/77

:

() (N)

ORTHOMYXOVIRIDAE

: ,

:


40/77

,


41/77

:1) (1, 2 )

2) (NP)

3) ()4) () , 550, 16

5) (N) ( 450 ..), 9


42/77

(1-3) N (N1-N2)

: DRIFT IFT

:

,


43/77

( RNK II)

,


44/77

1-4

()


45/77


46/77

-)

REYEOV SINDROM ( )


47/77

: N

:

IgA

,


48/77

: DCK( ) LLC-MK2 ( )


49/77


50/77

:- (RIH)

- , ,

-

,


51/77


52/77

- , - (

15

g )

-

N


53/77


54/77

PARAMYXOVIRIDAE

(gr.myxa-sluz)

ORTHOMYXOVIRUSIMA

MYXO VIRUSA


55/77

,

1-4 ,

,

,

RNK

RNK 8

9 nm 18 nm

RNK


56/77

PARAMYXOVIRIDAE

: , , 150-300nm

18nm

: (-) , , 5-7 D

: (1%), (73%), (20%), (6%)


57/77

PARAMYXOVIRIDAE :

: HN

:

:


58/77


59/77

VIRUS MORBILA


60/77

PARAMYXOVIRINAE

ROD RESPIROVIRUS(virusi parainfluence 1 i4)

ROD HENIPAVIRUSHendra I Ni ah virus

PARAMYXOVIRIDAE

ROD RUBULAVIRUS (v. parainfluence 2 I 4, v.mumpsa)

MORBILLIVIRUS

PNEUMOVIRINAE

ROD PNEUMOVIRUS (RSV)

ROD METAPNEUMOVIRUS


61/77

N

-


62/77


63/77

:

,

-


64/77

MORBILI (RUBEOLA)

- , ,

,


65/77

MORBILI (RUBEOLA)

1) ,

2) RES-A

3) (, )


66/77

KOPLIKOVE MRLJE NA

BUKALNOJ SLUZNICI


67/77


68/77

MORBILI (RUBEOLA)

CNS-a , 1:1000

(SSPE)

SSPE


69/77

MORBILI (RUBEOLA)

( )


70/77

1) (, )

)

3) - (RIH, RVK,NEUTRALIZACIONI TEST)


71/77

,

- ,


72/77

MUMPS VIRUS

() ()

, , ,

30%


73/77

MUMPS VIRUS

() ,

20% 13 . ( )


74/77

( 1%)

: , ,,

: , ( ) (RVK, RIH, ELISA)


75/77

MUMPS VIRUS

: ( ), (R)

(MMR)


76/77


77/77

RNK Virusi Slajdovi Farmaceutska Mikrobiologija Farmacija

Documents

Transcript of RNK Virusi Slajdovi Farmaceutska Mikrobiologija Farmacija