Rita Ellithorpe, MDBoard Certified in Anti-Aging and Integrative Medicine

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• Optimize Your Patient’s Health

• Expand Your Practice

• Increase Your Revenue

How to Integrate Heavy Metal

Detox into Your Practice:

What every health care professional should know.

• Contents• HM toxicity - significant clinical conditions

• Impact of HM on the health of your patients

• Diagnosis

• Chelation therapy

• Clinical benefits

• How to integrate chelation into you practice

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Toxic Heavy Metals

Heavy Metal Toxicity A Significant Clinical Condition

Emerging Diseases, many with environmental factors associated with their causation, and Ecological Issues are pointed to by the CDC as

being among the top 10 major health risks in the 21st century.

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Toxic Metals are Everywhere!

l They invade our bodies (fat)

l They cause advanced aging

l They cause devastating diseases

l They erode our lives

l They cripple our children

l They can kill us and our families

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Blood vessels are key to your youth, beauty, health and life.

It’s OK to be vein as long as you protect your arteries

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Blood is your

Life’s Breath

Prevention is Key6

We must detect disease long before it get worse

We can stop it naturally

Toxic Metal Effects Need Antioxidant Rescue

• Toxic Metals• Act as oxidative catalysts

• Deplete cells of antioxidants and enzymes

• Increase hydroxyl radical hydrogen peroxide

• Increased cell and tissue damage occur

Data suggest that antioxidants play a role in abating some hazards of toxic metals.

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Ref: Ercal.N, “Toxic metals and oxidative stress in metal-induced oxidative damage,”

Curr. Top Med Chem. 2001 Dec;1(6):529-39

Toxins Damage Cell Membranes 8

Time-Lapse Microphotography of Toxins in Human Cells

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Major Toxic Heavy Metals

l Most Common Toxic Metals • Lead

• Cadmium

• Mercury

• Aluminum

• Nickel

• Arsenic

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Lead-induced Hypertension: Role of Oxidative Stress

l Chronic, low-level lead exposure causes hypertension in both animals and humans

l Inactivation of endogenous nitric oxide

l Reactive oxygen species (ROS) lowers enzyme activity

l Functional deficiency in nitric oxide

l Increase sympathetic activity & plasma norepinephrine

l Lead-induced inhibition of vascular smooth muscle

l ACE, angiotensin II, aldosterone, thromboxane

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Ref: Vaziri ND, Lead-induced Hypertension: Role of Oxidative Stress,

Curr Hypertens Rep. 2004 Aug;6(4):314-20

There are NO Safe Levels of Heavy Metals

l Low levels are becoming dangerous

l Low levels accumulate

l Low levels become stored

l Low levels become higher

l Multiple toxins compound the danger

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Death Rates of Participants with Low Pb Levels in NHANES III Survey

17

39

4646

68

0

10

20

30

40

50

60

70

80

10 20 30

All Causes

Cardiovascular Diseases

Cancer

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Perc

ent In

cre

ase in M

ort

alit

y

Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality. Arch Intern

Med, 2002, 162: 2443-2449

Blood Lead Levels (µg/dL)

Random Blood Sampling of Dr. Ellithorpe’s Patients: Presence Excessively High Heavy Metals

100

22

17

0

25

50

75

100

Presence of Heavy Metals

Elevated Heavy Metals

Potentially Toxic Heavy Metals

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Perc

ent of P

atients

N=251

Health Conditions Associated with Heavy Metal Toxicity - Lead

• Central nervous system

• Kidneys

• Decrease reaction time

• Weakness in fingers, wrists, ankles

• Memory

• Anemia

• Carcinogenic

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Source: Agency for Toxic Substances & Disease Registry

*Source: DHHS

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Impact of Heavy Metals on the health of your patients

• Recognized by:• US Environmental Protection Agency (EPA)

• Food & Drug Administration (FDA)

• Centers for Disease Control (CDC)

• State Health Departments

• Treatment standards are needed• Preventative measures

• Comprehensive medicine with proven results

• Reduction of crisis management

Global Chronic Low Level Metal Toxicity

Cancers Associated with Heavy Metals

Skin, Lung, Bladder, Kidney, Liver, Prostate

Liver, Esophageal, Lung, Prostate

Bladder, Kidney, Brain

Lung, nasal

Prostate

Lung

Lung

Lung

Lung

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Type of CancerHeavy Metal

Arsenic

Mercury

Aluminum

Nickel

Cadmium

Uranium

Tungsten

Antimony

Beryllium

An Important Major Research Discovery

• Ninety Percent Reduction in Cancer Mortality after Chelation Therapy with EDTA

• Blumer, W., Cranton, E. Textbook on EDTA Chelation Therapy, 2nd ed. Ch, 12, Pp. 185-201

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Lab Diagnosis of Heavy Metals

• Provocation Agents

Common Agents ~ Half Life Collection

Period

EDTA 1 hr. 6-24 hrs.

DMPS (IV) 1 hr. 2-6 hrs.

DMPS (oral) 9 hr. 6-9 hrs.

DMSA 4 hrs. 6-9 hrs.

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Lab Diagnosis of Heavy Metals

• Urine - Home Mailer

• Feces - Home Mailer

• Hair - Home Mailer

• Blood - Blood draw – process and mail

Diagnostic Lab: Doctors Data Labs - www.doctorsdata.com

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Doctors Data Labs

Sample HM Report

www.doctorsdata.com

What can we do about Toxins?

l Remove Toxins

l Repair Damaged Cells

l Revitalize Your Health

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Detoxamin Chelation Suppositories 23

Chelation Cost comparison

• IV Chelation• Average IV Price - $125 or more per treatment

• 30 treatments recommended• Average Cost: $3750

• Detoxamin• Average Price: $199/container (2 month’s supply)• 6 month’s supply = 30 IV dosages• 6 months supply Cost: $ 597

84% less cost compared to IV Chelation

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Published pharmacokinetic study on Detoxamin

Proving Detoxamin’sAbsorption Rate and EDTA Permeability

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EDTA levels in blood over time following intravenous administration of 14 C-EDTA

0 2 4 6 8

0.0

0.5

1.0

1.5

2.0

2.5

3.0

55914

55915

55917

55918

Ppm

ED

TA

Equiv

ale

nts

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EDTA levels in blood over time following rectal administration of 14C-EDTA

0 2 4 6 8

0

5

10

15

20

25

30

35

40

55912

55911

55906

Time (Hour)

Ppm

ED

TA

Equiv

alents

Detoxamin Suppositories Bioavailability

Intravenous Detoxamin

Bioavailability 100% 36 %

Amount in

Tissue*

4 14

Time in blood 1.5 hours 8 hours +

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*Blood - tissue ratio

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Before

After

treatment

with 60

Detoxamin

suppositories

Effects of Detoxamin on Elevated Lead Urine Levels in Children

4.2

61.45

9

22.7

0

20

40

60

80

100

0 1 10 20 30

Pre-Treatment Baseline

After 1st Suppository

10 Days of Suppository

10 Days After Suppository

10 Days Additional Suppository

30

325.6

µg/d

L

Treatment Day

N=20

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Treatment with Detoxamin Chronic Prostate Pain Symptom - Total Scores

0

2

4

6

8

10

12

Total Mean Score

Pre Treatment

Post Treatment

*P<0.05

31

*

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Treatment with Detoxamin International Prostate Symptom Score (IPSS) Results

0

1

2

3

4

Incomplete

Emptying

Frequency Intermittency Urgency Weak Stream Straining Nocturia QOL Score

Pre Mean

Post Mean

*P<0.05

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*

*

*

*

*

Date Ar Cd Pb Hg Ni

8/02 220 2.5 20 24 49

12/02 4.5 2.1 7.4 15 25

5/03 45 3.2 12 8.9 18

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42 y/o – W – F 145 lbs. – Photographer – Fibromyalgia – Chronic Fatigue – Hypothyroid

Practical Clinical Case Study With Detoxamin

Outcome: 11/04– Energy good – Exercise daily (45 mins) with mild to moderate

pain of fibromyalgia – increase daily activities

Patient F.K.

Practical Clinical Case Study with Detoxamin

Date Cd Hg Pb Ni

5/03 1.7 30 43 9.5

2/04 1.0 2.6 27 17

2/05 1.0 18 27 13

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55 y/o – W – F – 131 lbs – School Teacher – Chronic LBP – Fatigue - Hypothyroid

Patient K.M.

Outcome: 7/04– Excellent energy – Exercise 3x/daily – water aerobics – Back

pain stable – Reduced need for medications

Comparison of IV Chelation vs Detoxamin

IV

Chelation

Detoxamin

Non-Invasive No Yes

Quick and easy to use No Yes

Inexpensive No Yes

Increased safety No Yes

Broad spectrum metal removal Yes Yes

Clinically proven Yes Yes

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• Comprehensive Metabolic Panel• Albumin - Total Protein

• Total Bilirubin - Sodium

• Calcium - AST (SGOT)

• Chloride - Urea Nitrogen (BUN)

• Creatinine, Serum - Bicarbonate (CO2)

• Glucose - ALT (SGPT)

• Alkaline Phosphatase - C-Reactive Protein

• Potassium

No statistical difference in above lab parameters between pre and post treatment with Detoxamin in all subjects

Detoxamin Safety

Dr. Ellithorpe’s Clinical Safety Experience with Detoxamin

• 9 years +, 4000 patients, over 400,000 doses of Detoxamin

• Results in General• Improved mental clarity• Increased energy• Increased endurance• Reduced blood pressure• Enhanced cardiovascular performance• Improved libido and erectile function and prostate conditions• Improved overall quality of life

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Begin with Positive Lifestyle Changes

• Patients should manage stress

• Don’t take on more than they can handle

• March in place 7 min/day

• Get enough sleep• 8 is the magic number

• Reduce carbohydrates

• Drink plenty of water

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Positive Lifestyle Changes

• Drink non-fluoridated, non-chlorinated water

• Half their weight in pounds as ounces

• Exercise on a regular basis• Even if it’s just walking for

30 minutes a day

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