Risks of Emerging Infectious Diseases in ASEAN · infectious diseases do not go away, actually...
Transcript of Risks of Emerging Infectious Diseases in ASEAN · infectious diseases do not go away, actually...
Risks of Emerging Infectious Diseases in ASEANPrasit Palittapongarnpim, M.D.
Department of Microbiology, Faculty of Science, MahidolUniversity
Despite the socio-economic progress of ASEAN and increased importance of NCD, infectious diseases do not go away, actually ASEAN (+China) becomes a hot spot of EID and reemerging diseases. • Nipah encephalitis- Sungai Nipah village Malaysia 1998• SARS- Guangdong China 2002• H5N1 influenza-first human cases in Hong Kong 1997 and
major outbreaks in 2004• Pandemic influenza H1N1 2009 • H7N9 influenza- China 2013• H10N8 influenza-China Dec 2013• Chikungunya- Tanzania 1962, 2005/6 outbreak on La
Réunion Island in the Indian Ocean followed by outbreaks in SE Asia 2005-2008.,
• Streptococcus suis- Denmark 1968 and an outbreak in Sichuan China 2005
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There are also threat of EID from other parts of the world.• Ebola (1976) major outbreaks in Africa 2014• Enterohemorrhagic E. coli (104:H4) 2011• MERS (2012) outbreak in Korea 2015• West Nile encephalitis
• Dengue virus infections• Hand-foot-mouth diseases• Melioidosis• Plague-Surat India 1994• Cholera• Leptospirosis• Salmonellosis• MDR and XDR-TB and other resistant bacteria
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As well as threat from re-emerging endemic diseases.
Are there any things else?
• Many patients with fever are of unknown etiology.▫ No attempts for microbiological diagnosis
▫ Limited facility
▫ Totally unknown even with aggressive attempts.
• Possible causes▫ Unknown rickettsial pathogens
▫ Unknown viruses, particular zoonotic ones.▫ New variants of known pathogens.
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Risk Factors for New EID
• More human population
• Shifting human population profiles. (More aging and immunocompromised population, relatively less children populations, more urbanization)
• Much more domestic animal populations▫ Chicken, pigs, cow
▫ Exotic pets
• More international and domestic travels
• Climate changes and changing environments
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Principles in dealing with the urgent situations such infectious diseases outbreak
• Capacity of personnel
• Availability of essential equipment▫ Preparedness plan
▫ Drilling
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Mitigating Biosecurity Threats in Southeast Asia by APEIR (Asia Partnership on Emerging Infectious Diseases Research)
MBDS (Mekong Basin Disease Surveillance Network)
FETN (Field Epidemiology Training Network)
and CORDS (Connecting Organizations for Regional Disease Surveillance)
Proposal originally prepared by Boonlay Phommasak &
Prasit Palittapongarnpim
Funded by
ASEAN-Canada’s GPP and IDRC
Updated Research Part for ASEAN East-West Corridor
Overview
• 30 month joint project between APEIR, MBDS, and ASEAN+3 FETN▫ Funded by IDRC and GPP
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Asia Partnership on Emerging Infectious Diseases Research
specific objectives
• Develop a greater understanding of the risks of an infectious agents at high-traffic border crossings in Southeast Asia.
• Strengthen laboratory and field surveillance, diagnostics, prevention and response capacities towards infectious pathogens cross-border outbreak potential.
• Synergize efforts among partner GPP projects in laboratory capacity strengthening and risk assessment.
• Build effective and efficient mechanisms for research to directly inform and shape regional policies and practices in surveillance, outbreak investigation and response.
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MBDS (Disease Surveillance)
Strengthen Bio Threat
Surveillance
Risk Management workshop
Develop Biosafety Training
manual
Capacity building
Surveillance equipment & PPE
Surveillance app development
Policy synthesis workshop
Biosafety and Biosecurity web
page
Collaboration with APEIR
Ext Consultant
M & E
APEIR (Research)
Lead research
Data collection
Capacity building: lab,
researchers, MBDS, border
health personnel
Early disease detection
Risk management
workshop (with MBDS)
Collaboration
Ext consultant
M & E
Policy synthesis workshop
OTHERS(Lab, Technical)
ASEAN
WHO EDPLN
Bio Diaspora
IFBA
CORDS
Research activity and collaboration
Activity APEIR MBDS ASEAN+3
FETN
CORDS Bio Diaspora
WHO EDPLN
Research
Surveillance
Training
Technical consultation
Others
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Asia Partnership on Emerging Infectious Diseases Research
Outline
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Asia Partnership on Emerging Infectious Diseases Research
• Background
• APEIR-MBDS-ASEAN+3 FETN-Joint Project▫ Background
▫ Objectives
▫ Project activities
• Moving forward
Background of APEIR
• 2006: Initiated as Asia Partnership For Avian Influenza Research (APAIR)
• 2009: Expanded scope to cover all emerging infectious diseases (EIDs) research
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Asia Partnership on Emerging Infectious Diseases Research
Background
• Regional research network composed of researchers, practitioners, and senior government officials
• Generates 3M collaborative research and actions on EIDs based on Eco Health/One Health concepts▫ Multi-disciplinary
▫ Multi-sector▫ Multi country
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Asia Partnership on Emerging Infectious Diseases Research
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Asia Partnership on Emerging Infectious Diseases Research
APEIR Network
• Missions▫ Research
▫ Knowledge translation
▫ Policy advocacy ▫ Capacity building
APEIR Member Countries
Background: Vision
• To be the leading EIDs research network in Asia by 2015
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Asia Partnership on Emerging Infectious Diseases Research
Background
• ASEAN Community (AC) in 2015 will lead to more travel between ASEAN countries
• Need to have the knowledge, capacity and policy to mitigate the risks from potentially dangerous infectious diseases that can cross borders.
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Asia Partnership on Emerging Infectious Diseases Research
General objective
• To strengthen regional capacity for understanding, preventing, preparing for, and responding to disease agents with bioterrorism and/or pandemic potential in Southeast Asia
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Asia Partnership on Emerging Infectious Diseases Research
Research Objectives
• Assessing the risk of infectious diseases transmission across borders.
• Increasing capacity for disease detection
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Studied organisms
• Influenza▫ Air-borne transmission: endemic, continuously
emerging and potential pandemic.
• Melioidosis▫ Soil transmission: direct impact from increase
road traffic and frequently fatal.
• Salmonellosis▫ Food-borne transmission: spreading of drug
resistance genes.
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Asia Partnership on Emerging Infectious Diseases Research
Study locations
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Asia Partnership on Emerging Infectious Diseases Research
A
B
C
APEIR-MBDS Joint Project Action Plan (September 2014-September 2016)
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Activities2014 2015 2016
Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3
Inception workshop X
Budget analysis X
Ethical/government clearance X X
Budget analysis X
Evaluation of all facilities X
Test running all facilities X
Training X
Sample collection - processing X X X X X
Data sharing and result analysis X X X
Interim technical
report/financial report X X X X
Progress report X X X X
Meeting for reviewing research,
summarizing data and
synthesize policy
X X
Project activities
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Activity Place and date
First preliminary meeting
HSRI Thailand: 19 March 2014
Second preliminary meeting + site visit
Savannakhet and Lao-Vietnam border: 24-26 April 2014
First International Conference on MBDS Collaboration
Mukdahan Grand Hotel, Thailand: 2-3 June 2014
East-West Corridor Inception Workshop
Savannakhet Health Department, Lao PDR: 11-12 September 2014
Laboratory Trial Mukdahan-Amnatcharoen, Thailand: 8-20 December 2014
• As a collateral consequences of an unexpected situation in HSRI, the project budget is suspended since the last quarter of 2014.
• It is expected to resume by the last quarter of 2015.
• This workshop is done as a preparation for resuming the research activities.
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Purpose of Today Workshop
• Face-to-Face Discussion on each subproject▫ Objectives ▫ Sampling methods▫ SOP▫ Requirement: authorization, budget, etc.▫ Limitation▫ Opportunity for training and capacity building▫ Action plan and timelines Next step and contact
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To build laboratory capacity to handle dangerous pathogens, sharing knowledge on some potential pathogens as well as provide laboratory practicing experiences
THANK YOU VERY MUCH
For
YOUR ATTENTION
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Asia Partnership on Emerging Infectious Diseases Research