Rheumatoid arthritis and seronegative spondylarthritides
Transcript of Rheumatoid arthritis and seronegative spondylarthritides
Rheumatoid arthritis and seronegative
spondylarthritides
Nov 24, 2017
György Nagy
Rheumatoid arthritis
Rheumatoid arthritis
Chronic, progressive, autoimmune disorder of the joints with extra-articular features.
Prevalence: 1% (0.3-2.1%)
Female/male = 3:1
Age at onset 30-40 years
Early RA
Advanced RA
End stage RA
Extra-articular features
Extra-articular features
Iain B. McInnes, F.R.C.P., Ph.D., and Georg Schett, M.D. N Engl J Med 2011;
The pathogenesis of rheumatoid arthritis
The pathogenesis of rheumatoid arthritis
Iain B. McInnes, F.R.C.P., Ph.D., and Georg Schett, M.D. N Engl J Med 2011;
Autoantibodies in RA
Rheumatoid factor
- against the Fc portion of IgG
- occurs in 70% of the RA patients
- not specific for RA
Autoantibodies targeting citrullinated proteins
- highly specific for RA
- occurs in 70% of the RA patients
Baka Z, Buzás E, Nagy G - Arthritis Res. Ther. (2009)
The pathogenesis of rheumatoid arthritis
DAS 28 = disease activity score
Swollen and tender joints, patient’s global opininion, CRP or We
Philip S. Hench and
Edward C. Kendall
Mayo Clinic, 1950
Nobel Prize
Synthetic DMARD, NSAID and steroid
therapy in RA
Ronald F. van Vollenhoven
Nature Reviews Rheumatology 7, 205-215 (April
2011)
Biological therapy in RA & side effects
Ankylosing spondylitis
Ankylosing spondylitis
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