Rhabdomyolysis: Challenges in the ICU
description
Transcript of Rhabdomyolysis: Challenges in the ICU
![Page 1: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/1.jpg)
Leanna R. Miller, RN, MN, CCRN-CSC, PCCN-CMC, CEN, CNRN, CMSRN, NP
Education Specialist LRM ConsultingNashville, TN
![Page 2: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/2.jpg)
ObjectivesIdentify the causes of rhabdomyolysis.Describe signs and symptoms of rhabdomyolysis.Utilizing a case study, identify management strategies of a patient with renal dysfunction resulting from rhabdomyolysis.
![Page 3: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/3.jpg)
“Rhabdomyolysis was first reported in 1881, in the German literature” (Abbeele, Parker, 1985).“Rhabdomyolysis was first described in the victims of crush injury during the 1940-1941 London, England, bombing raids of World War II” (Craig, 2006).
![Page 4: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/4.jpg)
Rhabdomyolysis accounts for an estimated 8-15% of cases of acute renal failure.the overall mortality rate for patients with Rhabdomyolysis is approximately 5%Rhabdomyolysis is more common in males than in femalesmay occur in infants, toddlers, and adolescents
![Page 5: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/5.jpg)
disintegration of striated muscleresults in the release of muscular cell constituents into the extracellular fluid and the circulationmajor component released is myoglobin
![Page 6: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/6.jpg)
massive amounts of myoglobin are released the binding capacity of the plasma protein is exceededmyoglobin is then filtered by the glomeruli and reaches the tubules, where it may cause obstruction and renal dysfunction
![Page 7: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/7.jpg)
syndrome characterized by muscle necrosis and the release of intracellular muscle constituents into the circulationcreatine kinase (CK) levels are typically markedly elevated, and muscle pain and myoglobinuria may be present
![Page 8: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/8.jpg)
severity of illness ranges from asymptomatic elevations in serum muscle enzymes to life-threatening disease associated with:
extreme enzyme elevationselectrolyte imbalancesacute kidney injury
![Page 9: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/9.jpg)
Rhabdomyolysis is the breakdown of muscle fibers, specifically of the sarcolemma of skeletal muscle, resulting in the release of muscle fiber contents (myoglobin) into the bloodstream.
![Page 10: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/10.jpg)
The sarcolemma is the cell membrane of a muscle cell. The membrane is designed to receive and conduct stimuli
Source: (Muscle Anatomy & Structure, 2007)
![Page 11: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/11.jpg)
when muscle is damaged, a protein pigment - myoglobin is released into the bloodstream and filtered out of the body by the kidneys. broken down myoglobin may block the structures of the kidney, causing damage such as acute tubular necrosis or kidney failure.dead muscle tissue may cause a large amount of fluid to move from the blood into the muscle, leading to hypovolemic shock reduced blood flow to the kidneys.
![Page 12: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/12.jpg)
![Page 13: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/13.jpg)
may result from a large variety of diseases, TRAUMA, or toxic insults to skeletal musclehereditary myopathies
![Page 14: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/14.jpg)
Causes trauma burns compression syndrome infection seizures heat intolerance heat stroke
![Page 15: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/15.jpg)
Causes vascular occlusion prolonged shock electrolyte disorders drugs (cocaine, alcohol,
statins, amphetamine) low phosphate levels shaking chills
![Page 16: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/16.jpg)
Clinical Manifestations muscle tenderness myalgias muscle swelling &
weakness DIC color of urine
![Page 17: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/17.jpg)
• Additionally some possible symptoms include: − Overall fatigue− Joint pain− Seizures− Weight gain
![Page 18: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/18.jpg)
Diagnosisan examination reveals tender or damaged skeletal musclesCreatine Phosphokinase (CK) levels are very highserum myoglobin test is positiveserum potassium may be very high
![Page 19: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/19.jpg)
serum CK begins to rise within 2 to 12 hours following the onset of muscle injury and reaches its maximum within 24 to 72 hoursdecline is usually seen within three to five days of cessation of muscle injury
![Page 20: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/20.jpg)
CK has a serum half-life of about 1.5 days and declines at a relatively constant rate of about 40 to 50 percent of the previous day’s valuepatients whose CK does not decline as expected, continued muscle injury or the development of a compartment syndrome may be present
![Page 21: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/21.jpg)
DiagnosisUrinalysis may reveal protein and be positive for hemoglobin without evidence of red blood cells on microscopic examination Urine myoglobin test is positive
![Page 22: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/22.jpg)
Urine Myoglobinvisible changes in the urine only occur once urine levels exceed from about 100 to 300 mg/dLcan be detected by the urine dipstick at concentrations of only 0.5 to 1 mg/dL half-life of only two to three hours, much shorter than that of CK. rapidly excreted and metabolized to bilirubin, serum levels may return to normal within six to eight hours
![Page 23: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/23.jpg)
Lab Values elevated muscle
enzymes (CK) hyperkalemia hyperphosphatemia hypocalcemia
![Page 24: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/24.jpg)
ComplicationsKidney damageAcute renal failureHyperkalemiaCardiac arrestDisseminated Intravascular CoagulationCompartment syndrome
![Page 25: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/25.jpg)
Treatment volume replacement treat electrolyte
abnormalities protect renal
perfusion alkalinization of urine fasciotomy
![Page 26: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/26.jpg)
• early and aggressive fluids (hydration) may prevent complications by rapidly remove myoglobin out of the kidneys.
• administer isotonic crystalloid fluids (Normal Saline or Lactated Ringer’s)
• give as much fluid as you would give a severely burned patient.
![Page 27: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/27.jpg)
studies of patients with severe crush
injuries resulting in Rhabdomyolysis
suggest that the prognosis is better
when prehospital personnel provide
FLUID RESUCITATION!
![Page 28: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/28.jpg)
medicines that may be prescribed include diuretics and sodium bicarbonate.hyperkalemia should be treated if presentkidney failure should be treated as appropriate
![Page 29: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/29.jpg)
if urinary flow is >20 mL/hour add mannitol to the intravenous alkaline solution providing an increase in urine output is demonstrated following a test dosesuggested test dose is 60 mL of a 20 percent solution of mannitol administered intravenously over three to five minutes
![Page 30: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/30.jpg)
if urine output increases by at least 30 to 50 mL/h above baseline levels in response to the test dose, 50 mL of 20 percent mannitol (1 to 2 g/kg per day [total, 120 g], may be given at a rate of 5 g/hour. mannitol is contraindicated in patients with oliguria
![Page 31: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/31.jpg)
The outcome varies depending on the extent of kidney damage.
Source: Silberber, 2007
![Page 32: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/32.jpg)
![Page 33: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/33.jpg)
Renal Failure Index (RFI)RFI = UNa x SCr/UCrIntrepretation
RFI < 1 (prerenal failure)RFI > 1 (intrarenal failure)
![Page 34: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/34.jpg)
Fraction Excreted Sodium (FENa)
FENa = Una X PCr / Pna X Ucr x 100Intrepretation
FENa < 1 (prerenal failure)FENa > 1 (intrarenal failure)
![Page 35: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/35.jpg)
Renal Failure Index (RFI)RFI = UNa x SCr/UCrExampleRFI > 1 UNa>40 mEq/L FENa > 2-3% UCr/SCr<20
![Page 36: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/36.jpg)
Renal BiomarkersUrine interleukin – 18 (IL – 18)Urine or blood NGAL
neutrophil gelatinase – associated lipocalin
Increase 24 to 48 hours earlier than creatinine
![Page 37: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/37.jpg)
IntrinsicDiagnostics
BUN/Creatinine ratioRFI/FENaurinalysis
![Page 38: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/38.jpg)
Treatmentunderlying causeprevention on injury
high risk patienthydrationlimit exposure
![Page 39: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/39.jpg)
Management Principlesmaintain fluid balancemanage hyperkalemia• glucose & insulin• sodium bicarbonate• calcium gluconate• albuterol
![Page 40: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/40.jpg)
Clinical Manifestationshyperkalemiahypocalcemiahypermagnesemiahyperphosphatemiaacid – base imbalance
![Page 41: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/41.jpg)
hypocalcemia occurs in up to two-thirds of patients with significant rhabdomyolysis
increase in serum phosphate deposition of calcium phosphate into injured muscledecreased bone responsiveness to parathyroid hormone
![Page 42: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/42.jpg)
Management Principlescontrol hypertension in presence of encephalopathybicarbonate for severe acidosis (pH < 7.2)manage anemia
![Page 43: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/43.jpg)
Renal Replacement Renal Replacement TherapiesTherapies
![Page 44: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/44.jpg)
TreatmentReplacement Therapies
acidosisHCO3 < 10 mEq/LK+ > 6.5 mEq/Lneed high protein dietdeteriorating
![Page 45: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/45.jpg)
Treatment:Types
hemodialysiscontinuous renal replacement therapy
![Page 46: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/46.jpg)
Treatmentfluid balanceanticoagulationprevent clottingprevent blood lossultrafiltration
![Page 47: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/47.jpg)
Case Study 20 – year old male with friends “doing
drugs – cocaine” police break up party – male runs from
police but collaspes – states legs became so weak that he fell
admitted to ED – lower extremity weakness and severe pain in legs
![Page 48: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/48.jpg)
Case StudySerum Electrolytes ABGsNa 141K 6.7Cl 104CO2 7Creatinine 4.5BUN 20Ca 5.0Mg 2.0PO4 11.2
pH 7.11PaCO2 27PaO2 97SaO2 98%HCO3 7
![Page 49: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/49.jpg)
Case Study
Serum Enzymes Hematology Values Clotting Profile
CK 4,780LDH 812
Hct 30WBC 18,400
PT 28PTT >180Platelets 80,000
![Page 50: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/50.jpg)
Case Study Urinalysis Sediment Urine Chemistries
Color Reddish brownSG 1.008pH 5.0
RBC 0-1WBC 4-5Casts granular & epithelial
Urine Na 42Urine Osm 280
![Page 51: Rhabdomyolysis: Challenges in the ICU](https://reader035.fdocuments.us/reader035/viewer/2022062520/56815ad9550346895dc8a5b3/html5/thumbnails/51.jpg)
wide variety of situations that cause rhabdomyolysisfocus is fluid resuscitation and surgical intervention if compartment syndrome developsARF is a common consequence – treat as you would any type of intrinsic ARF