Revolutionizing Modern Health with Ancient Medicine · 2019-02-18 · 32. Mikaeili A, Karimi I,...
Transcript of Revolutionizing Modern Health with Ancient Medicine · 2019-02-18 · 32. Mikaeili A, Karimi I,...
Revolutionizing Modern
Health with Ancient Medicine
A Study in Traditional Chinese Medicine,
Ayurveda and the Ketogenic Diet
Dr. Josh Axe
Conflict of Interest Statement
Dr. Josh Axe is the founder of DrAxe.com.
He is also the co-founder of Ancient Nutrition.
Traditional Chinese Medicine
(TCM) Tenets and Beliefs
• Dates back over 3,500 years
• Qi (or “vital energy”) is essential for overall health.
– Circulates throughout the body along meridians (body
pathways)
– Proper Qi keeps all systems in balance
• Meridians are believed to be connected to specific
organ systems.
• Yin and Yang (opposing but complementary
energies) should be in balance.
How TCM Works
TCM treatments work in following ways:
• Looking to the root cause of disease
• Treating the body holistically and optimizing how organ
systems function synergistically
Types of TCM Therapies
• Acupuncture: Used to help lower pain, improve
hormonal balance and combat stress
• Cupping Therapy: Used for pain management,
improving immunity and aiding digestion
• Nutrition: Used to help prevent deficiencies, boost
energy and improve detoxification
• Exercise (such as Qi gong or Tai chi): Used to
promote flexibility, strength and concentration
• Herbal medicine: Used to support organ function
and transform internal environment
Health Conditions Associated
with TCM Therapies
• Chronic pain
• Arthritis
• Fatigue
• Infertility
• Liver disease
• Headaches
• Indigestion
• Hormonal imbalances
• High blood pressure
• PMS or menopause
symptoms
• Cancer recovery or
chemotherapy
• Lowers inflammation and might offer increased
cancer protection1,2
• Reduces chronic pain and headaches3-5
• Balances hormones and improves fertility6,7
1. Tsai WH, Yang CC, Li PC, Chen WC, Chien CT. Therapeutic potential of traditional Chinese medicine on inflammatory diseases. J Tradit Complement Med. 2013 Jul;3(3):142-51. doi:
10.4103/2225-4110.114898.
2. Hybertson BM, Gao B, Bose SK, McCord JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug;32(4-6):234-46. doi:
10.1016/j.mam.2011.10.006. Epub 2011 Oct 15.
3. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for tension-type headache. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007587. doi:
10.1002/14651858.CD007587.
4. Vickers AJ, Cronin AM, Maschino AC, Lewith G, MacPherson H, Foster NE, Sherman KJ, Witt CM, Linde K; Acupuncture Trialists' Collaboration. Acupuncture for chronic pain: individual
patient data meta-analysis. Arch Intern Med. 2012 Oct 22;172(19):1444-53. doi: 10.1001/archinternmed.2012.3654.
5. Hsieh LL, Liou HH, Lee LH, Chen TH, Yen AM. Effect of acupressure and trigger points in treating headache: a randomized controlled trial. Am J Chin Med. 2010;38(1):1-14.
6. Pandey A, Tripathi P, Pandey R, Srivatava R, Goswami S. Alternative therapies useful in the management of diabetes: A systematic review. Journal of Pharmacy & Bioallied Sciences.
2011;3(4):504-512. doi:10.4103/0975-7406.90103.
7. Huang DM, Huang GY, Lu FE, Stefan D, Andreas N, Robert G. Acupuncture for infertility: is it an effective therapy? Chin J Integr Med. 2011 May;17(5):386-95. doi: 10.1007/s11655-011-
0611-8. Epub 2011 May 25.
TCM Benefits
• Improves liver health8
• Protects cognitive health9-11
• Helps lower the body’s stress response12
• Preserves muscle strength, flexibility and balance13
8. Wu X, Zeng J, Hu J, Liao Q, Zhou R, Zhang P, Chen Z. Hepatoprotective effects of aqueous extract from Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher
basidiomycetes) on α-amanitin-induced liver injury in mice. Int J Med Mushrooms. 2013;15(4):383-91.
9. Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H. A randomized, observer-blind, controlled trial of
the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry. 2005
Feb;66(2):248-52.
10. Howes MJ, Houghton PJ. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol Biochem Behav. 2003 Jun;75(3):513-
27.
11. Jia L, Zhao Y, Liang X-J. Current Evaluation of the Millennium Phytomedicine— Ginseng (II): Collected Chemical Entities, Modern Pharmacology, and Clinical Applications Emanated
from Traditional Chinese Medicine. Current medicinal chemistry. 2009;16(22):2924-2942.
12. Wang F, Lee EK, Wu T, Benson H, Fricchione G, Wang W, Yeung AS. The effects of tai chi on depression, anxiety, and psychological well-being: a systematic review and meta-
analysis. Int J Behav Med. 2014 Aug;21(4):605-17.
13. Taylor-Piliae RE, Haskell WL, Stotts NA, Froelicher ES. Improvement in balance, strength, and flexibility after 12 weeks of Tai chi exercise in ethnic Chinese adults with
cardiovascular disease risk factors. Altern Ther Health Med. 2006 Mar-Apr;12(2):50-8.
TCM Benefits
Tongue Diagnosis
Pulse Diagnosis
Ayurveda: Meals are Medicine
• What is Ayurveda?
– The 3 doshas: Vata, Pitta and Kapha
– Disease and illness originate from an imbalance in these
three energies.
• Primary goal: Help people live long, healthy and
balanced lives
– Avoid need for prescription drugs or surgeries
– Eliminate suffering from painful conditions
• Use specific herbal formulations
– Turmeric golden milk = turmeric + trikatu (ginger, black
pepper and long pepper) + ghee/coconut milk
Top TCM Herbs
Fo Ti14
Schisandra15
Anti-Aging Herbs
14. Guan S, Su W, Wang N, Li P, Wang Y. Effects of radix polygoni multiflori components on tyrosinase activity and melanogenesis. J Enzyme Inhib Med Chem. 2008 Apr;23(2):252-5. doi:
10.1080/14756360701463403.
15. Szopa A, Ekiert R, Ekiert H. Current knowledge of Schisandra chinensis(Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components,
pharmacological properties, analytical and biotechnological studies. Phytochem Rev. 2016;16(2):195-218.
Anti-Inflammatory Herbs
Turmeric16
Ginger17
16. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and
cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9;23(57):9247-9258.
17. Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int
J Prev Med. 2013;4(Suppl 1):S36-42.
Digestion
Ginger18
Peppermint19
18. Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J
Prev Med. 2013;4(Suppl 1):S36-42.
19. Cash BD, Epstein MS, Shah SM. A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. Dig Dis Sci. 2015;61(2):560-71.
Liver Cleansing Herbs
Milk Thistle20
Bupleurum21
20. Mulrow C, Lawrence V, Jacobs B, et al. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary. 2000. AHRQ Evidence Report Summaries.
Rockville (MD): Agency for Healthcare Research and Quality (US); 1998-2005. 21.
21. Law BY, Mo JF, Wong VK. Autophagic effects of Chaihu (dried roots of Bupleurum Chinense DC or Bupleurum scorzoneraefolium WILD). Chin Med. 2014;9:21. Published 2014 Sep
11. doi:10.1186/1749-8546-9-21.
Hormone Balancing Herbs
Vitex22
Dong Quai23
22. Van Die MD, Burger H, Teede H, Bone K. Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials. Planta Medica. 2013; 79(7): 562-575.
23. Circosta C, Pasquale RD, Palumbo DR, Samperi S, Occhiuto F. Estrogenic activity of standardized extract of Angelica sinensis. Phytother Res. 2006;20(8):665-9.
Testosterone Supporting Herbs
Fenugreek24
Ginseng25
Deer Antler26
24. Steels E, Rao A, Vietta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother
Res. 2011;25(9):1294–300.
25. Leung KW, Wong AS. Ginseng and male reproductive function. Spermatogenesis. 2013;3(3):e26391.
26. Sleivert G, Burke V, Palmer C, Walmsley A, Gerrard D, Haines S, Littlejohn R. The effects of deer antler velvet extract or powder supplementation on aerobic power,
erythropoiesis, and muscular strength and endurance characteristics. Int J Sport Nutr Exerc Metab. 2003;13:251-65.
Thyroid Supporting Herbs
Ashwagandha27
Bacopa28
27. Sharma AK, Basu I, Singh S. Efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled
trial. J Altern Complement Med. August 22, 2017; [epub ahead of print]. doi: 10.1089/acm.2017.0183.
28. Kar A, Panda S, Bharti S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol.
2002;81(2):281–5.
Adrenal Supporting Herbs
Rehmannia29
Reishi Mushroom30
29. Wang JM, Pei LX, Zhang YY, Cheng YX, Niu CL, Cui Y, Feng WS, Wang GF. Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a rat chronic
unpredictable mild stress model by involving monoamines and BDNF. Metab Brain Dis. 2018 Jun;33(3):885-892. doi: 10.1007/s11011-018-0202-x.
30. Chu W, Cheung SCM, Lau RAW, et al. Bilberry (Vaccinium myrtillus L.) In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.
Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4.
Candida Killing Herbs
Pau D’Arco31
Astragalus32
31. Hussain H, Krohn K, Ahmad VU, Miana GA, Green IR. Lapachol: an overview. ARKIVOC, 2007; 2:145-171.
32. Mikaeili A, Karimi I, Shamspur T, Gholamine B, Modaresi M, Khanlari A. Anti-candidal activity of Astragalus verus in the in vitro and in vivo guinea pig models of cutaneous and
systemic candidiasis. Rev. bras. farmacogn. 2012 Oct; 22(5): 1035-1043.
Immune Boosting Herbs
Elderberry33
Turkey Tail
Mushroom34
33. Barak V, Halperin T, Kalickman I. The effect of Sambucol®, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines.
Eur Cytokine Netw 2001;12:290-296.
34. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014;13(1):32-
44.
Brain Boosting Herbs
Lion’s Mane35
Ginkgo Bilboa36
Cannabidiol
(CBD)37
35. Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health - can culinary and medicinal mushrooms help?. J Tradit Complement Med. 2013;3(1):62-8.
36. Silberstein RB, Pipingas A, Song J, Camfield DA, Nathan PJ, Stough C. Examining brain-cognition effects of ginkgo biloba extract: brain activation in the left temporal
and left prefrontal cortex in an object working memory task. Evid Based Complement Alternat Med. 2011;2011:164139.
37. Bhattacharyya S, Wilson R, Appiah-Kusi E, et al. Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of
PsychosisA Randomized Clinical Trial. JAMA Psychiatry. 2018;75(11):1107–1117. doi:10.1001/jamapsychiatry.2018.2309
Stem Cell Therapy
What is it?• Regenerative injections using the patient’s own cells to
stimulate healing and repair for various conditions
What are the benefits?• Offer relief for patients with chronic pain and difficult-to-heal
injuries, all without medications or risky surgeries
How is it most commonly used?• Orthopedic uses include:
• Repairing injured joints
• Repairing stretched or torn ligaments or tendons
• Permanently stabilizing weak, damaged and/or painful
joints
Boosting Stem Cell
Production Naturally Both scientific research and TCM show that certain nutrients can help:38-40
• Promote the proliferation of healthy human adult stem cells
• Protect stem cells from the effects of oxidative stress
• Improve cognitive and memory function in animals
Top Nutrients for Boosting the Body’s Stem Cell Production:Today’s Research:
• Turmeric41
• Berries42
• Green tea42
• Astragalus42
TCM Methodologies:
• Bone Broth43
• Rehmannia44
• Ginseng45
• Goji46
• Reishi47
38. Acosta S, Jernberg J, Sanberg CD, et al. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease
inflammation in the aged rat. Rejuvenation Res. 2010;13(5):581-8.
39. Bickford PC, Tan J, Shytle RD, et al. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006;15(1):118-23.
40. Shytle RD, Ehrhart J, Tan J, et al. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds. Rejuvenation Res. 2007;10(2):173-8.
41. Hucklenbroich J, Klein R, Neumaier B, et al. Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Res Ther. 2014;5:100.
42. Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KW, Swindlehurst CA, Minev B, Patel AN, Murphy MP, Smith L, Ramos F, Ichim TE, Riordan NH. Nutraceutical augmentation of
circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. J Transl Med. 2010;8:34.
43. Somaiah C, Kumar A, Mawrie D, et al. Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells. PLoS One. 2015;10(12):e0145068. Published 2015 Dec 14.
doi:10.1371/journal.pone.0145068
44. Wang YB, Liu YF, Lu XT, Yan FF, Wang B, et al. Rehmannia Glutinosa Extract Activates Endothelial Progenitor Cells in a Rat Model of Myocardial Infarction through a SDF-1 α/CXCR4 Cascade.
PLoS One. 2013;8(1): e54303.
45. Kim YY, Ku SY, Rosenwaks Z, et al. Red ginseng extract facilitates the early differentiation of human embryonic stem cells into mesendoderm lineage. Evid Based Complement Alternat Med.
2010;2011:167376.
46. Wang H, Lau BW, Wang NL, et al. Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells. Neural Regen Res. 2015;10(12):1976-81.
47. Chen WY, Yang WB, Wong CH, Shih DT (2010) Effect of Reishi polysaccharides on human stem/progenitor cells. Bioorg Med Chem 18(24):8583–8591.
Cannabidiol (CBD)What is it?• The major nonpsychoactive component of Cannabis sativa.
What are the benefits?• 2013 study published in the British Journal of Clinical Pharmacology:
CBD can act as an anti-inflammatory, anticonvulsant, antioxidant,
antiemetic, anxiolytic and antipsychotic agent.
• A potential medicine for the treatment of
neuroinflammation, epilepsy, oxidative injury, vomiting and
nausea, anxiety and schizophrenia.48
How should it be used?• Consuming with a fat source could aid in absorption, so high-fat diets
may be the key for optimum brain health benefits.
48. Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J. Cannabidiol for neurodegenerative
disorders: important new clinical applications for this phytocannabinoid? Br J Clin Pharmacol. 2013 Feb;75(2):323-33. doi: 10.1111/j.1365-
2125.2012.04341.x.
1. 70% Healthy Fat
2. Bone Broth/Collagen Daily
3. Alkalizing Foods/Herbs
4. Adaptogenic Herbs
5. Probiotics/Enzymes
6. 30-90 Days then Keto Cycling
Ketogenic Diet
Ketogenic Diet Benefits
• Promotes weight loss49
• Balances insulin levels50
• Fights cancer cells51
• Reduces cravings and balances
hunger hormones52
• Helps reverse diabetes53
• Helps treat neurological
disorders (Alzheimer’s,
headaches, Parkinson’s,
autism, MS and more!)54
• Reduces inflammation55
• Balances gut bacteria56
• Supports longer life57
49. Bueno NB, Viera de Melo IS, Lima de Oliveira S, Ataide TR. Very-low-carbohydrate ketogenic diet v. low-fat diet for long term weight loss: a meta-analysis of randomised controlled trials. Br J
Nutr. 2013; 110(7): 1178-87.
50. Kinzig KP, Honors MA, Hargrave SL. Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet. Endocrinology. 2010;151(7):3105-14.
51. Allen BG, Bhatia SK, Anderson CM, et al. Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biol. 2014;2:963-70.
52. Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, & Proietto J (2013). Ketosis and appetite-mediating nutrients and hormones after weight loss. European journal of
clinical nutrition. 2013 Jul;67(7):759-64.
53. Mobbs CV, Mastaitis J. Isoda F. Poplawski M. Treatment of diabetes and diabetic complications with a ketogenic diet. J Child Neurol. 2013 Aug;28(8):1009-14.
54. Paoli A, Rubini A, Volek JS, Grimaldi KA. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr. 2013;67(8):789-96.
55. Masino SA, Ruskin DN. Ketogenic diets and pain. J Child Neurol. 2013;28(8):993-1001.
56. Ma D, Wang A, Parikh I, Hoffman JD, Green SJ, Chlipala G, Murphy MP, Sokola BS, Bauer B, Hartz AMS, Lin AL. (2018). Ketogenic Diet Enhances Neurovascular Function with Altered gut
Microbiome in Young Healthy Mice.Scientific Reports 8: 6670.
57. Roberts MN, Wallace MA, Tomilov AA, et al. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017;26(3):539-546.e5.
Q&A