Reversing diabetes

Consultant Obstetrician & Gynaecologist

M.B.B.S. (Madras), F.R.C.O.G (London) Board Certified Anti-Aging Physician

ABAARM & IHS

By Datuk Dr. Selvam RengasamyPresident, SAHAMM

(Society for Advancement of Hormonesand Healthy Aging Medicine, Malaysia)

SAHAMM ROADSHOW MALACCA , 15th June 2013

2Datuk Dr. Selvam Rengasamy

Society for Advancement of Hormones and Healthy Aging Medicine, Malaysia

(SAHAMM) website : www.sahamm.orgemail : [email protected] : 03-62030190 / 016-3078074Fax : 603-62049223


http://www.sahamm.org/

Datuk Dr. Selvam Rengasamy

SPEAKERSDatuk Dr. Selvam

Dr. Karel Hromek

Prof. Mel Sydney Smith

Dr. Robyn Cosford

CPD Points: 10

4


Topics:Introduction to Nutritional Medicine

Nutritional Bio Chemistry

Diabesity

Cancer Causes & Nutritional Support

Children’s Health in the 21st Century

Pediatric Allergy

Injectable Nutrients

The Sensitive Patients

Skin Prick Testing with Practical Demonstrations5


The SUPERIOR doctor prevents sickness;

The doctor attends to impending sickness;

The INFERIOR doctor treats actual sickness.

Chinese Proverb

6

High Blood Glucose

Insulin Excess / Insulin Resistance

Insulin Deficiency

But Treatment Is The Same !!!

DIABETES



INSULIN RESISTANCE

INSULIN RESISTANCE = PRE DIABETES

2.5% Increase In Type 1 Diabetes Annually

9


INCEDENCE OF HYPERINSULINEMIA

10

TEST INSULIN FASTING

SUGAR%

TOTAL TESTED 700 700 47

LEVELS > 11 uU/ml 331 247 35

2007 - 2009


INCEDENCE OF HYPERINSULINEMIA

11

Test Yr 2010 Yr 2011 Yr 2012

TOTAL TESTED 468 533 496

LEVELS > 11 uU/ml 223 231 202

Datuk Dr. Selvam Rengasamy 12

0

100

200

300

400

500

600

Yr 2010 Yr 2011 Yr 2012

TOTAL TESTED

LEVELS > 11 uU/ml

HYPERINSULINEMIA & PRE - DIABETES

No Of Patients

020406080

100120140160180

10-20 21-30 31-40 41-50 51-60 61-70

Gt <5.2 Gt >5.2Is <11 Is >11


GLUCOSE & INSULIN STUDY

* 2 Years Data

Age Group Gl <5.2 Gl >5.2 In <11 In >1110-20 11 8 9 10

21-30 172 25 117 80

31-40 152 80 127 105

41-50 78 67 66 79

51-60 36 45 39 42

61-70 4 22 11 15

Gl ≤5.2

In < 11

Gl >5.2

In > 11

13

Control Blood Sugar

Reduce Glycation - HbA1c Reduce Oxidative Stress

Controlling Blood Sugar only Does Not Reduce / Prevent Complications

DIABETES



Excess Sugar

Excess HbA1c

Rust In Your Body

SystemicOnce Formed - Permanent &

Cannot Be ReversedCannot Metabolized Or Eliminated( Until Death Of RBC’S )

HbA1c


INSULIN & HISTORY

1980’s - Insulin Resistance Recognized

AND DIABETES STILL REMAINS

IRREVERSIBLE !!!

18


Aging Increases Gluconeogenesis

- 3 Times More Gluconeogenesis In The Liver

HYPERGLYCEMIA

INSULIN DOES NOT DECREASE GLUCONEOGENESIS

19


Insulin Is Not The Best

Option For Type 2 Diabetes

with Insulin Resistance

20

(HYPERINSULINEMIA)


INSULIN

Storage Hormone - Fat Anabolic Hormone - Muscle Hypoglycemic Potassium, Magnesium &

Amino Acids into Cells

POTENT INFLAMMATORY HORMONE IN EXCESS !!!

21

Society for Advancement of Hormones and Healthy Aging Medicine, Malaysia (SAHAMM)

website : www.sahamm.orgemail : [email protected] Tel : 03 - 62030190 / 016 - 3078074Fax : 603 - 62061627

HYPERINSULINEMIA=

Insulin Resistance Metabolic Syndrome Syndrome X Cardio-metabolic Syndrome CHAOS

. . .more terms to come!!!23Datuk Dr. Selvam Rengasamy

http://www.sahamm.org/


HYPERINSULINEMIA

A Severe Imbalance Of The Endocrine System - Destroy Our Ability To Metabolize Food

Balanced / Healthy Diet Replacing The Missing Essential Elements of

Nutrition - mostly MINERALSCorrecting Hormone Deficiencies

Exercise

Eliminating Toxins In Food Supply

24

HYPERINSULINEMIA

High Insulin = Chronic Silent Inflammation

CHRONIC DEGENERATIVE DISEASES



HYPERINSULINEMIA

CAN REMAIN ASYMTOMATIC FOR YEARS

NEED TO SCREEN AND TREAT THIS CONDITION

26


Weight Gain Sugar Cravings Intense Hunger Weakness , Fatique Need For Frequent Meals Poor Concentration , Memory Loss Emotional Instability - Anxiety Or

Panic Attacks

SYMPTOMS= HYPOGLYCEMIA

27


HYPERINSULINEMIA

FASTING INSULIN

> 11 uU / ml

HEALTHY LEVELS5 - 7 uU / ml

28


HYPERINSULINEMIA Fasting Glucose 3.5 - 4.8 mmol / L

BMI 25 or more

TGL > 1.68 mmol / L ( 150mg ) HDL < 1.53 (40mg) for men / > 1.93

(50mg ) for women BP > 130 / 85 mm / Hg Waist Circumference > 40 in (men)

& > 35 (women)

29


INSULININSULIN IN EXCESS

IS A DEATH HORMONE

Damages Vascular Endothelium

Promotes Atherosclerosis

Promotes Weight Gain

Promotes Cancer

“A SILENT KILLER”30


Premature Aging

Insulin Resistance

Diabetes Mellitus

Metabolic Syndrome

Hypertension - Angiotensin

Clotting - PAI Complex

HYPERINSULINEMIA

31


HYPERINSULINEMIA

Chronic Degenerative Diseases

Heart Failure, Stroke, Kidney Failure, Impotence, Neuropathy, Retinopathy And A Host Of Other Diseases

Likely To Be Implicated, Very Closely in ADHD & ADD

32


HYPERINSULINEMIA

Hypertension

Central Obesity

Decreased HDL

Increased TGL

33


Hyperinsulinemia The Delta-desaturase Enzyme

Conversion Of Omega 6 Fatty Acid To Arachidonic Acid And PGE2

Chronic Silent Inflammation

HEART CONNECTION

34

HEART CONNECTION


“GOOD” Eicosanoids (EPA / DHA) Decrease Insulin

Inhibited By EPA

Effects Of Insulin On EFA Production

ActivatedBy Insulin

Delta 5 Desaturase

Omega 6 Fatty Acids

Arachidonic Acid

“Bad” Eicosanoids

Increase InsulinProduction

35


THROMBOXANE A2

HEART CONNECTIONARACHIDONIC ACID

(Inhibited By Eating Less Insulin-stimulating Carbohydrates, Meat And By Consuming More Cold-water Fish, Fish Oil And Sesame Lignans)

COX – 1(Inhibited By

Low-dose Aspirin)

COX – 2(Inhibited B y Celebrex, Curcumin, Resveratrol

And Green Tea)

5 - LIPOXYGENASE(Inhibited By Zyflo,

Curcumin And 5-LOXIN)

PROSTAGLANDIN E2 LEUKOTRIENE B4 5 - HETE

Abnormal Platelet

AggregationInflammation,

Atherosclerosis and Joint Destruction

Interferes With Cancer Cell Death (Apoptosis)

36


Hyperinsulinemia Leads To Visceral Fat

Inflammatory Cytokines ( TNF α , PAI Complex, Adiponectin e.t.c )

&Free Radicals

Interaction With TNF α Receptors

More Insulin Resistance

OBESITY / INFLAMMATION CONNECTION

37


Decreased IGF- 1 Premature Aging

Homocysteine

Leads To Mood And BehaviourDisturbances - Depression, Anxiety,Panic Attacks, ADHD e.t.c

HYPERINSULINEMIA

38


HYPERINSULINEMIA

Increased Uric AcidLevels

- Gouty ArthritisAcanthosis NigricansHaemochromatosis

39


HYPERINSULINEMIA

ISCHEMIC EVENTS

AN INCREASED SUSCEPTIBILITY TO INFECTIONS (Dental) & INFLAMMATION

INLAMMATION RECOGNISED BY IMMUNE SYSTEM

PATCHES UP THE DAMAGE WITH MACROPHAGES , PLATELETES , FIBRIN , Lip(a), CALCIUM E.T.C.

ATHEROMA

40

More Inflammation

Leaky Gut Syndrome


CANDIDA CONNECTION1. Intestinal Candidal Overgrowth

2. Increased AGE Products

Host Of Problems Like Multiple And Changing Food AllergiesUnexplained IllnessesFibromyalgia e.t.c.

41


IMMUNE CONNECTION

HyperinsulinemiaSuppresses Immune

System

ACTIVATES ONCOGENES

42


INSULIN & CANCER

Metformin Alone – Reduced CancersInsulin Alone - 80% Higher Risk of Cancer or CVD or

Death from any causeInsulin + Metformin – 31% Higher Risk of the above

Increases IGF-1 Receptors

Cell Proliferation

Increased Cancers esp. GIT & Pancreas

Ref: Cardic University 2000-2010 / 84622 Patients Clin Endocrinol Metab. 2013 Jan 31

43

Temporary Glucose Intolerance in Pregnancy

- 7 Fold Increase in PancreaticCancer

Ref: SellaT, ChodickG, BarchanaM , et.al . Cancer Causes Control . 2011 Nov;22 (11:1513-20)


Gestational Diabetes & Cancer


INSULIN & DHEA

DHEAAnti - DiabeticAnti - ObesityAnti - AtherogenicBoost Immune SystemLowers Cancer RiskAppetite SuppressantNeuro - Hormone

HYPERINSULINEMIA = LOW DHEA

Ref: Nestler J.E, Beer N.A, Jukubowicz D.J. J Clin Endocrinol Metab, 1994 Mar; 78(3):549 -554 Nestler J.E, CloreJ.N, Blackard W.G FASEB J, 1992, Sept; 6(12): 3073-75

45


INSULIN & MAGNESIUMInsulin Is Necessary For Mg Entry Into The Cells

HYPERINSULINEMIA = INCREASE URINARY LOSS

LOW SERUM MAGNESIUM

Hypertension / CVD Cardiac Arrhythmias Migraine, Cramps & etc. Low Thyroid Function PMS

More Than 300 Enzymatic Reactions Affected

Ref: Drug the Bull 1995; 33:25-7 Chen MD, Chew WH J Trace Elem Med Biol 2001;14:228-3146

Reduces Blood Pressure

Regulates Heart Rhythm

Improves Nerve Conduction

Reduces Tissue Edema

PMS CONNECTIONIncreased Blood Glucose

=Increase Insulin, Cortisol, Adrenaline And PRL


Estrogen Dominance

Block Progesterone Activity

PCO CONNECTION

Increased Insulin =

Decreased Conversion Of Androstenedione To Estrogen


Androgen Dominance

49

CORTISOL - INSULIN CONNECTION


Increased Cortisol

Increased Blood Glucose

Increased Insulin

Chronic Inflammation

50


HbA1cThe Rust In Your Body

Complex Molecule of Glucose and Protein

Once Formed, Is Permanent & Irreversible

Once Formed , Cannot Be Metabolized & Excreted Once Formed , Remains In The Body Until

Death of RBC’s

HbA1C IS INFLAMMATORY Affects All Cells

Optimum Level : < 5% 51


ETIOLOGY

AGEINGPhysical Activity

Excess Caloric IntakeObesityInsulin ResistanceVitamin Deficiency ( Vitamins B & D )Cellular Mineral Deficiencye.g. Chromium, Magnesium, ZincManganese, Vanadium

52


Toxic OverloadGenetics

HYPER INSULINEMIA

RARE CAUSESInsulinomaExcess β Cells In ThePancreas

53

WHEAT AND DIABETES


GLUTENRaises Glucose Level Higher Than Sucrose ( Table Sugar )Acidic

Inflammatory

Triggers Autoimmune Reaction - Pancreatic Damage

Increases Visceral Fat Inflammation

Insulin Resistance

Diabetes

54


SUGAR

Inflammatory

Suppresses Immune System

Suppresses Hormones

Acidic

55


Artificial Sweeteners & Iron ( Lean Meat) increase Insulin Resistance

HYPER INSULINEMIA

56

Ref: Corkey BE. Banting Lecture 2011. Diabetes . 2012 Jan; 61 (1):4-13

Poor Muscle Mass Central Obesity Insulin ResistanceDecrease Physical Performance Effects On Other Hormones

WATCH XENO – ESTROGENS !!!Datuk Dr. Selvam Rengasamy

HORMONES

57

Testosterone & Diabetes

Moller from 1950 – 1984 treated > 10000 men & women with

Testosterone injections to treat D. M, Gangrene & Heart Disease

Ref: Oh JY, Barrett- Connor E et al. Diabetes Care 25:55-6058Datuk Dr. Selvam Rengasamy


Decreases Fat Mass

Increases Muscle Mass

Improves OGTT Values

Improves Fasting and Postprandial Blood Sugar

Improves HbA1c

Reduces Diabetic Related Complications & Mortality

Increases Haemoglobin – Beneficial For Dialysis Patients

59

Ref: Ding EL. Sex Differences of Exogenous Sex hormones and Risk of type II Diabetes.Journal of the American Medical Association 2006; 295:1288-1299Hayward RA, Maning WG, Kaplan SH, Wagner EH, Greenfield S. Starting insulin therapy in patients with type 2 diabetes: effectiveness, complications and resource utilization. JAMA. 1997; 278:663-69Gascan AM, Belvis JJ, et al. Nandrolone decanoate is a good alternative for the treatment of anemia in elderly male patients on hemodialysis. Geriatric Nephrology & Urology. 1999; 9(2):67-72

Testosterone Improves Insulin Sensitivity

Testosterone Increases - Glucose To Glycogen- Glycogen To Glucose

↓Prevents Hypoglycemia


Ref: Gascon AA. Nandrolone Decanoate is a good Alternative for the treatment of Anaemia in elderly male patients on Hemodialysis. Geriatric Nephrology and Urology. 1999; 9(2):67-72

Teruel JL, et al. Androgen versus erythropoietin for the treatment of anaemia in Hemodialyzed Patients: A prospective study. Journal American Society of Nephrology. 1996; 7(1):140-4

Average Increase in Muscle Mass - 1.2 kg

Average Decrease in Fat Mass - 1.5 kg

Exercise Induced Fat Loss Is Accelerated with Testosterone Therapy

Ref :

Bhasin S , Storer TW, Berman N, et al J. of Clin. Endocrinol. and Metabol 82: 407-13

Kupelinn V, Page ST, Aramijo AB, et al J. of Clin, Endocrinol, and Metabol 91:843-50

Wang C, Swerd Coff RS, Iranmanesh A, et al J. of Clin. Endocrinol and Metabol 85 (8):2839-53

6 MONTHS of TESTOSTERONE


TESTOSTERONE REFERENCES


Kapoor D, Goodwin E, et al. Testosterone Replacement Therapy Improves Insulin Resistance, Glycemic Control, Visceral Adiposity & Hypercholesterolemia in Hypogonadal Men with Type 2 Diabetes. European Journal of Endocrinology. 2006; 154(6):899-906

American Diabetes Association. Type 2 Diabetes in Children and Adolescents. Diabetes Care. 2000; 3:381-389

Cohen PG. Diabetes mellitus is associated with subnormal levels of free testosterone in men. British Journal of Urology. 2006; 97(3):652-3

Small M, et al. Metabolic Effects of Stanzolol in type II Diabetes Mellitus. Hormones Metabolic Research. 1986; 18:647-8

DHEA & DIABETES“Disease Predicting Hormone ”

Main Actions:Increases Liver Glucose OxidationReduces Gluconeogenesis ( Glycogen to Glucose )Promotes Fat LossIncreases Muscle MassImproves Insulin Sensitivity Balance the effect of Cortisol on Fat Storage

Ref: Lardy H, Stratinan F, Elsevier N.Y, 1988;337-42Nestler JE, Clone JN, Blackard WG J Steroid Biochern Mol Vol. 1991;40(6):599-605Nestler JE, Mc Clanahan MA Ballieres Chin Endocrinol Metab, 1992 Oct: 6(4):829-47



DHEA & DIABETES

Increases Metabolism ( via Thyroid Function )

Reduces Complications of D.M & Islet Cell Exhaustion

Reduces Appetite

Inhibits Fat Synthesis and Storage

Ref: Cleary MP, Shepherd P, Jenits B, J Nutr. 1984;114:1242-51Coleman DL, Laiter EH, Applerweig N. Endocrinol 1984;115:239-43Kurtz BR, Givens JR et al. Chin Endocrinol Metab (64),1262-67

64

DHEA & REVERSING DIABETES


Low DHEA & Testosterone → High Insulin Levels

DHEA & Free Testosterone have Reverse correlation with Blood Glucose

DHEA & Free Testosterone improve InsulinSensitivity in Aging & Obese Patients

Reduces complications of D.M esp Atherosclerosis

65

Ref: Heffner JE, Milain M, Ain J. Respir. Cell Mol (2)1990:257-61Buffington CK, Givens JR, Kitbachi AE Chin. Res (36), 1988:41Barrett – Corner E, Khaw T N. Eng. J. Med. (315), 1986;1519-1524


Decreases Obesity

Increases Muscle Mass

Increases Physical Performance

Reduces Insulin Resistance

Effects On Other Hormones


Increases Metabolism

Reduces Fat Mass

Improves Immune Function

THYROID

67


In Most Cases It Is Curable Permanently, Quickly, Economically And Often Easily And By :Natural Means: L i t t le O r N o D e s ign e r

D ru gs A re N e e d e d

A Cure Will Effect Financially The Orthodox MedicalCommunity, The Drug Business And The Food Processing Industries

“ In A Time Of Universal Deceit, Telling The Truth Is A Revolutionary Act”

George Orwell

TREATMENT

68


Inhibit AmylaseImprove Insulin SensitivityReduce Insulin ResistanceInhibit Glucose - 6 - PhosphataseIncrease Leptin LevelsReduce Leptin resistanceCorrect Hormone Deficiencies Correct Mineral Deficiencies

69

TREATMENT


TREATMENT

DIET & ExerciseMaintain Healthy Weight

70


TREATMENT

- Chlorogenic Acid (Coffee Bean Extract)- White Kidney Bean Extract- Cinnamon- Brown Sea Weed- Fenugreek etc.

Fiber

71

CHROMIUM


Improves Carbohydrate Metabolism

Improves Insulin Sensitivity

Reduce Blood Sugar

Increases Insulin Receptors

Reduces Appetite (In Higher Doses)

Anti-oxidantDose : 500 - 1000 mg / day

Ref: Althuis MD, Jordon NE et al. Am J Clin Nutr 76(1)(2002:148-55)Amato P Morales AJ, Yen SS. J Gerontol A Biol Sci Med Sci 55(5)(2000:M260-3)Bahijri SM . Saudi Med J 21(1)(2000:45-50)Bagchi B, Stohs SJ , et al. Toxicology 180(1) (2002:5-22)

72

ZINC


Constituent of > 300 MetalloenzymesImproves Carbohydrate MetabolismImproves Insulin Sensitivity &Pancreatic Function Useful in Diabetic Leg UlcersAnti-oxidant - Improves Immune FunctionUseful in Both Type I & II DiabetesDiabetes Increases Urinary Loss of Zinc

Dose : 25 - 50 mg / dayRef: DiSilvestro RA. J Nutr 130.55 Suppl (2000:1509-115)

Illouz R et al. Biochem Biophys Res Commun 295.1(2002:102-6)Niewoehner CB et al. AM J Med 81.1(1986:63-8)Haeger K Lanner E. Vasa 3.1(1974:77-81) 73


MAGNESIUM

Involved in > 300 Enzymatic Reactions

Improves Insulin Sensitivity

Improves Glucose MetabolismReduces Diabetic Complications e.g. CCF, IHD, Hypertension, Arrhythmias

Ref: Paulisso et al. AM J Clin Nutr 55.6 (1992: 1161-7)Rodriguez - Moran M , Guerrero Romero F. Diabetes Care 26.4(2003:1147-52)Rodriguez - Moran M , Guerrero Romero F. Acta Diabetol 39.4(2002:209-13)Frishman WH, Grattan JG, Mamtani R. Current Prob Cardiol 30.8(2005:383-459)Rasmussen HS et al. Arch Intern Med 148.2(1988:329-32)

74


ADDITIONAL MINERALSFOR BETTER GLYCEMIC

CONTROL

VANADIUM

MANGANEESE


TAURINE - THE WONDER AMINO ACID

Prevents & Treats ObesityReduces Blood Sugar Prevents Type II DiabetesPrevents & May Reverse Complication of

Diabetes - esp. Cardiovascular + Neuropathy,Retinopathy & Nephropathy

Ref: Zhang M, Bi LF Fang, JH, et al. Amino Acids. 2004 June ;26(3):267-71Tsuboyama – Kasaoka N, Shozawa C, et al . Endocrinol. 2006 July;141(7):3276-84Franconi Floizzo A, et al. Curr Opin Clin Nutr Metab Care. 2006 Jan; 9(1):32-6Kim KS , Ohda H, Kim Jy, et al. Exp Mol Med. 2012 Nov 30;44(11):665-73Tippia PS, Thliveris J, et al. Exp Clean Cardiol. 2011 Fall;16(3):e 17-22Lee F, Abatan OI. Neurobiol Dis. 2006 June ;22(3):669-76Yu X, Xu Z, Mi M, et al. Neurochem Res. 2008 Mar; 33(3):500-7

NIACIN (VIT. B3)


Improves Insulin Secretion

Enhances Insulin Sensitivity

Good Results In Early Onset IDDMEffective In The Prevention of IDDM In Children with Islet Cell Antibodies

Dose : 2.5 mg / kg / dayRef: 32000 population based study in NZ

Bingley PJ, et al. Diabetologia 36, 675-676,1993Elliot Rb, Pilcher CC. Diabetes Res Clin Pract 14, S85, 1991Mandrup Paulsen T et al. Diabetes Metabol Rev 9, 295-309, 1993

77


Avoid Hydrogenated Oils / Saturated Fats

Omega 3 Fatty AcidsVitamin D₃

REDUCING COMPLICATIONS

78


Natural ANTI INFLAMMATORYAgents:

- Curcumin- Quercetin- Bromelain- Boswellia- Ginger


79


Natural ANTI-GLYCATION Agents:

- Benfothiamine- Methylcobalamin- Carnosine- Alpha Lipoic Acid


80


ANTI OXIDANTS - Vit , C, E, D & A- CoQ10- Bio-Flavanoids- Carotenoids


81


HORMONES

TestosteroneDHEAThyroid Hormones Growth Hormones

82


METFORMIN39 % Reduction In M.I36 % Reduction In Death From Any Cause62 % Reduction In Pancreatic CancerKills Cancer Stem Cells

NO INCREASE IN LACTIC ACIDOSIS

Ref: Hirsch HA, Lliopoulos D, Struhl K. Proc Natl Acad Sci USA. 2013 Jan 15:110(3):972-7

83


Decrease Gluconegenesis ( Insulin Has No Such Action)Increase Insulin SensitivityDecrease Sr. Insulin LevelsDecrease TGLDecrease HbA1cActivates AMPK - Insulin Signaling

- Metabolism Of Glucose And Fats

Both Chlorogenic Acid And Curcumin Has The Same Beneficial Effects

METFORMIN

84


METFORMIN• DECREASE GLUCONEOGENESIS• INCREASE INSULIN SENSITIVITY• DECREASE SERUM INSULIN LEVELS • ACTIVATES AMPK - INSULIN SIGNALING

- METABOLISM OF GLUCOSE & FATS• DECREASE TGL• DECREASE HbA1c

METFORMIN - SIDE EFFFECTS

B12 Deficiencies - Increase Homocysteine- B12 & Folic Acid

Decrease Total & Free Testosterone?

Sulphonylureas - Increase Weight Gain- Increase CVD

85


REFERENCESJung JW, Park SB, Lee SJ, Seo MS - PLoS 1. 2011; 6 (11:e), 28068

Hardy TM, Tollefsbol TO - Epigenomics. 2011 Aug; 3(4): 503-18

Bachmeier BE, Mohrenz IV - Carcinogenesis. 2008 Apr ; 29 (4): 779-89

Soerjomataram I, de Vries E, Pukkala E – Int J Cancer 2007 Mar 15; 120 (6: 1336-43)

Proceedings of Am. Coll. Of Endocrin. Insulin Resis. Aug 25-26, 2002

Endocr. Pract, 2003 Sep-Oct; 9 Suppl 2:22-112

Howard, G., etal. Circulation, 1996 May 15;93(10):1809-17

Duvnjak, L. and Duvnjak, M.J Physiol Pharmacol, 2009 Dec,:60 Suppl 7:19-24

86


REFERENCES

Endemann, D.H. and Schiffrin, E.L. J Mam Soc Nephrol, 2004 Aug; 15(8):1983-92

Hemkens, L.G., etal. Diabetologia, 2009 Sep; 52(9):1732-44

Samy, N., etal. Dis Markers, 2009:26(4):163-70

deKort, S., etal. Leaky Gut Obes Rev, 2011 Jun;12(6):449-58

Schrijvers, E.M., et al. Neurology, 2010 Nov 30;75(22):1982-7

McGeer, E.G. and McGeer, P.L. J Alzheimers Dis. 2010;19(1):355-61

Matsuzaky, T., et al. Neurology, 2010 Aug 31;75(9):764-70

de la Monte, S.M. and Wands, J.R. J Diabetes Sci Technol, 2008 Nov;2(6): 1101-13

87

TREATMENT Calorie Restriction Prolongs Life – 60% SIRT – 1 Gene Activation Delays Neuro-degeneration


You’re only as good as your last meal !!!

Ref: Tsai LH. J of Neurosience May 22, 2013

88

HIGH FRUCTOSE CORN SYRUP

Promotes Obesity More Readily Than Regular Sugar

Increases Appetite (Central Action)

More Addictive Than Cocaine

D.M

C.S.I


This Sugar Cannot Be Used By Muscles For Energy Production Shunt To Liver - Non Alcoholic

Fatty Liver 89

Datuk Dr. Selvam Rengasamy1800 10 20 30 6050 7040 19009080 2010 4030 6050 8070 10200090

RISE IN SUGAR CONSUMPTION 1800 - 2008Su

gar C

onsu

mpt

ion

in p

ound

s pe

r per

son

per y

ear

World War

I1815

1895

19141939

19551970

World War

II

Years 90

OUR CHILDRENDo We Need To Screen Their

Fasting Insulin Levels ?



MILK TOXIN!!!!!

Bovine Albumin Peptide -β Cell Antibodies

Ref: Gerstein HC. Diabetes Care 17, 13-19, 199492

HYPERINSULINEMIC DIET



CF

P

Longevity Diet

94


HOMO VITRUVIAN- Da Vinci

HOMO FATRUVIAN

95


HYPERINSULINEMIA1. have sugar / carbohydrate cravings

2. Eating Carbohydrates gives me temporary boost / energy and mood. I later crash.

3. I get irritable, tired, anxious and get headaches intermittently butfeel better after meals

4. I feel shaky 2 to 3 hours after a meal

5. I have a family history of Diabetes, Hypoglycemia

6. I have difficulty in loosing weight

7. I feel weak, tired and irritable if I miss a meal

8. I feel sleepy, dull and feel “drugged” after eating a meal full of pasta, bread, potatoes, rice, desert but feel better after a protein meal

9. I get palpitation after eating sweets

10.I get panic attacks in the afternoon If I skip breakfast

Yes NoQUESTIONAIRE

96


11. My memory is poor

12. I get night sweats

13. I am tired most of the time

14. My waist – to – Hip ratio is > 0.8

15. I have polycystic ovaries

16. I have irregular menses / infertility

17. I have facial hair (for women only)

18. I have Heart disease

19. I have Diabetes Mellitus

20. I have recurrent fungal infections (vaginal candidiasis, jock itch)

If your score is > 7, you are likely to have Hyperinsulinemia / Insulin Resistance

QUESTIONAIRE Yes No

97

THANK YOU….For learning Medicine that

HEALS and be

HEALERS


HYPERINSULINEMIA ON YOUR BRAIN, YOUR BODY AND YOUR HEALTH

Thrombosis

Sti. Growth of Cancer Cells

Inflammation & Oxi. Stress

Homocystine By B6 & Folate

-Affects Methylation Cycle (Broken Brain)

Infertility & Hirsutism


Reversing diabetes

Health & Medicine

Transcript of Reversing diabetes