RESPIT™Regionally-specific immunotherapy

• Standardized allergen extracts defined by geographic region

• Inclusion based on– Aerobiology– Allergenicity– Cross-reactivity

RESPIT Regions

Background evidence

• There is no consensus as to the most accurate testing technique, which display significant variability and in some cases poor reliability

• Varied testing techniques and immunotherapy protocols produce similar results

• Studies support the role of non-specific tolerance in humans

• A double-blinded study found that stock mixture IT produced the same benefit as customized IT

Garfield, R. Injection Immunotherapy in the Treatment of Canine Atopic Dermatitis:Comparison of 3 Hyposensitization Protocols. 1992, Members Meeting of the AAVD & ACVD, p. 7-8.

High dose customized immunotherapy

Low dose customized immunotherapy

Standardized immunotherapy

0102030405060708090

100Good-excellent response rate (%)

n=27 n=22 n=29

Customized vs. Standardized Immunotherapy for Canine Atopic Dermatitis

Comparison of standardized and allergen-specific IT

• Allergy test required• Avoids false (-) and false (+) results• RCT supporting effectiveness• High-quality, placebo-controlled

trials to establish efficacy• Guides allergen avoidance• Oral cavity & injectable

administration available

Standardized ASIT