Respiratory Disease in poultry
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Respiratory Disease complex
§ By§ Prof. Dr. Mohamed
H. H. Awaad§ Faculty of Veterinary
Medicine, Cairo University
§ By§ Prof. Dr. Mohamed
H. H. Awaad§ Faculty of Veterinary
Medicine, Cairo University
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Economic losses
§ High mortality (e.g. Avian influenza).§ Down grading of carcasses and condemnation at slaughter (e.g.
CCRD).§ Lowering fertility and hatchability (e.g. Mycoplasmosis). § Severe drop in egg production and egg quality (e.g. ND and IB). § Loss of weight and poor feed conversion (e.g. Colibacillosis).§ Increased medication costs.§ Increased post vaccination reaction.
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A-Feed:Mycotoxins, antibiotics, pesticides, chemicals, deficiency (vitamins, Protein & minerals).
B-Environment:Bad ventilation (ammonia and dust), temp. extremes, high relative humidity.
C-Organisms:Viral (CAV, ALV,REV, Reo, IBDV, MDV, NDV & AIV). Bacterial: MG & MS. Coccidiosis.
1-System of management (Multiage).2-Distance to the nearest farm and between houses. 3-Stocking density (over crowding - social stress). 4-Chick quality.5-Poor biosecurity (Rodents, Insects, Animals, man).6- Litter (dry or wet).7-Duration between successive cycles.8-Vaccination and medication.
I- Immunosuppressive factors
Predisposing factors (Stresses)
II- Management factors:
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Classification of Respiratory Diseases according to etiological agent(s)
1- Viral (ND, IB, ILT, Paramyxoviruses other than ND, Avian influenza, Adenoviruses, Reoviruses,and Avian poxvirus “Avian diphtheria” ).
2-Bacterial (Colibacillosis, ORT, Salmonellosis, Pasteurellosis, Mycoplasmosis, Infectious coryza, and Chlamydiosis).
3- Mycotic (Aspergillosis “Brooder pneumonia).4-Parasitic (Cryptosporidia,Syngamus trachea in
chickens and turkeys, and Cyatostoma bronchialis). 5-Non-infectious (Vitamin A deficiency).
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Classification according to site of affection
1- Outbreaks which affect the upper respiratory tract; nasal discharge anddistended sinuses with or without lower respiratory symptoms) e.g.Infectious coryza, Mycoplasmosis, Diphtheritic form of Avian pox and Avitaminosis A.
2- Outbreaks that affect mainly lower respiratory tract without obviousnasal discharge or sinusitis are likely to be due to mild ND,IB,ILT orAspergillosis.
N.B.:This classification depends on the early detection of the first clinical signs. (Complications).
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EpizootiologyI-Susceptibility:a-Species:*Limited to species (e.g. IB, ILT, IC) *Wide host range (e.g. ND, AI, FC)b-Age:*First few weeks (E.coli, Asp., Salm., Mycoplasm).*Semimature and Adults (ILT, IC, FC).*All ages (ND, IB).
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Epizootiology( continue)
II-Mode of infection and transmission:*Inhalation (Most of Respiratory Diseases).*Ingestion (AI, ND, IC, FC).*Conjunctival infection (ILT, FC).*Insect biting (Fowl Pox).*Vertical transmission (MG, MS, Salmonellosis, E.coli).
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Epizootiology( continue)
III-Incubation period:
*Very short (1-3 days e.g. IB, IC, AI).
*Moderate (4-6 days e.g. ND).
*Long (Over 6 days e.g. Mycoplasmas, ILT, Avian Pox).
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Symptoms:§ Respiratory signs include nasal discharge, sneezing,
coughing, rales, gasping, and dyspnoea. § + General clinical signs of ruffling of feathers, loss of
appetite, huddling together, constant peeping young birds, and depression.+Specific signs of each disease.
Post mortem lesions:Rhinitis, pharyngitis, laryngitis, tracheitis, bronchitis, lung congestion or pneumonia.+ Specific lesions of each disease.
Clinicopathological picture
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Specific clinicopathological picture of certain
Respiratory diseases
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Septicaemic contagious- respiratory and/or nervous, facial edema, greenish diarrhea, Lowering egg production (quantity and quality).
Variation of clinicopathology depends upon1- Virus agent (Virulence, degree of exposure).2-Host (Age, general health condition, immune status).
forms:I- Acute lethal VVND (Doyle’s form).II- Acute often lethal respiratory + nervous NVND (Beach’s form).III- Less pathogenic NVND-mesogenic (Beaudett’s form).IV- Mild respiratory-lentogenic (Hitchener’s form).V- Non obvious disease (Asymptomatic-enteric form).
Newcastle disease
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Infectious bronchitis (IB) Contagious disease of chickens only Mainly
respiratory, may cause problems in intestine, kidneys (INNS) or reproductive system.
Caseous plugs (pathognomonic lesion). Drop in egg production, misshapen eggs with watery albumin, false layers with abdominal ovulation.
Severe nephrosis and nephritis (INNS) with lesions of gout (nephrotoxic strains).
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Infectious laryngeotracheitis (ILT)
Contagious disease of chickens andpheasants-dyspnoea and expectoration
of bloody exudate.
Hemorrhagic tracheitis - free blood or bloodtinged cheesy plugs is pathognomonic
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Avian pox (Avian Diphtheria)
§ Contagious disease - Skin eruptions of unfeathered parts and / or diphtheritic lesions on mucus membranes of upper respiratory and digestive tracts (Pseudombrane).
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Avian influenzaVariety of disease syndromes ranging
from subclinical to acute generalized fatal disease (Fowl plague).
Fowl plagueRapidly fulminating - increasing mortality - periorbital edema - edema of the head - swollen sinuses - cyanotic hemorrhagic wattles, comb and legs.
Post mortem lesions consist of a varietyof congestive-hemorrhagic-transductive-
necrotic changes.
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Infectious coryza
*Acute respiratory disease of only chickens.
*Acute spread with nasal discharge -swelling of eye-lids and sinusitis - edema of the wattles - 10-40% drop in egg production
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Avian Mycoplasmosis“CRD”
§ Uncomplicated Inapparaent or very mild with poor egg production and reduced hatcability.
§ In turkeys severe sinusitis “ IS” .§ Airsacculitis is so far a pathognomonic
lesion.
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Avian Colibacillosis
§ Air sac disease either separately or complicating mycoplasmosis (CCRD).
§ Poor feed conversion and lesions of pericarditis, perihepatitis and airsacculitis (serous to caseous).
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Salmonellosis
§ Subacute form of S.gallinarum in baby chicks may show respiratory signs.
§ Lesions are whitish nodules in lungs, cardiac muscle or pancreas - Ceca may contain caseous cores -Swollen joints - Retardation of yolk sac absorption).
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Avian Pasteurellosis
§ Catarrhal or Roup form of Chronic fowl cholera.
§ Rattling respiration or rales - Catarrhal discharge from nostrils - Conjunctivitis.
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Chlamydiosis
§ Latent infection
§ Stress conditions
§ Acute disease§ (Respiratory signs, diarrhea, trembling, locomotor
disturbances, leg paralysis, spleenomegaly and hepatomegaly, serofibrinous exudates in
abdominal cavity).
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Ornithobacterium rhinotracheale (ORT)
Respiratory manifestation with different clinical courses.
Discovered since December 1991
Mild respiratory symptoms and sinusitis)
MortalityEgg productionPerformance
Foamiest “yogurt-like”exudateFibrinous Pneumonia and Pericarditis.
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Aspergillosis
§ Respiratory lesions:Milliary nodules up to larger nodules with localized hepatization in lungs. Visible mycelial masses in air passages and bronchi. Disc-shaped necrotic mass or nodules with concave surface. Thickened air sacs that covered with fur-like growth of mold.§ Eye lesions:
Yellow cheesy pellet beneath the nictitating membrane causing plugging of the eye-lids.Central ulceration of the cornea.§ Nervous manifestations:
Torticollis and lack of equilibrium.
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Tracheal worms
§ Parasitising the trachea and bronchi giving signs similar to ILT (Dyspnoea).
Syngamus trachea (chickens , turkeys, peacocks and pheasants).
Cytostoma bronchialis (ducks, geese and turkeys).
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Avitaminosis A (Nutritional Roup)
§ Poor growth - Inflamed eyes - Nasal catarrh - Swelling of sinuses -Keratoconjunctivitis - Excessive lacrimation - Drop in egg production.
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Diagnosis§ * Clinicopathological picture (Tentative).§ * Lab. Diag.(Definite diagnosis):
l Early stages (Isolation and identification of pathogenic agent-Direct methods).
l Convalescent stages (Detection of rising Ab titers in sera).
l N.B.:§ Lab. Diag. Is necessary to rule out the § possibilities of a mixed infection.
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Prevention and Control
Lines of Defense In Avian Respiratory Tract
*Cilia:(lining mm of trachea and bronchi) act as moving brush.*Mucus producing cells:secrete protective layer of mucus.*Local antibodies:Harderian gland, floods mm of upper respiratory tract with antibodies(IgA).Lymphoid tissues in submucosa of conjunctiva, nasal cavity, larynx and trachea.
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Prevention and Control
3-Veterinary biosecurity + hatchery hygiene.
2- Destruction of large numbers of invaders:
ii Disinfection.Disinfection.
ii Feed decontamination Feed decontamination Physical destruction of microorganisms ( irradiation, pelting)Physical destruction of microorganisms ( irradiation, pelting) Chemical mechanisms (Dietary acid additives).Chemical mechanisms (Dietary acid additives).
1- Strengthen resistance of the hosti Breeding for resistance.i Improved nutrition.i Vaccination.i Chemotherapy (Prophylactic and therapeutic).i Competitive exclusion (CE) and Probiotics.
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Thank you