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2019 RESEARCH REPORT

Table of Contents

Structure and Governance 1

Mission and Aims 2

Report - Chair 3

Executive Profiles 5

Research Theme Reports 6

Research Funding 14

Research Supervision 17

Publications 18

CRE REDUCE Update 24

Collaborators 25

Enquiries 30

Level 8, UQ Centre for Clinical Research, Building 71/918

Royal Brisbane and Women's Hospital Herston QLD 4029

Proudly Supported By

Our Partners

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Our Structure and Governance The Burns Trauma & Critical Care Research Centre (BTCCRC) was established in 2004 in response to the Bali bombings. The devastation and tragedy of this event focused national and international attention on burns victims and emphasized that there was a critical need to improve the early and on-going treatment and outcomes of burns and critically ill patients. The outstanding response from the critical care, burns and anaesthetics teams of the Royal Brisbane & Women’s Hospital (RBWH) highlighted the skill and expertise we possess in this area. Our Centre is directed by Prof Jeffrey Lipman, chaired by Prof André van Zundert, Professor of Anaesthesia and managed by research manager Dr Sia Athanasas. The stability of the BTCCRC exists by virtue of our major supporter and partner, the RBWH Foundation and our partners The University of Queensland (UQ), the Queensland Government and the Australian Defence Force. The research within the centre is continually expanding and is divided up into five core themes.

Critical Care - Management and outcome of critically ill, head injury, renally dysfunctional and long stay ICU patients.

Drug Dosing and Pharmacokinetics - Pharmacokinetics, drug distribution and antibiotic resistance in critically ill patients. We have

laboratories across two campuses, within the Antimicrobial Optimisation (AMO) Group at RBWH and within the Centre for Translational

Anti-infective Pharmacodynamics (CTAP) at PACE, PAH.

Burns - Management and outcome of burns patients encompassing prevention, acute injury, long term outcomes and skin culturing.

Anaesthesia - Evaluating new procedures and safety of procedures for anaesthetising critically ill and difficult to anaesthetise patients.

Military & Trauma Medicine - Managing pre-hospital care, trauma and rehabilitation medicine.

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MISSION AND AIMS

Our Mission The BTCCRC was established to further advance and improve the level of treatment and care given to burns and critically ill patients through world-class research-based clinical practice. It began as a collaborative venture between the RBWH Burns and Intensive Care Units, UQ and has incorporated the Department of Anaesthesia. In recent years the centre has undertaken research into military medicine.

Our Aims The main aims of our research centre are to:

Improve both the survival and outcome of patients by conducting high quality research in the area of Burns, Trauma, Critical Care, Military Medicine and Anaesthesia in general.

Provide a research-driven evidence base that informs clinical practice and policy in the above research themes.

Establish local, national and international collaboration in these areas thereby increasing research opportunities.

Enhance the research training and knowledge base of postgraduate students and staff in the above areas.

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50 Years of Internet – A milestone breakthrough to connect scientists all over the world Traditional research has changed drastically over the last 50 years with the introduction of the Internet, supercomputers which can handle massive data, modern search machines and smartphones. The Internet is easy to use and gradually took over the global communication landscape, including the emerging global phenomenon of mobile leapfrogging and its importance for research access and dissemination. It all started on 21 November 1969, when two minicomputers connected the University of California (UCLA) and Stanford Research Institute (SRI) in Palo Alto. This ARPANET (Advanced Research Projects Agency Network), funded by the US Department of Defence, initial ly meant to exploit new computer technology to meet military needs. However, it was also born out of frustration as there were only a limited number of powerful research computers available, with researchers geographically separated from them. More computers were connected and within no time the US East Coast was reached. Norway was the first country outside the USA to be connected to the ARPANET in 1972, with a transatlantic satellite link between the Norwegian Seismic Array (NORSAR), while a terrestrial circuit added a London IMP. Soon, the whole world would follow with an unprecedented network, providing almost unlimited exchange of data. Internet technology leapfrogged with ARPANET from being an idea to connect all communication networks together, providing a network of networks. The Internet was born. The term ‘Internet” was reflected in ‘Internet Transmission Control Program’, a short term for internetworking. Computer-scientist Tim Berners-Lee who worked for CERN (Switzerland) invented the World Wide Web in 1989, making it possible to link hypertext files into an information system that could be accessed from any node on the network using a web-browser and web-based applications (apps). A major technical improvement was the release of the first mobile phone with Internet connectivity in Finland in 1996, the beginning of the ‘smartphone’ era. The Internet would gradually take over the global communication landscape and have a revolutionary and immeasurable impact on people’s daily lives all over the globe e.g. on communication (e.g. mobile smartphones using a variety of input sensors, i.e. camera, voice, touch, GPS), social network (e.g. text messages, emails, photographs, movies, videos, music, podcast, mobile gaming, blogs, Facebook, Twitter, Instagram, WhatsApp), news, books and culture, business, commerce and manufacturing, technology, travel, finance (banking, transactions and insurance), weather, science, research and scholar activities, education, health (medicine, nutrition, fitness), to share content quickly, efficiently and in real-time. How much data is on the Internet and how is the size of the World Wide Web estimated?

The Internet's size is a moving target, creating a deluge of information. The total data stored by big online storage and service companies like Google, Amazon, Microsoft and Facebook on Internet increases daily and is currently (January 2020) estimated to be at least 1,200 petabytes (1.2 million terabytes). This figure excludes other big providers like Dropbox, Barracuda and SugarSync, to say nothing of massive servers in industry and academia. It is growing by leaps and bounds. The size of the indexed World Wide Web and that of Google are both >60 billion webpages (January 2020).

The mobile health industry and the digital assistant in research

Health Care took advantage of the Internet, especially with the development of mobile technologies, creating new opportunities to improve health and streamline communication between health care workers to exchange medical knowledge and research. Numerous knowledge sharing apps for medical professionals saw the light of day. Doctors happily use these apps to search topics they used to look up in books and files. But a library is usually not at hand when you need information right now. The Internet, accessed via a smartphone, provides a much better, faster, on-demand, often free, answer anytime anywhere, while the doctor need not go to a desktop or laptop computer. This freedom is embraced by the medical profession across all specialities. They all welcome the Internet as a valuable and immediate access tool to science and existing medical knowledge in an attempt to get an answer to their query, limiting the shear endless abundance of medical information that exists.

CHAIR’S REPORT

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Need for regulations, accreditation and official oversight of apps in anaesthesia and intensive care.

Hundreds of thousands of health care apps are available at this moment, with numerous topics of care in anaesthesia and intensive care. However, anybody can produce a medical/anaesthesia app and sell it on the Internet. There is lack of oversight of these apps and no official regulation or accreditation rules exist. Clinicians and researchers are left out of well-controlled, up-to-date peer-reviewed apps and risk similar counterfeit actions of cybercriminals victimising the scholarly publishing world. Indeed, the new millennium saw a revolution in electronic “open-access” publishing, triggered by the technical options offered by the Internet and the low cost of setting up novel electronic journals. Similar to the scholarly world of publishing scientific articles, where various anomalous threats resulted in paid publishers, predatory and hijacking journals, which left duped authors without service, empty pockets and worse, no published article, as peer-review often is not delivered or unreliable with a lack of ethical guidelines during the submission process. This negative by-product of the Internet revolution has resulted in a massive influx of unscrupulous and dishonest publishing operators, driven by profit, promising rapid decisions and quick publishing using misleading marketing strategies and false claims, i.e. citation of fake impact factors, abusing real journal names, stealing web domains (web-swooping) and even using their logos. Informing our colleagues of these deceitful publishing practices is a must. We therefore need a regulatory organisation that checks medical apps using a peer-review process, labels and classifies them and marks these apps according to an internationally agreed app quality scoring and accreditation system. Publication of genuine scientific work, whether it is a scientific article or a medical app, should be considered alike as a mark of academic achievement. Anaesthetists and Intensivists all over the world use the Internet to get across scientific information and research data. The Internet, mobile smartphones, apps and email exchange have become standard tools in research. We now cannot image a world without them. We were again prolific in our publications this year, with staff and students publishing 127 peer-reviewed journal articles, 6 book chapters and 11 published abstracts. Once again…..a brilliant achievement! This year, we were awarded 29 grants, with our researchers securing just over $15.2 million in research funding. An outstanding effort! Research not only relies on funding bodies for vital research funds but also on our generous donors and sponsors whose financial support has helped boost our research endeavours. I would like to thank Dr Sheena Burnell for her wonderful gift of $10,000 to our research program in Anaesthesia and Mr John Fletcher of The University of Queensland in America, Inc. for his gift of $492. We whole-heartedly thank the RBWH Foundation, MSD and Pfizer for their continuing support and sponsorship and we acknowledge our partners The University of Queensland, the RBWH Foundation, the Queensland Government and the Australian Defence Force for their on-going alliance and support of our research programs within the centre. Congratulations to the following staff and students on being awarded grant funding this year - Suzanne Parker, Anthony Holley, Jeffrey Lipman, Jeremy Cohen, Michael Reade, Angela Tognolini, Dwayne Jackson, Jason Roberts, Victoria Eley, Julie Lee, Judith Bellapart, Kevin Laupland, Alexis Tabah, Jayesh Dhanani, Menino Cotta, Tavey Dorofaeff, Fekade Sime, Michelle Roets, Joel Dulhunty. We were awarded grants from MNHHS, Jamieson Trauma Institute, Australian and New Zealand College of Anaestetists (ANZCA) Project Grant, Haematology in Obstetrics & Women’s Health (HOW), HSANZ, Australian Infectious Disease Research Centre (AID), Redcliffe Hospital, Medical Research Futures Fund (MRFF), NHMRC, Brisbane Diamantina Health Partners (BDHP), UQ, Medical Research Institute of New Zealand, European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Australian Society of Anaesthesia (ASA), Children’s Hospital Foundation (CHF) and RBWH Foundation. We would like to recognise the hard work and efforts of our talented RHD students and proudly congratulate our students who graduated this year: Dr Gloria Wong—PhD; Dr Jayesh Dhanani—PhD; Dr Judith Bellapart—PhD; Dr Orlando Flores—PhD. We wish you every success in your research careers. Finally, I wish to thank our talented and industrious researchers and staff for making this yet another successful year and I wish you all the very best for 2020.

Prof André van Zundert

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Professor Jeffrey Lipman MBBCh DA (SA) FFA (SA) FFA (CritCare) (SA) FCICM MD Director of BTCCRC; Professor, Anaesthesiology & Critical Care, UQ; Snr Staff Specialist, Dept of Intensive Care Medicine, RBWH; RBWH Research Ambassador Jeff is the Director of the BTCCRC, Professor of Anaesthesiology & Critical Care, UQ, Honorary Professor, Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Honorary Professor of Nursing (QUT) and RBWH Research Ambassador. He has qualifications in anaesthesia and intensive care and has set up and run a number of Intensive Care and Trauma Units in South Africa before coming to Australia in 1997. He is the author of over 550 peer reviewed publications, 33 book chapters, has been invited to present at many national and international conferences and is a

reviewer for a number of high quality international journals and granting committees, including the NHMRC. Jeff has been instrumental in developing the anaesthesiology & critical care component of the graduate medical program for Queensland and continues to lecture to medical and postgraduate students. He is site Principal Investigator for numerous multi-national and international trials. Research interests include all aspects of management in intensive care, resuscitation of burns and pharmacokinetics of antibiotic dosage. His research into antibiotic usage in acute situations has received international recognition whilst he has received multiple national and international awards. Jeff is involved in most research projects, oversees the direction of the research centre, mentors staff and supervises postgraduate students. In 2017, he was elected the RBWH Research Ambassador due to his extensive research track record and in this pivotal role, he has implemented systems to enable better integration of research at the Herston campus between RBWH, UQCCR, QIMR Berghoffer and QUT and better liaison between RBWH and its co-located Academic partners. He was recognized as one of the most cited authors in 2018 in his field by Clarivate Analyticss and in 2019 was top ranked scientist (in the top 1% most cited) in the fields of Clinical Medicine and Pharmacology and Toxicology. In 2019, the International Society of Antimicrobial Chemotherapy (ISAC) awarded Prof Lipman the merit title of ISAC-Fellow (FISAC) – a newly established honorary title of ISAC which recognises individual professionals who excel within their field or have delivered outstanding service to the society.

Professor André van Zundert MD, PhD, FRCA, EDRA, FANZCA Professor & Chair, Anaesthesiology & Critical Care; Chair BTCCRC, UQ; Snr Staff Specialist, Dept of Anaesthesia & Perioperative Medicine, RBWH; Professor of Anesthesiology at the Universities of Ghent (Belgium) and Maastricht (Netherlands) André has qualifications in anaesthesia, intensive care and trauma care, graduating as a medical doctor cum laude, at the University of Leuven (Belgium) in 1978 and with a PhD in obstetric anaesthesia from the University of Leyden (Netherlands) in 1985. He is the author of over 400 peer-reviewed publications, 60 book chapters and three standard textbooks, of which his book, the ‘Atlas Functional Anatomy for Regional Anaesthesia and Pain Medicine’, published in 2015 has enjoyed > 500,000 chapter downloads. In 2017, he authored a new book “Regional Nerve Blocks”, an illustrative book on virtually all

existing nerve blocks used in anaesthesia. He has been invited to present at hundreds of international conferences and is a reviewer for a number of highly regarded international journals, including Editor-in-Chief of the International Journal of Regional Anaesthesia. Under his leadership, he supported anaesthesia education by producing the bimonthly ‘Anaesthesia Research Review’, sent to all anaesthetists in Australia. He has held several positions (Secretary-General, President and Honorary Member) in Anaesthesia Societies in Europe and was President of several international and world congresses. André has been instrumental in developing the joint RBWH-UQ ‘Centre for Excellence and Innovation in Anaesthesia’ (CEIA) at RBWH, which underpins the importance of teaching, training via simulation, testing anaesthesia equipment, quality care (audits and incident reporting) and research. His aim to boost research in anaesthesia within the department and to collaborate with other departments and colleagues from all over Australia and beyond has been achieved through his leadership. André is a strong believer in ‘Teach the teacher’ and in ‘Problem oriented education’. His research interest is in airway management, regional anaesthesia and obstetrics, for which he received international recognition and 2 Royal Distinctions (from HRH Queen Beatrix, The Netherlands & HRH King Albert II, Belgium). He was a founding member of The European Society of Anaesthesiology and founder of the Pain Society (Netherlands). Since his arrival in Brisbane, he was appointed as co-convenor of the annual ANZCA conference and the ANZCA Special Interest Group in Difficult Airway Management. Furthermore, he is a member of the ANZCA Research Committee and ANZCA Research Grant Committee and has been greatly acknowledged for his contributions to: 1) Pain Relief in Childbirth (the suggested technique is still practiced all over the world in the labour ward) 2) providing safe and effective airway management using videolaryngoscopy and 3) Pain therapy. For the CEIA, André received the UQ 2014 Innovation Award. He holds several professorial appointments at UQ, QUT, Victoria University and 3 professorial appointment overseas, at the Universities of Ghent (Belgium), Maastricht (Netherlands) and Udayana (Indonesia). In 2019, Andre is recognised as one of the Top Ten World Experts in Airway Management (USA). Dr Michael Rudd MBBS FACS OAM PhD

Co-Director BTCCRC, UQ; Acute Trauma Surgeon, RBWH Michael is the Co-Director of the BTCCRC and the Director of the Adult Burns Unit at RBWH. He has fellowships in Burns and General Surgery. Michael has completed a PhD in transplantation immunobiology. His research interests are in all aspects of burn management, burn pathophysiology and immunobiology. His clinical and research background make him uniquely qualified to work as a burns surgeon and scientist at both the bedside and in the laboratory.

EXECUTIVE MEMBERS

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Our laboratory research is closely allied with our clinical research. The five (5) major themes researched within the centre are:

1) Critical Care - Management and outcome of critically ill, head injury, renally dysfunctional and long stay ICU patients

2) Drug Dosing and Pharmacokinetics - Pharmacokinetics, drug distribution and antibiotic resistance in critically ill patients

3) Burns - Management and outcome of burns patients encompassing prevention, acute injury, long term outcomes and skin

culturing

4) Anaesthesia - Improving anaesthetic care for critically ill and difficult to treat patients.

5) Military & Trauma Medicine - Investigating all aspects of trauma from medications to stop bleeding in pre-hospital care, to

determining the microenvironment dynamics in wounds, to longitudinal health outcomes.

We conduct a large number of multi-centred clinical trials across the five research themes, involving national and international

collaborators and sites ensuring that our research impacts on a global scale.

RESEARCH PROJECTS

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1) Critical Care Management and outcome of critically ill, head injury, renally dysfunctional and long stay ICU patients Patients who survive intensive care often are weak, debilitated and with a poorer quality of life compared to their pre morbid status. We are actively investigating methods to prevent weakness and loss of function in long stay intensive care patients. There are also many projects investigating the optimum delivery of standard procedures to ensure that the best quality of care is offered to intensive care patients. Cortisol, aldosterone and Vitamin C measurements in septic shock. Cohen J Gene expression in septic shock. Evans D, Cohen J. Funder: NHMRC. Sodium measurement in subarachnoid haemorrhage. Cohen J Mortality and functional outcomes in subarachnoid haemorrhage in ANZ. Cohen J Pharmacokinetics of nicotine patches in critically ill patients. Cohen J, Liu D National variation in the management of patients with subarachnoid hemorrhage (PROMOTE study). Cohen J WNT expression in sepsis. Cohen J Vascular responsiveness in septic shock. Cohen J Fludrocortisone treatment in septic shock. Cohen J Saving blood and money - introduction of laboratory testing guidelines and its effect on blood loss and cost of therapy in an intensive care unit. Dhanani J, Barnett A, Lipman J, Boots R, Ford M, Jarrett P. Funder: AusHSI Stimulus Grant. Inflammation and Augmented Renal Clearance in Traumatic brain injury (INFARCT) Study. Udy A, Lipman J, Jarrett P. Funder: RBWH. Assessment of the Microcirculation in Shocked Critically Unwell Patients during the First 24 hours of Resuscitation. Holley A, Udy A, Boots R, Paratz J, O’Donoghue S, Douglas A, Roberts J, Hurn C, Lukin B, Lipman J. Funder: RBWH Foundation/Wormald. A point prevalence survey of venous thromboembolism prophylaxis management in the critically ill and an epidemiological observational audit of venous thromboembolism prophylaxis management in critically ill patients with severe sepsis (VTE AUDIT). Gowardman J Optimal pattern of manual hyperinflation in the ventilated patient. Paratz J, Thomas P, Savian C, Lipman J A RCT of the effect of hydrocortisone on mortality in critically ill patients with septic shock (ADRENAL Study). Venkatesh B, Myburgh J, Finfer S, Webb S, Cohen J. Funder: NHMRC. Developing a research base for intravenous peripheral catheter resites. The DRIP trial. Rickard C, Webster J, Gowardman J, Wallis M, McCann D. Funder: NHMRC. SAVED - Study of practices and complications associated with central venous and arterial catheterisation in an ICU population. Gowardman J, Rickard C

An exploratory study of perceived risks, benefits and barriers to the use of Selective Decontamination of the Digestive Tract in Australasian ICUs (SuDDICU). Seppelt I, Marshall A, Myburgh J, Lipman J, Francis J, Cuthbertson B, Glass P. Funder: ANZCA, NHMRC. Endothelin, a marker of severity in subarachnoid hemorrhage vasospasm. Bellapart J, Lassig-Smith M, Stuart J, Boots R, Paratz J Exogenous melatonin in critically ill patients: the impact on sleep and ICU psychosis. Bellapart J, Boots R, Zappala C, Paratz J, Morrison S, Brown M. Funder: RBWH i-PERFORM Trial—Mobilising the Critically Ill: Physiological and Functional Outcomes following Early Rehabilitation in Sepsis. Kayambu G, Paratz J, Boots R Intravascular Device administration sets: Replacement after standard versus prolonged use (RSVP Trial). Rickard C, Wallis M, Young J, Gowardman J, Whitby M, Fraser J, McMillan D, Zhang L. Funder: NHMRC. A Real-time and Self-Adaptive Stream Data Analyser for Intensive Care Management. Zhang Y, Yi X, He J, Pang C, Steyn M. Funder: ARC Low molecular weight heparin in critically ill trauma patients: a dosing study. O’Donoghue S, Lipman J, Udy A. Funder: RBWH.

Cerebral microcirculation in head injury during normovolemic anemia: an experimental model. Bellapart J, Boots R, Reade M, Fraser J. Funder: RBWH Foundation. Welcome ICU - a research program on visiting policies in the ICU. Tabah A Eurobact II:A worldwide cohort study on the Epidemiology and determinants of outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care. Tabah A, Koulenti D Improving outcomes in sepsis: a randomized controlled trial. Boots R, Paratz J, Kenardy J, Mitchell G, Coyer F, Comans T, Thomas P, Iwashyna J, Martin-Loaches I, Hodgson C, Bissett B. Funder: RBWH Foundation. Functional electrical stimulation assisted cycling (eStimCycle): A novel intervention to improve outcomes in the critically ill. Berney S, Denehy L, Needham D, Paratz J, Koopman R, Hopkins R. Funder: NHMRC. Identification and location of secretion retention in mechanically ventilated patients. Paratz J, Thomas P, Ntoumenopolous G, Jones A, Li Bassi G, Torres A. Funder: RBWH Foundation. Centre for Research Excellence in Advanced Cardio-respiratory Therapies Improving Organ Support (ACTIONS). Fraser J, McGiffin D, Lovell N, Bannon P, Tansley G, Pellegrino V, Roberts J, Barnett A, Gregory S. Funder: NHMRC CRE. Saline installation in respiratory therapy in ICU, a crossover study. Paratz J, Thomas P, Stockton K

RESEARCH PROJECTS

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PneumoINSPIRE: International Study on NoSocomial Pneumonia in Intensive CarE. An international multi-centre prospective observational

cohort study of nosocomial pneumonia in ICUs. Koulenti D

2) Drug Dosing and Pharmacokinetics

Pharmacokinetics, drug distribution and antibiotic resistance in critically ill patients. Critically ill patients often have varying physiological needs to an average patient and often require different dosages of antibiotics and other drugs, particularly if they are on renal replacement therapies. There is also a controversy over whether bolus dosing or continuous infusion of β-lactams is more effective in antibiotic delivery in critically ill patients. Prof Lipman has pioneered work that demonstrates that patients in intensive care are not receiving adequate doses of antibiotics to achieve optimal levels to kill pathogens. This in turn leads to poorer health outcomes for patients and antibiotic resistance. Antibiotic resistant infections commonly occur in long stay, debilitated patients and contribute to increased risk of death, longer ICU and hospital stay, further weakness and long term dysfunction. This problem also contributes to patients being unable to be discharged from ICU or hospital and so exacerbating the shortage of acute hospital beds and increases in surgery waiting time. This theme of research has expanded considerably in the last few years that it now conducts its research over two campuses, within the Antimicrobial Optimisation (AMO) Group at RBWH and within the Centre for Translational Anti-infective Pharmacodynamics (CTAP) at PACE, PAH. Ketorolac pharmacokinetics in joint replacements. Roberts J, Wallis S, Gurunathan U, Parker S Pharmacokinetics of Enteric Coated Mycophenolate Sodium in Lupus Nephritis (POEMSLUN). Ranganathan D, Roberts J, John G, Fassett R, Healy H, Lipman J, Kubler P, Ungerer J, Aziz H. Funder: RBWH. Epidemiology of Pneumonia in the Central Australian Intensive Care Unit. Tsai D, Goud R, Hewagama S, Stewart P, Hnin K-M, Tin K-S, Sun H, Roberts J. Funder: NHMRC Postgraduate Scholarship (D Tsai); Australian Academy of Science (AAS; D Tsai). Pharmacokinetics of broad spectrum antibiotics in extracorporeal membrane oxygenation (ECMO) - using plasma concentrations to optimize antibiotic therapy. Welch S, Roberts J, Burrows F, Levkovich B, Ray J, Pellegrino V, Bui T, Wallis S, Marriott D, Rudham S. Funder: Society of Hospital Pharmacists of Australia (SHPA), RBWH Foundation. Antibiotic, sedative and analgesic drug pharmacokinetics during ovine extracorporeal membrane oxygenation - understanding altered pharmacokinetics to improve patient outcomes. Shekar K, Roberts J, Smith M, Fung Y, Fraser J, Wallis S, Mullany D, Diab S, McDonald C, Barnet A, Ghassabian S, Platts D, Dunster K. Funder: ANZCA, TPCH Foundation, Australia and New Zealand Intensive Care Society (ANZICS). The Pharmacokinetics of Vancomycin and Ticarcillin-Clavulanate in Critically Ill Patients undergoing Sustained Low-Efficiency Dialysis (SLED). Economou C. Funder RBWH Scholarship. Sampling Antibiotics in Renal Replacement Therapy (SMARRT Study). Roberts J, Lipman J, Roberts M, Paul S, Peake S, Turnidge J, Joynt G, Lee A, Gomersall C, Choi G. Funder: NHMRC; Chinese University of Hong Kong (CUHK).

Does inhaled antibiotics deliver optimal concentrations to the lung to improve treatment of pneumonia. An animal in vivo study using the microdialysis technique. Dhanani J, Paterson D, Roberts J, Chew M, Fraser J. Funder: RBWH. Dosing to maximise bacterial killing and prevent resistance in ICU. Roberts J, Lipman J, Wallis S, Kirkpatrick C, Landersdorfer C, Bulitta J, Bergen P. Funder: NHMRC. PARITY: Paracetamol in Traumatic Brain Injury. Principal Investigator: Gowardman J, Roberts J, Lipman J, Wallis S, Saxena M Antibiotic pharmacokinetics in Slow Low Efficiency Dialysis (piperacillin, meropenem and vancomycin; collaboration with The Ottawa Hospital). Roberts J, Kanji S, Zelenitsky S An Observational Pharmacokinetic sudy of Ceftolozane-Tazobactam in Intensive Care Unit in patients with and without continuous renal replacement therapy. Roberts J A prospective observational pharmacokinetic evaluation of the plasma and cerebrospinal fluid concentrations of a single dose ceftolozane/tazobactam in infected critically ill patients with an indwelling external ventricular drain” Roberts J, Lipman J Pharmacokinetics of Antibiotics in the critically unwell children. Dorofaeff T. Funder: AHEPA. CAMERA: Combination antibiotic treatment for Methicillin Resistant Staphylococcus Aureus Bacteraemia – an RCT. Davis J, Tong S, Paterson D, Fowler V, Howden B, Cheng A, Chatfield M, Lipman J, van Hal S, O’Sullivan M. Funder: NHMRC. Validation of Microsampling Versus Traditional Blood Sampling For Antibiotic Pharmacokinetics. Chikatamarla A, Parker S, Wallis S, Lipman J, Presneill J, Roberts J, Dorofaeff T, Jarrett P. Funder: RBWH Foundation; AHEPA. Population pharmacokinetics of meropenem in critically ill patients and development of dosing software (Collaboration with University of Liverpool). Roberts J, Hope W, Belen A Meropenem and ciprofloxacin pharmacokinetics in ICU patients with shock (MaC-DIPPS). Roberts J, Lipman J, Sjovall F, Christrup L, Kreilgaard M, Perner A, Frimodt-Møller N Plasma and tissue pharmacokinetics of lincomycin in patients with burn wound infection. Muller M, Wang L, Roberts J, Lipman J. Funder: RBWH Foundation.

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Pharmacokinetic Australasian Collaborative. Lipman J, Roberts J, Joynt G, Udy A, Nicholas M. Funder: ICF. Optimising benzylpenicillin dosing for critically ill patients with severe pneumonia. Roberts J, Cotta O, Boots R. Funder: RBWH Foundation. Levetiracetam pharmacokinetics in critically ill patients with severe traumatic brain injury and subarachnoid hemorrhage. Cotta O, Roberts J, Presneill J. Funder: Intensive Care Foundation (ICF), RBWH Foundation. Optimising ceftriaxone dosing for critically ill patients with severe pneumonia. Roberts J, Cotta O, Boots R. Funder: RBWH Foundation. Residual antibiotics post reconstitution: REPORT Study. Jarrett P, Coyer F, Cook J, Wallis S, Cotta O, Cohen J Advanced treatment of infectious diseases for critically ill children, through innovation in blood sampling. Roberts J, Dorofaeff T, Parker S. Funder: CHF Pharmacokinetics study of Levofloxacin prophylaxis in Multi Drug Resistant (MDR) Latent Tuberculosis Infection (LTBI).—VQUIN Study. Burke A, Fox G, Parker S, Roberts J, Nguyen V-N, Nguyen T-A, Marks G. Funder: UQ ECR (S Parker) Optimising the Treatment of Infection in critically ill Neonates, through application of an innovative microSampling approach (OPTIONS). Davies M, Irwin A, Hosking F, Parker S, Roberts J. Funder: RBWH Foundation

3) Burns

Management and outcome of burns patients encompassing prevention, acute injury and long term outcomes Thermal injury is a devastating injury, not only for the immediate concern of risk of loss of life and extreme pain, but in the long term cosmetic and functional issues. As a means of improving the treatment and outcomes of these patients, the Burns Unit at RBWH, one of the largest in Australia, has instituted a large number of studies investigating skin production in the lab, initial cardiac function, management of pain, antibiotic efficacy, nutrition issues, exercise post burns, and prevention of scaring. With increased collaboration with other burns units in Australia, improvement in both the survival and health outcomes of burns patients is being achieved. Improving donor site epithelisation and scar maturation times following split skin grafting in burns patients: a novel research study using compression therapy. Rudd M, Spermon M, Muller M IMPACT: Improving Psychological health And decreasing Cardiovascular risk in patients post burns. Paratz J, Druery M, Plaza A, Cohen J, Muller M, Stockton K, Younger J Are burns patients at increased risk of cardiovascular disease? Paratz J, Paul S, Younger J, Cohen J, Muller M A prospective, non-controlled evaluation of the synthetic NovoSorb™ - Biodegradable Temporising Matrix (BTM) for dermal repair after deep

burn injury. Brown J, Miller J, Lisec C Feasibility, acceptability, costs and preliminary effect of an innovative ablative fractional CO2 laser service for people with burn scars. Brown J, Donovan M, Tyack Z, McPhail S A retrospective review of the management and functional outcomes of patients who developed Heterotopic Ossification in one or bilateral upper limbs post severe burn injury at RBWH between 2006 and 2016. McKittrick A, Jones A, Brown J Evaluating the effectiveness of a home based telerehabilitation model for the delivery of physiotherapy exercise programs following burn injury. Plaza A, Cottrell M, Paratz J The lived experience of pressure garments: an exploration of the partnership between expert consumers and occupational therapists in a tertiary MDT burns centre. Strong J, O’Reilly S, Trevor D, Copley J, Aplin T, Mollison J, Coghlan N, Laracy S, Brown J POSAS 3.0: refinement of the patient scale using focus groups in Australia and the Netherlands (Australian study arm). Tyack Z, Carrière M, Mokkink L, Westerman M, van Zuijlen P, de Vet H, Brown J Investigating the use of elastic based tapes for management of hypertrophic scar formation to the upper limb post burn injury. O’Reilly S, Ziviani J, Strong J, Brown J Measurement of skin donor site healing with clinical assessment, high resolution ultrasound and transepidermal water loss. Brown J, Muller M, Miller J, O'Donoghue S, Towsey K. Funder: RBWH Foundation Practice variation in treatment of severe burns in ANZ. Cohen J 3D Patient Assessment and Surgical Planning: Machine Learning for accurate assessment of percentage total body surface area (%TBSA) to guide essential early treatment and surgical planning. Brown J, Powell S, Nightingale R 3D Patient Assessment and Surgical Planning: Early and accurate assessment of burn depth to guide surgical treatment and planning . Brown J, Powell S, Nightingale R Reversing Metabolic Changes Post Burn Injury. Flores O, Paratz J, Stockton K, Muller M, Brown J, Younger J. Funder: Becas Chile program, CONICYT, Chilean government. Mortality in burns survivors. Paratz J, Younger J, Paul S, Stockton K Quality of life outcomes post-major burns injuries in adults—a longitudinal exploratory study. Druery M. Funder: RBWH Foundation—Red Blanket Funding; Professor Stuart Pegg Adult Burns Centre, RBWH Scholarship Burn prevention, an advertising campaign utilizing functional MRI. Muller M, Paratz J, Reutens D, Burianova H, Dulhunty J Using MRI for advanced imaging of burns scar tissue for intervention, concurrent with laser treatment (ELATE). Brown J, Vujcich L, Donovan M Developing 3D printing TE material for patient specific dermal templates: Tissue Engineering/Polynovo. Cuttle L, Dawson R, Gillies P, Brown J Developing 3D scanning and computer vision-based approaches for automatic measurement of patient dimensions for personalised pressure garment fabrication. Powell S, Brown J, Nightingale R, Donovan M, Laracy S

RESEARCH PROJECTS

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Comparison of traditional vs 3D printed rigid transparent facial orthoses (TFOs) for treating hypertrophic scar due to severe burns. Powell S, Lamers T, Ross M, Allenby M, McKittrick A, Cortez I, Brown J, Wood-ruff M Clinical 3D scanner for capturing high resolution scans of patient anatomy for 3D printed treatments and patient diagnostics. Powell S, Nightingale R, Brown J Adopting a technique to produce human decellularised dermis. Brown J, Cuttle L, Shafiee A, Gillies P, Dalley A Producing a bio-ink/hydrogel from human decellularised dermis. Brown J, Cuttle L, Shafiee A, Gillies P, Dalley A Developing a specialised spray apparatus for the delivery of keratinocyte colonies immersed in bio-ink. Brown J, Cuttle L, Shafiee A, Gillies P, Dalley A Remote virtual reality and augmented reality for pain management in burns trauma care. Vujcich L, Brown J VR: Co-design of an Innovative Virtual Reality (VR) Environment as a Pain and Anxiety Augmented Relief Method (PARM) in Burns Survivors and Adolescents and Young Adults (AYAs) with Cancer. Desselle M, Holland L, Brown J, Vujcich L, McKittrick A, Cuttle L Intravenous iron therapy in patients with big burns at the Royal Brisbane and Women’s Hospital. Brown J Feasibility, acceptability, cost and sustainability of ablative fractional CO2 laser (retrospective). Brown J ELATE- Early versus Late Ablative CO2 Fractional Laser Treatment Evalu-ation (prospective). Brown J Initial experience with a novel biodegradable temporising matrix in burns over 40%. Brown J

4) Anaesthesia Improving anaesthetic care for critically ill and difficult to treat pa-tients. Our research aims to improve the efficiency and efficacy of anaesthesia care as well as improving the patient experience. Areas of research in-clude airway management, blood management, point of care coagulation testing, obstetric anaesthesia, pharmacokinetics, oxygenation and blood pressure monitoring in obesity. Tongue morphology on MRIs as a predictor of difficult intubation; defining upper airway radiological parameters to predict difficult intubation. Lee J, Fripp J, Thomas J, Dowling J, Cervin A, Groundwater A, van Zundert A Respiratory Sonification Trial. Sanderson P, Watson M, Reynolds H, van Zundert A, Taraporewalla K Therapeutic concentrations of cephazolin in bariatric surgical patients. Ryan R, Jackson D, Eley V, Christensen R, van Zundert A, Roberts J, Lipman J Pain in Pelvic Exenteration. Tognolini A, Jackson D Bundled interventions for care of peripheral arterial catheter in adult pa-tients: the ALICE (Arterial Line Insertion and Care) protocol. Reynolds H, Gowardman J

Ultrasound-Guided REgional Anaesthesia in Patients receiving Dressing Change After SPlit-Skin GrAfting for Upper Limb Burn Injuries: A Prospec-tive Randomized Study. REPAIR Study. Town C, Johnson J, Lee J, Van Zundert A, Brown J Ultrasound-Guided Regional Anaesthesia in Patients receiving Split-Skin Grafting for Various Burns with Donor Sites from the Upper Thigh: A Pro-spective Randomized Study, RELIEVE study. Town C, Johnson J, Lee J, Van Zundert A, Brown J Does including routine use of focused cardiac ultrasound improve learning outcomes (Infocis). Peters N Validation of blood pressure readings from the Clearsite finger-cuff com-pared with invasive blood pressure readings in pregnant women undergo-ing elective caesarean section, who have arms which don’t suit regular arm cuffs. Eley V, Christensen R, Barret H, Van Zundert A, Smith M, Stowasser M Transnasal humidified Rapid-insufflation ventilator exchange (THRIVE) in obese adults: a randomised controlled trial. Guy L, Christensen R, Eley V, Dodd B, Wyssusek K, Van Zundert A Validation of Clearsite finger-cuff in patients with problematic non- invasive blood pressure measurement undergoing elective bariatric surgery. Chris-tensen R, Eley V, Callaway L, Wyssusek K, Van Zundert A, Dodd B, Stowasser M Intra-arterial catheter insertion and maintenance: Adult - Development of a procedural document with care bundle. Reynolds H, Gowardman J Auditory display of respiratory status of anaesthetised patients: Longitudi-nal study of various cases. Taraporewalla K, Sanderson P, Watson M, Reynolds H, Van Zundert A Does transfusion-related immune modulation occur following intraoperative cell salvage? A pilot study (TRIMICS). Roets M, Sturgess D, Obeysekera MP, Tran TV, Wyssusek K, Punnasseril JEJ, Da Silva D, Van Zundert A, Gordon L, Tung JP, Flower R, Dean MM ADTRIMICS: An assessment of the association between Anaesthetic Drugs and Transfusion Related Immune Modulation during Intraoperative Cell Salvage (AD-TRIMICS). Roets M, Sturgess D, Wyssusek K, Pun-nasseril JEJ, Van Zundert A, Gordon L, Dean MM COSTOMICS: Intraoperative cell salvage as an alternative to avoid alloge-neic (donated) blood transfusion, comparing usage potential and cost ef-fectiveness. Roets M, Wyssusek K, Van Zundert A, Dean MM, Gordon L, Sturgess D Pre-existing Iron Deficient Anaemia and patient Blood Management prac-tices at RBWH. Wyssusek K, Town C, Roets M, Van Zundert A Pre-existing Iron Deficient Anaemia and patient Blood Management prac-tices at RBWH in accordance with NSQHS standards Guide: Standard 7. Wyssusek K, Town C, Roets M, Van Zundert A Intraoperative Lignocaine Infusions: Development of an optimised infusion dosing regimen for obese patients. Tognolini A, Jackson D, Eley V, Roberts J, Lipman J, Wyssusek K, Van Zundert A Microcirculatory dysfunction and Skin Failure in Critically ill patients. An exploratory study. Dalgleish L, Coyer F, Campbell J, Finlayson K, Van Zundert A

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Ten Year Review of Transfusion Practises During Rapid Transfer In Urgent Trauma Cases (RUPTURE). Wyssusek K, Wagner M, Lee J, Roets M, van Zundert A A prospective audit of Patient Blood Management knowledge in a subgroup of junior doctors at RBWH. Concha Blamey S, Wyssusek K, Taylor K The effectiveness of regional anaesthesia before and after the introduction of a dedicated regional anaesthesia service incorporating a block room. Chin A, Heywood L, Lu P, Pelecanos A, Barrington M

ROTEM® and platelet function in pre-eclamptic women. Lee J, Eley V, Krepska A, Manning C, Kimble R, Rowell J, van Zundert A

Positioning of supraglottic airway devices. van Zundert A, Wyssusek K, Hade A

Intraoperative cell salvage as an alternative to allogeneic (donated) blood transfusion: An evaluation of immune related adverse outcomes and cost (PhD title). Roets M, Gordon L, Dean M, Wyssusek K, van Zundert A, Sturgess D Perioperative Patient Blood Management data project. Linking databases to enable PPBM related (ICS, ROTEM and IDA) outcome assessment . Roets M, Wyssusek K Autotransfusion database update: an assessment of ICS related adverse outcome. Roets M, Wyssusek K LMA Protector™ Study. van Zundert A Steroids and Hyperbaric Oxygen for Sudden Sensorineural Hearing Loss (SHOOSH): a randomised controlled trial . Sherlock S, Bennett M, Kelly S, Banham N, Kramer D, Tabah A, Cooper D, Fock A, Jeliffe C, Way M, Rose C Steroids and Hyperbaric Oxygen for Sudden Sensorineural Hearing Loss (SHOOSH): a pilot study to calculate sample size for RCT. Sherlock S, Bennett M Audit of referral patterns for use of Hyperbaric Oxygen Treatment (HBOT) for Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) in Australia and New Zealand 2010-2015. Sherlock S, Verghese R

Randomised controlled trial of effect of Hyperbaric Oxygen Treatment on saliva microbiome in patients with xerostomia after radiotherapy for head and neck cancer. Sherlock S, Zakrewski M

5) Military & Trauma Medicine Trauma is the leading cause of death and disability amongst the young, active population in Australia. Our trauma teams are engaged in research investigating all aspects of trauma care trials of medications to stop bleeding in pre-hospital care, to determining the microenvironment dynamics in wounds, to longitudinal health outcomes. With the Australian Defence Force as an established presence in our centre since 2012, research in military trauma medicine has expanded, particularly in the treatment of traumatic coagulopathy, traumatic brain injury, pulmonary contusion and trauma systems design. Much of this work also benefits civilian patients, particularly those in rural hospitals. Investigation of the Cerebral Microcirculation after Head Injury. Bellapart J, Boots R, Fraser J, Maybauer M, Helps S. Funder: Brain Foundation, Defence Health Foundation, RBWH Tranexamic acid blood levels in patients achieved using CRASH-2 dosing: the PATCH-LEVELS study. Reade M, Lipman J, Wallis S, Gruen R. Funder: ICF Pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage-2 (The PATCH2 Study). Bernard S, Mitra B, Gruen R, Gantner D, Reade MC, Burns B, Balogh Z. Funder: NHMRC

Alpha 2 agonists for sedation to produce Better outcomes from critical illness (A2B Trial): A randomised, parallel-group, allocation concealed, controlled, open, phase 3 pragmatic clinical and cost effectiveness trial with internal pilot. Walsh T, McKenzie C, Lone N, Aitkin L, Parker R, Kydonaki C, Reade M, Dark P, Gordon A, Morris S, McAuley D, Weir C, Blackwood B, Page V, Perkins G. Funder: National Institute for Health Research An international prospective observational StudY on iNtrAcranial PreSsurE in intensive care (ICU): the SYNAPSE study. Funder: ESICM A prospective, multicentre, randomised, double-blind placebo controlled, stratified phase III trial of EPOetin alfa vs placebo in critically ill TRAUMA patients (EPO-TRAUMA). French C, Nichol A, Bellomo R, Cooper D, Bailey M, Higgins A, McArthur C, Reade M, Duranteau J, Gabbe B, Pettila V, Skrifvars M, Napolitano L, Rosenfeld J. Funder: MRFF A phase III multicentre blinded randomised controlled clinical trial of cryopreserved platelets vs conventional liquid-stored platelets for the management of post-surgical bleeding (The Cryopreserved vs Liquid Platelets trial: CLIP-II). Reade M, Marks D, Weinberg L, Irving D, McQuilten Z, French C, Royse A, Bannon P, Johnson L, Gattas D. Funder: NHMRC Clonidine at Low dOsage postoperatively to Nocturnally Enhance Sleep (CLONES) phase II pilot trial. Liu D, Pincus J, Hallt E, Reade M. Funder: RBWH & RBWH Foundation Establishing UQ Centre for Clinical Research as the centre for Aerosol therapy in critical care by optimising particle size of aerosols for effective drug delivery. Dhanani J, Roberts J, Lipman J, Shekar K, Wallis S, Reade M, Eley V. Funder: UQ Major Equipment Grant

RESEARCH PROJECTS

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Inhaled delivery of sedatives and analgesics. Dhanani J, Reade M A randomised controlled trial of dexmedetomidine to lessen postoperative agitation in children undergoing elective surgery or radiology. Long D, Lee-Archer P, Reade M Effects on the glycocalyx of resuscitation with immunomodulatory drugs and cryopreserved blood products in preclinical and clinical trauma. Milford E, Reade M. Funder: NHMRC Blood CRE Effect of storage conditions and duration on the clinical effect of platelet and red blood cell transfusion. Simonova G, Reade M, Tung JP, Dean M. Funder: ARCBS. A randomised controlled trial of dexmedetomidine to lessen postoperative agitation in children undergoing elective surgery or radiology. Lee-Archer P, Long D, Regli-VonUngern B, Reade M. Funder: ANZCA A geospatial approach to quantitative quality assurance in trauma. Mahoney A, Cameron C, Vallmuur K, Reade M. Funder: Australian Defence Force Observational studies of critical care practice in the management of severe burns patients in Australia and New Zealand. Holley A, Cohen J, Lipman J, Reade M Retrospective analysis of the effect of platelet transfusion on infection complications in critical illness. Flint A, Reade M, McQuilten Z, Wood E. Funder: NHMRC Blood CRE Does delay to neurosurgical intervention after trauma affect outcome? If so, what (if any) delay is acceptable? Analysis of Queensland Health data. Biggins P, Cameron C, Vallmuur K, Reade M Retrospective analysis of the effect of platelet transfusion on infection complications in critical illness. Flint A, Reade M Brain Oxygen Neuromonitoring in Australia and New Zealand Assessment – The BONANZA trial . Udy A, Adamides A, Anstey J,Bailey M, Cooper J, Bellapart J, Delaney A, Drummond K, Trapani T, Higgins L, Hunn M, Nichol A, Menon D, Murray L, Reddi B, Rosenfeld J, Vallance S Funder: NHMRC Multi-Centre Trials The Abdominal Sepsis Study: Epidemiology of Etiology and Outcome. Koulenti D, Blot S SMARRT: Sampling Antibiotics in Renal Replacement Therapy. Roberts J ADP Trauma: A randomised controlled clinical trial of Augmented Dosing of Piperacillin-tazobactam in TRAUMA patients with suspected or confirmed infection. Udy A, Roberts J, Lipman J ARTISAN 123: A randomized, double–blind, placebo– controlled, phase 3 study to assess the safety and efficacy of art-123 in subjects with severe sepsis and coagulopathy. Gowardman J ASAP-ECMO: Extracorporeal Membrane Oxygenation: A study evaluating the pharmacokinetics of antibiotics, antifungals, sedatives and analgesics in critically ill patients receiving ECMO. Roberts J

SAFE-ICU: Screening Anti-Fungal Exposure in Intensive Care Units. Roberts J

Improving Physical Activity with Treadmill training following stroke: the stroke-IMPACT trial. Brauer S, Paratz J PLUS: A multi-centre, blinded, randomised, controlled trial to determine whether fluid resuscitation and therapy with a “balanced” crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality in critically ill patients requiring fluid resuscitation when compared to the same treatment with saline. Lipman J Pneumo-INSPIRE: International Study on NoSocomial Pneumonia in Intensive CarE An international multi-centre prospective observational cohort study of nosocomial pneumonia in ICUs. Koulenti D PROMOTE-aSAH: A prospective multicentre observational study of aneurysmal subarachnoid haemorrhage in Australasian intensive care. Cohen J, Udy A RESIST: Recognising Sepsis in SIRS Trial (RESIST). Denny K Evaluation: SPICE III: A Prospective Multicentre Randomised Controlled Trial of Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive Care O'Donoghue S ALL SPICE: Allostasis and Sedation Practices in Intensive Care Evaluation. Reade M

TASTE: Potential Taste Receptor Association with Myocardial Depression Susceptibility in Treated sEpsis. Lipman J DIANA: DetermInants of Antimicrobial use and de-escalAtion in critical care. A multicentre, international, prospective, observational cohort study of critically ill patients receiving empirical antibiotic therapy for suspected or confirmed infections at ICU (endorsed by the ESICM). Cotta M AMINO III— An international survey on aminoglycoside practices in critically ill patients: AMINO Critically III survey. Roberts J, Roger C OACES: A prospective two-centre observational pharmacokinetic study evaluating and Optimizing Antibiotic CSF ExposureS in critically ill patients with in situ external ventricular drains (EVD) for the treatment and prevention of nosocomial central nervous system infections associated with ventriculostomy. Lipman J, Roberts J, Kumta N BLING III : A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients Dulhunty J Optimising ceftriaxone dosing for critically ill patients with severe pneumonia. Cotta M, Roberts J, Lipman J Da-Vinci: Detailed assessment of risks and benefits of inferior vena cava filters on patients with complicated injuries (the da Vinci Trial). Holley A ENDO 2: The prognostication value of plasma Endothelin-1 in sub arachnoid Haemorrhage. Bellapart J

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Multi-Centre Trials (cont’d) TBI Study: A Comparison of the Total and Free Cortisol Response to a Standard Short Synacthen Test in Patients with Traumatic Brain Injury. Cohen J FEISty: Fibrinogen Concentrate vs. Cryoprecipitate in Traumatic Haemor-rhage: A Pilot Randomised Controlled Trial DEM with ICU assistance . Winearls J, Campbell D, Wullschleger M, Wake E, Walters K, Czuch-wicki S GUPPIE: An Observational Study to assess aspiration risk using gastric ultrasound in ventilated ICU patients prior to extubation. O'Donoghue S LEVETY: Levetiracetam pharmacokinetics in critically ill patients with se-vere traumatic brain injury and subarachnoid haemorrhage. Cotta M, Rob-erts J LMA Protector™ Study: A comparison of the new laryngeal mask airway (LMA), LMA-Protector with the LMA-Supreme in surgical patients requiring airway management with an LMA. van Zundert A. Microscan: Assessment of the Microcirculation in Shocked Critically Un-well Patients during the First 24 hours of Resuscitation. Holley A Micro sampling: Validation of microsampling versus traditional blood sam-pling for antibiotic pharmacokinetics. Lipman J, Wallis S OASES: The Pharmacokinetics of Ceftriaxone, Meropenem, Piperacillin-Tazobactam and Vancomycin in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges. Roberts J, Kumta N PATCH TRAUMA: Pre-hospital Anti-fibrinolytics for Traumatic Coagulopa-thy and Haemorrhage (The PATCH Study) A multi-centre randomised, double-blind, placebo-controlled trial of pre-hospital treatment with tranex-amic acid for severely injured patients at risk of acute traumatic coag-ulopathy. Reade M, Holley A

PADDI – CTG trial: Perioperative ADministration of Dexamethasone and Infection. The study aims to definitively establish the safety profile of dexa-methasone in the perioperative setting. Specifically, it will address the impact of dexamethasone on surgical site infection (primary outcome) and will be stratified according to diabetes status. Lee J, Eley V, Collins G NIRVANA (Near Infra Red Vascular ANAlysis). Higgins N The free cortisol response to Synacthen and other aspects of endocrine physiology in healthy participants. Cohen J, Nethathe G National study of family experiences of organ and tissue donation. Data exchange study -follow up of families who declined organ donation Wid-dicombe N Validation of a 10 minute spontaneous breathing trial to predict time to circulatory death in organ donation candidates Widdicombe N

European Society of Intensive Care Medicine. An international prospective observational StudY on iNtrAcranial PreSsurE in intensive care (ICU): the SYNAPSE study. Reade M TAME: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardi-ac Arrest A Phase III Multi-Centre Randomised Controlled Trial. Reade M, Lipman J Colonic Flora: Assessing the effects of antibiotic choice on gut microbiota of ICU patients; a metagenomic approach. Paterson D, Harris P, Schle-busch SHOOSH trial. A randomised controlled multi centre trial using steroids versus steroids and hyperbaric oxygen in ISSHL. Sherlock S, Bennett M, Kelly S, Banham N, Kramer D, Tabah A, Cooper D, Fock A, Jeliffe C, Way M, Rose C

RESEARCH PROJECTS

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Grant Title Granting Body Investigators Amount

Pharmacokinetics of tranexamic acid in adult patients undergoing elective primary hip

replacement: an in-vivo study

MNHHS Collaborative research grant 2020 Parker S, Gurunathan U $49,722

A Prospective Evaluation of Australasian Critical Care Burns Patient

Jamieson Trauma Institute Holley A, Lipman J, Cohen J, Reade M

$86,207

Intraoperative Lignocaine Infusions: Development of an optimised infusion dosing

regimen for obese patients.

ANZCA Project Grant Tognolini A, Jackson D, Roberts J, Eley V

$22,500

Optimizing perioperative blood pressure measurement in obese patients: a program of

research

ANZCA Academic Enhancement Grant Eley V $100,000

ROTEM and coagulation profiles in the progression of pre-eclampsia – a prospective

observational study on labour ward

2019 Haematology in Obstetrics & Women’s Health (HOW) Collaborative

HSANZ Clinical Fellowship

Lee J $60,000

Diagnostic Sensitivity of Plasma Endothelin-1 for Cerebral Vasospasm after Subarachnoid

Hemorrhage

MNHHS Collaborative research grant Bellapart J, Laupland K, Nasrallah F $46,100

Exploiting developmental signalling networks as biomarkers and new therapeutic targets in

sepsis

Australian Infectious Disease Research Centre (AID)

Blumenthal M, Cohen J, Venkatesh B $50,000

Welcome ICU project Redcliffe Hospital Private Practice Fund Tabah A $3,000

Inhale for comfort and analgesia- innovation in providing analgesia and sedation using

nebulisation.

MNHHS Clinician Researcher Fellowship 2019

Dhanani J $160,000

ErythroPOietin alfa to prevent mortality and reduce severe disability in critically ill TRAUMA patients: a multicentre, stratified, double blind, placebo randomised controlled trial. (The EPO-

TRAUMA trial).

MRFF Project Grant French C, Nichol A, Bellomo R, Cooper DJ, Bailey M, Higgins A,

McArthur C, Hodgson C, Gabbe B, Duranteau J, Presneill J, Rosenfeld J, Napolitano L, Skrifvars M, Reade MC,

Pettila V

$3,500,000

Addressing Australia’s National Transfusion Research Priorities.

2019 NHMRC Synergy Grant Wood E, McQuilten Z, Cooper J, Reade MC, French CJ, Trotman J, Bielby L, Stanworth S, Higgins A, Harris A, Coiera E, Mo A, Flint A,

Sanderson B, Reynolds J, Sparrow R, Nailon S, Martin A

$3,000,000

Early Sedation with Dexmedetomidine in Older Ventilated Critically Ill Patients: SPICE IV Trial.

2019 NHMRC Clinical Trials Grant Shehabi Y, Reade MC, Campbell L, Howe B, Webb S, Bellomo R,

McArthur C, Presneill J, Hodgson C, Bailey M, Murray L

$5,000,000

RESEARCH FUNDING

15

Grant Title Granting Body Investigators Amount

Personalising Antibiotic Therapy to Improve Outcomes in Patients with Severe Infections

BDHP/ MRFF Rapid applied research Translation Program

Roberts J, Lipman J, Cotta MO, Kruger P, Schlapbach L,

Irwin A, Shekar K, Comans T, Paterson P, Harris P, Ungerer J,

McWhinney B

$332, 868

Reducing time to appropriate antibiotics and optimal doses to treat sepsis using rapid whole

genome sequencing combined with dosing software

MRFF Rapid Applied Research Translation Program Grant

Roberts JA, Lipman J, Paterson DL, Harris P, Kruger P, Dorofaeff T,

Schlapbach L, Beatson S, Schembri M

$250,829

Intraoperative lignocaine infusions: Development of an optimised infusion dosing regimen for

obese patients

ANZCA Project Grant Tognolini A, Jackson D, Roberts JA, Eley V

$22,500

Pharmacokinetics of inhaled fentanyl and morphine.

MNHHS Collaborative Research Grant

Dhanani J, Reade M, Eley V, Williams J

$50,000

Maximising the outcomes of antibiotic therapy in the management of gum disease caused by a

community of multi-species bacteria

HaBS Research Collaboration Seeding Grant

Roberts J, Ivanovski S, Sime F, Lee R

$34,000

Does transfusion-related immune modulation occur following intraoperative cell salvage? A

pilot study.

ANZCA scholarship grant. Roets M $20,000

BLING III Medical Research Institute of New Zealand

McGuinness S, Parke R, Freebairn R, Henderson S, McArthur C,

Roberts S, Young P, Dulhunty J, Lipman J

$1,195,807

ASA PhD support

ASA Ryan R $10,000

Optimising antibiotic dosing in critically ill paediatric patients by applying innovation in

microsampling

CHF 2020 Research Travel Grant Round Parker S $5,000

Establishing an effective treatment of Sedation for Neonates requiring life-saving Tracheal

Intubation (SoNaTlna Study)

RBWH & RBWH Foundation Koorts P, Parker S, Lai M, Roberts J $39,979

Intraoperative cell salvage as an alternative to avoid allogeneic (donated) blood transfusion,

comparing usage potential and cost effectiveness (COSTOMICS)

RBWH & RBWH Foundation Research Scholarship (renewed)

Roets M $45,992.57

ROTEM(R) in Obstetrics

RBWH & RBWH Foundation Research Scholarship

Lee J $44,977.62

Innovation in delirium management: Comparative plasma pharmacokinetics of

nebulized and intravenous clonidine in mechanically ventilated patients.

RBWH & RBWH Foundation Dhanani J, Reade M, Eley V, Williams J, Douglas C

$38044.51

RESEARCH FUNDING

16

Grant Title Granting Body Investigators Amount

SAHaRA TRIAL: Understanding the best red cell transfusion practice in patients with intracranial

bleeding from a ruptured aneurysm

MRFF Delaney A, English S, Finfer S, Myburgh J, Assaad N, McIntyre L, Ferguson D, Bellapart J, Fitzgerald

E, Anderson C

$902,750

Screening anti-fungal exposure in intensive care unit: The SAFE-ICU study

ESCMID Study Group Research Grants Roberts JA, Luque S, Zeitlinger M, Sime F

$47,200

Optimising the treatment of invasive infection in critically ill neonates, through application of an

innovative microsampling approach

MNHHS Collaborative Research Grant Davies M, Parker S, Irwin A, Hosking F, Roberts J

$41,944

Investigating the feasibility, acceptability and safety of advanced early burn scar interventions

on burn scar outcomes.

Jamieson Trauma Institute Brown J $91,869

RESEARCH FUNDING

RBWH Foundation Sponsorship

Donations MSD Sponsorship Pfizer Sponsorship

$16,796 $16,492.47 $3,500 $10,000

17

Name Degree BTCCRC Supervisor

Eko Setiawan PhD Prof J Roberts / Prof J Lipman / Dr M Cotta

Julian Williams PhD Prof J Lipman

Caleb Economou PhD Prof J Roberts / Prof J Lipman

Kersi Taraporewalla PhD Prof A van Zundert / Prof J Lipman

Paul Williams MPhil Prof J Roberts / Dr M Cotta

Christopher Anstey PhD Prof J Roberts

Julie Lee PhD Prof A van Zundert / AProf J Cohen / AProf K Wyssusek / AProf V Eley

Tavey Dorofaeff PhD Dr S Parker / Prof J Lipman / Prof J Roberts

Martha Druery PhD Prof J Lipman / AProf J Paratz

Lisa Wang MPhil Prof J Roberts / Prof J Lipman / Prof M Muller

Nilesh Kumta PhD Prof J Lipman

Rochelle Ryan MPhil Prof J Roberts / Prof J Lipman / Prof A van Zundert / AProf K Wyssusek

Andrew Burke MPhil Prof J Roberts

Elissa Milford PhD Prof M Reade

Yarmarly Guerra Valero PhD Prof J Roberts / Dr S Parker / Dr S Wallis / Prof J Lipman

Vesa Cheng PhD Prof J Roberts / Dr H Abdul-Aziz

Angela Tognolini MPhil A/Prof V Eley/Prof J Roberts

William Franks MPhil Prof J Roberts / Dr H Abdul-Aziz / Dr M Cotta

Cienwen Town PhD Prof A van Zundert

Michelle Roets PhD Prof A van Zundert / AProf K Wyssusek

Louis Guy MPhil AProf V Eley / Prof A van Zundert / Prof J Lipman

Anton Booth PhD Prof A van Zundert / AProf K Wyssusek

Sophie Jayamaha MPhil Prof A van Zundert

Annette Sultana MSc Prof M Reade

Gabrielle Simonova PhD Prof M Reade

Paul Lee-Archer PhD Prof M Reade

Saiyuri Naicker PhD Prof J Roberts / Dr F Sime / Dr S Parker

Anthony Holley PhD Prof M Reade/AProf J Cohen/Prof J Lipman

Adam Mahoney PhD Prof M Reade

Johanna Ljungberg PhD AProf J Cohen

Michele Cree PhD Dr S Parker

BTCCRC Research Higher Degree Supervision

RHD SUPERVISION

Completions - UQ Students Dr Gloria Wong—PhD; Dr Jayesh Dhanani—PhD; Dr Judith Bellapart—PhD; Dr Or-lando Flores—PhD Completions - non-UQ Students with BTCCRC Supervisor Dr Julie Adsett (PhD, Griffith University) - AProf J Paratz; Jemima Boyd (MPhil, Grif-fith University) - AProf J Paratz; Rebecca Kelly (MPhil, Griffith University) - AProf J Paratz Supervision—Non-UQ Dr Gavin Day (MPH, QUT) - Prof M Reade; Mr Aaron Heffernan (PhD, Griffith) - Prof J Roberts, Prof J Lipman; Dr Andrew Flint (PhD, Monash University) - Prof M Reade; Lauren O’Connor (MPhil, Griffith University) - AProf J Paratz; Maureen Peasy (MPhil, Griffith University) - AProf J Paratz

18

Journal Articles Abdul-Aziz MH, Roberts JA. Antibiotic dosing during extracorporeal membrane oxygenation: does the system matter? Curr Opin

Anaesthesiol 2019;

Abdul-Aziz MH, Shekar K, Roberts JA. Antimicrobial therapy during ECMO - customised dosing with therapeutic drug monitoring: The way to

go? Anaesth Crit Care Pain Med 2019;38:451-3

Abraham J, Sinnollareddy M, Roberts MS, Williams P, Peake SL, Lipman J, Roberts JA. Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically patients with sepsis. Int J Antimicrob Agents

2019;53:137-42

Adsett JA, Morris NR, Kuys SS, Paratz JD, Mudge AM Motivators and barriers for participation in aquatic and land based exercise training programs for people with stable heart failure: a mixed methods approach.

Heart Lung 2019;48(4):287-93

Afonso E, Blot S. Late onset sepsis in NICU – are we all looking through

the same lens? Infect Dis (Lond.) 2019;51:625-6

Baldwin C, Parry S, Kaymabu G, Paratz J Early detection of muscle weakness and functional limitations in the critically ill: a retrospective evaluation of bioimpedance spectroscopy. J Paren Ent Nutrition. 2019

Oct 3. doi: 10.1002/jpen.1719

Ballot DE, Bandini R, Nana T, Bosman N, Thomas T, Davies VA, Cooper PA, Mer M, Lipman J. A review of -multidrug-resistant Enterobacteriaceae in a neonatal unit in Johannesburg, South Africa.

BMC Pediatrics 2019;19:320

Baptista JP, Roberts JA, Sousa E, Freitas R, Devesa N, Pimentel J. Attainment of therapeutic vancomycin level within the first 24 h: Authors'

response. Crit Care 2019;23:354

Baptista JP, Roberts JA, Udy AA. Augmented renal clearance: A real phenomenon with an uncertain cause. Anaesth Crit Care Pain Med

2019;38:335-6

Barach P, van Zundert A. The crucial role of human factor engineering in the future of safe perioperative care and resilient providers. Euro Soc

Anaesth 2019;76:1-5

Bissett BM Wang J Neeman T Leditschke IA Boots R, Paratz J Which ICU patients benefit most from inspiratory muscle training? Retrospective

analysis of a randomized trial. Physiother Theory Pract. 2019;9:1-6

Blot K, Hammami N, Blot S, Vogelaers D, Lambert M-L. Increasing burden of Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecium in hospital-acquired bloodstream infections (2000-2014): A national dynamic cohort study. Infect Control Hosp Epidemiol

2019;40:705-9

Blot S, Antonelli M, Arvaniti K, Blot K, Creagh-Brown B, de Lange D, De Waele J, Deschepper M, Dikmen Y, Dimopoulos G, Eckmann C, Francois G, Girardis M, Koulenti D, Labeau S, Lipman J, Lipovestky F, Maseda E, Montravers P, Mikstacki A, Paiva JA, Pereyra C, Rello J, Timsit JF, Vogelaers D; Abdominal Sepsis Study (AbSeS) group on behalf of the Trials Group of the ESICM. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Med.

2019;45:1703-17

Blot S, Poulakou G, Timsit J-F. Catheter-associated bloodstream

infection rates: how low can you go? Intensive Care Med 2019;45:896-7

Blot S, Rello J, Koulenti D. Diagnosing invasive pulmonary aspergillosis in ICU patients: putting the puzzle together. Curr Opin Crit Care

2019;25:430-7

Blot S. Effect of antifungal exposure on the etiology of candidemia. Med

Mal Infect 2019;49:357

Blot S. Setting the baseline to fight Gram-negative bacteremia: the

necessity of epidemiological insights. Infect Dis (Lond.) 2019;51:23-5

Boidin C, Bourguignon L, Cohen S, et al. Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual

Patients. Antimicrob Agents Chemother 2019;63

Bos M, van Zundert AAJ. Internal jugular vein location and sono-

anatomy. Acta Anaesthesiol Belg 2019;70:49-50

Bos MJ, van Zundert AA. Giant internal jugular vein. Indian J Anaesth

2019;63:329-30

Cameron PA, Fitzgerald MC, Curtis K, McKie E, Gabbe B, Earnest A, Christey G, Clarke C, Crozier J, Dinh M, Ellis D, Howard T, Joseph A, McDermott K, Martin B, Matthew J, Ogilvie R, Pollard C, Rao S, Reade MC, Rushworth N, Zalstein Z. Major Injury in Australia – Implications for

Trauma System Design. Injury 2019; S0020-1383(19)30561-3

Chaboyer WP, Thalib L, Harbeck EL, Coyer FM, Blot S, Bull CF, Nogueira PC, Lin FF. Pressure injury research in the ICU: getting rid of a

black spot – the authors reply. Crit Care Med 2019;47:e162-3

Charlesworth M, van Zundert AA. Digital dystopias: will the electronic

health record ever fulfil its potential? Anaesthesia 2019;74:1361-4

Charlesworth M, van Zundert AA. Medical device regulation: the need for

clinical vigilance and oversight. Anaesthesia 2019;74:693-5

PUBLICATIONS

19

Journal Articles (cont’d) Cheng V, Abdul-Aziz MH, Roberts JA, Shekar K. Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients. Expert

Opin Drug Metabol Toxic 2019;15:103-12

Cheng V, Rawlins M, Chang T, Fox E, Dyer J, Allen C, Litton E, Page M, Hoad K, Roberts JA. Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy.

Chemotherapy 2019;64:17-21

Cohen J, Venkatesh B. Adjunctive corticosteroid treatment in septic

shock. Anesthesiol 2019;131:1-419

Colin PJ, Allegaert K, Thomson AH, Touw DJ, Dolton M, de Hoog M, Roberts JA, Adane ED, Yamamoto Y, García MJ, Simon N, Taccone FS, Lo Y-L Barcia E, Eleveld DJ. Vancomycin pharmacokinetics throughout life: results from a pooled population analysis and evaluation of current

dosing recommendations. Clin Pharmacokinet 2019;58:767-80

De Backer D, Cecconi M, Lipman J, Machado F, Myatra SN, Ostermann M, Perner A, Teboul J-L, Vincent J-L, Walley KR. Challenges in the management of septic shock: a narrative review. Intens Care Med

2019;45:420-43

Denny KJ, Gartside JG, Alcorn K, Cross JW, Maloney S, Keijzers G. Appropriateness of antibiotic prescribing in the Emergency Department. J

Antimicrob Chemother. 2019;74:515-20

Dhaese S, Farkas A, Colin P, Lipman J, Stove V, Verstraete A, Roberts J, De Waele J. Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight

pharmacokinetic models. J Antimicrob Chemother 2019;74:432-41

Dhaese S, Colin P, Willems H, Heffernan A, Gadeyne B, Van Vooren S, Depuydt P, Hoste E, Stove V, Verstraete A, Lipman J, Roberts J, De Waele J. Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion. Int J Antimicrob Agents 2019;54:741

–9

Dhaese S, Roberts JA, Carlier M, Verstraete AG, Stove V, De Waele JJ. Corrigendum to "Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients". [Int J Antimicrob Agents 51 (2018) 594

-600]. Int J Antimicrob Agents 2019;54:380

Dhaese S, Roberts JA, Carlier M, Verstraete AG, Stove V, DeWaele JJ. Corrigendum to 'Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients' [Int J Antimicrob Agents 51 (2018) 594-

600]. Int J Antimicrob Agents 2019;54:271

Dhaese S, Thooft ADJ, Farkas A, et al. Corrigendum to "Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: A prospective observational study" [J

Crit Care 52 (2019) 75-79]. J Crit Care 2019;

Dhaese S, Thooft ADJ, Farkas A, et al. Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill

patients: A prospective observational study. J Crit Care 2019;52:75-9

Dhanani J, Lipman J, Pincus J, Townsend S, Livermore A, Wallis SC, Abdul-Aziz M-H, Roberts JA. Pharmacokinetics of total and unbound cefazolin during veno-arterial extracorporeal membrane oxygenation: a

case report. Chemotherapy 2019;64:115-8

Dhanani J, Roberts J, Reade MC. Nebulized tranexamic acid for hemoptysis associated with submassive pulmonary embolism. J Aerosol

Med Pulmon Drug Deliv, 2019; Jun 4. doi: 10.1089/jamp.2019.1534

Dhanani J, Diab S, Chaudhary J, Cohen J, Parker SL, Wallis SC, et al. Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model.

Anesthesiology 2019;131:344-55

Dimopoulos G, Koulenti D, Parker SL, Roberts JA, Arvaniti K, Poulakou G. Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens? Expert Rev Anti

Infect Ther. 2019;17:201-10

Economou CJP, Xie J, Comadira G, et al. Population pharmacokinetics of ticarcillin in critically ill patients receiving extended daily diafiltration.

International journal of antimicrobial agents 2019;54:351-5

Eley VA, Chin A, Sekar R, Donovan T, Krepska A, Bell S, Lawrence M, McGrath S, Robinson A, Webb L, Marquart L. Increased maternal abdominal subcutaneous fat thickness and body mass index are associated with increased cesarean delivery: A prospective cohort study.

Acta Obstetricia et Gynecologica Scandinavica 2019; 98:196-204

Eley VA, Chin A, Sekar R, Donovan T, Krepska A, Lawrence M, Bell S, Ralfe K, McGrath S, Webb L, Robinson A, van Zundert A, Marquart L. Increasing body mass index and abdominal subcutaneous fat thickness are associated with increased skin-to-epidural space distance in

pregnant women. Int J Obstet Anesth 2019;38:59-65

Epstein CR, Forbes JM, Futter CL, Hosegood IM, Brown RG, Van Zundert AA. Frequency and clinical spectrum of in-flight medical incidents during domestic and international flights. Anaesth Intensive

Care 2019;47:16-22

Flores O, Tyack Z, Stockton K, Paratz JD. The use of exercise in burns rehabilitation: A worldwide survey of practice. Burns. 2019 Dec 18. pii:

S0305-4179(18)30679-X.

Fox E, Cheng V, Rawlins M, et al. Pharmacokinetics of flucloxacillin during prolonged intermittent renal replacement therapy in a 76-year-old

man. J Chemother 2019:1-5

Fragkou PC, Poulakou G, Blizou A, Blizou M, Rapti V, Karageorgopoulos DE, Koulenti D, Papadopoulos A, Matthaiou DK, Tsiodras S. The Role of Minocycline in the Treatment of Nosocomial Infections Caused by Multidrug, Extensively Drug and Pandrug Resistant Acinetobacter baumannii: A Systematic Review of Clinical Evidence. Microorganisms.

2019;7(6). pii: E159.

Grimmett W1, Lee J2, Doherty J3, Cheung B4, Chinthamuneedi M1,5. A case report of pre-eclampsia causing severe hyponatremia. Rare or

rarely reported?" A & A Practice. 2019;12:261-3

Guerra Valero Y, Roberts JA, Lipman J, Fourie C, Starr T, Wallis SC, Parker SL. Analysis of capillary microsamples obtained from a skin-prick to measure vancomycin concentrations as a valid alternative to conventional sampling: a bridging study. J Pharmaceut Biomed Anal

2019;169:288-92

Gurunathan U, Parker SL, Maguire R, et al. Population Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total

Knee Replacement Surgery. Anesth Analg 2019;129:701-8

Hagel S, Fiedler S, Hohn A, et al. Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised

controlled trial. Trials 2019;20:330

20

Journal Articles (cont’d) Harley A, Johnston A, Denny K, Keijzers G, Crilly J, Massey D. Emergency nurses’ knowledge and understanding of their role in recognising patients with sepsis: A qualitative study. Int Emerg Nurs.

2019;43:106-12

He J, Chen J, Huang G, Zhang Z, Zheng H, Zhang P, Zarei R, Sansoto F, Wang R, Ji Y, Xie Z, Wang X, Guo M, Chi C-H, De Souza PA, Zhang J, Lo Y, Chen X, Shi Y, Green D, Taraporewalla K, van Zundert A. A polynomial-time algorithm for simple undirected graph isomorphism.

Concurr Comput Pract Exp 2019;e5484

Heffernan A, Sime FB, Lipman J, Dhanani J, Andrews K, Ellwood D, Grimwood K, Roberts JA. Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review. Int J Antimicrob Agents

2019;53:234-45

Heffernan AJ, Germano A, Sime FB, Roberts JA, Kimura E. Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient? Eur J Clin

Pharmacol 2019;75:1219-26

Hidayat F, Prayitno A, Setiawan E. Antibiotics Utilization Review in a Neonate Intensive Care Unit of a Public Hospital in Surabaya. Indones

J Clin Pharm 2019;8:58-71

Ho KM, Rao S, Honeybul S, Zellweger R, Wibrow B, Lipman J, Holley A, Kop A, Geelhoed E, Corcoran T, Misur P, Edibam C, Baker RI, Chamberlain J, Forsdyke C, Rogers FB. A multicenter trial of vena cava

filters in severely-injured patients. N Engl J Med 2019;381:328-37

Holley AD, Reade MC, Lipman J, Delaney A, Udy A, Lee R, et al. Survey of critical care practice in Australian and New Zealand burn

referral centres. Crit Care Resusc 2019;21:303-4

International Surgical Outcomes Study (ISOS) group. Prospective observational cohort study on grading the severity of postoperative complications in global surgery research. Br J Surg. 2019;106(2):e73-

e80. (D. Koulenti: Collaborator)

Irving A, Higgins A, Ady B, et al. (incl. Reade MC). Fresh Red Cells for Transfusion in Critically Ill Adults: An Economic Evaluation of the Standard Issue Transfusion Versus Fresher Red-Cell Use in Intensive

Care (TRANSFUSE) Clinical Trial. Crit Care Med 2019;47:e572-e579

Jager N, van Hest R, Lipman J, Roberts J, Cotta M. Antibiotic exposure at the site of infection: principles and assessment of tissue penetration.

Expert review of clinical pharmacology 2019;12:623-34

Kelly R, Walsh J, Paratz J, Yerkovich S, Mc Kenzie S, Morris NR. Quadriceps muscle strength and body mass index are associated with estimates of physical activity post heart transplantation. Transplantation

2019;103:1253-9

Kleinpell R, Blot S, Boulanger C, Fulbrook P, Blackwood B. International critical care nursing considerations and quality indicators

for the 2017 Surviving Sepsis Campaigne Guidelines. Intens Care Med

2019;45:1663-6

König C, Rohr AC, Frey OR, Brinkmann A, Roberts JA, Wichmann D, Braune S, Kluge S, Nierhaus A. In vitro removal of anti-infective agents

by a novel cytokine adsorbent system. Int J Artificial Org 2019;42:57-64

Koulenti D, Parisella FR, Xu E, Lipman J, Rello J. The relationship between ventilator-associated pneumonia and chronic obstructive pulmonary disease: what is the current evidence? Eur J Clin Microbiol Infect Dis. 2019;38:637-47. Erratum in: Eur J Clin Microbiol Infect Dis.

2019 Feb 28;

Koulenti D, Song A, Ellingboe A, Abdul-Aziz MH, Harris P, Gavey E, Lipman J. Infections by multidrug-resistant Gram-negative Bacteria: what's new in our arsenal and what's in the pipeline? Int J Antimicrob

Agents 2019;53:211-24

Koulenti D, Xu E, Mok IYS, Song A, Karageorgopoulos DE, Armaganidis A, Lipman J, Tsiodras S. Novel Antibiotics for Multidrug-

Resistant Gram-Positive Microorganisms. Microorganisms. 2019;7:270

Koulenti D, Xu E, Yin Sum Mok I, Song A, Karageorgopoulos DE, Armaganidis A, Lipman J, Tsiodras S. Lefamulin. Comment on: ‘Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms.

Microorganisms, 2019;7:270

Laupland KB, Tabah A, Kelway C, Lipman J. Does intermittent pneumatic compression PREVENT deep vein thrombosis in the ICU?

Anaesth Crit Care Pain Med. 2019;38:303-4

Lee J, Eley VA, Wyssusek KH, Coonan E, Way M, Cohen J, Way M, Rowell J, van Zundert AA. Baseline parameters for rotational thromboelastometry (ROTEM®) in healthy women undergoing elective caesarean delivery: A prospective observational study in Australia.

International Journal of Obstetric Anesthesia 2019;38:10-8

Lee J, Reynolds H, Pelecanos AM, van Zundert AA. Bi-national survey of intraoperative cuff pressure monitoring of endotracheal tubes and supraglottic airway devices in operating theatres. Anaesth Intensive

Care 2019;47:378-84

Lee J, Wyssusek K, Reynolds H, Khatun M, van Zundert A. Intraoperative cuff pressure measurements of supraglottic airway devices in the operating theatre: a prospective audit. Acta Anaesth Belg

2019;70:185-91

PUBLICATIONS

21

Journal Articles (cont’d) Leone M, Roberts JA, Bassetti M, et al. Update in antibiotic therapy in intensive care unit: report from the 2019 Nimes International

Symposium. Anaesth Crit Care Pain Med 2019;38:647-56

Leopold-George N, Nethathe G. Frailty in perioperative patients in three

South African academic hospitals. S Afr Med J 2019;109:535-40

Leopold-George N, Nethathe G. Frailty: what the South African surgeon

needs to know. S Afr Med J 2019;57:24-9

Lipman J, Brett SJ, DeWaele JJ, Cotta MO, David JS, Finfer S, Glass P, Knowles S, McGuinness S, Myburgh J, Paterson DL, Peake SL, Rajbhandari D, Rhodes A, Roberts JA, Shirwadkar C, Starr T, Taylor C, Billot L, Dulhunty JM. A protocol for a Phase 3 multicentre randomised controlled trial of continuous versus intermittent beta-lactam antibiotic infusion in critically ill patients with sepsis: the BLING III trial. Crit Care

Resus 2019;21:63-8

Lonsdale D, Lipman J. Antimicrobial resistance, we must pursue a collaborative, global approach and use a “one health” approach.

Antibiotics 2019;8:237

Luque S, Munoz-Bermudez R, Echeverria-Esnal D, et al. Linezolid Dosing in Patients With Liver Cirrhosis: Standard Dosing Risk Toxicity.

Ther Drug Monitor 2019;41:732-9

Maertens B, Blot S. Endotracheal tube cuff pressure changes during manual cuff pressure control manoeuvres: a call for continuous cuff

pressure regulation? Acta Anaesthesiol Scand 2019;63:700-1

Maertens B, Blot S. Tapered cuff versus conventional cuff for ventilator-

associated pneumonia. Can Respir J 2019;2019:2679513

Mathiba, R M; Mathivha, L R; Nethathe, G D. Artesunate compared with quinine for the treatment of severe malaria in adult patients managed in an intensive care unit: A retrospective observational study. SAJCC

2019;35:12-7

McCalman J, Kippen R, McMeeken J, Hopper J, Reade M. Early results from the ‘Diggers to Veterans’ Longitudinal Study of Australian men who served in the First World War. Short- and long-term mortality of early enlisters. Historical Life Course Studies (European Science Foundation),

2019;8:52-72

McIlroy P, King R, Garrouste-orgeas M, Tabah A, Ramanan M. The effect of intensive care unit diaries on psychological outcomes and quality of life of survivors of critical illness and their relatives: A

systematic review and meta-analysis. Crit Care Med 2019;47:273-9

Milford EM and Reade MC. Resuscitation fluid choices to preserve the

endothelial glycocalyx. Crit Care, 2019;23:77

Mohd Sazlly Lim S, Sime FB, Roberts JA. Multidrug-resistant Acinetobacter baumannii infections: Current evidence on treatment options and the role of pharmacokinetics/pharmacodynamics in dose

optimisation. Inter J Antimicrob Agents 2019;53:726-45

Mohd Sazlly Lim S, Zainal Abidin A, Liew SM, Roberts JA, Sime FB. The global prevalence of multidrug-resistance among Acinetobacter baumannii causing hospital-acquired and ventilator-associated pneumonia and its associated mortality: A systematic review and meta-

analysis. J infect 2019;79:593-60

Nethathe G, Kirchner U. Accurate cost estimation in medical studies.

Anaesth 2019;74:402-3

O’Connor LR, Morris NR, Paratz J Physiological and clinical outcomes associated with use of one-way speaking valves on tracheostomised

patients : a systematic review. Heart Lung 2019;48:356-64

Parker IG, Hartel G, Paratz J, Choy NL, Rahmann A. A systematic review of the reported proportions of diagnoses for dizziness and

vertigo. Otol Neurotol 2019;40:6-15

Parker SL, Pandey S, Sime FB, Lipman J, Roberts JA, Wallis SC. A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study. Anal

Bioanal Chem 2019;411:7831-40

Paul SK, Roberts JA, Lipman J, Deans R, Samanta M. A Robust Statistical Approach to Analyse Population Pharmacokinetic Data in Critically Ill Patients with Renal Impairment. Clin Pharmacokinet

2019;58:263-70

Ramanan M, Cohen J, Venkatesh B. Steroids and Sepsis: the Debate

Continues. Inter Anesthesiol Clin 2019;57:17-30

Ranganathan D, Abdul–Aziz MH, John GT, McWhinney BC, Fassett RG, Healy H, Kubler P, Lim A, Lipman J, Purvey M, Roberts M, Reyaldeen R, Ungerer J, Roberts JA. Pharmacokinetics of Enteric Coated Mycophenolate Sodium in Lupus Nephritis (POEMSLUN). Ther Drug

Monit 2019;41:703-13

Raza A, Sime FB, Cabot PJ, Maqbool F, Roberts JA, Falconer JR. Solid nanoparticles for oral antimicrobial drug delivery: a review. Drug Discov

Today 2019;24:858-66

Reade M, Marks D, Bellomo R, Deans R, Faulke D, Fraser J, Gattas D, Holley A, Irving D, Johnson L, Pearse B, Royse A, Wong J. A randomized, controlled pilot clinical trial of cryopreserved platelets for perioperative surgical bleeding. The CLIP-I trial. Transfusion 2019;59:

2794-2804

Reade M. Addressing surprisingly high practice variability in reported

management of burns. Crit Care Resus 2019;21:233-35

Reade M. Delirium: one size does not fit all. Int Med J 2019;49:1469-71

Rello J, Ramírez-Estrada S, Romero A, Arvaniti K, Koulenti D, Nseir S, Oztoprak N, Bouadma L, Vidaur L, Lagunes L, Peña-López Y; EUVAE Study Group. Factors associated with ventilator-associated events: an international multicenter prospective cohort study. Eur J Clin Microbiol Infect Dis 2019;38:1693-9 Rello J, Sarda C, Mokart D, Arvaniti K, Akova M, Tabah A, Azoulay E. Antimicrobial Stewardship in Hematological Patients at the intensive care unit: a global cross-sectional survey from the Nine-i Investigators Network. Eur J Clin Microbiol Infect Dis 2019;39:385-92

22

Journal Articles (cont’d) Richter D, Frey O, Rohr A, et al. Therapeutic drug monitoring-guided continuous infusion of piperacillin/tazobactam significantly improves pharmacokinetic target attainment in critically ill patients: a retrospective analysis of four years of clinical experience. Infection 2019;47:1001-11 Roberts J, Alobaid A, Wallis S, Perner A, Lipman J, Sjovall F. Defining optimal dosing of ciprofloxacin in patients with septic shock. J Antimicrob Chemother 2019;74:1662-9 Roberts J, Roger C, De Waele J. Personalized antibiotic dosing for the critically ill. Intens Care Med 2019;45:715-8 Roets M, Sturgess D, Wyssusek K, van Zundert A. Intraoperative cell salvage: A technology built upon the failures, fads and fashions of blood transfusion. Anaesth Intens Care 2019;47:17-30 Setiawan E, Suwannoi L, Montakantikul P, Chindavijak B. Optimization of Intermittent Vancomycin Dosage Regimens for Thai Critically Ill Population Infected by MRSA in the Era of “MIC Creep” Phenomenon. Acta Medica Indonesiana - Indones J Intern Med 2019;51:10-8 Setiawan E, Wibowo Y, Setiadi AP, Nurpatria Y, Sosilya H, Kusuma D, et al. The Implementation of Antimicrobial Stewardship Program in Asia Region: a Systematic Review. Indo J Clin Pharm 2019;9:141-56 Setiawan E, Widyati W, Marpaung F, Sukandar E, Susaniwati S, Lukas D, Wijono H, Warindra T, Kurniawan R. A Narrative Review on Pharmacokinetics of Antibiotics among Critically Ill Patients: the Implication on the Pharmacokinetics-Pharmacodynamics Target Attainment. Pharmaceut Sci Res 2019;6:1-12 Shehabi Y, Howe B, Bellomo R, Arabi Y, Bailey M, Bass F, Kadiman S, MacArthur C, Murray L, Reade MC, Seppelt I, Takala J, Wurz J, Wise M, Webb S. Early-Goal Directed Sedation in Critically Ill Ventilated Patients. NEJM 2019;380:2506-17 Sime F, Lassig-Smith M, Starr T, Stuart J, Pandey S, Parker S, Wallis S, Lipman J, Roberts J. Population pharmacokinetics of unbound ceftolozane and tazobactam in critically ill patients without renal dysfunction. Antimicrob Agents Chemother 2019;63:e01265-19 Sime F, Byrne C, Parker S, Stuart J, Butler T, Starr T, Pandey S, Wallis S, Lipman J, Roberts J. Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients. Crit Care 2019;23:205 Sumi C, Heffernan A, Lipman J, Roberts J, Sime F. What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review. Clin Pharmacokinet 2019;58:1407-43 Tenorio-Cañamás T, Grau S, Luque S, Fortún J, Liaño F, Roberts J. Pharmacokinetics of micafungin in critically-ill patients receiving continuous veno-venous hemodialysis with high cut-off membranes. Ther Drug Monit 2019;41:376-82 Town C, Johnson J, Van Zundert A, Strand H. Exploring the Role of Regional Anesthesia in the Treatment of the Burn Injured Patient: A Narrative Review of Current Literature. Clin J Pain 2019;35:368-74 van Zundert A, Klein A. How to avoid predatory and hijacking publishers? Euro J Anaesthesiol 2019;36:807-9

van Zundert AAJ, Hendrickx JFA, Soetens F, Van Gorp J, De Wolf AM. Contributions to Belgian anesthesia: Dr. Leo Vaes. Acta Anaesthesiol Belg 2019;70:13-21 Venkatesh B, Cohen J. Hydrocortisone in Vasodilatory Shock. Crit Care Clin 2019;35:263-75 Venkatesh B, Cohen J. Why the Adjunctive Corticosteroid Treatment in Critically Ill Patients With Septic Shock (ADRENAL) Trial Did Not Show a Difference in Mortality. Crit Care Med 2019;47:1785-8 Venkatesh B, Finfer S, Cohen J, Rajbhandari D, Arabi Y, Bellomo R, et al. Hydrocortisone Compared with Placebo in Patients with Septic Shock Satisfying the Sepsis-3 Diagnostic Criteria and APROCCHSS Study Inclusion Criteria A Post Hoc Analysis of the ADRENAL Trial. Anesthesiology 2019;131:1292-300 Venkatesh B, Khanna AK, Cohen J. Less is more: catecholamine-sparing strategies in septic shock. Intens Care Med 2019;45:1810-2 Walsh JR, Pegg J, Yerkovich ST, Morris N, McKeough ZJ, Comans T, Paratz JD, Chambers DC Longevity of pulmonary rehabilitation benefit for chronic obstructive pulmonary disease—health care utilisation in the subsequent 2 years. BMJ Open Resp Res 2019;6:e000500

Wan W, Guerra Valero Y, Choi, GYS, Ordonez MJ, Wallis SC, Joynt GM, Lipman J, Gomersall CD, Roberts JA. In-vitro adsorption and sieving coefficient of ticarcillin-clavulanate during continuous haemofiltration. Int J Antimicrob Agents 2019;54:261-4 Weber N, Jackson K, Ungerer J, McWhinney B, Kennedy G, Lipman J, Roberts J. Evaluation of pharmacokinetic/pharmacodynamic and clinical outcomes with 6-hourly empiric piperacillin-tazobactam dosing in hematological malignancy patients with febrile neutropenia. J Infect Chemother 2019;25:503-8 Weiss E, Zahar JR, Alder J, Asehnoune K, Bassetti M, Bonten MJM, Chastre J, De Waele J, Dimopoulos G, Eggimann P, Engelhardt M, Ewig S, Kollef M, Lipman J et al. Elaboration of consensus clinical endpoints to evaluate antimicrobial treatment efficacy in future HABP/VABP clinical trials. Clin Infect Dis 2019;69:1912-8 Williams P, Cotta MO, Roberts JA. Pharmacokinetics/Pharmacodynamics of beta-Lactams and Therapeutic Drug Monitoring: From Theory to Practical Issues in the Intensive Care Unit. Seminars in respiratory and critical care medicine 2019;40:476-87

PUBLICATIONS

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Journal Articles (cont’d)

Wyssusek KH, Keys MT, van Zundert AAJ. Operating room greening initiatives - the old, the new, and the way forward: A narrative review. Waste Management 2019;37:3-19 Xie F, Mantzarlis K, Malliotakis P, Koulouras V, Degroote S, Koulenti D, Blot S, Boussery K, Van Bocxlaer J, Colin P; LIMOP study collaborators . Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia. J Antimicrob Chemother. 2019;74:667-74 Zahar J-R, Blot S, Nordmann P, Martischang R, Timsit J-F, Harbarth S, Barbier S. Screening for intestinal carriage of ESBL-producing Enterobacteriaceae in ICU patients: expected benefits and evidence-based controversies. Clin Infect Dis 2019;68:2125-213 Zhang P, Curley C, Mudie K, Nakagaki M, Hill G, Roberts JA, Tey SK. Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer. Bone Marrow Transplantation 2019;54:2110-6

Book Chapters

Milford E, Reade M. Resuscitation fluid choices to preserve the endothelial glycocalyx. In: Annual Update in Intensive Care and Emergency Medicine 2019. Berlin: Springer-Verlag, 2019, pp259-76 Reade M, Bleeker C. Military anaesthesia. In: Manual of the Definitive Surgery in Trauma Care, 5th edition. Boffard K, ed. Boca Raton: CRC Press, 2019, pp329-43 Reade M, White J, Bleeker C. Trauma Critical Care. In: Manual of the Definitive Surgery in Trauma Care, 5th edition. Boffard K, ed. Boca Raton: CRC Press, 2019. pp277-302 Roets M, Dean M, Punnasseril J, Wyssusek K, van Zundert A. Anaesthesia and Immune Modulation. In: Australasian Anaesthesia. R. Riley R, ed. Melbourne, Australia, Australian and New Zealand College of Anaesthetists, 2019, pp265-75 Tabah A, Lipman J. Antibiotics in the ICU, In: Evidence based review of Core topics in Critical Care 2019. Freebairn R, Kulkarni A eds. Asian Pacific Association of Critical Care Medicine. Jaypee Brothers Medical Publishers Pvt van Zundert A. Spinal Anesthesia. In: Hadzic’s Textbook of Regional Anesthesia and Acute Pain Management Hadzic A, ed. McGraw Hill, New York, 2019, pp99-102

Published Abstracts

Adsett J, Morris N, Kuys S, Paratz J, Mudge A. Motivators and barriers for participation in aquatic and land based exercise training programs for people with stable heart failure: a mixed methods approach. Heart Lung 2019;48:287-93 Butson B, Pearson A, Reade MC. Project Wantok Haus Sik. J Milit Veter Health 2019;27:67-8 Kelly R, Walsh J, Paratz J, Yerkovich S, Mc Kenzie S, Morris N. Quadriceps muscle strength and body mass index are associated with estimates of physical activity post heart transplantation. Transplant 2019;103:1253-9 O’Connor LR, Morris NR, Paratz J Physiological and clinical outcomes associated with use of one-way speaking valves on tracheostomised patients : a systematic review. Heart Lung 2019;48:356-64 Parker IG, Hartel G, Paratz J, Choy NL, Rahmann A. A systematic review of the reported proportions of diagnoses for dizziness and vertigo. Otol Neurotol 2019;40:6-15 Reade M. How urgent is an urgent craniotomy in the deployed military context? A retrospective observational study. J Milit Veter Health 2019;27:48-9 Reade M. Prehospital antibiotics – a narrative review and rationale to change ADF practice. J Milit Veter Health 2019;27:66 Simonova G, Dean MM, Reade M, Tung JP. Characterization Of Immunomodulatory Mediators In Conventional And Cryopreserved Sheep Platelet Concentrates. ISBT Meeting Basel 2019 Vox Sanguinis 2019;114(suppl.1):226 Simonova G, Dean MM, Reade M, Tung JP. Characterization of immunomodulatory mediators in sheep packed red blood cells: development of a robust transfusion model. ISBT Meeting Basel 2019 Vox Sanguinis 2019;114(suppl.1):226 Simonova G, Dean MM, Reade M, Tung JP. Towards understanding of post-transfusion immunomodulation: sheep immune responses to lipopolysaccharide. ISBT Meeting Basel 2019 Vox Sanguinis 2019;114(suppl.1):226 Simonova G, Temple F, Johnson L, Marks DC, Reade M, Tung JP. The storage mode of sheep platelet concentrates differentially affects microparticle formation. ISBT Meeting Basel 2019 Vox Sanguinis 2019;114(suppl.1):111

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The Centre’s activity throughout the year has continued to focus on championing change as evidenced by over fifty publications resulting from our work during 2019, translating our dosing regimens into internationally followed guidelines and by extending some our mechanistic studies into controlled trials. We continued our collaboration with our industry partners and our administering institution - The University of Queensland – in the delivery of educational and capacity building seminars focusing on pharmacokinetic modelling and optimisation of antimicrobial use. We aimed to achieve this in multiple health care contexts, from acute care of adult and paediatric critically ill patients to Hospital in the Home (HITH) and Outpatient Parenteral Antimicrobial Therapy (OPAT). In February 2019, our centre delivered OPAT/HITH seminar at the Garvan Institute of Medical Research in Sydney. Over one hundred delegates from a variety of disciplines, including pharmacy, medicine, nursing, microbiology, pharmaceutical industry, publishing, as well as policy makers representing NSW State Government attended. Key areas of research need in this context were identified as a result of this productive meeting and the Centre has subsequently engaged in the process of developing grant applications to address some of these important questions. We cultivated regional collaboration across Asia Pacific with the delivery of the Antimicrobial Resistance & Optimisation Seminar in Ho Chi Minh City, Vietnam. Our clinician researchers collaborated with Ton Duc Thang University in bringing together Asia-Pacific leaders in antimicrobial resistance research in Ho Chi Minh City, Vietnam. We linked with the University of Sydney to deliver this important regional collaboration. In early July 2019, we again collaborated with the University of Nîmes, France in the delivery of a seminar focused on the topic of antimicrobial optimisation. Topics discussed included the emerging resistance in Europe, new and old drugs for problematic pathogens, guideline development in the era of resistance and antimicrobial stewardship optimisation in different settings. This meeting attracted a range of practitioners involved in complex drug dosing including clinical pharmacists, infectious diseases physicians, intensive care physicians, transplant physicians and clinical pharmacologists. A major achievement of the year has been the Centre’s partnership with The University of Queensland and several other nationa l institutions and international partners on the delivery of the 3rd National Antimicrobial Resistance (AMR) Forum, held in Brisbane on November 8, 2019. In addition to the CRE REDUCE, the key partners included the Queensland State-wide Antimicrobial Stewardship Program, the UQ Primary Care Clinical Unit, the UQ School of Veterinary Science, the UQ School of Dentistry, the UQ Institute of Molecular Bioscience and the National Centre for Antimicrobial Stewardship, based in Melbourne. Over two hundred physicians, nurses, pharmacists, veterinarians, dentists, policy makers, and others, were attracted to this meeting under a multidisciplinary umbrella of effective action against antimicrobial resistance in human and animal medicine. On the days prior and post Forum, we convened the Forum associated workshops, including on antimicrobial optimisation in general practice, antimicrobial stewardship implementation and the development and use of antimicrobial dosing guidelines in veterinary practice. The Centre continued its work in rapid diagnostics and dosing software, integrating the research administration work between the institutions involved in this flagship research program, including Queensland Pathology, the Princess Alexandra Hospital, Queensland Children’s Hospital, Royal Brisbane and Women’s Hospital and The Prince Charles Hospital. The Centre hosted and enjoyed the contribution of multiple visiting researchers throughout the year, including from Universidad Autónoma de San Luis Potosí, Mexico, the Amsterdam University Medical Centre, the Netherlands and the University of Pittsburgh, Pennsylvania. We are very grateful to our funding body NHMRC, for enabling our research and our work around building research capacity, which will benefit us all in the future.

CRE REDUCE UPDATE

Centre of Research Excellence for Redefining anti-microbial use to reduce resistance and prolong the clinical utility of antimicrobials

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QUEENSLAND Prof David Paterson, Casey Pfluger, A/Prof S Brauer, A/Prof Paul Mills, Prof Paul Colditz, Dr Barbara Lingwood, Prof Alastair McEwan, Prof Michael Jennings, A/Prof Mark Schembri , A/Prof Scott Beatson, Dr Ian Shiels, Prof Stephen Taylor, Dr Trent Woodruff, A/Prof Xiu Li, A/Prof Michael QZ Sheng, Prof April Wright, Dr Zephanie Tyack, Dr Kellie Stockton, Prof David Reutens, Dr Hana Burianová, Dr Nana Sunn, Dr Antje Blumenthal, Prof David Evans, Dr Andreas Obermair, Prof Michael Roberts, Dr Greg Medley, Estrella Paterson, Lars Erickson, Dr Antje Blumenthal, Prof Elizabeth Eakin The University of Queensland A/Prof Graham Nimmo, Dr John Rowell, Sue Williams, Natasha Keary, Alan Westacott Queensland Health Pathology Prof Claire Rickard, Dr Li Zhang, Prof Paul Scuffham, Alliance for Vascular Access Teaching and Research (AVATAR) Griffith University Dr Peter Kruger, Prof Bala Venkatesh, Dr Geoff Playford, Dr Rob Eley, A/Prof David Sturgess Princess Alexandra Hospital Prof John Fraser, A/Prof Kiran Shekar, Dr Fran Kinnear The Prince Charles Hospital Dr James Lind, Dr Jonathan Field, A/Prof Gerben Keijzers Gold Coast Hospital Dr Phillip Cowlishaw Mater Hospital Dr Jee Poh, Dr Isabelle Tham Logan Hospital Dr Matthew Howes Mater Mother’s Hospital Dr Deborah Long, Dr Adrian Mattke, A/Prof Luregn Schlapbach Queensland Children’s Hospital Dr Steve Rashford Queensland Ambulance Service Dr Christopher Hammet, Dr William Parsonage, Dr Jonny Younger, Dr Jacobus Ungerer, Dr John Cardinal, Dr Carel Pretorius, Dr Brett McWhinney, Ms Jill Tate, A/Prof Mark Coulthard, Dr Helen Healy, Dr Adrian Kark, Dr Dwarka Ranganathan, Prof Rob Fassett, Dr Vincent D'Intini, Dr Queenie Lau, Dr Thomas Robertson, Dr Merrilyn Banks, Dr Lynda Gillen, Dr Lynda Ross, A/Prof Cliff Pollard, Dr R Webb, Dr Kenneth Thistlethwaite, Dr Alison Mudge, Dr Peter Donovan, Ms Prue McCrae, Dr Caroline Acton, Prof Graeme Dickie, Dr Craig Readdy, Dr Tracey Comans, Dr Renuka Sekar, Dr Tim Donovan, Dr Sharon Kelly, Hollie Cummins, Charles Cheung, Kaylee Britain, Chantelle Moore, Andrew Reilly, Dr Adam Stewart, Dr Krispin Hajkowicz, Dr Andrew Redmond, A/Prof Ian Coombes, Dr Andrew Dalley Royal Brisbane and Women’s Hospital Prof Gerry FitzGerald, Dr Jannah Baker, Dr Monika Janda, Prof Zee Upton, Prof Kerrie Mengersen, Prof Fiona Coyer, A/Prof Carol Windsor, Dr Karen Sullivan, A/Prof Kirsten Vallmuur, A/Prof Cate Cameron, Prof Michael Schuetz Queensland University of Technology

Dr Jurgen Fripp The Australian eHealth Research Centre A/Prof Melinda Dean, Dr John-Paul Tung, Prof Robert Flower, Thu Tran, Dr Maheshi Obeysekera Australian Red Cross Blood Service, QLD Dr David McMillan, A/Prof David Whiteman, Prof Grant Montgomery, Dr D Reid, Lutz Krause, Mandy Way, Martha Zakrzewski, A/Prof Louisa Gordon, Anita Pelecanos, Dr Bridget Barber QIMR Berghofer Medical Research Institute Dr Mark Elcock Retrieval Services Queensland Dr Tim Warhurst Redcliffe Hospital Dr Nai An Lai QEII Jubilee Hospital Dr Indranil Chatterjee Toowoomba Hospital Dr Kylie Baker Ipswich Hospital Prof Dennis Shanks Australian Army Malaria Research Institute, Gallipoli Barracks, Enogerra Kylie Taylor, Sachin John, Deepak Regmi Metro North Health & Health Services Dr Jurgen Fripp, Dr Jason Dowling CSIRO

COLLABORATORS

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NATIONAL Dr John Gallagher, Dr Vineet Nayyar Westmead Hospital, Sydney Prof Andrew Udy, Dr Arne Diehl The Alfred Hospital, Melbourne Prof Rinaldo Bellomo, Dr Sue Berney, Prof Lindsay Grayson Dr Barrie Mayall, Dr Glenn Eastwood Austin & Repatriation Hospital, Melbourne Prof John Myburgh, Prof Simon Finfer, Dr Manoj Saxena, Dorrilyn Rajbhandari The George Institute for International Health, Sydney Prof Mike Bennett Prince of Wales Hospital, Sydney Dr Neil Banham, Dr Matthew Rawlins, Dr Edward Raby Fiona Stanley Hospital, Perth Dr Joshua Davis Menzies School of Health Research, Darwin Prof Steve Webb,Dr Geoff Dobb, Dr Paul Ingram, Dr KM Ho, Dr Andrew Heard, Dr Richard Riley Royal Perth Hospital Prof Hergen Buscher, Susie Welch, Fay Burrows, A/Prof Darren Roberts St Vincent’s Hospital, Sydney Dr Dianne Stephens Royal Darwin Hospital Dr David Cooper Royal Hobart Hospital University of Tasmania Dr Frank van Haren, Ms Margot Green, Dr Marta Kot, Dr Kathryn Daveson Canberra Hospital, ACT Elizabeth Skinner, A/Prof Ben Rogers Monash Medical Centre, Melbourne Dr Reny Segal Royal Melbourne Hospital Prof Carl Kirkpatrick, Dr Cornelia Landersdorfer, Dr Philip Bergen, Prof P Myles, Prof Jamie Cooper, Ms Lynne Murray, Prof Kim Bennell, Prof Janet McCalman, Prof Linda Denehy, A/Prof Sue Berney, Prof S Paul, Dr Erica Wood, Dr Zoe McQuilten Monash University Dr Chris Acott, Philip Selby, Prof Sepehr Shakib Royal Adelaide Hospital Prof Nick Taylor La Trobe University, Melbourne Dr George Kotsiou Royal North Shore Hospital, Sydney

Dr David Noble Biodevices International Pty Ltd., Victoria Dr David Irving, Dr Denese Marks, Dr Lacey Johnson Australian Red Cross Blood Service, NSW Dr Charudatt Shirwadkar Blacktown Hospital, NSW Dr Milind Sanap, Dr Peter Thomas, Dr David Durham Flinders Medical Centre, Adelaide Prof Michael Bennett University of NSW Dr Stuart Baker, A/Prof David Mountain Sir Charles Gairdner Hospital, Perth Dr Jason Fletcher Bendigo Hospital Bendigo, Victoria Dr Neil Orford, Dr Claire Cattigan Geelong Hospital, Victoria Dr Rob Cameron Gosford Hospital, NSW Dr David Gattas Royal Prince Alfred Hospital, Sydney Dr Andrew Cheung St George Hospital, Sydney Dr Martin Sterba Wollongong Hospital, NSW Prof Tomás Corcoran The University of Western Australia Prof Michael Paech King Edward Memorial Hospital Dr Morgyn Warner, Prof Sandra Peake Queen Elizabeth Hospital, Adelaide

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INTERNATIONAL Prof Charles Gomersall, Prof Gavin Joynt, Dr Gordon Choi, Dr Lowell Ling Chinese University of Hong Kong A/Prof Timothy Short University of Auckland, New Zealand Prof Wolfgang Krueger

Tübingen University Hospital, Germany Dr Noelle Lim Changi General Hospital, Singapore Prof Jordi Rello, Dr Elsa Afonso, Dr Laura Ruano Hospital Vall d'Hebron, Spain A/Prof Beverley Kramer, Ms Juan Scribante University of Witwatersrand, South Africa Dr A Peter Wilson University College London, UK Prof Tony Whitehouse Queen Elizabeth Hospital, Birmingham, United Kingdom Prof Jesus Rodriguez-Bano Hospital Macarena Seville, Spain Prof Dale Needham John Hopkins University, USA

Prof Jack Iwashyna University of Michigan, USA Prof Ignacio Martin-Loaches University of Dublin, Ireland Prof Alistair Nichol National University of Ireland Prof M Kollef Washington University, Missouri, USA Dr Shahed Omar Baragwanath Hospital, South Africa Dr Dick Dinsdale, Prof Paul Young Wellington Regional Hospital Wellington, New Zealand Dr Colin McArthur, Dr Shay McGuinness Auckland City Hospital, New Zealand Dr Seton Henderson Canterbury District Health Board, New Zealand

Dr Alex Kazemi Middlemore Hospital, New Zealand Dr Ross Freebairn Hawkes Bay Hospital, New Zealand Prof Alan Merry University of Auckland, New Zealand Prof Jamie Sleigh, Dr Rob Frengley Waikato Clinical School of Medicine, New Zealand Prof Andries Gous University of Limpopo, South Africa A/Prof Andrew Shorr Washington Hospital Center, USA Colonel Stacy Shackleton United States Department of Defense Joint Trauma System Prof Tim Walsh University of Edinburgh Dr Andrew Rhodes St George’s Healthcare NHS Trust and St George’s University of London, England Dr Suresh Kumar, Dr Shanthi Ratnam, Dr Zubaidah Abd Wahab Hospital Sungai Buloh, Malaysia Prof George Dimopoulos, Prof Apostolos Armaganidis Attikon University Hospital, Athens, Greece Dr Murat Akova, Dr Arife Özveren Hacettepe University Hospital, Turkey Prof Matteo Bassetti Ospedale, San Martino, Genova, Italy Prof Philippe Montravers Centre Hospitalier Universitaire Bichat-Claude Bernard AP-HP, Université Paris VII, Paris, France Prof Saul Faust University of Southampton, UK Prof Marc Leon Hospital Nord, Marseille; AzuRea Group, France Prof Jan de Waele, Dr Luc De Crop, Dr Sofie Dhaese Ghent University Hospital, Ghent, Belgium Prof Stijn Blot Ghent University, Ghent, Belgium Colonel Rob Russell Royal Centre for Defence Medicine, Birmingham, UK. Prof Derek Angus University of Pittsburgh, USA Prof Kathy Rowan UK Intensive Care National Audit and Research Centre London, England

COLLABORATORS

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Dr Christopher McCoy, Dr John Marshall, Dr Daniel Dalmor Beth Israel Deaconess Medical Centre, Boston, USA Dr Fabio Taccone, Prof Jean-Louis Vincent Erasme Hospital, Free University of Brussels Dr Antonio Margarit Ribas Hospital Nostra Senyora de Meritxell, Escaldes-Engordany, Andorra Prof Otto Frey, Prof Alexander Brinkmann Heidenheim Hospital, Heidenheim, Germany Jana Stojanova, Leslie Escobar, Marcial Cariqueo Santiago, Chile Dr Ramona Hopkins Brigham University USA Dr Herbert Spapen Universitair Ziekenhuis Brussels, Belgium Dr Joost Wauters Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium Dr Thierry Dugernier Clinique Saint Pierre, Ottignies, Belgium Dr Philippe Jorens Universitair Ziekenhuis Antwerpen, Edegem, Belgium Dr Ilse Dapper Algemeen Ziekenhuis Monica, Deurne, Belgium Dr Francisco Alvarez-Lerma, Dr Maria Pilar Gracia-Arnillas, Dr Sonia Luque Hospital Del Mar, Barcelona, Spain Dr Francisco Fernández Centro Médico Delfos, Barcelona, Spain Dr Neus Feijoo, Dr Neus Bardolet, Dr Assumpta Rovira Hospital General de L’Hospitalet, Barcelona, Spain Dr Pau Garro, Dr Diana Colon Hospital General de Granollers, Barcelona, Spain Dr Carlos Castillo, Dr Juan Fernado Hospital Txagorritxu, Vitoria, Spain Dr Maria Jesus Lopez, Dr Jose Luis Fernandez, Dr Ana Maria Arribas Hospital Universitario de Burgos, Spain Dr Jose Luis Teja, Dr Elsa Ots Hospital Universitario Marques de Valdecilla, Santander, Spain Dr Juan Carlos Montejo, Dr Mercedes Catalan Hospital Universitario 12 de Octubre, Madrid, Spain Dr Isidro Prieto, Dr Gloria Gonzalo Hospital Ramon y Cajal, Madrid, Spain Dr Beatriz Galvan Hospital Universitario La Paz, Madrid, Spain

Dr Miguel Angel Blasco, Dr Estibaliz Meyer, Dr Frutos Del Nogal Hospital Universitario Severo Ochoa, Madrid, Spain Dr Loreto Vidaur, Dr Rosa Sebastian, Dr Pila Marco Garde Hospital Universitario de Donostia, Donostia, Spain Dr Maria del Mar Martin Velasco Hospital Universitario Nuestra Señora de Candelaria, Spain Prof Jean-François Timsit Bichat Hospital, Paris, France University of Paris, France Prof Michael Sharland Great Ormond Street Hospital Prof Mariano Esperatti, Prof Antoni Torres Institut Clínic del Tòrax, Hospital Clinic, Barcelona, Spain; Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CibeRes). Prof Stephan Harbarth, Prof Angela Hunter University Hospital of Geneva, Switzerland Prof Rishi Dhillon University Hospital of Wales , Wales Prof Olivier Baldesi Centre Hospitalier Pays D Aix, Aix en Provence AzuRea Group, France Prof Herve Dupont Centre Hospitalier Universitaire d'Amiens, Amiens, France Prof Sigismond Lasocki Centre Hospitalier-Universitaire d'Angers, France Prof Jean Michel Constantin Centre Hospitalier Universitaire de Clermont-Ferrand AzuRea Group, France Prof Jean François Payen Centre Hospitalier-Universitaire Grenoble AzuRea Group, France Prof Jacques Albanese Hopital Nord, Marseille AzuRea Group, France Prof Yannick Malledant Hôpital Pontchaillou, Rennes, France Prof Julien Pottecher University Hospital, Strasbourg AzuRea Group, France Prof Jean-Yves Lefrant , Dr Claire Roger Centre Hospitalier-Universitaire Nimes AzuRea Group, France Prof Samir Jaber Hospitalier-Universitaire Montpellier AzuRea GroupFrance

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Prof Olivier Joannes-Boyau Centre Hospitalier-Universitaire Bordeaux AzuRea Group, France Prof Christophe Orban Centre Hospitalier-Universitaire Nice AzuRea Group, France Prof Julien Pottecher University Hospital, Strasbourg AzuRea Group, France Prof Jean-Yves Lefrant , Dr Claire Roger Centre Hospitalier-Universitaire Nimes AzuRea Group, France Prof Samir Jaber Hospitalier-Universitaire Montpellier AzuRea GroupFrance Prof Olivier Joannes-Boyau Centre Hospitalier-Universitaire Bordeaux AzuRea Group, France Prof Christophe Orban Centre Hospitalier-Universitaire Nice AzuRea Group, France Prof Francesca Rubulotta, Prof Anthony Gordon Charing Cross Hospital, London, United Kingdom Dr Marlies Ostermann St Thomas' Hospital, London, United Kingdom Prof Stephen Brett Hammersmith Hospital, Imperial Healthcare NHS Trust, London, United Kingdom Prof Martin Stotz, Prof Maie Templeton St Mary's Hospital, Imperial Healthcare NHS Trust, London, United Kingdom Prof Claudia Ebm, Prof Carl Moran St George's Hospital, St George's Healthcare NHS Trust, London, United Kingdom Dr Kirsi-Maija Kaukonen, Dr Ville Pettilä, Dr Miia Valkonen, Dr Sari Sutinen Helsinki University Central Hospital, Helsinki, Finland Prof Chiara Adembri, Prof Gianluca Villa Azienda Ospedaliero Universitaria Careggi, Florence, Italy Prof Antonio Giarratano, Prof Santi Maurizio Raineri, Prof Andrea Cortegiani, Prof Francesca Montalto, Prof Maria Strano Università degli Studi di Palermo, Palermo, Italy Prof V. Marco Ranieri, Prof Rosario, Prof Urbino Ilaria Mastromauro, Prof Francesco G. De Rosa Universitaria San Giovanni-Battista Molinette, Turin, Italy Prof Claudio Sandroni, Prof Gennaro De Pascale Catholic University School of Medicine, Rome, Italy

Prof Alexandre Molin, Prof Paolo Pelosi University of Genoa, Genoa, Italy Prof Luca Montagnani Universitaria San Martino, Genova, Italy Prof Federico Pea University of Udine, Udine, Italy Prof Teresa Cardoso Hospital de Santo António, Porto, Portugal Prof Susana Afonso Hospital de St António dos Capuchos, Lisbon, Portgual Prof João Gonçalves-Pereira Hospital de São Francisco Xavier, Lisbon, Portugal Professor Robert Loeb, University of Florida College of Medicine, USA

COLLABORATORS

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Projects for Honours, postgraduate (Masters and PhD) and postdoctoral researchers are possible through the Burns, Trauma & Critical Care Research Centre. There is high expertise in postgraduate supervision within our research centre. The centre is also keen to support clinical staff who wish to undertake research projects. Prospective candidates can obtain further information about postgraduate study from the UQ Graduate School at https://graduate-school.uq.edu.au/home This site contains information on the various postgraduate degrees available and how to apply for each.

Postgraduate Enquiries A/Prof Jenny Paratz

Honorary Research Fellow

Burns Trauma & Critical Care Research Centre

Email j.paratz@uq.edu.au

Dr Sia Athanasas Research Manager Burns Trauma & Critical Care Research Centre Email btccrc01@uq.edu.au Phone 61 7 3346 5020 Fax 61 7 3346 5598

General Enquiries Dr Sia Athanasas

Research Manager

Burns Trauma & Critical Care Research Centre Email btccrc01@uq.edu.au Phone 61 7 3346 5020 Fax 61 7 3346 5598 Postal Address Burns Trauma & Critical Care Research Centre Level 8, UQ Centre for Clinical Research (UQCCR) Royal Brisbane and Women’s Hospital QLD, Australia, 4029 https://btccrc.centre.uq.edu.au/

ENQUIRIES