Research Plans Computational Neuroscience
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Transcript of Research Plans Computational Neuroscience
Research Plans Computational Neuroscience
Jutta Kretzberg
University of Antwerp7.6.2007
http://www.uni-oldenburg.de/sinnesphysiologie/en/
Important response features
Individual cells
Cell ensembles
Origin of neuronal responses
Cellular properties
Network interactions
Reliability of responses
time
Central question: Neural coding
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Vertebrate retina
Currently used systems
Leech nervous system
Latency-based retinal coding of visual stimuli during eye movements
Retinal ensemble coding under dynamic conditions
Mechanisms of retinal coding for global image movement
Multi-electrode recordings and data analysis (Bayesian reconstruction, metric-based clustering,
information-theoretic methods)
Retinal coding - current projects
Simulations based on physiological data(networks of simplified models, multi-compartment models)
Retinal coding - future projects
Retinal network interactions
Horizontal cell physiology
Kolb 1974
200
Leech CNS - current project
Electrophysiology and Simulations(intracellular recordings, multi-compartment models)
Influence of ion channel distribution on spike activity
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Experiment Simulation
Leech CNS - future projects
Local bend network
Stimulus
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Electrophysiology and Simulations(intracellular recordings, multi-compartment & network
models)
Encoding of touch stimuli
Interaction of inputs to interneurons
Sources of variability
Network interactions between sensor cells
Role of electrical connections in the network
Common interests with TNB group
Neural coding
Origin of response dynamics
Methods
Single cells
Relevant response features
Cell-intrinsic anatomy and biophysics
Intracellular & patch clamp recordings
Multi-compartment models
Spike time analysis
Multiple cells
Correlations between responses
Network interactions
Multi-electrode recordings
Network models
Correlation analysis
New impulses
Sensory coding
Well-defined input and output
Direct link to behavior
Analysis of retinal network
Multi-electrode recordings
Several data analysis methods
Analysis of leech network
Easily approachable microcircuit
Close sensory-motor interaction
Similar questions and methods: Comparison of different systems