Research Literature Pack RL 1 Lit A4
description
Transcript of Research Literature Pack RL 1 Lit A4
-
Research
Precision Instrumentation for Life Science Research
Volume Flow Measurements
Pressure & PV Loops
Telemetry
Tissue Perfusion
Courtesy of: Microsurgery Research and Training Laboratory, Dept. of Orthopedic Surgery, Columbia U
-
AMERICASTransonic Systems Inc.34 Dutch Mill RdIthaca, NY 14850U.S.A.Tel: +1 607-257-5300Fax: +1 [email protected]
EUROPETransonic Europe B.V.Punterweg 316222 NW MaastrichtThe NetherlandsTel: +31 43-407-7200Fax: +31 [email protected]
ASIA/PACIFICTransonic Asia Inc.6F-3 No 5 Hangsiang RdDayuan, Taoyuan County33758 Taiwan, R.O.C.Tel: +886 3399-5806Fax: +886 [email protected]
JAPANTransonic Japan Inc.KS Bldg 201, 735-4 Kita-AkitsuTokorozawa Saitama359-0038 JapanTel: +81 04-2946-8541Fax: +81 [email protected]
Research
www.transonic.com
Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells gold standard transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems.
VOLUME FLOWMake absolute volume flow measurements with Transonic Gold Standard Research Flowmeters. Whether used to measure arterial or venous blood flow in mice to calves with versatile acute/chronic perivascular Flowprobes, or to quantify flow in laboratory tubing, Transonics ultrasonic transit-time Flowmeters are reliable, easy to use and referenced worldwide as the system of choice for research applications. There is a Probe or Sensor to fit every flow application.
PRESSURE & PRESSURE-VOLUMEScisense high fidelity pressure catheters span the entire range of animal sizes from mice to cows. Minimally invasive ADVantage System pressure-volume catheters provide cardiac researchers the unique ability to measure almost every imaginable hemodynamic and contractile index of ventricular function with a single instrument. It is the only catheter-based system to accurately quantify true ventricular volume in real time.
TELEMETRYFully implantable EndoGear biotelemetry system is customizable to meet specific experimental requirements and can measure Doppler flow velocity, pressure, ECG and temperature from a single implant. PhysioGear pocket telemetry system for large animals measures volume flow with transit-time perivascular Flowprobes.
Advancing Meaningful Measurements
TISSUE PERFUSIONLaser Doppler technology measures microvascular blood flow, mass and velocity as a relative indicator of tissue perfusion. A range of surface and needle style Probes cater to specific application needs.
RL-1-fly Rev. A 12/12
-
RL-52-ds-A4 Rev.B 12/12
Volume Flow
Selection of compatible perivascular Flowprobes
TS420 Flow Module requires a T400 Console in order to take measurements. Consoles can hold multiple Modules of various functionality.
T403 Console with TS410 and TS420 Modules
Transonic TS420 Perivascular Flow Modules provide unprecedented waveform quality and resolution. They incorporate plug and play features with virtually maintenance-free construction for the perfect combination of sophisticated and simple. TS420 Flow Modules and compatible Flowprobes measure absolute blood flow in arteries, veins & ducts for acute and chronic cardiovascular research applications.
UNLIMITED APPLICATIONS Small Animal Cardiovascular; Even Mice!
Renal Hypertension Studies
Carotid Occlusion Thrombosis Models
Large Animal Cardiovascular
Exercise Physiology, Heart Failure Models, Pregnancy Research, Myocardial Ischemia & Reperfusion
VAD Implantation & Heart Assist Models
Novel Species: Comparative Physiology
COMPATIBLE FLOWPROBES (0.5 - 36 MM) PR/PS/V-Series Flowprobes & Nanoprobes
PAU-Series COnfidence Flowprobes for Cardiac Output and great vessels
PMP-Series - Handle style Flowprobes for acute intraoperative applications
TS420 Perivascular Flow ModulePrecision Blood Flow Measurements for In Vivo Animal StudiesGold Standard Ultrasonic Transit-Time Technology
-
TS420 Perivascular Flow Module Specifications
www.transonic.com
GENERAL FEATURESSize 5.125 h x 4 w x 9.062 d
Weight: 2.2 lbs.
Module fits 2 Console slots (20HP) in T402 or T403 Consoles
Power: Derives input power from 400-Series Consoles. Installation in a Console is required.
OPERATIONAL TECHNOLOGYUltrasonic Transit-time
FLOWPROBE COMPATIBILITYPS-, V-, PR-, PMP- & PAU-Series
PROBE CONNECTORFront panel 10-pin connector. Accepts research perivascular Flowprobes and extension cables with male CRA 10-pin connectors.
AUTOMATIC ADJUSTMENTSProbe size identification and corresponding flow output ranges. Volume flow calibration of applied Probe.
DIGITAL DISPLAY4-Digit (14 segment) LED displays Flow / Probe data / Error Messages
Bar Indicator Light: Displays received signal amplitude for continuous monitoring of Probe signal quality
ANALOG DISPLAYTaut-band needle (-0.2 volts to +1.2 volts ) displays Flow / Received Signal Amplitude/Calibration information
ZERO ADJUSTRecessed momentary push button to zero flow reading at stopped flow
MODE BUTTON CONTROLSSelect modes of operation of displays and outputs
MEASURE MODE: Displays current volume flow values. Indicator light bar shows received signal strength
TEST MODE: Displays Probe size & received signal amplitude
ZERO MODE: Sets outputs to zero flow to calibrate external recording device
SCALE MODE: Sets outputs to scale factor flow to calibrate external recording device
LOW RANGELow Range increases flow gain by a factor of 4
FILTER PROPERTIES 0.1, 10, 40 Hz: 2nd order
Butterworth, with a third passive pole at 160 Hz
160 Hz: 3rd order Butterworth
INVERTInvert the polarity of analog flow outputs and flow displays
SIGNAL OUTPUTS8 accessible signals via 400-Series Flowmeter Consoles back-panel terminal block: Pulsatile Volume Flow; Mean Volume Flow, Received Signal Amplitude (2); Phase (4)
ULTRASONIC FREQUENCY RANGE600 KHz to 14.4 MHz; Probe size dependent.
FLOW OUTPUTFront panel mounted BNC output connector & rear panel terminal block:
Pulsatile/Average Volume Flow
Filtering controlled by front panel selectable filters
Voltage range: -5 to + 5 volts
Output resistance: 500 Ohm
Full Range for Flow: -5 to +5 V (bidirectional flows, with range of 5 x scale factor flow)
AUTOMATIC DIGITAL PROBE ID & CALIBRATIONTS420 circuitry reads Probe operational data (size, scale & calibration) programmed in the probes EPROM.
Probes with 10 or 12-pin connectors: EPROM installed in the connector.
4-pin Probe connectors require separate EPROM keys
CAL KEY PORT: Front panel socket accepts 3-pin EPROM calibration keys for Flowprobes with 4-pin connectors. Flowmeter reads and uses CAL KEY data if both a separate calibration key and connector EPROM are present.
SYNCHRONIZATIONRear panel jumpers select synchronization mode
Self-Triggering Mode: SYNC IN to SYNC OUT jumper on each Module
Sequential Triggering Mode: SYNC IN crossed to SYNC OUT between Modules
-
RL-54-ds-A4 Rev.B 12/12
Volume Flow
ME-PXN Inline Flowsensor and ME-PXL Clamp-on Flowsensor on tubing
Whether you require tubing flow measurements in the animal lab or in the R&D engineering suite, Transonics TS410 Tubing Flow Module gives you precision volume flow measurements in tubing with user friendly features applicable to laboratory bench settings, in vitro and extracorporeal use.
True Volume Flow
Measurement Capability for Diverse Fluids: Blood, Saline, Water, Cell Culture, Physiological Buffers, Blood Analogs such as Glycerine/Water Solutions
Programmable Alarm Conditions:
High / Low Flow Threshold Alarm Bubble / Received Signal Alarm
On-site recalibration of Flowsensors for new parameters or conditions
ALL TYPES OF FLOW CIRCUITS Circulatory support device development (VAD
Performance & Artificial Heart)
Isolated heart and perfused organ studies
Mock circulatory models
Non-contact sterile flow measurement of biologicals and bioreactors
Flow phantoms and any experimental, or non-human clinical or process application where flow measurement in tubing is needed.
COMPATIBLE FLOWSENSORS ME-PXN Inline Flowsensors
ME-PXL Clamp-on Sterile Tubing Flowsensors TS410 Flow Module requires a T400 Console in order to take measurements. Consoles can hold multiple Modules of various functionality.
T403 Console with TS410 and TS420 Modules.
TS410 Tubing Flow ModulePrecision Volume Flow Measurements for In Vitro & Extracorporeal TubingGold Standard Ultrasonic Transit-Time Technology
-
www.transonic.com
TS410 Tubing Flow Module SpecificationsGENERAL FEATURESSize: 5.125 h x 4 w x 9.062 d
Weight: 2.3 lbs.
Module fits 2 Console slots (20HP) in T402 or T403 Consoles
Power: Derives input power from Transonic 400-Series Consoles. Installation in a Console is required.
OPERATIONAL TECHNOLOGYUltrasonic Transit-time
FLOWSENSOR COMPATIBILITYME-PXL- & ME-PXN-Series
SENSOR CONNECTORFront panel 16-pin connector. Accepts research Inline and Clamp-on Flowsensors and extension cables with male CC16 or CP16 connectors.
AUTOMATIC ADJUSTMENTSSensor size identification and corresponding flow output ranges. Volume flow calibration and serial number displayed of active Flowsensor.
DIGITAL DISPLAY4-Digit (14 segment) LED displays Flow / Sensor data / Error Messages
Bar Indicator Light: Displays received signal for continuous monitoring of Sensor signal quality.
LCD DISPLAYOne line 16-character alpha numeric LCD displays program parameters, Sensor and Meter status, alarm settings. Default displays Sensor serial number.
SET-UP/STATUS & PROGRAM PARAMETERSSTATUS MODE: (White labels) Status message displayed on LCD.
Sensor Status: sensor type & calibration
Meter Status: Active flowmeter settings & alarm status
Alarm Mute: Audible alarm On/Off
PROGRAM MODE: (Blue labels)
Sensor Controls: Select pre-programmed factory calibration options; Adjust Flowsensor gain to change calibration on-site.
1/4 Flow Scale: increases flow gain by factor of 4 for low flow measurements.
Calibrate Scale: sets output to 0 and 1 Volt to calibrate external recording devices with scale factor flow.
Invert flow: inverts polarity of analog outputs & flow display
Alarms Menu: 3 level program to select, set thresholds, and activate Alarms for Low Flow, High Flow and Received Signal Interruption
FILTER PROPERTIES 0.1, 10, 40 Hz: 2nd order
Butterworth, with a third passive pole at 160 Hz
160 Hz: 3rd order Butterworth
ZERO FLOW ADJUSTRecessed momentary push button to zero flow reading at stopped flow.
FLOW OUTPUTFront panel mounted BNC output connector & rear panel terminal block:
Pulsatile/Average Volume Flow
Filtering controlled by front panel selectable filters
Voltage range: -5 to + 5 volts
Output resistance: 500 Ohm
Full Range for Flow: -5 to +5 V (bidirectional flows, with range of 5 x scale factor flow)
AUTOMATIC DIGITAL SENSOR ID & CALIBRATIONTS410 reads operational data (size, scale & calibration) programmed in the sensors EPROM.
ULTRASONIC FREQUENCY RANGE600 KHz to 14.4 MHz; Sensor size dependent
SIGNAL OUTPUTS8 accessible signals via 400-Series Flowmeter Consoles back-panel terminal block: Pulsatile Volume Flow; Mean Volume Flow; Received Signal Amplitude (2); Phase (4)
SYNCHRONIZATIONRear panel jumpers select synchronization mode
Self-Triggering Mode: SYNC IN to SYNC OUT jumper on each Module
Sequential Triggering Mode: SYNC IN crossed to SYNC OUT between Modules
-
For Use With TS420 Flowmeter Modules
Volume Flow
Precision Perivascular Flowprobes
Absolute volume flow data from mice to large animals
Acute use and implantable Flowprobes for arteries, veins and ducts
Multiple configurations to meet experimental needs of many animal models
Unparalleled accuracy & signature high resolution flow waveforms
PS-SERIES INCLUDING NANOPROBES0.5-1.5 mm Nanoprobes are scaled to fit mouse anatomy for acute or chronic use.
2-20 mm Flowprobes offer the greatest diversity of customizable features for the perfect fit in any application.
PR-SERIES1 & 1.5 mm Flowprobes for small acute or chronic applications where a more robust design than the Nanoprobes is needed.
PAU-SERIES8-36 mm COnfidence Flowprobes with Ultrafit Liners for ascending aorta and pulmonary artery cardiac output studies.
PMP-SERIES2-14 mm Handle Flowprobes for intraoperative measurements in preclinical animal trials where devices that match those used in clinical settings are preferred.
V-SERIES0.5 & 0.7 mm Microcirculation Flowprobes for acute use only. Larger body and more robust than Nanoprobes. Requires more acoustic gel for larger lumen.
Volume Flow
PS- Nanoprobes
PS-Series
PR-Series
PMP-Series
V-Series
PAU-Series
RL-26-fly-A4 Rev. E 12/12
-
Volume FlowVolume Flow
Ordering PS-, PR-, PAU-, PMP- & V-Series Flowprobes
Catalog #: MA - Size Series
Examples:
MA-2PSS (Acute use 2 mm PS-Series Probe with side cable exit)
MA-0.5PSB (Acute use 0.5 mm PS-Series Nanoprobe with back cable exit)
MA-20PAU (Acute use 20 mm PAU-Series Probe)
Catalog #: MC - - - - - - Size
Application:
Examples:
MC-1.5PSL-JN-WC04-CA4S-GC (Custom 1.5 mm PS-Series Probe with lateral cable, J reflector, 4 cm cable, CA4S connector and chronic calibration)
MC-20PAU-WC60-CRS10-GAC (Custom 20 mm PAU-Series Probe with 60 cm cable, CRS10 connector and acute/chronic calibration)
Cable Orientation
Series Cable Orient.
Reflector Cable Length
Connector Calibration
Custom Configured FlowprobesCustom configured Probes are available for most Probe series to meet individual application and implant needs. Contact Customer Service for species/vessel recommendations or configure Probes from the table codes. Please note intended application for confirmation when ordering custom Probes as this will assist with determining the most ideal configuration. Custom Probes cannot be exchanged.
Standard Acute Use FlowprobesAll MA- Flowprobes come with the standard maximum cable length, CRA10 connector, and acute calibration (acute/chronic calibration for PAU-Series)
* Cable orientation and reflector style available for PS- & PR-Series only
* Cable orientation available for PS- & PR-Series only
Extension Cable
Cable Length
Cable Orientation*
Reflector Style*
Probe Size & Series
* *
*
MRI COMPATIBILITYTransonic Flowprobes can be made from nonmagnetic components for flow measurements during MRI. Contact Customer Service to special order: ceramic or brass reflector, nonmagnetic connector, Probe ID key for use with extra long extension cables.
Connector
PhysioGear
Species, Vessel
-
B- Back: perpendicular to vessel
S- Side: parallel to vessel
L- Lateral: for thoracotomy
Custom Ordering of Perivascular Flowprobes
CABLE ORIENTATION*
CODE ORIENTATION PS-SERIES PR-SERIES
B Back 0.5 - 20 1 - 1.5
S Side 0.5 - 20 1 - 1.5
L Lateral 0.5, 1.5 - 2.5 N/A
REFLECTOR STYLES FOR SPECIAL APPLICATIONSMA- STANDARD
CODE DESCRIPTION PS-SERIES PR-SERIES
LS L w/ slide cover 3 - 20 N/A 3-20PS
LSF L w/ slide & silicone flange 3, 4, 6 N/A
JN J w/o slide 0.5 - 16 1 - 1.5 1.5PSL
JFH J w/o slide w/ flexi-handle 0.5 - 2.5 1 - 1.5 0.5, 0.7PS
JS J w/ slide cover 2 - 16 1 - 1.5 2-2.5PS, 1-1.5PR
JSF J w/ slide & silicone flange 2, 2.5 N/A
U U reflector 3 - 20 N/A
USW U w/ wide silicone shield 6 - 20 N/A
USN U w/ narrow silicone shield 6 - 20 N/A
MRI non-magnetic reflector 2 - 20 N/A
STANDARD MAX CABLE LENGTH
CODE DESCRIPTION PS-SERIES PR-SERIES PAU-SERIES
WCxx Up to 60 cm Nanoprobes 1 - 1.5
WCxxx Up to 100 cm 2 - 20* N/A
WCxxx Up to 200 cm N/A N/A 8-36*
CONNECTORS SERIES
CODE DESCRIPTION ACUTE/CHRONIC ANIMALS ID KEY REQUIRED PS- / PR- PAU-
CRA10 10-pin Redel acute connector Acute All No all sizes
CRS10 10-pin Redel sealed connector w/ cap ChronicDog & larger No all sizes
CS12 12-pin titanium connector w/ cap ChronicDog & larger No 1 - 20
all sizes
CB12 12-pin titanium skin button w/ cap ChronicDog & larger No 1 - 20
all sizes
CM4B 4-pin mini connector w/ cap & straight cable ChronicRat, Rabbit & larger Yes all sizes N/A
CM4S 4-pin mini connector w/ cap & right angle cable ChronicRat & Rabbit Yes all sizes N/A
CA4B 4-pin micro connector w/ straight cable ChronicRat & Mouse Yes 0.5 - 10 N/A
CA4S 4-pin micro connector w/ right angle cable ChronicRat & Mouse Yes 0.5 - 10 N/A
CALIBRATION SERIES
CODE DESCRIPTION PS- / PR- PMP- / V- PAU-
GA Acute calibration all sizes
GC Chronic calibration all sizes N/A
GAC Acute/Chronic calibration N/A N/A all sizes
GX Custom calibration all sizes N/A
-P PhysioGear normalization 1-20 N/A all sizes
SILICONE FLANGE (SF) FOR CORONARY IMPLANTSMesh-reinforced silicone flange cemented around the perimeter of Probe is sutured to the myocardium to stabilize the Probe on the heart in LAD artery application; also used in umbilical artery (fetal sheep) application. Can also be used to hold coupling gel in place during acute experiments and to keep the Probe aligned on the beating heart.
SILICONE SHIELDS (USW & USN)U-reflectors on PS-Series Probes may be silicone encapsulated for chronic implant. Cushions vessel for ascending aorta and pulmonary artery implant. Stabilizes Probe on collapsible vessels (i.e. portal vein); keeps fat from infiltrating Probe.
*Determined by anatomy and surgical approach.
Wide Silicone Shield (USW) Narrow Silicone Shield (USN)
L reflector with slide
J reflector with slide
U reflector
Probe with Silicone Flange (SF)
*Substitute xx for shorter lengths
-
PROBE ID KEY FOR 4-PIN CONNECTORSFlowprobes configured with 4-pin connectors require Probe ID Keys. Probe scale, signal normalization and calibration gain are programmed into the serialized EPROM key. Keys plug into the port of the TS420 Module during Probe use.
CM4B (STRAIGHT) & CM4S (RIGHT ANGLE) 4-PINImplantable plastic mini connectors come with a threaded cap with suture hole, sealing gasket, and Probe ID key. Use with 4-pin extension cables. CM4B has a straight cable entry to ease tunneling subcutaneously and can be stored in an animal jacket pocket when not in use. The CM4S connector has a right angle cable entry and is used with silicone or rigid cuffs to stabilize connector in mid-scapular region. Can be used for most species including: rats, rabbits, and dogs.
CA4B (STRAIGHT) & CA4S (RIGHT ANGLE) 4-PINMinimal impact micro connectors, the 4-pins terminate the Probe cable with a bare minimum of housing. Use with 4-pin extension cables. Comes with Probe ID key. CA4B (straight cable entry) can be threaded into spring stock for use with electrical swivels. CA4S connectors have a right angle cable entry and can be stabilized in the mid-scapular region with a rigid or silicone cuff. For rats and mice.
CRA10 ACUTE REDELMA- Standard for Acute Use Probes: Plugs directly into Flowmeter or extension cable.
CRS10 SEALED REDELImplantable plastic connector has conical threaded cap with suture hole for easy subcutaneous tunneling. Cap contains sealing gasket. Plugs directly into Flowmeter or extension cable.
CS12 SEALED TITANIUMSealed Titanium Connector with pointed cap. Connector includes the Flowprobe calibration EPROM.
CB12 TITANIUM SKIN BUTTONFor long term implantation with any style Probe. The Probe ID EPROM is integrated in the connector. The connector comes with a flat Delrin cap. A pointed cap (CB12-PC) can also be ordered separately. Use with 12-pin extension cables. For dogs, pigs and other large animals.
CONNECTOR DIMENSIONS IN MM
CODE HEIGHTCAP DIAMETER
SHANK DIAMETER
FLANGE DIAMETER
CRA10 44.5 N/A 14 N/A
CRS10 40.3 15.3 11.1 N/A
CS12 32 11.5 9.4 N/A
CB12 21.5 11.5 9.4 18.3
CM4B 15 8 8 N/A
CM4S 15 8 8 N/A
CA4B 10 N/A 4.1 N/A
CA4S 10 N/A 4.1 N/A
Connectors & Accessories for Acute & Chronic Precision Perivascular Flowprobes
CALIBRATION INFORMATIONTransonic Precision Perivascular Flowprobes are each precalibrated for absolute blood flow measurement at 37C using a gravity-fed constant flow setup with water (see RL-5-tn). We calibrate Probes for their intended use to compensate for the different acoustic conditions when using an acoustic gel in acute applications versus fibrotic tissue infiltration that stabilizes the Probe in a chronic implant. Probes calibrated for acute use are calibrated to read 10% higher than Probes for chronic implant (Except PAU-Series with acute/chronic calibration). Sub-acute applications (12 days) more closely mimic an acute preparation and should be calibrated for such. Acute calibration is also recommended for Probes that are used for both acute and chronic application since acute measurements are more often interpreted in absolute terms rather than relative changes in flow over time. Custom calibration for atypical use is available (ex: for fish at 10C).
CRS10
CRA10
CS12
CB12
CA4B
CA4S
PHYSIOGEAR COMPATIBILITYTransonic Flowprobes (1-28 mm) are compatible with PhysioGear pocket telemetry system for large animals. Contact Customer Service for Flowprobe recommendations for all applications.
CM4BCM4S
-
EXTENSION CABLES
CATALOG # TYPE DESCRIPTION
CRA10-S-CRA10 10-pin 1.25 meter
CRA10-M2-CRA10 10-pin 2 meter (not for use with nanoprobes)
CRA10-M3-CRA10 10-pin 3 meter (not for use with nanoprobes)
CRA10-X-CRA10 10-pin Custom length for MRI
CM12-S-CRA10 12-pin 1.8 meter
CM12-X-CRA10 12-pin Custom length
CM4-S-CRA10 4-pin 1.8 meter with spring
CM4-M3-CRA10 4-pin 3 meter (not for use with nanoprobes)
CM4-X-CRA10 4-pin Custom length; no spring
CA4-S-CRA10 4-pin 1.8 meter; mouse cable; no spring
CODE DESCRIPTIONCOMPATIBLE CONNECTOR
HEIGHT (MM)
DIAMETER (MM)
AAPC102 Silicone cuff CM4S 18.9 5.4
AAPC103 Silicone cuff CA4S 15 5.4
AAPC104 Rigid cuff CM4S 19 7.1
AAPC105 Rigid cuff CA4S 9 3.7
Soft silicone cuffs aid stabilizing mini (CA4 & CM4) connectors for short term implant. Suture holes in base of flange allow attachment on top of skin. Supplied in packages of 10.
Delrin rigid cuffs convert mini connectors to skin buttons for small animal use. Suture holes allow attachment on top of skin; set screw holds connector in place. Robust for long-term or multiple use.
ACOUSTIC COUPLANT FOR ACUTE APPLICATIONSAcoustic couplant gel is used to displace the air between the Flowprobe and the vessel during acute application because air will block transmission of the ultrasound signal. Appropriate coupling gels for use with Transonic Flowprobes have acoustic properties at various temperatures that closely match blood. See RL-9-tn for complete listing.
Surgilube: (# ZC510 4.25 oz. tube) Bacteriostatic Surgical Lubricant from E. Fougera & Co.
NALCO 1181 (# APNALCO 6 oz.) Superabsorbant powder to thicken Surgilube gel for long experiments. For terminal use only.
PROBE & CONNECTOR STABILIZATION PRODUCTSMERSILENE MESH (APMERSILENE): 6 x 6 square soft interlocked polyester fiber mesh implanted under connector fortifies thin skin for cuff or button sutures.
SILICONE WRAPPING STRIP (APWRAP): Thin silicone strip reinforced with mesh wraps around outside of a Probe to stabilize the Probe on a vessel. Provides additional suture points and keeps fat from infiltrating the Probe over long implants.
PROLENE MESH (APPROLENE) & ULTRACELL SPONGE (ASPONGE): Used in chronic implant to protect the ascending aorta against long-term erosion. For use with Probes without full liners (PAX & 32, 36PAU).
Cuffs for Chronic Probe Implants
Connectors & Accessories for Acute & Chronic Precision Perivascular Flowprobes
AAPC103
AAPC105
AAPC104
AAPC102
APMERSILENE
Nanoprobes require 185 cm total cable length (probe + extension cable) to meet specification.
CRA10 Connector
EPROM ID Key
CM4S 4-pin Connector
CM4-S-CRA10 1.8 m Extension Cable with Spring
2.5PSL Probe
Silicone Wrap sutured around Flowprobe
-
AMERICASTransonic Systems Inc.34 Dutch Mill RdIthaca, NY 14850U.S.A.Tel: +1 607-257-5300Fax: +1 [email protected]
EUROPETransonic Europe B.V.Punterweg 316222 NW MaastrichtThe NetherlandsTel: +31 43-407-7200Fax: +31 [email protected]
ASIA/PACIFICTransonic Asia Inc.6F-3 No 5 Hangsiang RdDayuan, Taoyuan County33758 Taiwan, R.O.C.Tel: +886 3399-5806Fax: +886 [email protected]
JAPANTransonic Japan Inc.KS Bldg 201, 735-4 Kita-AkitsuTokorozawa Saitama359-0038 JapanTel: +81 04-2946-8541Fax: +81 [email protected]
www.transonic.com
Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells gold standard transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems.
Volume FlowVolume Flow
CLEANING & STERILIZATIONFollow the directions included with each Flowprobe (I1041).
CUSTOMER SERVICEContact your local distributor or sales representative for quotations, shipping information and payment terms. Please feel free to contact us if you have questions or visit our website www.transonic.com for the most up-to-date product offerings, applications and technical support, and reference materials.
LIMITED WARRANTYTransonic Systems Inc. warrants that perivascular Flowprobes are free from defects which are the result of faulty material or workmanship by Transonic Systems Inc. for a period of six (6) months (Nanoprobes: 3 months) from their date of shipment. The warranty of Transonic shall not apply to: defects caused by abuse, neglect or misuse; damage due to accident or casualty; or un-authorized alterations or repairs made by anyone other than Transonic Systems Inc.
Transonic Systems Inc. will, at no charge to the user, either repair or replace a defective Flowprobe during its warranty period. The Buyer pays shipping charges to Transonic Systems Inc. Transonic will pay for the return shipping charges. No other warranty oral or written, expressed or implied. Transonic is not liable for incidental or consequential damages. Warranty is valid only if equipment is purchased through Transonic or a duly appointed distributor or licensed representative.
CALIBRATION CERTIFICATION & REPAIR SERVICETransonic Flowprobes are precalibrated at the factory with equipment that has been calibrated traceable to the standards of National Institute of Standards and Technology and to Transonic Systems Inc. equipment performance standards. At purchase, Flowprobes are issued a Certificate of Calibration valid for one year. Probes may be returned to Transonic for recalibration if Calibration Certification is required for GLP studies.
Transonic will also perform repairs on Flowprobes which have been damaged or cut. Contact Transonic or your local distributor for an RMA # (Return Materials Authorization).
Volume Flow
-
Volume Flow
RL-20-ds-A4 Rev. D 12/12
PS-Series, V-Series, PR-Series, PAU-Series & PMP-Series
Perivascular Flowprobe Specifications
PROBE SIZE & SERIES
VESSEL OD BIDIRECTIONAL FLOW OUTPUTS ACCURACY SPECIFICATIONS5ULTRASOUNDFREQUENCYMA-ACUTE
APPLICATIONMC-CHRONIC APPLICATION
RESOLUTION1LOW FLOW ( SCALE)2
STANDARD SCALE2
MAX FLOW3 (STD SCALE)
ZERO OFFSET4
ABSOLUTE ACCURACY
RELATIVE ACCURACY
mm mm ml/min1V output in ml/min
1V output in ml/min
5V output in ml/min
ml/min% of reading
% MHz
0.5PS 0.3 - 0.5 0.3 - 0.48 0.03 1.5 6 30 0.12 15 2 14.4
0.7PS 0.5 - 0.7 0.4 - 0.7 0.05 2.5 10 50 0.2 15 2 9.6
1.5PS 1.2 - 1.5 1.2 - 1.5 0.075 10 40 200 0.8 15 2 4.8
0.5V 0.25 - 0.5 N/A 0.05 2.5 10 50 0.25 15 3 7.2
0.7V 0.35 - 0.7 N/A 0.075 5.0 20 100 0.5 15 3 4.8
1PR 0.7 - 1.2 0.7 - 1.0 0.05 5 20 100 0.2 10 2 7.2
1.5PR 1.2 - 1.8 1.0 - 1.5 0.075 10 40 200 0.4 10 2 4.8
2PS 1.5 - 2.0 1.3 - 1.8 0.1 25 100 500 1 10 2 3.6
2.5PS 1.8 - 2.5 1.5 - 2.4 0.1 25 100 500 1 10 2 3.6
3PS 2.5 - 3.7 2.4 - 3.4 0.4 50 200 1 L 2 10 2 3.6
4PS 3.3 - 4.4 3.0 - 4.0 0.8 100 400 2 L 4 10 2 2.4
6PS 4.4 - 6.6 4.0 - 6.0 2.0 250 1 L 5 L 10 10 2 1.8
8PS 6.6 - 8.8 5.8 - 8.0 4.0 500 2 L 10 L 20 10 2 1.2
10PS 8.3 - 11.0 7.3 - 10.0 4.0 500 2 L 10 L 20 10 2 1.2
12PS 9.8 - 13.0 8.6 - 12.0 8.0 1 L 4 L 20 L 40 10 2 0.9
14PS 11.3 - 15.0 10 - 14 8.0 1 L 4 L 20 L 40 10 2 0.9
16PS 13.3 - 17.7 12 - 16 20.0 2.5 L 10 L 50 L 100 10 2 0.6
20PS 16.0 - 21.0 14 - 19 40.0 2.5 L 10 L 50 L 100 10 2 0.6
8PAU 6 - 8 6 - 7 4 500 2 L 10 L 20 10 2 3.6
10PAU 8 - 10 8 - 9 4 500 2 L 10 L 20 10 2 3.6
12PAU 9 - 12 9 - 11 8 1 L 4 L 20 L 40 10 2 2.4
14PAU 11 - 14 11 - 13 8 1 L 4 L 20 L 40 10 2 2.4
16PAU 12 - 16 12 - 15 20 2.5 L 10 L 50 L 100 10 2 1.8
20PAU 16 - 20 16 - 19 20 2.5 L 10 L 50 L 100 10 2 1.8
24PAU 19 - 24 19 - 23 40 5 L 20 L 100 L 200 10 2 1.2
28PAU 22 - 28 22 - 27 40 5 L 20 L 100 L 200 10 2 1.2
32PAU 25 - 32 25 - 316 80 10 L 40 L 200 L 400 10 2 0.9
36PAU 28 - 36 28 - 356 80 10 L 40 L 200 L 400 10 2 0.9
2PMP 1.5 - 2.5 N/A 0.1 25 100 500 1 15 2 3.6
3PMP 2.5 - 3.7 N/A 0.4 50 200 1 L 2 15 2 3.6
4PMP 3.3 - 4.4 N/A 0.8 100 400 2 L 4 15 2 2.4
6PMP 4.4 - 6.6 N/A 2.0 250 1 L 5 L 10 15 2 1.8
8PMP 6.6 - 8.8 N/A 4.0 500 2 L 10 L 20 15 2 1.2
10PMP 8.3 - 11.0 N/A 4.0 500 2 L 10 L 20 15 2 1.2
12PMP 9.8 - 13.0 N/A 8.0 1 L 4 L 20 L 40 15 2 0.9
14PMP 11.3 - 15.0 N/A 8.0 1 L 4 L 20 L 40 15 2 0.9
1. Resolution: represents the smallest detectable change in flow, a factor in accuracy.2. Probes operate in either low flow or normal flow scales, determined by the flow range under study. Probes measure bidirectional flow up to 5 times the
selected scale setting. The scale settings calibrates the 1 volt reference signal for data collection; the linear range of the Flowmeter is equal to 5V. By using the low flow button, measurement sensitivity is increased four fold. This linear overrange is important for the proper recording of highly pulsatile peak flows.
3. Maximum Range for each Probe reflects the highest flow rate that can be processed and displayed via the analog connector.
4. Zero offset on individual Probes is often lower than this value.5. The Absolute Accuracy percentage can be raised to relative accuracy levels by in situ calibration.6. 32-36PAU Probes are only supplied with acute liners & may require modification for chronic use.
-
www.transonic.com
Probe Width
Lumen
Probe Length
Reflector Depth
Physical Specifications
PROBE SIZE & SERIES
PROBE PROBE LINER PROBE SHELL CABLE
WEIGHT ID DEPTH W/ FLANGE DEPTH LENGTH LENGTH DIAMETER
grams mm mm mm mm m mm
8PAU 2.0 8 7 8 16 2.0 2.7
10PAU 2.5 10 7 8 19 2.0 2.7
12PAU 4.0 12 10 10 21 2.0 2.7
14PAU 5.5 14 12 12 24 2.0 2.7
16PAU 9.0 16 13 14 26 2.0 2.7
20PAU 14.0 18 or 20 14 15 31 2.0 2.7
24PAU 22.5 22 or 24 18 18 36 2.0 2.7
28PAU 30.3 26 or 28 19 20 41 2.0 2.7
32PAU 45 30 or 32 22 22 46 2.0 2.7
36PAU 59 34 or 36 23 23 51 2.0 2.7
PROBE SIZE & SERIES
PROBE BODY REFLECTOR HANDLE CABLE
WEIGHT LENGTH WIDTH LENGTH WIDTH DEPTH LENGTH LENGTH DIAMETER
grams mm mm mm mm mm cm m mm
0.5PS 0.09 3.2 2.3 lumen = 0.471 1.02 53 60 cm 1.0
0.7PS 0.12 3.2 2.7 lumen = 0.701 1.22 53 60 cm 1.0
1.5PS 0.23 4.25 3.75 lumen = 1.651 2.02 N/A 60 cm 1.25
0.5V 0.2 6.5 4.0 2.0 1.5 1.1 53 60 cm 1.5
0.7V 0.25 7.6 3.5 2.5 1.7 1.8 53 60 cm 1.5
1PR 0.2 6.5 4.0 2.0 1.5 1.1 N/A 60 cm 1.5
1.5PR 0.25 7.6 3.5 2.5 1.7 1.8 N/A 60 cm 1.5
2PS 0.3 8.7 3.3 3.3 2.0 2.5 N/A 1.0 1.5
2.5PS 0.3 8.7 3.3 3.3 3.2 2.5 N/A 1.0 1.5
3PS 1.2 9.0 5.0 3.5 4.0 3.7 N/A 1.0 2.0
4PS 1.5 13.3 6.0 3.8 5.5 4.4 N/A 1.0 2.0
6PS 2.7 13.5 6.7 4.0 7.8 6.6 N/A 1.0 2.5
8PS 5.0 18.8 7.5 6.0 8.2 8.8 N/A 1.0 2.5
10PS 5.3 18.8 8.5 6.0 10.0 11.0 N/A 1.0 2.5
12PS 9.3 22.5 8.5 6.2 12.0 13.0 N/A 1.0 3.0
14PS 11.6 26.2 8.5 7.5 14.5 15.0 N/A 1.0 3.0
3.16PS 16.6 36.0 10.0 9.0 17.0 17.7 N/A 1.0 3.0
20PS 20.2 31.0 9.0 9.0 21.0 21.0 N/A 1.0 3.0
2PMP 14 7 5.5 3.0 3.0 2.7 17.5 2.0 2.2
3PMP 17 9 7.4 4.0 4.0 3.5 17.5 2.0 2.2
4PMP 17 10 6.8 3.4 5.0 4.6 17.5 2.0 2.2
6PMP 17 12.7 7.7 4.1 7.8 6.6 17.5 2.0 2.2
8PMP 21 15.2 8.5 4.6 9.0 8.6 17.5 2.0 2.2
10PMP 21 16.5 9.4 5.2 11.0 10.8 17.5 2.0 2.2
12PMP 21 19.5 10 5.8 13.0 12.8 17.5 2.0 2.2
14PMP 26 25 11 7.6 14.5 17.5 17.5 2.0 2.2
Liner Depth
Shell Depth
Shell Length
ID
Probe Length
Probe Width
Reflector Width
Reflector Depth
Reflector Length
1. Lumen is the ultrasonic window within the reflector. Dimensions are approximately equal.
2. Reflector depth is the external dimension for Nanoprobes.
3. Handle comes standard with indicated MA- acute Probes. MC- chronic or custom orders are available without a handle.
-
For Use With TS410 Flow Modules
Volume Flow
Precision Tubing Flowsensors
Volume Flow
Measurevolumeflowinmostnon-aeratedliquidsincludingsaline,buffersolutions,blood,water&evendieselfuelwithhighresolutionandlowzerooffset.ChooseClamp-onorInlinetomatchyourflowcircuitrequirements.
ME-PXL Clamp-on Flowsensors Non-contactClamp-onSensorsdonotbreakcircuitsterility
Preclinicalandmedicalflowapparatusdesign
SmalldiameterSensorsforindustrialuseInnovativetransit-timetechnologyrevolutionizedbloodflowmeasurementinmedicaltubingapplicationswiththeseFlowsensorsthatclipontotheoutsideofflexibletubingtomeasuretheflowwithin.TheyhavebecomethestandardforOEMmedicaldesignandpreclinicalextracorporealusebyprovidingnon-invasivemeasurementwithhighaccuracyandstability.Measurementsarereliableeveninchallengingelectromagneticenvironments.
Theeasyclip-onoperationofthePXLFlowsensorsalsomaketheseSensorsidealforindustrialflowmeasurementapplicationswhenprocesstestingneedstobequick,repeatableandappliedtomultiplecircuitswithoutflowinterruption.Unlikelargediameterindustrialflowmeasurementdevices,TransonicprovideshighresolutionClamp-onSensorsforsmalldiametertubingsdownto1/8OD.
ME-PXN Inline FlowsensorsMeasureflowoverawidedynamicrange
Flexibilityfortubingcircuitsthatmayvaryorarestillinthedesignphase
HighestsensitivitySensorsforlowflowapplicationsPXNInlineFlowsensorsutilizeaschemeofultrasonicilluminationthatmakesitpossibletomanufactureaflow-throughSensorwithasmooth,cylindricalinteriorwithoutcompromisingmeasurementaccuracy.TheseFlowsensorsoffermoreflexibilityoverClamp-onSensorsasmeasurementcalibrationdoesntdependonthetypeandexactsizeoftubingonwhichtheyareused.SmalldiameterPXNInlinesareidealforlowflowisolatedheartorperfusedorganstudies.
RL-28-fly Rev. C 1/13
-
Volume FlowVolume Flow
SENSOR SIZE
PHYSICAL SPECIFICATIONS1
DIMENSION ALONG TUBE
DEPTH LENGTH
in mm in mm in mm
2PXL 0.8 21 0.7 17 1.3 32
3PXL 0.8 21 0.7 17 1.3 32
4PXL 0.9 23 0.8 20 1.4 35
5PXL 0.9 23 0.8 20 1.4 35
6PXL 1.0 24 0.9 23 1.5 39
7PXL 1.0 26 1.0 25 1.7 42
8PXL 1.1 28 1.0 24 1.7 44
9PXL 1.3 33 1.0 25 1.8 47
10PXL 1.2 32 1.1 27 2.0 51
11PXL 1.4 35 1.1 28 2.2 56
12PXL 1.5 38 1.2 31 2.4 61
14PXL 1.6 41 1.4 36 2.6 66
16PXL 1.9 47 1.5 39 3.0 75
20PXL 2.3 58 1.8 46 3.7 93
ME-PXL Series Clamp-on Flowsensors
APPLICATIONS Artificial
Heart&VADPerformance
MedicalDevice&PumpEngineering
Manufacturing&ComplianceFlowTesting
TransonicPXLClamp-onTubingFlowsensorsclipontheoutsideofflexiblelaboratorytubing.Nophysicalcontactismadewiththefluidmedia.AthinsmearofVaselineorpetroleumjellyshouldbeappliedtothesectionoftubingwheretheSensorisappliedtoprovideagoodsealbetweenthetransducersandthetubeforbestultrasonicsignaltransmission.PXLSeriesFlowsensorscanbefactorycalibratedandprogrammedforupto4differentfluid,temperature,tubing,andflowratecombinations.Sensorsizeisdeterminedbytheoutsidediameterofthetubing.StandardPXLSensorsaresizedin1/16increments.Metricsizesareavailableformetrictubing.
Easy clip on application of PXL Sensor to tubing
1. Standard cable length is 2 meters.
SENSOR SIZE
BIDIRECTIONAL FLOW OUTPUTS SYSTEM ACCURACY SPECIFICATIONS2
ULTRASOUNDFREQUENCYRESOLUTION1
LOW FLOW ( SCALE)
STANDARD FLOW SCALE
MAX FLOW (STD SCALE)
MAX ZERO OFFSET
ABSOLUTE ACCURACY
LINEARITY
ml/min1V output in ml/min
1V output in ml/min
5V output in L/min
ml/min% of reading
% MHz
2PXL 0.5 50 200 1 4.0 10 4 3.6
3PXL 1.0 100 400 2 8.0 10 4 3.6
4PXL 1.0 100 400 2 8.0 10 4 2.4
5PXL 1.0 100 400 2 8.0 10 4 2.4
6PXL 2.5 250 1 L 5 15 10 4 2.4
7PXL 5 500 2 L 10 30 10 4 1.8
8PXL 5 500 2 L 10 30 10 4 1.8
9PXL 5 500 2 L 10 30 10 4 1.8
10PXL 10 1 L 4 L 20 60 10 4 1.2
11PXL 10 1 L 4 L 20 60 10 4 1.2
12PXL 10 1 L 4 L 20 60 10 4 1.2
14PXL 25 2.5 L 10 L 50 150 10 4 1.2
16PXL 25 2.5 L 10 L 50 150 10 4 1.2
20PXL 50 5 L 20 L 100 300 10 4 0.9Calibration is dependent on tubing material, wall thickness, ultrasound velocity of liquid flowing through the tube & temperature.1. Resolution represents the smallest detectable flow change at 0.1 Hz filter (average flow output).2. Stated system accuracy specifications apply to PXL Flowsensors with TS410 Flow Modules. (a) Absolute accuracy is comprised
of zero stability, resolution and linearity effects. Stated values apply when flow rate is greater than 5% of maximum range and zero offset is nulled. (b) If the Sensor is calibrated on-site with the system Flow Module for the tubing and liquid in use, absolute accuracy may be improved to the Linearity value. (c) On-site calibration is recommended if the Sensor is routinely used to measure flows less than 5% of the maximum range to account for non-linearities associated with flow profile.
-
SENSOR SIZE
TUBING SPECIFICATIONS INLINE FLOWSENSOR CALIBRATION RANGES1
TUBING ID BARB OD LOW FLOW (1/4 SCALE)2 STANDARD FLOW (FULL SCALE)
in mm in mmLOWER LINEAR
LIMIT3,4MAX MEASUREMENT
RANGE5LOWER
LINEAR LIMITMAX MEASUREMENT
RANGE5
1PXN 3/64 1.2Flexible tubing
5 ml/min -25 to +25 ml/min 10 ml/min -100 to +100 ml/min
2PXN 1/16 1.6 10 ml/min -50 to +50 ml/min 20 ml/min -200 to +200 ml/min
3PXN 3/32 2.4 25 ml/min -125 to +125 ml/min 50 ml/min -500 to +500 ml/min
4PXN 1/8 3.2 0.16 4.0 50 ml/min -250 to +250 ml/min 100 ml/min -1 to +1 L/min
5PXN 3/16 4.8 0.23 5.8 100 ml/min -500 to +500 ml/min 200 ml/min -2 to +2 L/min
6PXN 1/4 6.4 0.3 7.6 250 ml/min -1.25 to +1.25 L/min 500 ml/min -5 to +5 L/min
10PXN 3/8 9.5 0.44 11.1 500 ml/min -2.5 to +2.5 L/min 1 L/min -10 to +10 L/min
13PXN 1/2 12.7 0.58 14.7 1 L/min -5 to +5 L/min 2 L/min -20 to +20 L/min
16PXN 5/8 15.9 0.72 18.3 2.5 L/min -12.5 to +12.5 L/min 5 L/min -50 to +50 L/min6
19PXN 3/4 19.1 0.86 21.9 2.5 L/min -12.5 to +12.5 L/min 5 L/min -50 to +50 L/min6
25PXN 1 25.4 1.14 29.0 5 L/min -25 to +25 L/min 10 L/min -100 to +100 L/min6
ME-PXN Series Inline Flowsensors
APPLICATIONS IsolatedOrgan
Studies
FlowPhantoms&CirculatoryModels
VolumeFlowSensitiveApplications
1. Stated system accuracy specifications apply to PXN Flowsensors with TS410 Flow Modules
1. To meet accuracy specifications, Flowsensors should be calibrated for the flow rate range of use.2. Flowsensors calibrated for the low flow range should be used with the Flow Module in 1/4 Scale Mode.3. Measurements below the Lower Linear Limit may deviate from the stated accuracy specification.4. Custom calibration is available for average flow rates below the lower limit. This may compromise accuracy
for the max measurement range.5. Range includes zero: any flow peaks exceeding the Max Flow Value (-5 volt to +5 volt range) will be clipped.6. Standard calibration range is up to 30 L/min; contact factory for availability of higher flow rate calibrations.
PXNInlineFlowsensorsspliceintolaboratorytubingandmeasurevolumetricflowofbloodandotherfluids.Theyofferthemostflexibilityforflowmeasurementincircuitswheretubingrequirementshavenotbeenformalized.Thefour-transducerSensordesignofferspreciseandaccurateflowmeasurementforloworhighflowrates,steadystateorpulsatileflows.FlowresolutionisscaledtoSensorsize,andflowismeasuredaccuratelyacrosstheSensorsfulldynamicrangewithlittleeffectfromturbulence.TheSensorssmoothroundflowchanneliseasytocleananddoesnottrapairbubblesthatcandegradeultrasonicperformance.Sizes4PXN-25PXNhavebarbed,rigidtubingendswhichmateeasilywithflexiblelaboratorytubing.Plasticclampsmaybeappliedtotheoutsideforaddedsecurityinhighpressurecircuits.Miniaturesize1PXN-3PXNSensorsarefabricatedaroundflexibletubingwhichmaybecuttolengthforinsertionintosmalltubingcircuitsorperfusionapparati.TheflexibletubingendsmaybeexpandedtofitoverlargertubingOD(seeRL-31-tn).PXNInlineSensorscanbecalibratedandpre-programmedforupto4fluid,temperature,andflowratecombinations.
Size 4PXN - 25PXN have barbed, rigid tubing ends
SENSOR SIZE
BIDIRECTIONAL FLOW OUTPUTS SYSTEM ACCURACY SPECIFICATIONS1 PHYSICAL SPECIFICATIONS4
ULTRASOUNDFREQUENCYRESOLUTION
LOW FLOW
( SCALE)
STANDARD FLOW SCALE
MAXFLOW
(STD SCALE)
MAX ZERO OFFSET2
ABSOLUTE ACCURACY
LINEARITY3TOTAL
LENGTH W/ TUBE ENDS
CASE LENGTH W/O TUBE ENDS
at 10 Hz in ml/min
1V output in ml/min
1V output in ml/min
5V output in L/min
ml/min% of reading
% in mm in mm MHz
1PXN 0.02 5 20 100 0.4 8 2 3.9 100 0.3 8 9.6
2PXN 0.02 10 40 200 0.6 4 2 3.9 100 0.5 12 9.6
3PXN 0.05 25 100 500 1 4 2 3.9 100 0.6 14 7.2
4PXN 0.1 50 200 1 L 2 4 2 1.0 25 0.6 16 4.8
5PXN 0.2 100 400 2 L 4 4 2 1.2 32 0.8 20 3.6
6PXN 0.5 250 1 L 5 L 10 4 2 1.6 41 1.0 26 2.4
10PXN 1 500 2 L 10 L 20 4 2 2.0 51 1.3 33 1.8
13PXN 2 1 L 4 L 20 L 40 4 2 2.7 69 1.8 45 1.2
16PXN 5 2.5 L 10 L 50 L 70 4 2 3.3 83 2.1 52 0.9
19PXN 5 2.5 L 10 L 50 L 100 4 2 4.0 101 2.5 64 0.9
25PXN 10 5 L 20 L 100 L 200 4 2 5.0 128 3.1 80 0.6
2. Zero offset can be eliminated by Zero Adjustment prior to measurement
3. Within specified calibration range.
4. Standard cable length is 1.85 meters.
-
CALIBRATION CODES
FLUIDTEMPERATURE
23C 37C CUSTOM2
Water/Saline H2023 H2037 H20TX
Blood BL23 BL37 BLTX
Glycerine 40%, Water 60% (vol)1 GL23 GL37 GLTX
Custom Glycerine2 GLX23 GLX37 GLXTX
Krebs Solution KR23 KR37 KRTX
Custom Fluid2 FX23 FX37 FXTX
FLOW RANGE CATALOG CODE
Standard Flow SF
Low Flow LF
Custom Flow2 XF
Catalog #: ME PXN - - - Size Fluid/Temperature + Flow Rate Calibration Codes
Up to four per Flowsensor
How to Order a Flowsensor1. ME-indicatescompatibilitywithTS410FlowModules.
2. DetermineifaPXNInlineorPXLClamp-onFlowsensorisbetterforyourapplication.
a. IfPXNInline,choosetheSensorsizethatwillbestmatchthecircuitIDandanticipatedflowrates.
b. IfPXLClamp-on,choosetheSensorsizethatmatchesyourtubingOD.Thenspecifytubingtype.Supplya60cmlengthsampleifyourtubingisnotonourstocktubinglist.
3. SpecifythefollowinginformationforeitherFlowsensortype:
a. Anticipatedflowrange(averageandpeak)
b. Fluidandtemperatureforcalibration
4. Usethecodetables(right)toconstructthecatalognumber.
5. ContactCustomerServiceforanynon-standardrequests.
Example:ME4PXN-BL37SFKR37SFFX37LF,calibratedfor3differentuses:
Bloodat37Catstandardflowrate
Krebsat37Catstandardflowrate
Customfluidat37Catlowflowrate
FLOW MODULE COMPATIBILITYTS410TubingFlowModule
SENSOR SIZEPXNInlineFlowsensorsaresizedtofittheinternaldiameteroftheflexibletubinginyourcircuit.PXLClamp-onFlowsensorsclamparoundtheouterdiameterofflexibletubing.UsethetubingspecificationtablestodeterminethebestSensorsizeforyourtubingrequirements.
TUBING DIAMETER FOR PXN INLINESThePXNSensorthatmostcloselymatchesthecircuittubingIDshouldbeusedsothatperturbationsinfluiddynamicsareminimized.Reducingthetubingdiametercanaddresistancetoflow.
TUBING REQUIREMENTS FOR PXL CLAMP-ONSTransmittingtheultrasoundsignalthroughthetubingwallrequiresasnug,compressivefit,sotheSensorsizeisdependentonthetubingofthecircuit.Medicalgradeandlaboratorytubings(PVC,silicone,polyurethane)aregenerallycompatibleforusewithPXLSensors.Rigid
PVCandacrylic(Lucite)arenot.WestockcommonPVCtubingtypes.Forothertubingtypesormetricsizes,a60cmsampleisrequiredforSensorcalibration.
EXPECTED FLOW RATESTransonicFlowsensorsizesarescaledtoachievethehighestresolutioninflowmeasurement.ThesmallertheSensor,thehigherthesensitivitytolowvolumeflowsandthelowertheoffsetatzeroflow(seespecificationstable).AllPXLandPXNSensorshavetwodynamicflowranges:standardflowrange(fullscale)andlowflowrange(1/4scale).Sensorsarefactorycalibratedforthehighestaccuracyinthespecifiedflowrange.Tomeetperformancespecifications,indicateloworstandardflowwhenordering.Ifnoflowrangeisindicated,Sensorswillbecalibratedinthestandardflowrange.Calibrationforflowsbelowthelowerlinearlimitmayberequestedandwillincuranextracharge.
Considerations for Choosing the Most Appropriate Flowsensor
1. Glycerine calibration is custom for 1PXN-3PXN2. All custom requirements (X) incur an extra charge
Small 1 - 3PXNs use flexible tubing to connect with the fluid circuit
-
CLAMP-ON FLOWSENSOR TUBING SPECIFICATIONS
FRACTIONAL (1/16 INCH INCREMENTS) METRIC
SENSOR SIZE
TUBING IDWALL
THICKNESSTUBING
ODSTOCK
TUBING2TUBING OD SENSOR #
WITH SUFFIXmm
2PXL 3/32 1/321 1/8-5/32 A, B 4 2PXL-M4
3PXL 1/8 1/321 3/16-7/32 A 5 3PXL-M5
4PXL 1/8 1/16 1/4 A, B 67
4PXL-M64PXL-M7
5PXL 3/16 1/16 5/16 A 8 5PXL-M8
6PXL 1/4 1/16 3/8 A, B, C 9 6PXL-M9
7PXL 1/4 3/32 7/16 A, B, C 10 7PXL-M10
8PXL 3/8 5/16
1/163/32
1/2 A, BN/A 12 8PXL-M12
9PXL 3/8 3/32 9/16 A, B, C 14 9PXL-M14
10PXL 1/2 1/16 5/8 A, B 16 10PXL-M16
11PXL 1/2 3/32 11/16 A, B
12PXL 1/2 1/8 3/4 A, B 20 12PXL-M20
14PXL 5/8 11/16
1/83/32
7/8 AN/A 23 14PXL-M23
16PXL 3/4 1/8 1 A 25 16PXL-M25
20PXL 1 1/8 11/4 A
SENSOR SIZE
CLAMP-ON FLOWSENSOR CALIBRATION RANGES1
LOW FLOW ( SCALE)2 STANDARD FLOW (FULL SCALE)
LOWER LINEAR LIMIT3,4
MAX MEASUREMENT RANGE5
LOWER LINEAR LIMIT
MAX MEASUREMENT RANGE5
2PXL 50 ml/min -250 to +250 ml/min 100 ml/min -1 to +1 L/min
3PXL, 4PXL, 5PXL 100 ml/min -500 to +500 ml/min 200 ml/min -2 to +2 L/min
6PXL 250 ml/min -1.25 to +1.25 L/min 500 ml/min -5 to +5 L/min
7PXL, 8PXL, 9PXL 500 ml/min -2.5 to +2.5 L/min 1 L/min -10 to +10 L/min
10PXL, 11PXL, 12PXL 1 L/min -5 to +5 L/min 2 L/min -20 to +20 L/min
14PXL, 16PXL 2.5 L/min -12.5 to +12.5 L/min 5 L/min -50 to +50 L/min6
20PXL 5 L/min -25 to +25 L/min 10 L/min -100 to +100 L/min6
Suffix ifMetric OD
Catalog #: ME PXL - - - - Size Fluid/Temperature + Flow Rate Calibration Codes
Up to four per Flowsensor
Tubing: Example:ME6PXLBL37SFH2023LFisfor3/8ODtubing,calibratedfor2uses:
Bloodat37CatStandardFlowRatesonTygonS-50-HL(1/4IDx1/16wall)
Waterat23CatLowFlowRatesonTygonR-3603(1/4IDx1/16wall)
Considerations for Choosing the Most Appropriate Flowsensor
1. To meet accuracy specifications, Flowsensors should be calibrated for the flow rate range of use.2. Flowsensors calibrated for the low flow range should be used with the Flow Module in 1/4 Scale Mode.3. Measurements below the Lower Linear Limit may deviate from the stated accuracy specification.4. Custom calibration is available for average flow rates below the lower limit. This may compromise accuracy
for the maximum measurement range.5. Range includes zero: any flow peaks exceeding the Max Flow Value (-5 volt to +5 volt range) will be clipped.6. Standard calibration range is up to 30 L/min; contact factory for availability of higher flow rate calibrations.
1. In sizes 2-3PXL ratio of tubing wall thickness to OD must not exceed 1:5 for PVC; 1:3 for silicone
2. A= Tygon R-3603, B= Tygon S-50-HL, C= MEDIFLEX
STANDARD CONNECTOR TYPES CP16:Plastic16-pin;1-6PXN
CC16:Metal16-pin;10-25PXN&allPXLs
TS410 EXTENSION CABLESPXNscomewithastandardcablelengthof1.85meter.PXLscomewitha2metercable.ExtensioncablesareavailableforallSensorsizesexcept1-2PXN
CC16-S-CC16:Standard1meter
CC16-X-CC16:Specifiedcustomlength;upto5meterstandard
MRIsafe:specifyCP16connector
Specify type and size (ID x wall x OD)
FLUID / TEMPERATURE CALIBRATIONSincefluiddensityandtemperaturealterthetransittimeoftheultrasoundsignalandaffecttheacousticpropertiesofthetubing,wecalibratetheSensorspecificallyfortheseparameters.Operationalfluidtemperatureshouldbewithin2Cofthespecifiedcalibrationtemperature.Specifyupto4tubing,fluid,temperature,&flowratecombinationsforcalibration.FluidsamplesandMSDSinformationmayberequiredforcustomcalibrationrequests.
CALIBRATION CERTIFICATESSensorsaresuppliedwithacertificateofcalibrationforspecifieduse.Yearlyrecertificationisrecommended.
ME-PXL Clamp-on Flowsensor Parameters
-
AMERICASTransonic Systems Inc.34 Dutch Mill RdIthaca, NY 14850U.S.A.Tel: +1 607-257-5300Fax: +1 [email protected]
EUROPETransonic Europe B.V.Punterweg 316222 NW MaastrichtThe NetherlandsTel: +31 43-407-7200Fax: +31 [email protected]
ASIA/PACIFICTransonic Asia Inc.6F-3 No 5 Hangsiang RdDayuan, Taoyuan County33758 Taiwan, R.O.C.Tel: +886 3399-5806Fax: +886 [email protected]
JAPANTransonic Japan Inc.KS Bldg 201, 735-4 Kita-AkitsuTokorozawa Saitama359-0038 JapanTel: +81 04-2946-8541Fax: +81 [email protected]
www.transonic.com
Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells gold standard transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems.
Volume FlowVolume FlowVolume Flow
CLEANING & STERILIZATIONTransonicTubingFlowsensorsmaybecleanedwithasolutionofmildsoapandwarmwater(
-
Volume Flow
Precision Nanoprobes for MicePS-Series, PR-Series & V-Series Flowprobesfor use with TS420 Flowmeter Module
SizedtoFitMouseAnatomy
UnprecedentedCapabilityContinuousreal-timevolumeflowmeasurementsforcalculatingcardiacoutput,strokevolumeandvascularresistance.
Applicationsinclude:renalbloodflow,autoregulation,carotidthrombosisocclusion&femoralhindlimbstudies.
Foracuteorchronicapplicationswitharangeofcustomizablefeatures.
GoldStandardAccuracyUltrasonicTransit-timeTechnology
Waveformsdemonstratesignaturezerobaselinestabilityandhighresolutionevenwithflowslessthan1mL/min.
MURINE BLOOD FLOW MAPPING
VESSEL SUGGESTED PROBE
Ascending Aorta 1.5PSL
Lower Thoracic Aorta 1PR
Pulmonary Artery 1PR
Carotid Artery 0.5PS, 0.5V
Femoral Artery 0.5PS
Mesenteric Artery 0.7PS
Renal Artery 0.5PSL
Portal Vein 1PR
RL-18-fly-A4 Rev. D 11/12
Ascending AortaFor Cardiac Output
For Peripheral Vessels
-
VESSEL OD BIDIRECTIONAL FLOW OUTPUTS ACCURACY SPECIFICATIONS ULTRASOUND
PROBE SIZE & SERIES
MA-ACUTE APPLICATION
MC-CHRONIC APPLICATION
RESOLUTIONLOW FLOW ( SCALE)
STANDARD FLOW
MAX FLOW (STD FLOW)
ZERO OFFSET
ABSOLUTE ACCURACY
RELATIVE ACCURACY
FREQUENCY
mm mm ml/min ml/min ml/min ml/min ml/min % % MHz
0.5PS 0.3 - 0.5 0.3 - 0.48 0.03 1.5 6 30 0.12 15 2 14.4
0.7PS 0.5 - 0.7 0.4 - 0.7 0.05 2.5 10 50 0.2 15 2 9.6
1.5PS 1.2 - 1.5 1.2 - 1.5 0.075 10 40 200 0.8 15 2 4.8
1PR 0.7 - 1.2 0.7 - 1.0 0.05 5 20 100 0.2 10 2 7.2
0.5V 0.25 - 0.5 Acute use only
0.05 2.5 10 50 0.25 15 3 7.2
0.7V 0.35 - 0.7 0.075 5.0 20 100 0.5 15 3 4.8
Specifications & Accessories for Mouse Applications
PROBE SIZE & SERIES
CABLE ORIENTATION
PROBE BODY CABLE
WEIGHT LENGTH WIDTH HEIGHT LUMEN LENGTH DIAMETER
0.5PS any (B, S or L) 0.09 g 3.2 mm 2.3 mm 1.0 mm 0.47 mm 60 cm 1.0 mm
0.7PS back only 0.12 g 3.2 mm 2.7 mm 1.2 mm 0.70 mm 60 cm 1.0 mm
1.5PS lateral only 0.23 g 4.25 mm 3.75 mm 2.0 mm 1.65 mm 60 cm 1.25 mm
1PR back or side 0.2 g 6.5 mm 4.0 mm 1.1 mm 1.5 mm 60 cm 1.5 mm
0.5V back only 0.2 g 6.5 mm 4.0 mm 1.1 mm 1.5 mm 60 cm 1.5 mm
0.7V back only 0.25 g 7.6 mm 3.5 mm 1.8 mm 1.7 mm 60 cm 1.5 mm
0.5PSL Probe on Mouse Renal Artery with Flowtrace
www.transonic.com
See Tools & Techniques for Hemodynamic Studies in Rodents (RL-5-wb) for in depth application information and Perivascular Flowprobe Flyer (RL-26-fly) for more information on ordering.
WidthLumen
Length
Height
Nanoprobes (PS-Series) are very much smaller than V-Series Flowprobes.
ORDERING PRECISION PROBES MA-prefix:standardacuteconfiguration;specifysizeandcableorientation.Acute0.5PS&0.7PSandV-SeriesProbessuppliedwith5cmhandle.
MC-prefix:customorchronicconfiguration;specifysize,cableorientation&length,connectortype,&calibrationoption.
STABILIZATION ACCESSORIESForprecisionmeasurements,NanoprobesandV-Seriesshouldbestabilizedwithamicromanipulatorduringacuteuse.
CuffsforCA4:SiliconeFlange(AAPC103);RigidCuffwithsetscrew(AAPC105)
Surgicalmesilenemeshforimplantstabilization
CONNECTORSStandardacuteuseCRA10Redel
Chronicmicro4-pinconnectorscomewithacalibrationkey:CA4B(back)&CA4S(side)
EXTENSION CABLESCRA10-S-CRA10:10-pinacute;1.25meterstandard
CA4-S-CRA10:4-pinchronic;1.8meterstandard
Note: Nanoprobes must be used with the proper length extension cable (probe + cable = approx. 185 cm) to meet performance specifications.
Chronic MC1.5PSL with CA4S Connector for Mouse Ascending Aorta
MA0.7PSB
MA0.5PSB
MC0.5PSL
MC0.5PSS
MC0.7VB
MA0.5VB
-
Volume Flow
Precision Flowprobes for Rats & RodentsPS-Series & PR-Series for use with TS420 Flowmeter Module
Validated,Referenced,TrustedCitedinover500studiesinrats&rodents
GoldStandardaccuracy
UltrasonicTransit-timeTechnology
BloodFlowApplicationsContinuousreal-timevolumeflowmeasurementsfornumerousapplicationsincluding:cardiacoutput,renalorportalhypertension,hemorrhagicshock,ischemia/reperfusion,carotidthrombosisandstrokemodels.
Functional&FlexibleCompatiblewithelectricalswivelsandtethers
Widerangeofcustomizablefeatures
Acuteandchronicuseinvesselsfrom0.25mmdiameterandlarger
RAT BLOOD FLOW (wgt. 250-350 g)
VESSEL SUGGESTED PROBE
Ascending Aorta 2.5PS, 3PS
Abdominal Aorta 2PS
Pulmonary Artery 2PS
Carotid Artery 1PR, 0.7PS
Femoral Artery 1PR, 0.7PS
Mesenteric Artery 1PR
Renal Artery 1PR, 0.7PS
Portal Vein 1.5PR, 2PS
Hepatic Artery 0.5PS
Vena Cava 2PS, 2.5PS
RL-19-fly-A4 Rev. C 12/12
Ascen
dingAorta
-
PROBE SIZE & SERIES
VESSEL OD BIDIRECTIONAL FLOW OUTPUTS ACCURACY SPECIFICATIONS ULTRASOUND
MA-ACUTE APPLICATION
MC-CHRONIC APPLICATION
RESOLUTIONLOW FLOW ( SCALE)
STANDARD FLOW
MAX FLOW (STD FLOW)
ZERO OFFSET
ABSOLUTE ACCURACY
RELATIVE ACCURACY
FREQUENCY
mm mm ml/min ml/min ml/min ml/min ml/min % % MHz
0.5PS 0.3 - 0.5 0.3 - 0.48 0.03 1.5 6 30 0.12 15 2 14.4
0.7PS 0.5 - 0.7 0.4 - 0.7 0.05 2.5 10 50 0.2 15 2 9.6
1.5PS 1.2 - 1.5 1.2 - 1.5 0.075 10 40 200 0.8 15 2 4.8
1PR 0.7 - 1.2 0.7 - 1.0 0.05 5 20 100 0.2 10 2 7.2
1.5PR 1.2 - 1.8 1.0 - 1.5 0.075 10 40 200 0.4 10 2 4.8
2PS 1.5 - 2.0 1.3 - 1.8 0.1 25 100 500 1 10 2 3.6
2.5PS 1.8 - 2.5 1.5 - 2.4 0.1 25 100 500 1 10 2 3.6
3PS 2.5 - 3.7 2.4 - 3.4 0.4 50 200 1 L 2 10 2 3.6
Specifications & Accessories for Rat ApplicationsORDERING PRECISION PROBES MA-prefix:standardacuteconfiguration;specifysizeandcableorientation.Acute0.5PS&0.7PSProbesaresuppliedwitha5cmhandle.
MC-prefix:customorchronicconfiguration;specifysize,cableorientation&length,connectortype,&calibrationoption.
Probesize:approximatevesseldiameterinmm.
ProbeCableOrientation:
Back(B):perpendiculartovessel.
Side(S):paralleltovessel.
Lateral(L):forascendingaortaviathoracotomy
STABILIZATION ACCESSORIESForprecisionmeasurements,Nanoprobesshouldbestabilizedwithamicromanipulatorduringacuteuse.
CuffsforCA4:SiliconeFlange(AAPC103);RigidCuffwithsetscrew(AAPC105)
CuffsforCM4:SiliconeFlange(AAPC102);RigidCuffwithsetscrew(AAPC104)
Surgicalmesilenemeshforimplantstabilization
CONNECTORSStandardacuteuse:CRA10Redel
Chronicmini4-pinconnectorscomewithserializedcalibrationkeys.
CA4B(back)&CA4S(side)
CM4B(back)&CM4S(side)
EXTENSION CABLESCRA10-S-CRA10:10-pinacute;1.25meterstandardlength
CM4-S-CRA10:4-pinwithspring;1.8meterstandardlength
CA4-S-CRA10:4-pinnarrowgauge;1.8meterstandard
Note: Nanoprobes must be used with the proper length extension cable (probe + cable = approx. 185 cm) to meet performance specifications.
www.transonic.com
Chronic MC2.5PSL with CM4S connector
3PSS
Rigid Delrin Cuff with CA4S connector for chronic Probes
See Tools & Techniques for Hemodynamic Studies in Rodents (RL-5-wb) for in depth application information and Perivascular Flowprobe Flyer (RL-26-fly) for more information on ordering.
2PSB
2.5PSB
1.5PRB
1PRS
Probes pictured larger than actual size.
-
Volume Flow
RL-34-fly-A4 Rev. B 1/13
A completely new concept in ultrasonic Flowprobe design
Reusabletransducershellwitheasy-to-useflexibleUltrafitLiners
Gold standard measurement using X-pattern transit-time ultrasound illumination
Immediate,accuratebeat-to-beatflowmeasurementswithaminimumofcouplinggel
High resolution quality and uninterrupted signal continuity during intraoperative use & post implant recovery
Incrementallysizedlinersforoptimalvesselfit
Vesselprotectionandcushioningforthedurationoftheimplant
Compatible with TS420 Flowmeters and PhysioGear pocket telemetry system
For Ascending Aorta, Pulmonary Artery, Cardiac Output & other vessel sites
CustomcalibrationavailableforgraftsandVADs
COnfidence Flowprobes
PAU-Series Flowprobes and Ultrafit LinersFor TS420 Flowmeters
Transducer Shell
Chronic Liner Acute Liner
-
PROBE SIZE & SERIES
ULTRAFIT LINERS
VESSEL OD BIDIRECTIONAL FLOW OUTPUTS ACCURACY SPECIFICATIONS4ULTRASOUND FREQUENCYMA-
ACUTEMC-CHRONIC
RESOLUTION1LOW FLOW ( SCALE)2
STANDARD SCALE2
MAX FLOW (STD SCALE)
ZERO OFFSET3
ABSOLUTE RELATIVE
mm mm mm ml/min ml/min ml/min ml/min ml/min % % MHz
8PAU 8 6 - 8 6 - 7 4 500 2 L 10 L 20 10 2 3.6
10PAU 10 8 - 10 8 - 9 4 500 2 L 10 L 20 10 2 3.6
12PAU 12 9 - 12 9 - 11 8 1 L 4 L 20 L 40 10 2 2.4
14PAU 14 11 - 14 11 - 13 8 1 L 4 L 20 L 40 10 2 2.4
16PAU 16 12 - 16 12 - 15 20 2.5 L 10 L 50 L 100 10 2 1.8
20PAU 18, 20 16 - 20 16 - 19 20 2.5 L 10 L 50 L 100 10 2 1.8
24PAU 22, 24 19 - 24 19 - 23 40 5 L 20 L 100 L 200 10 2 1.2
28PAU 26, 28 22 - 28 22 - 27 40 5 L 20 L 100 L 200 10 2 1.2
32PAU 30, 32 25 - 32 25 - 315 80 10 L 40 L 200 L 400 10 2 0.9
36PAU 34, 36 28 - 36 28 - 355 80 10 L 40 L 200 L 400 10 2 0.9
1. Resolution: represents the smallest detectable change in flow, a factor in accuracy.2. Flowprobes operate in one of two scales: low flow or normal flow, determined by the range of flow under study. Flowprobes measure bidirectional flow up
to 5 times the selected scale setting. The scale settings calibrates the 1 volt reference signal for data collection; the linear range of the Flowmeter is equal to 5 volts. By using the low flow button, measurement sensitivity is increased by a factor of four. This linear overage is important for the proper recording of highly pulsatile peak flows.
3. Zero offset on individual probes is often lower than this value.4. The Absolute Accuracy percentage can be raised to relative accuracy levels by in situ calibration.5. 32PAU and 36PAU Probes are only supplied with acute liners and may require modification for chronic use.
COnfidence Flowprobe Ordering & Specifications
www.transonic.com
ULTRAFIT LINERSUltrafitLinersarerecommendedforsingleuseonly.
COnfidenceFlowprobes (size 8 - 28 mm) are sold with one acute (open) and one chronic (closed) UltrafitLinerofeachsizeavailablepershell.Sizes32&36mmaresuppliedwithacutelinersonly(maybemodifiedforchronicuse).
Replacementlinerssuppliedinpacketsoffiveofeachsizeandstyle.
Custom Catalog #: MC - PAU - - - GAC - Size
Example:
MC-16PAU-WC60-CRS10-GAC(Custom16mmPAU-SeriesProbewith60cmcable,CRS10connectorandacute/chroniccalibration)
Cable Length
Connector PhysioGear
Acute Catalog #: MA - PAUSize
Custom Flowprobe (MC-20PAU-WC200-CS12-GAC) with cable and connector.
Acute (open) liner
Chronic (closed) liner
Acuteconfigurationhasa2metercable & CRA10 Connector
Acute Liners Re-order #: PAUL - A
Chronic Liners Re-order #: PAUL - C Shell Size
Shell Size
Liner Size
Liner Size
Probes come with one of each available liner type & size.
-
RL-12-fly-A4 Rev. E 11/12
CardiovascularPhysiology
HeartFailureModeling
VentricularFunction&CardiacAssist
ExercisePhysiology
EfficacyofNewCardiacSurgeryTechniques
UltrasoundTransit-timeTechnology
Non-constrictiveFlowprobes
ProbeSizesforMicetoCalves
A c c u r a t e R e p e a t a b l e V a l i d a t e d
Instantaneousflowwaveformsareusedforcalculatingaveragecardiacoutput,strokevolume,peakflow,aorticinputimpedance,systemicvascularresistanceandheartrate.Flowmeasurementswithpressuredataareusedindeterminationofpressurevolumerelationsincardiacfunctionforlargeandsmallanimalmodels.
Volume Flow
Real-time Cardiac Output
Ascending Aorta & Pulmonary Artery Direct Cardiac Output Measurements for Acute & Chronic Applications
Ascending Aorta
Thein vivomeasurementstandardforcontinuouscardiacoutputagainstwhichallothertechnologiesarecompared.Visitwww.transonic.com forapplicationspecificreferences.
-
PS-Series Probe for small animal models
www.transonic.com
Acute PAU-Series Probe for large animal models
ASCENDING AORTA / PULMONARY ARTERY FLOWPROBE RECOMMENDATIONS
APPLICATION WEIGHT PROBE SIZE & STYLE* CABLE LENGTH CONNECTOR CALIBRATION CUSTOMIZATION
Pig: Acute 25-35 kg MA-16PAU, MA-20PAU WC200 (2 m) CRA10
PAU-Series
GAC- acute/chronic
PAU-Series
Momentary Acute Use: acute open liners
Extended Acute Use: closed liners
Chronic Use: chronic liners
Pig: Chronic25-50 kg MA-16PAU, MA-20PAU
WC50 (50 cm) CRS10, CS12, CB1260-80 kg MA-24PAU, MA-28PAU
Dog: Acute
8-12 kg MA-14PAU, MA-16PAU
WC200 (2 m) CRA10
12-15 kg MA-14PAU, MA-16PAU
18-22 kg MA-16PAU, MA-20PAU
22-25 kg MA-20PAU, MA-24PAU
25-30 kg MA-24PAU, MA-28PAU
Dog: Chronic MC-nPAU* WC50 (50 cm) CS12, CRS10
Sheep: Acute35-45 kg MA-16PAU
WC200 (2 m) CRA1045-60 kg MA-20-PAU
Sheep: Chronic35-50 kg MC-20PAU WC40 (40 cm) CRS10, CS12,
CB1250-60 kg MC-24PAU WC50 (50 cm)
Lamb: Acute6-8 kg MA-8PAU, MA-10PAU
WC200 (2 m) CRA1012-15 kg MA-12PAU, MA-14PAU
Lamb: Chronic MC-nPAU* WC100 (1 m) CS12, CRS10
Monkey: Chronic 4 kg
MC-6PSS, MC-8PSS, MC-8PAU, MC-10PAU WC38 (38 cm) CS12, CB12 GAC-
U reflector with silicone for PS-
Rabbit: Acute 3-4.5 kg MA-4PSB WC100 (1 m) CRA10 GA- acute
Rabbit Chronic MC-6PSB WC30 (30 cm) CM4B, CM4S GC- chronic
Rat: Acute
< 270 g MA-2PSB
WC100 (1 m) CRA10 GA- acute Choose cable orientation
270-400 g MA-2.5PSB, MA-2.5PSL
> 400 g MA-3PSB, MA-3PSL
Rat: Chronic MC-nPS* WC10 (10 cm) CM4S, CA4S GC- chronic
Mouse: Acute 17-50 g MA-1.5PSL WC60 (60 cm) CRA10 GA- acute
Mouse: Chronic 17-50 g MC-1.5PSL WC04 (4 cm) CA4S GC- chronic
DOG, PIG, SHEEP & CALF MODELS USE PAU-SERIESCOnfidenceFlowprobes(PAU)obtainahighlevelofaccuracyusingX-pattern,fullflowilluminationwhichallowsuniformsensingofturbulentflow.Ultrafitlinerscushionthevesselandminimizeneedforacousticgel.
Application Recommendations for Large & Small Animals
*n = size based on vessel diameter
All recommendations are based on vessel diameter estimates. Probe choice will depend on surgical approach, species and weight. MA-Probes are configured for standard acute application. Order MC-Probes for any customization or chronic configuration options.
CHRONIC IMPLANTChooseloosefittingProbessothatvesselfills75%-85%oftheProbe
PS-Series:Choosecableconfiguration(side,lateralorback)forpreferredsurgicalapproach
Chooseconnector&cablelength
Selectvesselprotectionmethod:
PAU-Series:UltrafitlinerspadthevesselfromtheProbeedges
PS-Series:siliconeshield(4&6mm)&siliconepaintforProbereflectoredge(2,2.5&3mm)
Allow3-5daysforfibrotictissuegrowthtoprovidegoodcoupling
ACUTE OPEN-CHESTChooseclosefittingProbesforeaseinmaintainingacousticcoupling
UseTransonicapprovedcouplinggelforsignaltransmission
AvoidplacingPS-SeriesProbesdirectlyonthecurvatureoftheaorta
RABBIT, RAT & MOUSE MODELS USE PS-SERIESLittleisolationbetweentheascendingaortaandPAisrequiredtoencirclethevesselwiththeProbesreflector.TheProbetransducerhousingfitseasilyinthethoraciccavity.
-
RL-11-fly-A4 Rev. E 1/13
Acute&chronicmyocardialhibernation&ischemiamodels
Experimentalrevascularization
CABGpatency&techniques
Stunnedmyocardium
Goldstandardflowmeasurementfornewmyocardialperfusionassessmenttechnologies
Non-constrictiveFlowprobes
DirectvolumeflowinmL/min
A c c u r a t e R e p e a t a b l e V a l i d a t e d
Chronic Dog LCx
Volume Flow
Coronary Artery Blood Flow Measurements
Continuous High Resolution Volume Flow Measurements for Acute & Chronic Applications Using PS-Series & PR-Series Flowprobes
Transonicisthein vivomeasurementstandardforcoronaryarterybloodflowmeasurementsagainstwhichallothertechnologiesarecompared.CoronarybloodflowresearchwithTransonicFlowprobeslaidthefoundationforclinicalsurgicalproceduresandpharmaceuticaltherapiesdevelopedforthesuccessfultreatmentofcoronaryarterydisease.Visitwww.transonic.com tosearchourextensivelistofapplicationspecificreferences.
Pig Coronary Artery
Side View: Probe stabilized with silicone flange
-
www.transonic.com
FLOWPROBE RECOMMENDATIONS
APPLICATION WEIGHT (KG) LAD LCx SF-SILICONE FLANGE CABLE LENGTH CONNECTOR CALIBRATION
Pig: Acute 25 - 35 MA-2.5PSB MA-3PSB optional WC100 (1 m) CRA10 GA- acute
Pig: Chronic 25 - 35 MC-2.5PSSMC-3PSS MC-3PSS suggested WC50 (50 cm)CM4B, CRS10, CS12 GC- chronic
Piglet: Acute 1.8 - 4 MA-1PRB optional WC60 (60 cm) CRA10 GA- acute
Dog: Acute10 - 15 MA-1.5PRB
optional WC100 (1 m) CRA10 GA- acute18 - 25 MA-2PSB MA-2.5PSB
Dog: Chronic
8 - 12 MC-1.5PRB
suggested WC40 (40 cm) CM4B, CS12, CB12 GC- chronic16 - 25 MC-2PSS MC-2.5PSS
20+ MC-2.5PSS MC-3PSS
Sheep: Acute35 - 45 MA-3PSB
optional WC100 (1 m) CRA10 GA- acute50 - 60 MA-4PSB
Sheep: Chronic35 - 45 MC-3PSS
suggested WC60 (60 cm) CRS10, CS12 GC- chronic50 - 60 MC-4PSS
Baboon: Chronic 10 - 15 MC-2.5PSS suggested WC75 (75 cm) CM4B, CS12 GC- chronic
LowzerooffsetandstablebaselinemakeTransonicthetechnologyofchoiceforcoronaryocclusionmodels.Highresolutionwaveformsareunaffectedbyelectromagneticnoise.Non-magneticMRIsafeFlowprobescanbeordered.TransonicsurgicalFlowprobesarenowusedwidelyduringCABGsurgery,bothoff(beatingheart)andonCPB.
ACUTE OPEN-CHESTChooseaclosefittingProbeforeaseinmaintainingacousticcoupling
UseTransonicapprovedcouplinggelforsignaltransmission(Surgilube;NALCOsuperabsorbant)
StabilizeProbeonbeatingheartwithsiliconecoronaryflange(alsoholdsgelinplace)
CHRONIC IMPLANTChoosealoosefittingProbe,sothatvesselfills75%-85%ofProbelumen
ChoosesidecableconfigurationforseatingProbeinpositiononvessel;providestrainreliefloopincable
Specifysiliconecoronaryflangeforstabilizationonmyocardium
Choosepreferredchronicstyleconnector&cablelengthforprotocol
Tissueingrowthprovidesexcellentsignalcouplingwithin3-5days
See surgical protocol RL-1-sp for more details.
Application Recommendations for LAD, LCx Coronary Artery
1PRS 2PSS2.5PSS
2.5PSB1.5PRB 4PSS3PSB
All recommendations are based on vessel diameter estimates. Probe choice will depend on surgical approach, species and weight. MA-probes are configured for standard acute application. Order MC-probes for any customization or chronic configuration options. See Perivascular Flowprobe Flyer (RL-26-fly) for complete ordering information.
Coronary Flowprobes
Probe with SF- Silicone Flange
-
Pressure
Pressure Measurement System for Basic Science Research
Pressure
ForoperationofallScisensePressureCatheters(singleanddualpressure)
Simpleelectroniccalibration
Compatiblewithvirtuallyanydataacquisitionsystemandsoftwarepackage
Scisense SP200
SP-1-fly-A4 Rev. A 2/13
-
SP200 Design & Technology
OPTIMIZED FOR YOUR RESEARCHTheSP200PressureSystemisdesignedtoprovidestable,accurate,high-frequencyresponsepressuremeasurementswhenusedwithScisensesolid-statePressureCatheters.
Withtwo(2)pressurechannels,pushbuttoncontrols,pre-amplifiedoutputsforintegrationwithanydataacquisitionsystem,andoptimizeddampeningcoefficient,theSP200isyourdependableandflexiblesolutionforpressuredetectioninvirtuallyanyresearchapplication.
THE SCISENSE PRESSURE CATHETER DIFFERENCE
Nofluids,flushing,air-bubblesorinterference:
Fluid-filledcathetersrequireconstantmaintenanceandmonitoringtoensuretherearenoleaks,bubbles,orblockagesthatmaycausemeasurementartifacts.Scisensesolid-statePressureCathetersarequicktocalibrateandwilldetectpressureaccurately,freeofartifacts.
Optimalfrequencyresponse:
Higherfrequencypressurewavesmeasuredbyinadequatedeviceswillshowattenuationortaper-off.OurPressureCathetersshowaflatfrequencyresponsewellbeyondtherequirementsofrodentheartrates(600BPM,10Hz).
AccuratedP/dtmeasurement:
MaximumdP/dtisaclassicindicyofcardiaccontractility.Tobeconfidentinthiscalculation,researchersmustbesurethatsignalsarefreeofartifactandattenuation.UsingaScisensePressureCatheterassuresaccuratesignaldetectionandcalculationofdP/dt.
COMMON APPLICATIONS & PARAMETERS
Scisense Pressure Catheter compared to a reference trace and a fluid-filled pressure catheter at 300 BPM (5 Hz). The fluid-filled catheter shows large distortion and wave artifact compared to the Scisense trace which reflects the true pressure waveform of the reference sensor.
HeartRate
Max&MindP/dt
DiastolicPressure
SystolicPressure
DevelopedPressure
ContractilityIndex
RelaxationTime
Tau
MAP
SystemicBloodPressure
VenousBloodPressure
Wedge&PAPressure
AtrialPressure
VentricularPressure
Pulse-WaveVelocity
InterstitialPressures
GastricPressures
Urogenital
-
Features & Benefits
Simplecontrols
Push-buttoncalibrationandbalancecontrolsmakeset-upquickandeasy
Electroniccalibration
Atwo-pointlinearcalibrationensuresaccuratedatareportinginmmHg
Pre-amplifiedanalogoutputs
Canbeintegratedwithvirtuallyanydataacquisitionsystem(5Vrangeminimum)withouttheneedforadditionalamplification
Twopressureinputs
PermitsuseofDual-PressureCathetersortwoSinglePressureCatheterssimultaneously
Calculatepressuregradientsandpulse-wavevelocity
Systemintegration
InterfacetheSP200withothermeasurementdevicessuchastransit-timeflow,echocardiography, andsonomicrometrysystems(additionalcablesmayberequired)
ESSENTIAL DESIGN ELEMENTS OF SCISENSE CATHETERSSolid-statepressuresensor
Sensorisside-mountedandrecessedwithinhousingforprotectionandsmoothnavigationwithinvessels
Ventedtoatmosphere,allowingforbarometricreference
Highlysensitive-accuratelyrespondstominuteandrapidchangesinpressure
Tubingmaterials
Idealbalanceofflexibilityandrigidityallowsforeasyinsertionandmaneuverability
Smoothandwillnotfrayovertime-noirritationtovesselliningorvalves
Tipoptions-straight,curved,angled,andpigtailoptionsareavailabletoassistwithnavigationandplacement
-
AMERICASTransonic Systems Inc.34 Dutch Mill RdIthaca, NY 14850U.S.A.Tel: +1 607-257-5300Fax: +1 [email protected]
EUROPETransonic Europe B.V.Punterweg 316222 NW MaastrichtThe NetherlandsTel: +31 43-407-7200Fax: +31 [email protected]
ASIA/PACIFICTransonic Asia Inc.6F-3 No 5 Hangsiang RdDayuan, Taoyuan County33758 Taiwan, R.O.C.Tel: +886 3399-5806Fax: +886 [email protected]
JAPANTransonic Japan Inc.KS Bldg 201, 735-4 Kita-AkitsuTokorozawa Saitama359-0038 JapanTel: +81 04-2946-8541Fax: +81 [email protected]
www.transonic.com
Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells gold standard transit-time ultrasound flowmeters and monitors for surgical, hemodialysis, pediatric critical care, perfusion, interventional radiology and research applications. In addition, Transonic provides pressure and pressure volume systems, laser Doppler flowmeters and telemetry systems.
PressurePressure
LIMITED WARRANTY & RECALIBRATION Transonicwarrantsforaperiodoftwo(2)yearsfromdateofshipmentthatSP200hardware,cables,powersupply,and
associatedhardwareaccessories,purchasedthroughTransonicoritsdulyappointeddistributororlicensedrepresentative,arefreefromdefectsthatresultfromfaultymaterialorworkmanshipbyTransonic.
Transonicwarrantsforaperiodoftwelve(12)monthsfromdateofshipmentthatCatheterslessthantwoFrench(2F)arefreefromdefectsthatresultfromfaultymaterialorworkmanshipbyTransonic.WarrantyisonlyvalidifCathetersarepurchasedthroughTransonicoritsdulyappointeddistributororlicensedrepresentative.
TheTransonicwarrantydoesnotapplyto:defectscausedbyabuse,neglectormisuse;damageduetoaccidentorcasualty;orunauthorizedalterationsbyanyoneotherthanTransonicoranappointedrepaircenter.
TheBuyerpaysshippingchargestotheTransonicplantorrepaircenter;Transonicwillpayforreturnshipmentcharges.
Ifmeasurementaccuracyisquestionedduringthetwoyearwarrantyperiod,TransonicshallinspectandrecalibrateSP200hardwarefreeofchargeprovidedthattheBuyerpaysforallshippingcharges.
CATALOG # NAME DESCRIPTION
FFS-095-DP01SP200 Pressure Foundation System
Includes all items below as a complete system:Control Unit, Power Supply, Power Cord, (2) HDMI catheter cables, (2) BNC-BNC cables
FP095B SP200 Pressure Control UnitControl unit for operation of all Scisense Pressure Catheters.Provides two (2) pre-amplified pressure signals via BNC output.
FS-PCM50UT04 XP Power Supply Medical class isolated power supply.
FC-PCNA* North American Power CordConnects XP power supply to power source. *Alternate country specific power cords are available - please specify when ordering.
FC-HDMI-V3Scisense HDMI Catheter Cable (30AWG - 10 FT)
Connects all Scisense Pressure or PV Catheters to SP200 or ADV500 control units (not for use with older legacy units).
FC-BNC-6 BNC-BNC Cable (6ft) BNC cable for connection of control unit to most data acquisition systems.
Ordering Information
-
Pressure-Volume
Pressure-Volume Measurement System for Cardiac Function Research in All Sizes of Hearts
Pressure-Volume
Includes Conductance and improved Admittance volume mode operation
True volume in real-time when using Admittance mode
Variable Segment Length (VSL) Catheters ensure proper fit and accurate results
Compatible with virtually any data acquisition system and software package
Scisense ADV500
RPV-1-fly-A4 Rev. A 2/13
-
Pressure-VolumePressure-Volume
In the realm of heart function and hemodynamics, scientists have historically relied on systemic blood pressure, blood flow, and ventricular pressure to report changes in heart performance.
Applications in this field of study include phenotyping, the study of drugs and their possible cardiac-protective effects, and the genetic/environmental factors linked to heart disease.
Advancing the limits of science, we strive for better understanding, better treatments, and ultimately possible cures for heart disease. To achieve this goal researchers need to quantify performance, including subtle changes in contractility, elastance, power, energetics and efficiency. Fortunately, there is an answer to this demand - the Pressure-Volume Loop.
By plotting ventricular pressure and volume in the XY plane, a researcher can study individual cardiac cycles or a family of loops. Ejection fraction, cardiac output, max & min dP/dt, stroke volume, and tau are just a small example of the many parameters that can be reported. Additionally, valuable measurements of contractility and elastance are obtained by creating pressure-volume relationship curves. Derived only by PV Loop analysis, these relationships are crucial to cardiovascular studies to generate a full report of heart function.
Simply put, PV loops are essential in the study of hemodynamics and cardiac function.
Why PV Loops?
-
ADV500 Design & Technology
SOFTWARE MODULESFlexibility is important. This is why the ADV500 has been developed with individualized options for animal operation mode and volume measurement process. This design allows researchers to have a customized system specific to their needs and budget.
There are 3 software modules available, all designed to improve system accuracy and user experience over the basic conductance operation mode:
Rodent Admittance Module
Large Animal Admittance Module
Variable Segment Length (VSL) Catheter Module
ADMITTANCE VOLUME... THE NEW GOLD STANDARDAdmittance is our patented technology for calculating absolute volume in real-time.
Part 1: Automatic Isolation of the Blood Signal
Using a traditional PV Catheter inserted into the ventricle, Admittance allows for the detection of overall conductance and parallel conductance coming from the surrounding muscle tissue. We call this muscle measurement Phase. This is extremely important because the muscle contribution changes during the cardiac cycle and during the course of an experiment - therefore, it must be removed in order to accurately report volume. With parallel conductance automatically quantified, the system can isolate the blood signal.
Part 2: Conversion to Volume
Taking things one step further, the ADV500 on-board processor uses Weis equation1 to convert the isolated blood signal to true volume: the result is a real-time streaming signal presented in L or mL. When paired with an appropriate data acquisition system, researchers can view PV loops and calculate hemodynamic reports in real-time. This allows you to confirm quality data and start analysis at the bench-top, ultimately increasing throughput.
VARIABLE DESCRIPTION
ESP End-Systolic Pressure
EDP End-Diastolic Pressure
ESV End-Systolic Volume
EDV End-Diastolic Volume
HR Heart Rate
Max dP/dt Maximum Derivative of Pressure
Min dP/dt Minimum Derivative of Pressure
Max dV/dt Maximum Derivative of Volume
Min dV/dt Minimum Derivative of Volume
CO Cardiac Output
EF% Ejection Fraction
SV Stroke Volume
SW Stroke Work
Ea Arterial Elastance
maxPwr Maximum Power
plPwr Preload Adjusted Power
Eff Efficiency
PE Potential Energy
PVA Pressure-Volume Area
ESPVR End-Systolic PV Relationship
EDPVR End-Diastolic PV Relationship
PRSW Preload Recruitable Stroke Work
E(t) Time-Varying Elastance
Tau Isovolumic Relaxation Constant
PRESSURE-VOLUME LOOP MEASUREMENTS
-
BASELINE PRESSURE-CONDUCTANCE DATA FROM A HEALTHY MOUSE
In Conductance mode, the system outputs two signals: Pressure (mmHg) and Magnitude (S or mS).
Magnitude data can be converted to volume using traditional calibration techniques, which include a hypertonic saline injection to remove parallel conductance, and the use of Baans equation1 to convert data to volume units.
BASELINE PRESSURE-VOLUME DATA FROM A HEALTHY MOUSE
In Admittance mode, the system outputs four signals: Pressure (mmHg), Volume (L or mL), Phase (degrees), and Magnitude (S or mS).
No post processing is required to obtain accurate volume. In addition, researchers can view the Phase signal to confirm proper and consistent Catheter location in the center of the ventricle.
HIGH-RESOLUTION ECHO COMPARISON FROM A HEALTHY MOUSE
On the far left, XY plots show Admittance (blue) and Conductance (black) PV loops in two different scenarios: central Catheter position (top) and off-center position (bottom). Vertical dashed lines show end-systole and end-diastole, as measured by high-resolution echo. In both scenarios, Admittance data better correlates with echocardiography.
CORRELATION WITH MRI IN SHAM AND HF PIGS
Bland Altman plots show strong correlation between MRI volumes and Admittance volume measurements in sham pigs (blue dots) and pigs following 2 hour myocardial infarction by left circumflex coronary artery occlusion (red dots).
-
Features & Benefits
Suitable for use in a variety of animal models and different heart sizes
Provides the flexibility needed to customize your research program
Offers both traditional conductance and improved Admittance Volume calculation modes
Get the latest, most accurate PV loop technology while having access to traditional methods
Continue to collaborate with researchers even if they have older equipment
Variable Segment Length (VSL) Catheters provide flexibility
Ensures an accurate fit for larger hearts and dilation studies
One Catheter is suitable for a wider range of applications and animal types
Pre-amplified analog outputs (Pressure, Volume, Phase, Magnitude, Pressure 2)
Can be integrated with virtually any data acquisition system ( 5V range minimum)
Includes Additional Volume (AdVol) Admittance software
Recalculate volume while having control over the coefficients in Weis equation
Digital controls and LCD display
Intuitive menu design makes set-up and system use easy
Key system settings are displayed during acquisition to keep the researcher informed
Two pressure inputs
Acquire PV loops and blood pressure simultaneously via two Catheters
Calculate pressure gradients or pulse-wave velocity
The ADV500 system is both effective and reproducible in measuring LV function and dysfunction in the mouse, without the need for complicated interventions to calibrate the measurements.
James E. Clark Ph.D, Kings College London
This system is easy to use and provides clear and concise control features. The ability to generate true-volume in real time makes the system invaluable.
Pamela Lucchesi Ph.D, Nationwide Childrens Hospital
-
Pressure-VolumePressure-VolumePressure-Volume
LIMITED WARRANTY & RECALIBRATION Transonic warrants for a period of two (2) years from date of shipment that ADV500 hardware, cables, power supply, and
associated hardware accessories, purchased through Transonic or its duly appointed distributor or licensed representative, are free from defects that result from faulty material or workmanship by Transonic
Transonic warrants for a period of twelve (12) months from date of shipment that Catheters less than two French (2F) are free from defects that result from faulty material or workmanship by Transonic. Warranty is only valid if Catheters are purchased through Transonic or its duly appointed distributor or licensed representative.
The Transonic warranty does not apply to: defects caused by abuse, neglect or misuse; damage due to accident or casualty; or unauthorized alterations by anyone other than Transonic or an appointed repair center.
The Buyer pays shipping charges to the Transonic plant or repair center; Transonic will pay for return shipment charges.
If measurement accuracy is questioned during the two year warranty period, Transonic shall inspect and recalibrate ADV500 hardware free of charge provided that the Buyer pays for all shipping charges.
Ordering Information
REFERENCE1. Porterfield JE, Kottam AT, Raghavan K, Escobedo D, Jenkin JT, Larson ER, Trevino RJ, Valvano JW, Pearce JA, Feldman MD. Dynamic correction for parallel
conductance, Gp, and gain factor, , in invasive murine left ventricular volume measurements. J Appl Physiol 107: 16931703, 2009.
AMERICASTransonic Systems Inc.34 Dutch Mill RdIthaca, NY 14850U.S.A.Tel: +1 607-257-5300Fax: +1 [email protected]
EUROPETransonic Europe B.V.Punterweg 316222 NW MaastrichtThe NetherlandsTel: +31 43-407-7200Fax: +31 [email protected]
ASIA/PACIFICTransonic Asia Inc.6F-3 No 5 Hangsiang RdDayuan, Taoyuan County33758 Taiwan, R.O.C.Tel: +886 3399-5806Fax: +886 [email protected]
JAPANTransonic Japan Inc.KS Bldg 201, 735-4 Kita-AkitsuTokorozawa Saitama359-0038 JapanTel: +81 04-2946-8541Fax: +81 [email protected]
www.transonic.com
Transonic Systems Inc. is a global manufacturer of innovative biomedical measurement equipment. Founded in 1983, Transonic sells gold standard transit-time ultrasound flowmeters and monitors fo