Research Design: The Progression of Study Designs that Address a Clinical Question.
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Transcript of Research Design: The Progression of Study Designs that Address a Clinical Question.
![Page 1: Research Design: The Progression of Study Designs that Address a Clinical Question.](https://reader036.fdocuments.us/reader036/viewer/2022071807/56649e205503460f94b0b1b9/html5/thumbnails/1.jpg)
Research Design: The Progression of
Study Designs that Address
a Clinical Question
![Page 2: Research Design: The Progression of Study Designs that Address a Clinical Question.](https://reader036.fdocuments.us/reader036/viewer/2022071807/56649e205503460f94b0b1b9/html5/thumbnails/2.jpg)
Edward P. Sloan, MD, MPH
Associate ProfessorDept of Emergency Medicine
University of Illinois College of Medicine
Chicago, IL
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Attending Physician Emergency Medicine
University of Illinois Hospital
Our Lady of the Resurrection
Medical Center
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OverviewGlobal Objectives
• Answer clinical questions
• Minimize work
• Get it done
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OverviewSession Objectives
• Know what options exist
• Examine the progression of designs
• Understand the linkage and rationale
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Study Types
•Case report
•Case series
•Case-control study
• Prospective observational
• Prospective randomized
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Case Report
• That was an interesting case…
•Why did that happen?
• That’s unusual.
• I’ll never do that again!
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Case Report
•One patient
•An important observation
•A unique teaching point
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Case Series
• Is this really unusual?
•Are there similar patients?
• Is there a trend?
• Should we look further?
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Case Series
• Strengthens observation
• Identifies trends
• Suggests relationships
• Supports case-control study
• Supports prospective work
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Case-Control Study
•Are the unusual pts different?
•What risk factors differ?
• Is it something we can change?
• Should we look further?
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Case-Control Study
• Tests associations
•Utilizes diseased, OK patients
•May be last necessary step
• Supports prospective work
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Prospective Observational
•What data was missing?
•Do we need consistent data?
•What do we wish to know?
•What about missing pts?
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Prospective Observational
•Consistent data
•No missing patients
•Details future interventions
• Supports clinical changes
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Prospective Interventional
•Now let’s compare 2 groups…•Who will do better?•Which way should we do it?•Can we improve outcomes,
reduce costs, enhance access?
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Prospective Interventional
•Best research
•Costly, but complete
•Answers the questions
•Always causes new questions to be asked
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A Real Life Example
•Abdominal trauma
• Peritoneal blood
• Is there an injury?
• Is an operation needed?
• Is there a better way?