REQUEST FOR NEW ADMINISTRATIVE, RESEARCH1

OR PUBLIC SERVICE UNIT

BACKGROUNDUniversity of Illinois at Chicago

1. Name of Institution: _________________________________________________________Center for Cognitive Medicine

2. Title of Proposed Unit: _______________________________________________________181023

3. CIP Code (6-digits): _________________________________________________________May 1, September 1, 20078

4. Proposed Date for Initiation of Unit: ___________________________________________John A. Sweeney, Ph.D.

5. Contact Person _____________________________________________________________312-413-9205

5.1. Telephone _____________________________________________________________

jsweeney@psych.uic.edu

5.2. E-mail ________________________________________________________________

312-413-8837

5.3. Fax __________________________________________________________________

PURPOSE: OBJECTIVES, MISSION AND PRIORITIES

6. Unit Objectives and Contributions

6.1. What are the goals and objectives of the new unit?

INTRODUCTIONThe Center for Cognitive Medicine is requesting approval for formal status as a Center at the University of Illinois at Chicago.

The Center was established informally in 2001 to organize a translational and interdisciplinary program of research focusing on pathophysiology and treatment of behavioral aspects of brain disorders. The Center has evolved over the last five years as one of the largest and most successful translational research programs bridging basic research and clinical practice at the university. To facilitate our growth and continued success, we are now applying for formal approval to officially operate as a Center at the University of Illinois at Chicago.

1 Temporary approval may be sought through reasonable and moderate extension for creation of a new, formally organized, research or public service unit that has a temporary mission up to five years. Following that time period, the institution must seek permanent approval if the unit continues operation.

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The Center’s mission is to develop new knowledge about the cognitive problems caused by brain disorders and normal aging, and to apply the scientific discoveries gained through research to improve the treatment and prevention of disease. Our mission will be achieved through the coordinated efforts of our core faculty team.

The proposed Center has 32 core faculty members with primary appointments in six Departments across four Colleges. Participating Colleges include Medicine (Departments of Psychiatry, Neurology, Anatomy and Cell Biology), Applied Health Sciences (Department of Movement Sciences), Pharmacy (Department of Pharmacy Practice) and Liberal Arts & Sciences (Department of Psychology). Our faculty members are PIs of active NIH grants supporting patient-oriented research in schizophrenia, autism, movement disorders, women’s health and aging, traumatic brain injury, stroke, Alzheimer’s disease, Parkinson’s disease and pediatric mood disorders. Clinical investigators in the Center also conduct studies of electrical shock injury, normal aging, endocrine disorders, pediatric neurological disorders, the sequelae of radiation and chemotherapy for pediatric cancers, and HIV effects on the aging brain.

To help expand medical knowledge through research in a clinical setting, the Center maintains specialty research clinics which include the First Episode Psychosis Clinic, Cognitive Neuropsychiatry Clinic, Pediatric Mood Disorders Clinic and Traumatic Brain Injury Clinic. In our clinical work, we use neuropsychological assessments, neurophysiological measurements and brain imaging to diagnose the causes of cognitive disabilities in our patients. In our research clinics, we treat patients with novel pharmacologic approaches designed to enhance and preserve cognitive abilities.

The Center is the lead site for cognitive studies of lithium treatment in a large multisite trial for pediatric bipolar supported by NIMH and a multisite study of Alzheimer’s disease treatment, and are conducting a multisite study of the role of dopamine in behavioral planning and control, an NIH P50 Center focusing on the pathophysiology and treatment of autism, a multisite study investigating familial phenotypes for schizophrenia and bipolar disorder, and an intervention to improve motor control in patients with movement disorders. Center faculty members at the UIC College of Pharmacy support our pharmacogenetic, pharmacodynamic and pharmacokinetic work. Links with the Health Statistics Program provide the basis for ongoing development in statistical models for the analysis of fMRI data sets and clinical trial data. The UIC Center for MR Research provides MRI scanners for our clinical studies of brain anatomy and function. Behavioral neuroscientists working with rodents in the Behavioral Neuroscience program in Psychology and in Anatomy and Cell Biology, and with collaborating investigators at pharmaceutical companies conducting related behavioral pharmacology studies, foster the development of novel drugs and translational strategies for improving the treatment of patients with brain disorders.

To facilitate training and continuing educational opportunities, as part of commitments to home departments, the Center’s faculty participates in and directs several interdisciplinary training programs. Many of the faculty members participate in the UIC interdisciplinary program in neuroscience. Our faculty also participates in doctoral

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training programs in the Departments of Psychology, Anatomy and Cell Biology, Pharmacy Practice and Movement Sciences, and in a wide variety of educational programs for undergraduates, medical students, graduate students, and resident physicians. Professional continuing education opportunities are provided through our clinical neuroscience seminars, geropsychology seminars, fMRI methodologies seminar, and weekly fMRI journal club, as well as those we provide at national meetings. The Center runs a highly regarded weekly colloquium program on clinical aspects of behavioral neuroscience. Our faculty members are heavily involved in training medical students and residents in the Departments of Neurology and Psychiatry, and consistently demonstrate their commitment to training and education.

The Center is also active in community outreach. We co-sponsor various community events with family groups in the areas of neurodevelopmental disorders such as autism and serious mental illness. We co-sponsor education forums for parents, educators and other professionals to teach them about the importance of early detection and treatment of brain disorders and how research advances affect diagnostic and treatment practice. Faculty and staff often volunteer to speak to various groups to educate them about mental illness and the importance of quality research, and sit on the board of directors of family groups related to brain disorders. We also maintain a web site to inform the community about our clinical treatment options, various research programs, general information about cognitive disorders and available treatment, and clinical trial outreach activities.

MISSIONNeuropsychiatric disorders comprise 5 of the 10 greatest causes of functional disability across the world. Cognitive deficits associated with these disorders are the best established cause of this disability. The Center was designed to provide organization and interdepartmental cohesion for a diverse group of faculty interested in the causes, treatment and prevention of disturbances in cognition over the life span. A primary aim is to integrate the work of basic neuroscience investigators working with animal models with clinical investigators in this effort. This is thus a fundamentally translational program of clinical research. Our mission is to achieve a better understanding of cognitive deficits and to develop and test new treatment strategies to improve the health of our population and to reduce personal and fiscal burdens of brain disorders on our society.

This goal will be accomplished through a series of coordinated efforts. Center faculty will:

Work together to develop new treatment models through scientific discovery, conducting studies to bring new ideas from animal research about the neuropharmacology of cognition into patient care ;

Test the utility of new treatment approaches and new models of the pathophysiology of brain disorders in patient oriented research, especially involving efforts to develop new effective medical treatment options;

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Develop new clinical tools (i.e., biomarkers) for evaluating the impact of drugs on brain function and cognitive systems.

Foster scholarship for undergraduates, medical students, graduate students, resident physicians, post-residency and postdoctoral fellows, and junior faculty.

Partner with the pharmaceutical industry to develop and evaluate novel treatment intervention strategies for disorders where available treatment options are often unsuccessful.

CENTER HISTORY

The following brief introduction to the history of the Center is written to provide a framework as to how the Center evolved to its current state.

The Center was designed to provide organization and interdepartmental cohesion for a diverse group of faculty interested in the causes, treatment and prevention of disturbances in cognition over the life span that are associated with a number of highly prevalent neurological and psychiatric disorders. A primary aim was to integrate the work of basic neuroscience investigators working with animal models with clinical investigators in this effort. This is thus a fundamentally translational program of clinical research.

Dr. John Sweeney, the Center Director, was recruited to UIC in 2001 by Dean Flaherty (then Head of Psychiatry) together with the Head of Neurology, the Chair of Psychology, Dean Moss of the College of Medicine and Dean Fish of the College of Arts and Sciences, to establish the Center for Cognitive Medicine. The Center was envisioned at that time as a program to integrate academic and clinical programs in the area of cognitive disorders across the lifespan. Neurosurgery provided some additional space to support the effort, and still does so. .

A great deal of progress has occurred since 2001. In Psychiatry, Dr. Neil Pliskin was recruited to run the Neurobehavioral Program, one of two large clinical programs in Psychiatry that are part of the Center. We recruited Dr. Lisa Stanford, to run pediatric neuropsychology, Dr. Michael Schrift to run the neuropsychiatry service with the recent addition of Dr. Gaston Baslett to assist him, Dr. Eric Prensky to expand services provided by Dr. Susan Labott in Health Psychology, Dr. Marilyn Kraus to set up a clinical research program for traumatic brain injury, and Dr. Pauline Maki to set up another research program examining endocrine effects on women’s cognitive and brain health over mid and late life. Dr. Mani Pavuluri joined the group to study brain disturbances in pediatric bipolar disorder. Other than Dr. Labott, this program was built from the ground up with external recruitment. In the Psychotic Disorders Program, the second clinical component of the Center in Psychiatry, we recruited Drs. Scot Hill, Ellen Herbener, Sarah Keedy, and James Reilly to UIC to join Drs. Robert Marvin and Ovidio DeLeon who have functioned as the directors of outpatient and inpatient clinical services for psychotic disorder patients respectively. Dr. Mani Pavuluri joined the group to study brain

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disturbances in pediatric bipolar disorder. Dr. Peter Weiden, a national expert in schizophrenia treatment, will joined the Center in May June 07 to serve as the new Director of the Psychotic Disorders Program, relieving Dr. Sweeney of that responsibility to allow him more time to function as Director of the growing Center. Dr. Sweeney has continued his NIH funding investigating treatment and outcomes in first episode psychosis, and is now also Co-Director of a new Center grant from NIH on autism, and is site director of a new $20 million grant from NIH to study family genetics of schizophrenia and bipolar disorder for which funding will begin in June 07 in collaboration with faculty in Child Psychiatry and Psychology.

Much of this progress in Psychiatry was due to Dr. Flaherty’s decision to reorganize programs in Psychiatry in a way that integrated clinical and research missions on a day-to-day basis. That was new to the Department, and at the time was a fairly radical step. In this reorganization, the Neurobehavioral Program and the Psychotic Disorders Program were formed to become the clinical arms of the Center for Cognitive Medicine in Psychiatry. This was a crucial step for the development of clinical research in Adult Psychiatry, and it was the leverage to help recruit the outstanding faculty that have since joined the department and begun or continued very promising research careers. Many of the senior faculty members in the Center are field leaders. Together, in only five years, we have made the adult clinical psychiatry program one of the strongest in the Midwest, easily stronger than any in Chicago.

Since joining the faculty, five of the assistant/associate professors in Psychiatry have received NIH mentored K awards to work with Dr. Sweeney to develop skills in neuroimaging and clinical research investigating cognitive outcomes of neuropharmacological treatments. Two new K applications for Career Development awards to junior faculty are under review. In addition, as detailed later in the application, several have also gone on to receive foundation grants, pharmaceutical industry grants, and R21 and R01 awards. Overall, our funding has grown dramatically over the past 3 years in large degree because of the multidisciplinary integration provided by the and resources in the Center available for us to pursue our academic mission. Thus, . oOver five years, dramatic changes have occurred in the level of patient orient research related to brain disorders at UICand clinical practice in Psychiatry, with our Center as the hub of much of the program development and progress. In parallel with this research and clinical program development, our clinical training programs have been greatly strengthened.

While these developments were occurring in Psychiatry, parallel advances began later in other departments. Dr. Scot Brady was recruited as head of Anatomy and Cell Biology. Dr. Brady recruited Dr. Chris Fall who has interest in dopamine regulations of neuronal activity in slice preparations. Psychology recruited Dr. Mitchell Roitman who examines dopamine in reward systems that are abnormal in schizophrenia, mood disorders and substance abuse, using sophisticated new in vivo measures of dopamine levels in animal models. He joined Dr. Michael Ragozzino, Director of the Behavioral Neuroscience program in Psychology, who studies serotonin and acetylcholine regulation of cognitive function in behaving rats, and is developing animal models for autism treatment

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mechanisms as part of our new NIH Center. Dr. Phillip Gorelick was recruited as Head of Neurology, which greatly increased academic activity in the department. Dr. Carol Macmillan, Director of Child Neurology, joined our autism research team. Dr. Gorelick recruited Drs. Little, Nyenhuis and Pedelty, all of whom became actively involved in our Center’s clinical, research (aging, dementias) and educational missions. Drs. Little and Nyenhuis each recently received independent NIH funding, and Dr. Laura Pedelty joined Dr. Michael Schrift to develop a major new fellowship program in behavioral neurology that recently received formal accreditation – the only program of its nature in Chicago. The College of Pharmacy recruited Dr. Jeffrey Bishop, with help from our Center which offered a team of clinicians very interested in working with him examining genetic predictors of beneficial and adverse effects of medications used to treat brain disorders. In a bit more than a year out of postdoc, he has four grants to support multiple lines of pharmacogenetics work with our varied clinical populations. This line of work is crucial for learning how to use genetic information to individualize drug therapies. Dr. Daniel Corcos recruited Dr. David Vaillancourt into the Department of Kinesiology, who now has R01 funding to conduct functional neuroimaging studies of the cognitive control of motor acts. With the integration of existing faculty and rapid faculty growth related to the Center’s primary missions, the Center has become the major inderdisciplinary human clinical/systems neuroscience program at UIC. And with that evolution over the past five years, we now propose to move forward with the plan that guided Dr. Sweeney’s initial recruitment to seek formal University Center status for our interdisciplinary program of clinical neuroscience.

In planning this proposal, Dr. Sweeney has met with staff in the Provost’s office and the Vice-Chancellor of Research who all enthusiastically both recommended that supported this effort. Both thought that with because of the strong clinical focus of the Center and the diverse departmental homes of Center faculty, of the Center, the reporting line for the Center Director should be through the office of the Dean of Medicine. Dr. Flaherty, Dean of Medicine, has agreed with this plan as indicated in his letter which is appended to this application..

To facilitate review of the Center’s developmental trajectory and current contributions, we include with this application a series of tables as appendices (focusing on the period from 2004 – 2006):

Appendix A Authorship of peer reviewed papers by Center facultyAppendix B Teaching commitments of Center faculty in their home departmentsAppendix C State dollars supporting Center facultyAppendix D Grants awarded to Center faculty

Note: two additional new grants to Drs. Sweeney and Corcos have been awarded, each for over $2.5million direct costs from NIH

Appendix E Number of staff and students working with each Center faculty memberAppendix F Total grant dollars per Center faculty membersAppendix G Clinical responsibilities of Center facultyAppendix H Departmental appointments of Center faculty

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6.2 What is the relationship of the unit to the university’s mission and priorities? Is the unit involved in instruction and, if so, to what extent?

The conduct of research, scholarship, and public service is at the core of the university's mission. Our research unit is designed to support and maintain each of the guiding principles of the university's mission. The university’s mission (italicized below) and the Center’s relationship to the mission are discussed below.

Create knowledge that transforms our views of the world, and through sharing and application transforms the world:

o Cognitive and behavioral problems associated with common psychiatric and neurological disorders are a major cause of functional disability across the lifespan for our citizens. Interdisciplinary and translational collaboration across basic and clinical neuroscience research programs is needed to speed drug-discovery and the wide use of new diagnostic and treatment strategies. Sharing knowledge and transforming medical care for our citizens is the primary mission of Center faculty.

Provide a wide range of students with the educational opportunity only a leading research university can offer:

o The Center’s research program is structured to support the University’s commitment to education and training. The Center runs a highly regarded weekly colloquium program on clinical aspects of behavioral neuroscience, and provides professional continuing education opportunities through our weekly clinical neuroscience seminars, geropsychology seminars, fMRI methodologies seminar and fMRI journal club. Our Health Psychology program has developed web based professional education programs to update skills of practicing clinicians. Dr. Pliskin directs educational programs of the International Neuropsychological Society. Last year we held the Midwest Neuropsychology Society annual meeting at UIC, and organized a multiuniversity day-long symposium held at Columbia College regarding the problem of suicide on college campuses. Our faculty, recognized for their excellence in teaching, participates in and directs training programs in the Departments of Psychiatry, Neurology, Anatomy and Cell Biology, Pharmacy Practice and Movement Sciences that impact educational programs for undergraduates, medical students, graduate students and resident physicians.

o Some Center faculty members are involved in undergraduate teaching as part of their commitments in their home department. However, the majority of our faculty participates in professional education programs

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for medical students, PharmD students, medical residents in Psychiatry, Neurology and Pediatrics, and postdoctoral clinical training fellowship in specialty areas.

o Graduate students and research-oriented post-docs have exceptional training opportunities in our laboratories to learn cutting edge scientific methodologies.

Address the challenges and opportunities facing not only Chicago but all Great Cities of the 21st century, as expressed by our Great Cities Commitment:

o The goal of the university’s Great Cities Committee is to address urban challenges facing Chicago through the strength of its faculty, staff, students and community leaders. The Center’s faculty and staff join the university in its commitment by dedicating their efforts to research, and focusing on developing new knowledge about brain disorders that affect thousands of residents in Chicago and all the Great Cities of the 21st century.

Foster scholarship and practices that reflect and respond to the increasing diversity of the U.S. in a rapidly globalizing world:

o By building an interdisciplinary research program, we promote collaboration in scholarship and create opportunities for clinicians to partner with clinical investigators and basic scientists in cutting-edge clinical research projects. This type of collaboration will help us more quickly translate new knowledge derived from scientific discovery into improved clinical care, and it will facilitate the education of healthcare professionals who are capable of addressing the increasingly diverse aspects of brain health and disease of our nation.

o The ethnic and cultural diversity of the patients seeking care at the University of Illinois Medical Center at Chicago provide an important opportunity for our clinical investigators to examine diversity effects in areas from pharmacogenetics to specialized family intervention programs for neuropsychiatric illnesses across the agespan.

o Each of the educational programs in which our Center faculty participates as part of their commitments to home departments has a strong commitment to the diversity of our student populations, from undergraduate to graduate/medical students to postdocs and medical residents. Our track record in this area is especially strong.

o Our area of research, like most, has become globalized. Our faculty maintains active collaborations not only across the country, but across

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the world. Europeans often seek fellowship opportunities in our programs, as reflected for example in two physician professors from Germany independently recently receiving fellowships for advanced training here in our Center. We also maintain peer-to-peer collaborations with investigators in many countries to bring in special expertise in laboratory research and computational methodologies to keep our work at the cutting edge.

Train professionals in a wide range of public service disciplines, serving Illinois as the principal educator of health science professionals and as a major healthcare provider to underserved communities:

Education is one of the Center’s primary areas of focus. Our faculty, as part of their commitment to their home department, participates in a wide range of educational programs including traditional course presentations, multiple seminar programs offering advanced training to medical residents, medical students, graduate students and post-doctoral fellows. We engage in public service and partner with community leaders to co-sponsor community programs. We are currently working with leaders of the Community Counseling Centers of Chicago, a behavioral health advocate and social service provider, to develop an early detection program to identify mental health problems early in students in the public school system.

6.3 What specific needs and measurable contributions will the unit make to statewide priorities and needs?

The Center supports the policy areas of the Illinois Commitment through its research activities, teaching commitments and community service endeavors. The policy areas addressed in the University Committee (italicized) and the Center’s commitment are listed below.

Policy Area One: Economic Growth Higher education will help Illinois sustain strong economic growth through its teaching, service and research activities.

o The Center will support Illinois’s economy by conducting biomedical research in conjunction with the state and federal governments, and the pharmaceutical industry, to develop new knowledge about cognitive problems caused by brain disorders and their treatment. Our aim is to improve the quality of life and economic circumstances of individuals affected by brain disease. We work directly to improve the care of Illinois residents who suffer from psychiatric and neurological disorders in our clinics. We hope to have much broader impact through development and implementation of cutting edge and new diagnostic and treatment practices that will lead to increased

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productivity and subsequent reductions in the economic burden of brain disorders on the state and its population.

Policy Area Two: P-20 PartnershipsHigher education will join elementary and secondary education to improve teaching and learning at all levels.

o Faculty members of the Center routinely partner with educators to help them identify cognitive problems that affect learning. One aspect of the Center’s educational mission is to help improve the quality of teaching and learning in elementary and secondary education by helping educators understand the struggles and strengths of children suffering from brain disorders that affect learning. School collaboration and consultation services are available through the Pediatric Mood Disorders Clinic (Director, Mani Pavuluri, MD) and the Learning and Neurodevelopment Program (Clinic Director, Lisa Stanford, PhD, Medical Director, Carol Macmillan, MD). In both programs, students are trained to be able to provide better consultation services to young students throughout their professional careers.

Policy Area Three: AffordabilityNo Illinois resident will be denied an opportunity for a college education because of financial need.

o Through the educational commitments of our faculty to undergraduate education in their home departments, we work to provide a high quality education to our student populations.

o As a research unit that offers clinical services in the Departments of Psychiatry and Neurology, and through the College of Pharmacy, the Center is committed to providing Illinois residents suffering from brain disorders with an opportunity to obtain high-quality and affordable health care services. Clinical services offered in our research clinics (First Episode Psychosis Clinic, Cognitive Neuropsychiatry Clinic, Metabolic Disorders Clinic, Pediatric Mood Disorders Clinic and Traumatic Brain Injury Clinic) are linked to the Center’s research programs, and through our research studies we provide low cost treatment to uninsured patients.

Policy Area Four: Access and DiversityIllinois will increase the number and diversity of residents completing training and education programs

o Our faculty, as part of their commitments in their home department, participates in the educational programs in four Colleges across the university (Medicine, Arts and Sciences, Pharmacy, Allied Health

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Sciences). Our Medical School is one of the largest and most diverse in the country. We contribute to large medical residency programs in neurology, psychiatry and pediatrics, and graduate and undergraduate programs where access and diversity issues receive active and very serious attention. Across the programs in which our faculty members participate, we have a very positive track record for supporting the education of a diverse student population, and for providing advance training to diverse students who will become the educators and clinical program directors of tomorrow.

o Our community outreach activities allow us to engage in public service and partner with community leaders to co-sponsor events and educational programs. We support activities that are designed to increase the number of Illinois residents with knowledge about brain disorders and help them gain access to scientific discoveries and available treatment options. We have partnerships with the National Alliance for Mental Illness, Chicago Public Schools, Columbia College and the Community Counseling Centers of Chicago.

o We maintain a website to inform the community about our clinical treatment options, various research programs, general information about cognitive disorders and available treatment, and clinical trial outreach activities.

o We maintain a research registry to promote community involvement and participation in research by providing individuals with a way to gain access to novel treatment options.

Policy Area Five: High QualityIllinois colleges and universities will be accountable for providing high quality academic programs and systematic assessment of student learning outcomes while holding students to ever higher expectations for learning and growth.

o The Center’s commitment to quality education is the focal point of our education agenda. Faculty members, as part of their commitment to their home department, participate in a wide range of educational programs across four Colleges ranging from traditional course presentations to seminar programs to individual clinical and research supervision. We teach our students to be innovative thinkers who can use their skills to lead the charge in scientific discovery and deliver high-quality and cost-efficient health care to the community. Our Faculty strives for excellence in education and seeks opportunities to develop high quality academic programs. An example of this achievement is the recent accreditation of the Behavioral Neurology and Neuropsychiatry training program, a new two-year clinical and

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research fellowship program developed by Drs. Schrift and Pedelty, that is the only one of its type in Chicago.

6.4. What is the demand for the unit’s services? What clients or population will the unit serve?

The demand for the Center’s clinical services is great, as is the need for research to show the way forward to more effective treatment and preventative interventions. Thus, the potential to impact the lives of all individuals who suffer from cognitive problems associated with brain disorders is enormous. We are located in the heart of the Chicago metropolitan area and service an urban population with considerable ethnic and socioeconomic diversity. We treat approximately 2900 patients per year in our clinics.

The impact of brain disorders on the health and productivity of residents in Illinois is tremendous. Key facts and core statistics about the impact of mental illness on the state of Illinois are listed below:

According to the U.S. Census 2000 and epidemiological prevalence estimates, more than 700,000 adult Illinois residents have a severe mental illness. An additional large number suffer from neurodevelopmental disorders and degenerative disorders of late life with great impact on personal functional abilities, family stress and costs to the health care system.

The Illinois Department of Corrections estimates that 16 percent of inmates suffer from mental illness, four or five times higher than rates of mental illness among the general population.

An estimated 720,000 Illinois residents have been homeless at some point. At least 140,000 of these individuals suffer from a severe mental Illness (Illinois Center for Mental Health Services).

Emergency room physicians report (including respondents from Illinois State) that the upsurge in people with mental illness seeking treatment in community emergency departments is negatively affecting patient care, causing longer wait times, and affecting everyone’s access to lifesaving treatment. (American College of Emergency Physicians, national survey).

In addition to serious mental illnesses typically treated in Psychiatry, a large number of additional individuals suffer serious cognitive problems from neurodevelopment disorders such as autism, head injuries typically in young adulthood (and now an increasingly common event in the lives of our servicemen and women), and degenerative disorders of late life such as Alzheimer’s and Parkinson’s diseases. Conservatively, across studies, these disorders impact 10% of our population at some point in life. Typically, these disorders lead to educational problems, unemployment and/or other serious functional disabilities, and a requirement for active care or support. The costs in terms of lost productivity and for medical care, together with the emotional sequelae for patients and family, are major societal burdens.

7. Organization

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Describe the proposed unit’s organizational structure.

The unit is structured as an interdisciplinary research program designed to facilitate the development of new knowledge about cognitive problems caused by brain disorders and normal aging. The Center is organized with three committees that serve to organize plans to achieve our Center missions. Two operational committees are designed to enhance progress in our two primary missions: research and education. Our participation in clinical practice occurs through our participation in the various activities of our home clinical Departments.

The Clinical Research Integration Committee has the aim of fostering interaction and integration of clinicians and scientists. The group will address issues such as: 1) developing intellectual synergies between those working with animal models and those conducting patient-oriented research, 2) developing practical strategies for integrating clinical research and clinical practice with the greatest benefit to both research programs and patient care, and 3) ensuring that solutions and progress in these areas are rapidly dispersed to all Center programs and their related clinical programs. We anticipate that this committee will not only help optimize the efficiency of our programs, but provide a framework for developing new translational research programs and plan for the grant applications needed to support them.

The second operational committee is the Education Committee. There are many ways in which integration of educational programs across Psychiatry, Neurology, Psychology, Pharmacy, Movement Sciences and other Departments will benefit from the interdisciplinary collaboration of our faculty in student mentoring and course preparation/delivery. Also, across clinical departments, sharing training opportunities across departments will foster our overall education mission. This Committee will organize special seminars, facilitate integration of the Center with the UIC Interdisciplinary Neuroscience Program, foster career development of undergraduates, graduate students, medical students, residents, postdoctoral fellows and junior faculty via mentorship models and special educational programs organized by the Center (colloquia, journal clubs, as well as formal courses implemented by faculty in their home departments). The Committee will disperse information about speakers and courses across home departments that may be of interest to Center faculty and students. One longer term aim will be to organize submission of NIH T32 training grants for postdoctoral students to work with Center faculty.

The third committee is our Executive Committee. This group will have representatives from the two operational Committees. The committee will monitor progress of the operational committees, make decisions about Center membership, provide for the linkage of the Center with home departments of Center faculty, and organize plans for resource allocation and professional development across the Center. We envision plans for Center and Program Project Grant applications to NIH that will be greatly facilitated by the multidisciplinary integration provided by the Center structure. The planning and organization for these efforts will to a significant degree be implemented by the

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Executive Committee. There also are going to be inevitable conflicts between people and priorities, and issues of professional ethics that will be resolved, when necessary, by the Executive Committee. Last, the Executive Committee will be well placed to evaluate hiring needs at the University to fill “holes” in the faculty that slow important multidisciplinary efforts, and to communicate those ideas to appropriate Deans and Department Heads/Chairs. The Committee will also communicate to higher levels of University leadership information related to programmatic needs of the Center with regard to major equipment, developing infrastructure to support large program grants, large equipment purchases, and important issues in the Center’s relation to Departments, Centers, Institutes and Colleges at the University.

An external advisory committee will be established to monitor academic progress of the Center, and to provide advice on prioritization of scientific aims. We anticipate that this Committee will be asked to the University on an annual or biannual basis, that the membership of the Committee will evolve to bring in new ideas and to have field leaders in the developing areas of excellence of the Center represented in the visitor group.

The Center Director will report to the Dean of the College of Medicine. Dr. Sweeney has a well established working relationship with Dr. Flaherty, and will meet with him on a quarterly basis and ad hoc as needed. Formal reports about Center progress will be prepared as per University guidelines.

Director and Co-DirectorThe Center Director, Dr. John Sweeney, and Co-Director, Dr. Neil Pliskin, maintain the day-to-day operations of the Center. Within Psychiatry, the Center Director coordinates and directs clinical and academic activities within the Psychotic Disorders Program and the Neurobehavior Program (including neuropsychiatry, neuropsychology and health psychology), which represents approximately half of the clinical activity in adult psychiatry. Within these clinical programs, the Center maintains several specialty clinics (First Episode Psychosis Clinic, Traumatic Brain Injury, Cognitive Neuropsychiatry Clinic, Clinic for Learning and Neurodevelopment). The Center Director has an overall mentorship responsibility for junior faculty members, and currently serves as the primary mentor of five active NIH mentored K awards to Assistant and Associate Professors. Within the next 12 to 15 months, three additional junior faculty members (two in Psychiatry, one in Pharmacy) are on course to apply for K awards, all with the Center Director as the mentor. The Center Director also supervises administrative staff positions in the Center, as well as the three programmers who maintain the Center’s Beowulf cluster for MRI image analysis, develop databases, design computer-controlled stimuli for psychological studies, and develop software for image analysis and for measuring neurophysiological data. The Director also manages the Center’s eye movement laboratory, and builds linkages between clinical investigators and basic neuroscientists. Last, the Director has fiscal responsibility for the Center’s budget, which involves salary coverage for faculty and staff in Psychiatry, balancing clinical and research commitments for all Psychiatry faculty in the Center, and for allocating supplementary funds as indicated for supporting pilot data collection and helping faculty through short-term

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funding gaps. He has an overall administrative responsibility for integrating the interdisciplinary academic programs of the Center.

The Co-Director of the Center coordinates educational programming in the Center. The Co-Director also manages clinical activities in the Neurobehavior Program, is Chair of the Psychiatry Department Space Committee, and plays an important role as a practicing clinician in maintaining an active interface between clinicians and clinical investigators in the Center.

8. Unit Outcomes

8.1. What targets have been set to assess the proposed unit’s success in achieving objectives?

The following targets have been set to assess the unit’s success in achieving its objectives.

We plan to enhance our group’s scientific impact on the national scene.

A primary target is to expand our research productivity. This goal will be accomplished by increasing our rate of

publication, boosting the impact factor of our publications by publishing in higher ranking journals, and acquiring more funding through the acquisition of NIH grants, financial support from pharmaceutical companies and donations from private foundations to support research and scientific efforts.

Success will be measured by calculating the annual scholarly activity (sum of publication rates times impact factor of journal where paper was published) of the Center’s faculty, the number of publications total, and the amount of extramural research funding received to support scientific efforts and activities. These three measures will be the primary indices of our success in the research domain.

We plan to increase collaborative research efforts and design new research models that will have a broad impact in our field of research. A primary benefit of the proposed unit’s organization is in its ability to foster collaborative interdisciplinary work that otherwise would not occur. This is the best pathway to successful high-impact clinically relevant neuroscience research, and for obtaining grant funding to support it.

Success will be indexed by the number of interdisciplinary collaborations among the Center’s faculty per year, and the number and quality of partnerships with federal agencies, other

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universities, pharmaceutical companies, private foundations and private donors. We will actively monitor the success and effectiveness of our efforts by encouraging collaboration among faculty and working to support functionality, providing access to shared resources and working to expand our current network of core faculty. Successful interdisciplinary collaboration is difficult to quantify numerically. If we are to be successful as a Center we will need an increasing number of examples of such successful interactions that will evolve in fundamentally different ways.

In this context, it is important to cite some successes in this regard. One sign of collaborations is grants that have been submitted. This is of course and early sign of intended collaboration rather than a sign of established success, but we are a young group in terms of our time working together and this is the first step toward success.

1. Autism Center grant, NIH P50 grant, includes Drs. Sweeney

and Keedy and others doing clinical work in Psychiatry with Dr. Ragozzino in Psychology doing animal modeling of drug effects to parallel human clinical trials with SSRI drugs.

2. Drs. Vaillancourt and Corcos in Movement Sciences submitted a R01 application to NIH with Dr. Sweeney in Psychiatry to study cognitive processes that impact movement deficits as seen in Parkinson’s disease. Pilot work for this project is underway.

3. Dr. Kraus in Psychiatry is working with Dr. Little in Neurology to study brain white matter changes subsequent to traumatic brain injury and its impact on cognition and mood. They have an R01 and a DoD application under review to support that work.

4. Drs. Ragozzino and Roitman in Psychology have internal UIC funding with Dr. Chris Fall in Anatomy and Cell Biology in the College of Medicine to study behaviorally relevant brain chemistry in animal models.

5. Dr. Bishop in Pharmacy Practice has a career development award under review to NIH with Dr. Sweeney as mentor to study pharmacogenetic predictors of outcome when acute schizophrenia is treated with a widely used antipsychotic medication. Dr. Bishop also has funding with Dr. Maki in Psychiatry and Psychology to examine genetic predictors of cognitive changes through menopause in HIV infected women, and with Dr. Pavuluri in Psychiatry to use genotype information to predict treatment outcome in children with bipolar disorder.

Revised: 05/01/0716

6. Dr. Zhou, a physicist in Neurosurgery, is now collaborating with several clinical investigators in funded grants and grants under review to develop new approaches for acquiring MRI data.

7. Dr. Gibbons in Biostatistics has funding with Drs. Sweeney and Keedy in Psychiatry to develop new statistical approaches for analyzing functional MRI data, and two additional grants under review with Dr. Sweeney to develop new statistical models for this purpose.

There are essentially three groups of faculty in our unit, and our success depends on our ability to enhance their mutual invigoration of each other’s professional activities:

Academically oriented clinicians primarily dedicated to patient care;

Clinical investigators working to improve understanding of disease and developing evidenced-based approaches to improve patient care;

Basic science investigators working with animal models to enhance the understanding of disease and treatment mechanisms

- We will work to ensure that considerable attention is paid to faculty retention so we can retain our best and attract new highly qualified personnel.

- Success in integration will manifest itself in courses and research projects for students, the promotion of cross-disciplinary collaboration and innovative thinking, and the establishment of new treatments and diagnostic practices that will translate into better care for our patient population and the residents of Illinois.

In our research clinics, we have the primary aim of improving the understanding, diagnosis and treatment of brain disease, and changes associated with normal aging.

o We work to produce new and improved diagnostic procedures using neuropsychological tests, neurophysiological assessments, and brain imaging with MRI and PET. New approaches will be tested, validated and described in scientific papers. We work to include genetic profiling in our clinical research programs to better individualize treatment selection and drug dosage in order to individualize care and enhance clinical outcomes. And, we work to

Revised: 05/01/0717

establish the efficacy of new medications and new uses for FDA approved medications, and to develop new psychosocial interventions that reduce morbidity to improve the clinical course of illnesses. Our success will be reflected in new discoveries with high impact on patient care.

Increase the unit’s participation in public service projects.

o Brain disorders are often under-recognized, misdiagnosed and poorly treated in the community. This is a problem because delay to optimal treatment often leads to poorer long-term outcomes. This is an important issue in pediatric neurodevelopmental disorders, in major psychiatric disorders of young adulthood, and degenerative disorders of late life. Our plans include:

Helping clinicians in the community recognize brain disorders by working with state agencies to enhance the education of front-line service providers;

Providing regular clinical educational programs to the broader medical community;

Providing family educational programming to individuals with loved ones or family members recently diagnosed with brain disorders;

Working with local and national professional organizations and clinical service providers in the community to coordinate continuing professional education programs;

Assisting local family support groups in planning annual and monthly meetings;

Maintaining a webpage that will inform the public about current practices, novel approaches and new discoveries for the treatment of brain disorders;

Continue to expand on-site clinical services and clinical-research programs while providing high-quality care.

Our success will be measured by calculating the number of public service projects completed within a year. We will use feedback received from participants to measure the quality of our service.

Revised: 05/01/0718

o To the extent possible given staffing, clinical space and academic priorities, we will continue to expand clinical services and clinical research programs for the local community.

Our success will be measured by calculating various outpatient/inpatient quality measures that will be determined by the Center’s Executive Committee.

Maintain our commitment to quality education by improving and expanding our educational programs.

o The unit’s faculty, through their commitments in their home department, plays a major role in the university’s educational programs. This includes traditional course presentations, mentorship of doctoral students and postdoctoral fellows, and clinical mentorship of medical students and residents, psychology fellows, and PharmD students. Our continued success in this area will be reflected in:

Continued development of the systems and human sections of the multidisciplinary PhD program in neuroscience;

Growth of the neuropsychology and health psychology predoctoral and postdoctoral training programs;

Continued development of our multiple seminar programs;

Increased numbers of completed doctoral dissertations supervised by CCM faculty.

We expect that our Center Executive Committee will continue to evolve new performance evaluation metrics based on how the progress of the Center evolves, and as we develop new ways to progress toward achievement of our Center mission.

9. Resources

9.1. Indicate the number of students, business, industries, and/or other clients to be served by this unit. Include a description of faculty participation and student involvement in the unit if applicable. Table II should be completed (even if no new state funding is requested in the budget year) and should reflect all sources of funds, both state and non-state, and reallocations. A narrative budget statement should be provided to explain Table II, to include the following information:

Revised: 05/01/0719

Explain projected increments in total resource requirements (line 1) in terms of projected staff requirements, equipment and materials, and contractual services.

Explain new state resources required (line 6) in the budget year in terms of assumptions and factors used to construct line items 7 through 11. If resource requirements in the budget year include non-recurring costs (e.g., one-time equipment purchases), describe how these resources will be reallocated in subsequent years.

Faculty Participation

The scientific diversity of the Center faculty across disciplines and departments reflects the breadth of neuroscience-related academic activity across UIC, and our desire to integrate diverse basic and clinical neuroscience research programs to address fundamental clinical problems. Our Center is designed to foster clinical services, clinical research, basic-clinical translational research integration, and educational programs in human and systems neuroscience. This structure aims to build linkages across neuroscience faculty without separating them from diverse home departments. This is crucial because in the field of neuroscience, faculty need linkage in their home department for professional development and methodological expertise as much as they need the collaboration of faculty in other Departments to move forward in innovative ways. Thus, salaries for faculty and their clinical and research staff, laboratory costs and space, and other research expenses are planned to be supported by external grants and existing departmental budgets. Similarly, the primary academic home of the Center faculty will remain with their primary Department, where salary, promotion and tenure decisions will be made.

Participating faculty are listed in the attached documents. Their participation in Center activities includes sitting on the three committees we maintain to govern our progress (executive, education, and clinical research integration). We coordinate several Center programs, including a weekly grand rounds/colloquium program on clinical behavioral neuroscience (Dr. Neil Pliskin), a weekly clinical neuroscience data presentation program (Dr. Pauline Maki), a weekly readings group on clinical neuroscience issues (Dr. Michael Schrift), and a weekly neuroimaging statistics methodology meeting (Dr. Sarah Keedy). Our faculty serves in various administrative leadership positions across campus:

Clinical ProgramsDirector of Inpatient Psychiatry (DeLeon) Director of Clinical Training in Psychology (Kassel) Director of Traumatic Brain Injury Clinic (Kraus)Director of Cognitive Rehabilitation (Laatsch)Director of Health Psychology (Labott)Director of Pediatric Neurology (Macmillan)Director of Pediatric Mood Disorders Program (Pavuluri)Director of the Neurobehavioral Program in Psychiatry (Pliskin)Director of Neuropsychology and Neurobehavioral Program in Psychiatry (Pliskin)

Revised: 05/01/0720

Director of Neuropsychiatry (Schrift)Director of Clinic for Learning and Neurodevelopment (Stanford)Director of Psychotic Disorders Program in Psychiatry (Weiden)

Research ProgramsDirector of Neural Control of Movement Laboratory (Corcos)Director of the Health Statistics Program (Gibbons)Director of Neuroimaging Research in Neurology (Little)Director of Clinical Research in Neurology (Nyenhuis) Director of Bipolar Disorder Research Program (Pavuluri) Director of Behavioral Neuroscience Division in Psychology (Ragozzino)Director of Behavior Sciences Animal Research Facility (Ragozzino)Research Director of Psychotic Disorders Program in Psychiatry (Sweeney)

Educational ProgramsDirector of Clinical Training in Psychology (Kassel)Co-Director of Clinical Psychology Internship Training (Labott)Director of Essentials of Clinical Medicine in Neurology (Macmillan)Director of Residency Training and Education Programs in Psychiatry (Marvin)Training Director, Clinical Neuropsychology Residency Program (Stanford)

The Center for Cognitive Medicine’s faculty serve as training faculty in doctoral degree granting programs at UIC in Psychology, Movement Sciences, Anatomy and Cell Biology, Bioengineering and Pharmacy Practice. Undergraduate teaching is an element of our commitment in most of these departments. Undergraduate students, graduate students, medical students, medical residents and postdoctoral fellows all receive training in our laboratories, conducting basic science and/or clinical research. Center faculty members play key roles in residency training in Psychiatry and Neurology. Many faculty members are active in the interdisciplinary PhD neuroscience program.

Our faculty provides diverse clinical services to patients living in the Chicago community, translating new findings into practice and conducting clinical research to study, and eventually enhance clinical diagnostic and treatment practices. Our clinical faculty maintains specialty research clinics in behavioral neurology/neuropsychiatry, first episode psychosis, pediatric mood disorders, traumatic brain injury, metabolic disorders associated with antipsychotic drugs, and neurodevelopmental disorders.

We maintain a Center website to inform patients and their families about our clinical programs and research studies. Another goal of the website is to inform the community about research advances in our programs and in laboratories across the world related to brain disorders.

We have linkages with the pharmaceutical industry and hope to develop them further. We conduct clinical trials of new medications or new applications of FDA-approved drugs, and serve on scientific advisory boards to drug companies as they plan

Revised: 05/01/0721

development of new treatments for brain disorders. We also consult regularly to various scientific journals as peer reviewers and as members of editorial boards. Our faculty members also sit on study sections for NIH, NSF, the VA, international funding agencies, and several private foundations, and serve on various boards for national professional organizations.

Budget Issues:The financial structure of the Center is supported through the home departments of the Center’s faculty. Administrative assistance, salaries, laboratory equipment and space are provided to Center investigators through existing mechanisms in their primary academic Department. This is working well and we see no reason to disrupt this status quo. State funds are currently used to support the salaries of key administrative positions in the Center. As a result, seeking direct indirect cost recovery (ICR) to the Center at this time is not necessary. And, from a practical perspective, engaging in struggles with multiple University Colleges and Departments over the control of ICR simultaneously would be highly disruptive to the flexible and collaborative interactions that are crucial to our success.

Some Centers and Institutes at UIC are structured in no small part to provide a mechanism for direct ICR recovery to research groups, and to maintain independence from existing departmental structures for various reasons. Reasonable ICR is already directed to our Center faculty from their home Departments, and none of our faculty desires operational separation from their home Department. Our faculty needs to maintain a strong position in their existing departmental structures for their long term scientific and professional success. Since we view our share of ICR recovery from Departments as reasonable, we do not want to pursue this path. Instead, we developed a Center organizational structure that facilitates our success by fostering interdepartmental organization and diversity while at the same time maintaining faculty integration and location in their home academic department. Department leaders and Center faculty are all in agreement that this is the best strategy for us to move forward.

Research support for Center faculty comes primarily from external grant funds, as outlined in the attached summary of existing funding to Center faculty. We believe our Center model will facilitate our ability to be even more successful in obtaining external support. The initial establishment of the Center has been primarily through state money through the Department of Psychiatry and indirect cost recovery from the Provost as part of the star recruit of the Center’s Director (Dr. Sweeney).

In the future, we may consider submitting NIH applications for fellowship programs (T32) through the Center to provide funds for more postdoctoral fellows to work with Center faculty, and potentially Center grant and shared equipment grant proposals to NIH.

The laboratories we need to do our work are established and functional. Faculty members that conduct animal work are either in new or recently refurbished space. The pharmacogenetics lab was recently established little more than a year ago, and already we

Revised: 05/01/0722

have three grants funded for this work and have had to buy additional –80 deg. freezers to store blood and a computerized tube labeling system for safer storage supported with funds across Colleges. Clinical space is always extremely difficult to find at the hospital, especially for a program such as ours that has largely grown de novo over the past five years. Approximately two-thirds of the Center faculty joined UIC within the past five years, often with the Center as a hub for collaboration that was crucial in recruitments. Most of these recruitments were new lines, not replacement for existing lines, so it has led to some space compression for faculty in our clinical departments. However, much as we would like to have more space, the fact is that without a new building for the hospital, there simply is not clinical space to be had. And, we need to be in clinical space to take care of patients in our research protocols and general clinical practice. Most importantly, we have the absolutely necessary clinical space that we need to function effectively, but space limitations for clinical services are certainly at times problematic.

As to major equipment, our faculty’s three animal labs were just fully established and are state of the art. For clinical research, we have three linked and redundant computer servers for data storage and image analysis maintained across the Departments of Psychiatry, Neurology and Movement Science. These are adequate in computational power (more than 70 total nodes on Beowulf clusters) and storage capacity (nearly 15 Tb) for our work.

For the future, new human neuroscience technologies are developing, and as that happens we will want to have access to them in the Center to keep our clinical research at the cutting edge. This typically involves ways to monitor brain anatomy and function. Our current 3 Tesla MRI system is nearing the end of its utility cycle as a research tool. Nearly all the funded human brain MRI studies at UIC are led by our Center faculty. We are beginning to consider applying together for a shared instrumentation grant to support the purchase of a new 3 Tesla MRI system for human research work fully dedicated to research use by Center faculty. This will greatly improve our access to scanners for research studies (the existing scanner is now shared 50% or more with clinical programs), and access to the scanner for students learning to conduct brain imaging research. Current charges at approximately $400/hr ($600/study) for scan costs makes it nearly impossible for students to learn MRI applications, which accounts in an nontrivial way to the failure of the east campus at UIC to become involved in human brain imaging, something most Psychology Departments and BioE departments actively pursue. In fact, many Psychology Departments are now purchasing their own MRI systems, and to that degree our educational programs are beginning to fall behind in competitiveness. In a related way, the lack of sufficient time to unfunded pilot approaches for new lines of work limits our future research potential. Housing a new 3T system in the Center would facilitate access, education, and get us back at the cutting edge of imaging technology. If we pursue this course, an idea still only in the initial phases of consideration, we will need some institutional commitment for support by way of appropriate space for the system, but such a request is some time off.

Other costs depend on the ongoing development of imaging technology, such as: 1) arterial spin labeling hardware for MRI to permit quantitative blood flow measurements,

Revised: 05/01/0723

2) high density EEG systems (128 or 256 leads) to monitor brain activity at high temporal resolution to delineate the sequences of how the brain processes and transfers information during complex cognitive activity and action planning, 3) support for positron emission tomography studies to measure cerebral metabolism or protein/receptor binding, 4) transcranial magnetic stimulation, and 5) near infrared blood flow monitoring at the cortical surface. These are all longer term options, and our decisions to move forward with them will depend on ongoing technology development, cost/benefit considerations, and faculty scientific interests.

Space:Research space available to Center faculty through departmental structures is adequate at this time. Because the space is departmental, the locations are diverse. Basic behavioral and systems neuroscience research with animal models is conducted in the basement of the Biological Science Building (BSB) (Psychology) and in the new biomedical sciences building at the medical school (Anatomy and Cell Biology). This keeps these investigators close to their animal colonies, and near multiuser laboratory equipment. The laboratory for pharmacogenetic research is housed in the College of Pharmacy, where shared equipment is also needed for drug level and gene analysis. The motor control laboratory in Movement Sciences is in the basement of the College of Allied Health Sciences building. It is a large and outstanding laboratory, housed where interaction with diverse motor control and physical therapy programs which are immediately nearby can be readily fostered. Clinical investigators need to run clinics in space approved for patient care (and so certified by the State), which includes the NPI (Neuropsychiatric Institute) building for Psychiatry (three floors in the South wing (2, 7 and 8 are fully devoted to Center clinical and clinical-research missions) and Neurology (floors 1, 7 and 8 on the North wing) as well as the Stroke Center space for some Neurology faculty who are members of our Center.

Additional information on space used by Center’s faculty:

The Pharmacogenetic Laboratory is located in the College of Pharmacy and directed by Dr. Jeff Bishop. This 1300 square foot facility is in close proximity to NPI (across the street) and is fully equipped for long term DNA storage and for conducting pharmacogenetic analyses.

The Psychiatric Inpatient Unit is located at the University of Illinois Medical Center at Chicago and directed by Dr. Ovidio DeLeon. The 34-bed unit is connected by an indoor overhead bridge to NPI, and has 700 dedicated research days/yr. provided by funds for Center investigators.

Anatomy and Cell Biology: The lab space for Dr. Fall is approximately 800 sq. ft and is located in the new College of Medicine Research Building. It is equipped for state of the art physiological imaging and three systems for electrophysiology of brain slice preparations, one being a real time confocal device.

Revised: 05/01/0724

Psychology: Mitchell Roitman’s laboratory, consisting of 1600 sq. ft of lab space, has a 16 channel Multichannel Acquisition Processor from Plexon Incorporated and accessories. This system permits the simultaneous recording of many individual neurons and electromyographic activity in awake and behaving rats. In addition, Dr. Roitman has 2 in vivo electrochemical stations to perform fast-scan cyclic voltammetry. This technique permits measurement of neurotransmitter release in real-time. These state-of-the-art stations are used in conjunction with 4 Med-Associates behavioral chambers so that stimuli can be delivered to rats in a carefully controlled manner and behavioral, neurophysiological and neurochemical responses can be recorded. Dr. Roitman also has a Kopf stereotaxic instrument, Narishige vertical electrode puller and other equipment for the fabrication of voltammetry electrodes. Finally, Dr. Roitman has an in vitro electrochemical station located in the laboratory of Dr. Chris Fall to measure electrically-evoked neurotransmitter release in brain slices. Michael Ragozzino has 1100 square feet of laboratory space including rooms set aside for small animal surgery and behavioral testing in the Department of Psychology. The major equipment in his laboratory include two high-pressure liquid chromatography machines for assaying acetylcholine and monoamines. There are also two separate microdialysis set-ups for collecting brain neurotransmitters in awake and behaving animals. He has one stereotaxic frame for conducting surgery for rats and mice, and one cryostat for sectioning brain tissue. The laboratory is equiped with a fume hood used for surgical and histological procedures, and for behavioral testing has 4 cross-mazes, 2 eight-arm radial mazes and one 12-arm radial maze. The laboratory contains one pH meter, a microscale, two water filtration systems for deionized and distilled water and two vortex machines for mixing different solutions.

Center for Stroke Research (CSR): The CSR is a 9,000 square foot complex located within walking distance of the University of Illinois Medical Center. The CSR includes four fully equipped patient examination rooms, two conference rooms, laboratory equipped with refrigeration and centrifuge equipment, computer resources and office space for study personnel. The CSR houses the neuropsychology, neuroepidemiology, data management units, and computing resources for data analysis and image analysis for the Department of Neurology and Rehabilitation (including resources for Drs. Little, Nyenhuis and Pedelty).

Planned increments in resource requirements:

There are no immediate fiscal needs for the Center. With the future growth, there may be needs in coming years for greater administrative assistance, and perhaps for purchasing large pieces of shared equipment as new approaches for human brain research are developed. We expect to seek funding for such equipment via federal shared equipment grants. We hope to be able to meet these needs via donors and external funding, but at some point we may need to seek additional funding from the University. We do not see that eventuality on the near term horizon.

New state resources required: None at this time.

Revised: 05/01/0725

o Focusing purely on research activities, at the time of the preparation of this application, the approximate total of the unit’s annual research budget of $10,234,060 is accrued from the following sources (details of total direct dollars in Appendix D):

Federal (NIH): $7,633,489Drug Companies: $ 569,834Foundations $ 307,258State: $1,723,479

This leaves a ratio of external to internal funds of 4.9, which is a positive number in the context of current NIH funding levels and the fact that we are a young program both in the duration of our unit’s organization and youth of most of our faculty.

There are two additional relevant points that are important to note. First, the fiscal estimates provided above are based on our research activities, and do not include effort or cost recovery from clinical work (which is approximately 268 hrs/wk in Psychiatry, 95 hrs/wk in Neurology, 24 hrs/wk in Pharmacy, and 5 hrs/wk in Psychology) or teaching (for which funding streams pay faculty salaries through traditional departmental funding mechanisms), which represent the primary funding stream for many of our faculty. Thus, funding for the unit’s activities is larger than the estimates provided above.

Second, of the total $1,723,479 state dollars/yr. that supports the unit’s current activities, all but $120,000 comes through the Department of Psychiatry. The Psychiatry department receives state funding directly to support mental health research as part of the transition of the Illinois State Psychiatric Institute to UIC approximately 10 years ago. This follows the historical funding pattern in the United States, in which states typically have accepted a special responsibility for funding and supporting research to improve mental health in their populations. The Psychiatry Department has generously allocated a portion of these state funds to support the development and operation of the Center for Cognitive Medicine. At present, about $950,000 directly supports the Center to cover costs such as administrative assistance, faculty salaries, equipment expenses and some support staff for the cognitive, neurophysiological and neuroimaging research programs in Psychiatry. The Department provides an addition amount equal to approximately half that amount for Dr. Gibbons’ group of statisticians in our Department. These funds provide salary support for faculty who are active collaborators to our group by way of analyzing data from clinical trials and developing new statistical approaches for analyzing functional brain imaging data. While their activities extend far beyond this Center’s mission, we list it as part of our estimated annual $1.7 million state dollars because of their group’s many close collaborations with our Center’s program. This contribution to our Center from the Psychiatry Department accounts for the large representation of Psychiatry faculty who are hired and supported with Center funds. Essentially the state funds were leveraged

Revised: 05/01/0726

to hire junior research faculty, whose success freed funds to recruit new faculty in Psychiatry. A parallel level of funding for faculty members from other departments is currently not available, though faculty members in other departments who are part of the Center are actively and strongly supported by their home department’s fiscal resources. It is important for us to state and express our appreciation for the support Deans and Chairs/Heads of Departments to the academic programs of participating Center faculty. This has been generous with regard to start up packages and funds to support the increasingly interdepartmental success of faculty in the Center.

We recognize that the funding strategy for the Center is atypical (we are accepting a share of indirect costs provided through department mechanism rather than asking for a direct transfer of such funds to the Center – or for additional funds to initiate a new Center). In part, this reflects the wide diversity of fields contributing to the field of neuroscience from basic animal research to its eventual clinical application, and the need for nimble flexibility in this new dynamically developing field. Faculty members from four Colleges at UIC participate in the Center, including Medicine (Psychiatry, Neurology, Anatomy and Cell Biology), Allied Health Sciences (Movement Sciences), Pharmacy (Pharmacy Practice) and Arts and Sciences (Psychology). Trying to move faculty to a common space, or direct ICR from home departments and colleges, would in our mind simply strain what now are very effective linkages of faculty with their home departments with far too little potential benefit. In short, this is not an area where the diverse faculty need or want to move into a Center from their home department, or where protracted contentious negotiations over ICR costs will help us since the Departments are giving us a reasonable component of their ICR recover already. For clinical neuroscience research programs to prosper long term, they need BOTH strong linkages to home Departments and strong linkages to interdisciplinary Centers. It is a somewhat atypical nature of our broad new field, and one reflected in our strategies for the proposed structural organization of our Center.

At this point, our faculty needs a structure that will foster career development, serve as a platform for training and center grant applications, and facilitate academic work in a field that needs to be highly interdisciplinary to function at the highest level. To do this, we believe our Center organization optimally builds on the intellectual and technical expertise of UIC colleagues in the Center to the best advantage of Center faculty and the University. It respects departmental structures, and builds upon them. The organizational plan proposed for this Center provides the structure for interdisciplinary integration human/systems neuroscientists need, while maintaining linkages of this diverse group to their home department which retains responsibility for research space, salaries, and tenure/promotion decisions for all faculty members in the Center. This is the fastest way to move forward to successfully pursue our primary mission, and in our view is the most functional organizational strategy in the long term.

Revised: 05/01/0727

Planned increments in resource requirements:

There are no urgent fiscal needs for the Center at this time. With the growth of our Center, there will be needs in coming years for greater administrative assistance, more funds for postdoctoral fellow salaries, and perhaps for purchasing large pieces of shared equipment such as for high-density EEG or other human brain imaging equipment.

New state resources required: None at this time

10. Quality Assurance Processes

10.1. Briefly describe the processes that will yield evidence to demonstrate the quality of the unit. Address the following elements:

The unit embraces the university’s mission of teaching, research, service and economic development through its research endeavors, academic training programs and community service initiatives.

o Our interdisciplinary design and program mission supports increased collaboration among our faculty, and provides the infrastructure necessary to conduct novel research to improve the quality of patient care. Teams of clinical investigators, physicians and basic scientists work together to develop new treatment paradigms for treating cognitive and behavioral problems caused by brain disorders and normal aging. Knowledge gained from collaborative efforts is translated into improved clinical care for patients treated in our specialty clinics (First Episode Psychosis Clinic, Cognitive Neuropsychiatry Clinic, Metabolic Disorders Clinic, Pediatric Mood Disorders Clinic and Traumatic Brain Injury Clinic) and to other hospitals across the world.

o Center faculty members, as part of their commitments to their home department, participate in a wide variety of educational programs for undergraduates, medical students, graduate students, and resident physicians. Faculty members participate in and direct training programs in the Departments of Neurology, Psychology, Anatomy and Cell Biology, Pharmacy Practice and Movement Science. Professional continuing education opportunities are available through our clinical neuroscience seminars, geropsychology seminars, fMRI methodologies seminar, and weekly fMRI journal club, as well as those we provide at national meetings. We also run a highly regarded weekly colloquium program on clinical aspects of behavioral neuroscience whose regular attendance has grown so dramatically that it has nearly outgrown the NPI auditorium.

o Community service is at the forefront of our mission. We provide therapeutic and educational resources to family members and patients who are seen in our clinics. We work with community partners to co-sponsor

Revised: 05/01/0728

events and support activities for families impacted by neurodevelopmental disorders such as autism and serious mental illness.

Evidence that the unit’s product or outcomes achieve stated objectives;

The primary metric for our Center’s success is in its development of interdepartmental collaboration that fosters new avenues of faculty exchange and research into the diagnosis and treatment of brain disorders. Examples of such integrative efforts include the following grant applications, some of which will be funded and others are or will soon be submitted:

o Excellence for Autism: Interdisciplinary Studies of Insistence on Sameness in Autism (Center Director, E. Cook; Co-Director: J. Sweeney; other participating Center faculty include Drs. Pavuluri and Ragozzino). – Funding to begin in June 07.

o Role of the Cortex and Cerebellum in Visually-Guided Motor Behavior. (D. Vaillancourt, PI, with Drs. Sweeney and Corcos) – pending

o Clinical and Computational Studies of Dopamine Function in Schizophrenia. (E Herbener and J Sweeney). To be funded

o Genetics of Cognition. (P Maki and J Bishop). To be funded.

o Our group now regularly submits more than 5 NIH applications per round of submissions, with the majority of applications combining the interdisciplinary strengths of Center faculty.

Determination of organizational effectiveness in clinical programs;

Currently, we treat approximately 2900 patients per year in our clinics. The numbers continue to grow.

Faculty and staff qualifications and reward structures;

We recruit physicians, scientists and clinical investigators with MD and/or PhD degrees who have a strong interest in cognitive disorders or normal aging, and an interest in contributing to the mission of the unit. All Center members are UIC faculty members, but this may change as our cross-university integration continues to grow. Our Center structure has and will enhance recruitment efforts in multiple Departments across the University. Monetary incentives and reward structures for faculty and staff are handled at the department level.

Determination of adequate support staff, equipment, and other resources;

Revised: 05/01/0729

Administrative support to manage grants is provided by the primary departments of each faculty member. Use of shared services and interdepartmental collaborations will be coordinated by the Center. Determination of adequate support will be decided by the Executive Committee, or any subcommittee that it may authorize. However, research staff, administrative assistance, laboratory space and other resources are provided to the Center’s investigators through existing mechanisms in their primary department.

Use of results from evaluations to improve the unit’s effectiveness.

The unit’s Executive Committee, or any subcommittee of the Executive Committee that it may authorize, shall define the expected results that will be used to improve the effectiveness of the Center.

Evaluation of expected results will be accomplished through production of high impact publications reflecting interdisciplinary integration, increased success in obtaining external funding for our Center projects, improved quality of clinical services provided to patients with brain disorders, increased involvement in interdisciplinary educational programs, and increased community outreach activities.

Revised: 05/01/0730

Appendices for Center of Cognitive Medicine Application

Appendix A Peer Reviewed Papers by Center Faculty

Appendix B Teaching/Supervisory Activity of Center Faculty

Appendix C State Dollars Supporting Center for Cognitive Medicine Faculty

Appendix D Current Grant Funding to Center for Cognitive Medicine Faculty

Appendix E Number of Academic Program Staff Members Working with Center Faculty

Appendix F Research Grant Dollars per CCM Faculty

Appendix G Clinical Responsibilities of Center Faculty

Appendix H Center Faculty and Their UIC Academic Appointments

Revised: 05/01/0731

Table II

TOTAL RESOURCE REQUIREMENTS FOR THE NEW UNIT

Current Budget 2nd 3rd 4thYear Year Year Year Year

1 Total Resource Requirements 10,234,060 10,234,060 10 mil. 10 mil. 10 mil.

2 Resources Available from Federal Sources1

7,633,489 7,633,489 7 mil. 7 mil. 7 mil.

3 Resources Available from Other Non-State Sources1

877,092 877,092 800K 800K 800K

4 Existing State Resources2 1,723,479 1,723,479 1.7 mil 1.7 mil 1.7 mil

5 Resources Available through Internal Reallocation3

0 0 0 0 0

6 New State Resources Required4 0 0 0 0 0

Breakdown: New State Resources Required

0 0 0 0 0

7 FTE Staff5 0 0 0 0 0

8 Personal Services 0 0 0 0 0

9 Equipment and Instructional Needs 0 0 0 0 0

10 Library 0 0 0 0 0

11 Other Support Services6 0 0 0 0 0

1These lines reflect funds available (not incremental funds) from non-state sources in any given year2Existing state resources in each successive year are equal to the sum of the previous year’s existing state resources (line 4); plus resources made available through internal reallocation (line 5); plus new state resources (line 6). If state resources allocated to a program in any given year (line 4) exceed state resource requirements needed to support the program in the following year, state resource requirements should be reduced with a negative dollar adjustment on line 5. The sum of lines 2 through 6 will always equal line 1.3Numbers can be either positive (allocated to the program) or negative (allocated away from the program).4Reflects the level of state funding requested in the referenced year. Dollars reported are incremental.5Reflects the number of FTE staff to be supported with requested funds. Not a dollar entry.6Other dollars directly assigned to the program. Do not include allocated support services.

Revised: 05/01/0732

Appendix APeer Reviewed Papers by Center Faculty (2004 – 2006)

Revised: 05/01/0733

Investigator Peer Reviewed Papers (in press, under review, or published)

Baslet, Gaston 1Bishop, Jeff 10

Corcos, Daniel 21DeLeon, Ovidio 0

Fall, Chris 5Gibbons, Robert 16Herbener, Ellen 11

Hill, Scot 12Kassel, Jon 13

Keedy, Sarah 4Kraus, Marilyn 2Laatsch, Linda 8Labott, Susan 4Little, Deborah 12

MacMillan, Carol 4Maki, Pauline 15Marvin, Robert 0

Nyenhuis, David 10Pavuluri, Mani 20Pedelty, Laura 0

Pliskin, Neil 7Prensky, Eric 0

Ragozzino, Michael 6Reilly, James 4

Roitman, Michael 8Schneiderhan, Mark 1

Schrift, Michael 2Shankman, Stewart 10

Stanford, Lisa 2Sweeney, John 61

Vaillancourt, David 18Weiden, Peter 9

Papers 296

Appendix B: Teaching/Supervisory Activity of Center FacultyInvestigator Course Lecture

yearlySupervision

Clinical (students/wk)

Supervision Masters students

Supervision

students

Baslet, Gaston Psychopharmacology Seminar - PGY - 2 4

Baslet, Gaston (con’t)

Essentials of Clinical Medicine Mental Status Workshop - 2nd year Medical Students 2

Baslet, Gaston (con’t)Introduction to Psychopharmacology – PGY –1 COURSE

Baslet, Gaston (con’t)Neuropsychiatric Clinic (M3, M4, PGY-3) 1

Bishop, Jeff

PHAR403 Pharmacology Drug Action and Therapeutics in Psychiatry for PharmD students 20 wks COURSE

Bishop, Jeff (con’t)BPS555 Pharmacogenomics for Graduate Students 20 wks COURSE

Corcos, DanielMovement Science 502 Graduate Students Fall COURSE

Corcos, Daniel (con’t)

Movement Neuroscience 472 Undergraduates and Graduate Students Spring COURSE

DeLeon, Ovidio Suicide (3rd yr medical students) 6    DeLeon, Ovidio (con’t) Psychopathology (PGY 2) 4    DeLeon, Ovidio (con’t) Neuropsychiatry Seminar (PGY 4) 2    DeLeon, Ovidio (con’t) Emergency Psychiatry 4    

DeLeon, Ovidio (con’t)

Psychiatry Clerkship for Medical Students – 2 students per rotation 6 rotations

2 students per rotation – 6 rotations/yr  

DeLeon, Ovidio (con’t)

Inpatient Psychiatry (PGY-1 5/yr 2 month rotation; PGY-2 4/yr 3

 

Revised: 05/01/0734

Investigator Course Lecture yearly

Supervision Clinical

(students/wk)

Supervision Masters students

Supervision

students

month rotation)

DeLeon, Ovidio (con’t)

Psychotherapy Supervision (PGY2, PGY3, PGY4 – one hour weekly/one per year)    

DeLeon, Ovidio (con’t)

Inpatient Psychosis PGY-4 (2/yr /6 month rotation)    

DeLeon, Ovidio (con’t)

Emergency Psychiatry PGY-4 (2 yr/6 months rotation)    

Fall, Chris Neuroanatomy - 8 weeks COURSEFall, Chris (con’t) Graduate Student MentoringGibbons, Robert None

Herbener, EllenClinical Research Methods PGYIII (10 weeks) COURSE 2

Herbener, Ellen (con’t) Limbic System (medical students) 1Hill, Scot None 4

Kassel, JonClinical Interventions (doctoral students in clinical psychology) 2 4

Keedy, Sarah Neuroanatomy Seminar COURSE 2Kraus, Marilyn Brain Behavior COURSE 1Laatsch, Linda None 2 3 3

Labott, Susan Health Psychology Seminar 5 5

Little, Deborah

Gross Human Neuroanatomy Laboratory (medical students - 10 weeks yr) COURSE

Little, Deborah (con’t) Neuroimaging – Residents 3/yr

Little, Deborah (con’t) Neuroanatomy – Residents 2/yr

Little, Deborah (con’t) Neuroanatomy - Interns 2/yr

Revised: 05/01/0735

Investigator Course Lecture yearly

Supervision Clinical

(students/wk)

Supervision Masters students

Supervision

students

Little, Deborah (con’t) MRI Physics 5

Little, Deborah (con’t) Human Neuroscience COURSE

Little, Deborah (con’t) None 3

Macmillan, CarolM2 Neurology Essentials of Clinical Medicine Workshops COURSE 3

Maki, PaulinefMRI Journal Data group (medical/graduate students) COURSE 3

Maki, Pauline (con’t)

Seminar in Cognitive Psychology PSCH 558 “Hormones and Behavior”

COURSE+4

lectures outside

of weekly course

Marvin, RobertM2 Behavioral Science - Psychotic Disorders

2 Lectures

Marvin, Robert (con’t)PGY2 Essentials of Modern Psychotherapy

COURSE 12

months

Marvin, Robert (con’t)PGY3 Introduction to Evidence Based Medicine

COURSE 4 months

Marvin, Robert (con’t)PGY2 Psychopathology Dissociative Disorders

2 Lectures

Marvin, Robert (con’t) PGY3 Intake Clinic Supervision 2

Marvin, Robert (con’t)PGY3 Psychosis Clinic Supervision 2

Marvin, Robert (con’t)M3, M4, PGY1, PGY2, PGY3, Morning Report 10

Marvin, Robert (con’t)M3, PGY3, PGY4 Continuity Clinic Supervision 6

Revised: 05/01/0736

Investigator Course Lecture yearly

Supervision Clinical

(students/wk)

Supervision Masters students

Supervision

students

Marvin, Robert (con’t)PGY2, PGY3, PGY4 Psychotherapy Supervision 2

Marvin, Robert (con’t) DMH Grand Rounds

Marvin, Robert (con’t)Lectures to campus and local organizations

Nyenhuis, David None 8 2

Pavuluri, ManiHuman Development (medical students) 2

12 bedside and individual supervision combined)

Pavuluri, Mani (con’t) Neurobiology-child (fellows) 2

Pavuluri, Mani (con’t) Research Methods (residents) 1

Pavuluri, Mani (con’t)Mood Disorders Series (Residents) 4

Pavuluri, Mani (con’t) Psychopathology (fellows) 2

Pavuluri, Mani (con’t)Treatment of Mood Disorders (fellows) 6

Pedelty, Laura

Clinical Neurology Series:Overview of the Dementias; Introduction to the Neurobehavioral Examination; Overview of Cognitive Neuroanatomy 12 2

Pliskin, NeilGeropsychology Distance Course: Neuropsychology COURSE 8

Pliskin, Neil (con’t) Brain and Behavior 3

Pliskin, Neil (con’t)Introduction to Psychological Assessment

Pliskin, Neil (con’t)Applied Neuropsychology Seminar 30

Pliskin, Neil (con’t)Behavioral Neurosciences Seminar 30

Pliskin, Neil (con’t) Geropsychology Seminar 4

Pliskin, Neil (con’t) Geriatric Psychiatry Seminar 1Pliskin, Neil (con’t) Neuroanatomy 2Pliskin, Neil (con’t) Medical Neuroanatomy 1

Revised: 05/01/0737

Investigator Course Lecture yearly

Supervision Clinical

(students/wk)

Supervision Masters students

Supervision

students

Pliskin, Neil (con’t) Professional Issues Seminar

Prensky, EricMental Status Workshops (residents) 2 1

Prensky, Eric (con’t) Health Psychology Seminar 3

Ragozzino, MichaelCurrent Issues in Behavior Neuroscience COURSE 1

Ragozzino, Michael (con’t)

Neural Basis of Learning & Memory COURSE

Reilly, James Neuroanatomy seminar 1 2  

Reilly, James (con’t)Applied Neuropsychology seminar 1

Reilly, James (con’t) Adult Neuropsychology Practicum 3

Roitman, Mitchell

PSCH 262 Introduction to Physiological Psychology (undergraduate). Taught in fall semester (15 weeks) COURSE

Roitman, Mitchell (con’t)

PSCH 363 Laboratory in Physiological Psychology (undergraduate) COURSE

Schneiderhan, Mark PGY4 Clerkship Rotations

Schneiderhan, Mark (con’t)

Pharmacology of Drug Action and Therapeutics in Psychiatry PHAR 403 COURSE 18

Schrift, MichaelNeuropsychiatry/Psychopathology(Year long, weekly) COURSE 6

Schrift, Michael (con’t)Advanced Psychopharmacology - Psychiatry Residents PGY-3 24

Schrift, Michael (con’t)Behavioral Neurology & Neuropsychiatry Course PGY-3 12

Schrift, Michael (con’t)Evidenced – Based Literature Seminar PGY 1-4 monthly 12

Schrift, Michael (con’t)Introduction to Brain & Behavior PGY-1 12

Schrift, Michael (con’t)Clinical Supervision of Psychiatry Residents PGY-3&4 3

Revised: 05/01/0738

Investigator Course Lecture yearly

Supervision Clinical

(students/wk)

Supervision Masters students

Supervision

students

Schrift, Michael (con’t)Neuropsychiatry of Conversion Disorder

Schrift, Michael (con’t)Introduction to Behavior Neuroscience COURSE

Schrift, Michael (con’t)Lecturer, Brain Behavior Course, M2

Schrift, Michael (con’t)

Neuropsychiatry Clinic and Consultation Service PGY-3&4 Residents

Schrift, Michael (con’t)

Neuropsychiatry Clinic and Consultation Service M3-M4 Medical Students

Shankman, StewartStatistics for Psychology for Undergraduates (semester) COURSE 3

Shankman, Stewart (con’t)

Psychopathology for Graduate Students (semester) COURSE

Stanford, LisaApplied Neuropsychology Assessment Seminar COURSE 9

Stanford, Lisa (con’t)Post-Doc Professional Development Seminar 12

Stanford, Lisa (con’t) Neuropsychological Assessment 12Stanford, Lisa (con’t) Neuroanatomy Seminar 2

Stanford, Lisa (con’t)Neuropsychological Case Conference COURSE

Stanford, Lisa (con’t) Brain Behavior, MS1 1

Sweeney, JohnBrain and Behavior course, MS1, annual lectures 1 1 2

Sweeney, John (con’t)

Clinical Research Methodologies, PGY II Psychiatry Residents

12

Sweeney, John (con’t)Cognitive and Behavioral Assessment, Psych 573 COURSE

Vaillancourt, DavidNEUS 588 Functional MR Imaging Lecture 1

Revised: 05/01/0739

Investigator Course Lecture yearly

Supervision Clinical

(students/wk)

Supervision Masters students

Supervision

students

Vaillancourt, David (con’t)

MVSC 501 – Current Research in Movement Science – Graduate class COURSE

Vaillancourt, David (con’t)

MVSC 472 - Movement Neuroscience Undergraduates and Graduates COURSE

Weiden, Peter

None yet – NEW TO UICPlanned courses include:

CBT for Psychosis

Advanced Topics in Psychopharmacology

Assessment and Management of Medication Noncompliance in Psychiatric Disorders COURSE

Revised: 05/01/0740

Appendix CState Dollars Supporting Center for Cognitive Medicine Faculty

Investigator Use of Funds $ per yearBaslet, Gaston None 0

Bishop, Jeff

Pharmacogenomics Lab Operations from College of Pharmacy 90,000

Corcos, Daniel None 0DeLeon, Ovidio None 0Fall, Chris None 0

Gibbons, RobertHealth Statistics Program Funds From Psychiatry 500,000

Herbener, Ellen None 0Hill, Scot None 0Kassel, Jon None 0Keedy, Sarah None 0Kraus, Marilyn None 0Laatsch, Linda None 50,000

Labott, SusanClinical Psychology Intern Stipends from Psychiatry 15,000

Little, DeborahDean's Start Up Package, College of Medicine 30,000

Macmillan, Carol None 33,479Maki, Pauline None 0Marvin, Robert None 0Nyenhuis, David None 0Pavuluri, Mani Faculty Salary from Psychiatry 20,000Pedelty, Laura None 0Pliskin, Neil None 0Prensky, Eric None 0Ragozzino, Michael

None0

Reilly, James None 0Roitman, Michael None 0Schneiderhan, Mark

None0

Schrift, Michael None 0Shankman, Stewart

None35,000

Stanford, Lisa None 0

Sweeney, John

Center for Cognitive Medicine Funds From Psychiatry for Academic, Educational and Clinical Activities 950,000

Vaillancourt, David None 0Weiden, Peter None 0  Total Dollars per Year 1,723,479

Revised: 05/01/0741

(blank page)

Revised: 05/01/0742

Appendix D: Current Grant Funding to Center for Cognitive Medicine Faculty

Investigator Grant Name Grant Type Begin Fund End Fund

Total Direct $$

Baslet, Gaston None N/A N/A N/A 0Bishop, Jeff ACCP Frontiers Career Development

AwardFoundation 7/1/06 12/31/08 30,000

Bishop, Jeff ACCP Investigator Development Central Nervous System Award

Foundation 10/1/06 9/30/07 20,000

Bishop, Jeff WIHS Subcontract (Co-PI with Pauline Maki

Federal Grant

4/15/07 12/31/07 28,860

Bishop, Jeff UIC Campus Research Board Foundation 7/1/06 6/30/07 12,258

Corcos, Daniel STN Stimulation Neural Control of Movement and Posture

Federal Grant

9/1/05 8/31/10 1,156,250

Corcos, Daniel Motor Deficits - Experimental and Clinical Correlates

Federal Grant

1/1/93 2/28/07 1,043,147

Corcos, Daniel Age of Onset: Neurophysiological Determinants of Disease Progression

Federal Grant

pending pending 0

Deleon, Ovidio Double Blind Placebo Controlled Investigation of Lamotrigine in the Treatment of Psychosis in subjects with Dementia

Drug Company

12/1/04 11/30/06 126,360

Deleon, Ovidio Double Blind Placebo Controlled Study Evaluating the Efficacy and Safety of Lamotrigine Treatment in Subjects with Mild to Moderate Alzheimer's Disease

Drug Company

12/1/04 11/30/06 126,360

Fall, Chris MH64611 Federal Grant

9/1/02 8/31/07 640,000

Fall, Chris NARSAD Foundation 9/1/06 8/31/08 60,000

Revised 05/01/0743

Investigator Grant Name Grant Type Begin Fund End Fund

Total Direct $$

Fall, Chris UIC-CRB University 9/1/06 8/31/07 10,000Gibbons, Robert Multimodal Treatment Study of

Children with ADHDFederal Grant

2/1/01 1/31/07 754,762

Gibbons, Robert A Multivariate Probit Model for Health Services Research

Federal Grant

6/1/04 5/30/07 450,000

Gibbons, Robert Statistical Testing and Powser for MH Services Research

Federal Grant

5/1/05 3/31/08 450,000

Gibbons, Robert Computerized Adaptive Testing - Depression Inventory

Federal Grant

9/20/02 8/31/11 3,703,950

Gibbons, Robert Antidepressant Treatment and Suicidality:Biostatistical/Methodlogical Solutions

Federal Grant

9/30/06 8/31/07 150,000

Herbener, Ellen Affective Deficits in Schizophrenia Federal Grant

1/1/04 12/31/08 720,921

Hill, Scot Enhancing Cognition in Schizophrenia

Federal Grant

3/1/06 2/1/11 736,298

Kassel, Jon Smoking's Effect on Emotion in Adolescent Smokers

Federal Grant

9/1/05 8/31/09 1,000,000

Keedy, Sarah None N/A N/A N/A 0Kraus, Marilyn Neuropsychiatry of Traumatic Brain

InjuryFederal Grant

4/1/04 3/31/09 894,755

Laatsch, Linda None N/A N/A N/A 0Labott, Susan Underserved and Chronic Illness Federal

Grantpending pending 0

Labott, Susan The Effects of Cytochrome P450 (CYP) 2D6 Genotype on Pain Management with Codeine in Sickle Cell Disease

University 1/1/07 12/31/07 49,979

Labott, Susan Geropsychology Education at UIC Federal 7/1/03 3/1/07 400,000

Revised 05/01/0744

Investigator Grant Name Grant Type Begin Fund End Fund

Total Direct $$

GrantLabott, Susan Emotional Risks of Survey Research Federal

Grantpending pending 0

Little, Deborah Role of Feedback to Facilitate Category Learning

Federal Grant

8/1/04 12/31/06 76,058

Little, Deborah Anatomical Correlates of Executive Function Decline in Normal Aging

Federal Grant

7/1/07 6/30/09 405,487

Macmillan, Carol Multicenter Trial of Vitamin E in Aging Persons with Down Syndrome

Federal Grant

2004 2007 9,375

Maki, Pauline Botanical Menopausal Therapies Mechanisms of CNS Action

Federal Grant

8/15/04 7/14/09 653,884

Maki, Pauline Effects of Botanicals on Cognition in Midlife Women

Federal Grant

8/15/04 1/1/08 389,674

Maki, Pauline Effects of Botanicals on Cognition in Midlife Women

Federal Grant

8/1/03 1/1/08 50,000

Maki, Pauline Cognition, Brain Function, and Affect in Midlife HIV + Women: The Influence of Menopause

Federal Grant

12/1/04 12/30/06 122,355

Maki, Pauline WIHS Subcontract Federal Grant

4/15/07 12/31/07 28,860

Maki, Pauline Effects of Hormone Therapy on Cognition in Midlife Women

Drug Company

4/6/02 no cost extension

94,849

Marvin, Robert None N/A N/A N/A 0Nyenhuis, David Validation of the NINDS VCI

Neuropsychology Protocols Federal Grant

7/1/07 6/30/10 1,312,145

Pavuluri, Mani fMRI Study of Cognition and Affective Circuitry in PBD

Federal Grant

2003 2008 736,830

Pavuluri, Mani fMRI and Neurocognitive Effects of Lamotrigine in PBD

Drug Company

2005 2008 301,875

Revised 05/01/0745

Investigator Grant Name Grant Type Begin Fund End Fund

Total Direct $$

Pavuluri, Mani Collaborative Lithium Trials (COLT) Federal Grant

2006 2009 2,476,937

Pavuluri, Mani Genomics in PBD Foundation 2006 2007 25,000Pavuluri, Mani fMRI study of Focalin XR in Pediatric

Bipolar DepressionDrug

Companypending pending 0

Pavuluri, Mani fMRI study of Paliperidone in PBD Drug Company

pending pending 0

Pavuluri, Mani fMRI study of Quetiapine XR in Pediatric Bipolar Depression

Drug Company

pending pending 0

Pavuluri, Mani Quetiapine XR compared to abilify and risperidal in PBD

Drug Company

pending pending 0

Pavuluri, Mani Affective Neuroscience of PBD Federal Grant

pending pending 0

Pavuluri, Mani DTI and fMRI study of Neural Circuitry in PBD

Foundation pending pending 0

Pavuluri, Mani Mood disorders Program in the Community

Foundation pending pending 0

Pavuluri, Mani ADHD vs. PBD: fMRI Study of Neural Circuitry Function

Foundation 2006 2008 60,000

Pedelty, Laura None N/A N/A N/A 0Pliskin, Neil None N/A N/A N/A 0Prensky, Eric None N/A N/A N/A 0Ragozzino, Michael Striatal Acetylcholine and Behavioral

FlexibilityFederal Grant

7/1/03 6/1/07 375,000

Ragozzino, Michael The Effects of 5-HT4 Agents and Acetylcholinesterase Inhibitors on Cognition

Drug Company

12/1/05 4/1/07 330,000

Ragozzino, Michael Neurohormonal Regulation of Cocaine-Induced Behaviors

Federal Grant

6/1/07 5/1/11 1,000,000

Revised 05/01/0746

Investigator Grant Name Grant Type Begin Fund End Fund

Total Direct $$

(pending)Ragozzino, Michael Aging, Serotonin & Reversal Learning

(pending)Federal Grant

6/1/07 5/1/09 100,000

Ragozzino, Michael The Effects of 5-HT6 Antagonists on Cognitive Flexibility (pending)

Drug Company

4/1/07 6/1/08 83,000

Reilly, James Performance on Translational Attention and Working Memory Tasks in First Episode Psychosis Before and After Atypical Antipsychotic Treatment

Foundation 7/1/07 6/1/09 60,000

Roitman, Mitchell Rapid Da-Acb Signaling In Ingestive Behaviors

Federal Grant

9/10/04 6/30/09 490,000

Schneiderhan, Mark None N/A N/A N/A 0Schrift, Michael None N/A N/A N/A 0Shankman, Stewart Anticipating Reward & Threat: A Test

of Biobehavioral Processes in MDD vs. Anxiety.

Federal Grant

pending pending 0

Shankman, Stewart Sensitivity to Reward and Threat: An Examination of Neurobehavioral Processes

Foundation pending pending 0

Shankman, Stewart UIC Campus Research Board Grant University 6/30/06 7/1/07 11,758

Stanford, Lisa Julie Foundation Foundation 1/1/07 1/1/08 20,000Stanford, Lisa PKU Foundation Foundation 1/1/07 1/1/08 10,000Sweeney, John In Vivo Quantification of Myelination

in Autism and Related Disorders. Foundation 6/1/06 6/1/08 100,000

Sweeney, John Insistence on Sameness in Autism: fMRI studies

Foundation 3/1/06 2/1/07 50,000

Sweeney, John Autism Center of Excellence: Interdisciplinary Studies of Insistence on Sameness in Autism

Federal Grant

6/1/07 6/1/12 8,303,000

Revised 05/01/0747

Investigator Grant Name Grant Type Begin Fund End Fund

Total Direct $$

Sweeney, John Neurobiologic and Cognitive Mechanisms of Autism

Federal Grant

6/1/02 5/1/07 1,836,602

Sweeney, John Oculomotor & Spatial Cognition Deficits in Schizophrenia.

Federal Grant

7/1/01 6/1/07 1,200,000

Vaillancourt, David Scaling and Sequencing Motor Output in Humans: an fMRI Study

Federal Grant

8/1/05 7/31/09 800,000

Vaillancourt, David Role of the Cortex and Cerebellum in Visually-Guided Motor Behavior

Federal Grant

pending pending 0

Weiden, Peter None N/A N/A N/A 0   

34,076,589

Revised 05/01/0748

Appendix ENumber of Academic Program Staff Members Working with Center Faculty (excluding clinical program staff)

CCM Faculty Last

CCM Faculty

First

Full Time Research Assistants

Administrative Staff

Post Docs

Graduate Students

Medical Students

Baslet Gaston 0 0 0 0 0Bishop Jeff 1 0 0 0 0Corcos Daniel 0 0 0.5 2 0DeLeon Ovidio 1 0 0 0 0Fall Chris 0 0 1 1 0Gibbons Robert 2 1 2 2 0Herbener Ellen 1 0 0 0 0Hill Scot 1 0 0 0 0Kassel Jon 2 6 2 5 0Keedy Sarah 0 0 0 0 0Kraus Marilyn 1 0 0 0 0Laatsch Linda 0 0 0 0 0Labott Susan 0 0.5 1 0.2 0Little Deborah 2 0 0 0 0Macmillian Carol 0 0 0 0 0Maki Pauline 2 0 0 2 0Marvin Robert 0 0 0 0 0Nyenhuis David 0 0.33 1 0 0Pavuluri Mani 2.5 0.5 1 0.5 4Pedelty Laura 0 0 0 0 0Pliskin Neil 0 2 2 0 0Prensky Eric 0 0 0 0 0Ragozzino Michael 1.5 0 0 2 0Reilly James 0 0 0 0 0Roitman Mitchell 0 0 0 0 0Schneiderhan Mark 0 0 0 0 0Schrift Michael 0 0 0 0 0Shankman Stewart 0 0 0 1.5 0Stanford Lisa 2 0 2 7 1Sweeney John 9.5 2 1 3 2Vaillancourt David 0 0 1.25 1.5 0Weiden Peter 1 0 0 0 0

Totals 29.5 12.33 14.75 27.7 7

Revised: 03/27/07

Revised: 03/27/07

Appendix FResearch Grant Dollars per CCM Faculty (current or soon to begin, total over all years)

Investigator Total Direct $$Baslet, Gaston 0Bishop, Jeff 91,118Corcos, Daniel 2,199,397Deleon, Ovidio 252,720Fall, Chris 710,000Gibbons, Robert 5,508,712Herbener, Ellen 720,921Hill, Scot 736,298Kassel, Jon 1,000,000Keedy, Sarah 0Kraus, Marilyn 894,755Laatsch, Linda 0Labott, Susan 449,979Little, Deborah 481,545MacMillan, Carol 9,375Maki, Pauline 1,339,622Marvin, Robert 0Nyenhuis, David 1,312,145Pavuluri, Mani 3,600,642Pedelty, Laura 0Pliskin, Neil 0Prensky, Eric 0Ragozzino, Michael 1,888,000Reilly, James 60,000Roitman, Mitchell 490,000Schneiderhan, Mark 0Schrift, Michael 0Shankman, Stewart 11,758Stanford, Lisa 30,000Sweeney, John 11,489,602Vaillancourt, David 800,000Weiden, Peter 0Grand Total 34,076,589

Revised: 03/27/07

Revised: 03/27/07

Appendix GClinical Responsibilities of Center Faculty

Investigator Wkly hrs committed to patient care

Baslet, Gaston 35Bishop, Jeff 4

Corcos, Daniel 0DeLeon, Ovidio 30

Fall, Chris 0Gibbons, Robert 0Herbener, Ellen 2

Hill, Scot 0Kassel, Jon 4

Keedy, Sarah 20Kraus, Marilyn 15Laatsch, Linda 25Labott, Susan 15Little, Deborah 0

MacMillan, Carol 33Maki, Pauline 0Marvin, Robert 12

Nyenhuis, David 12Pavuluri, Mani 8Pedelty, Laura 30

Pliskin, Neil 28Prensky, Eric 25

Ragozzino, Michael 0Reilly, James 20

Roitman, Michael 0Schneiderhan, Mark 20

Schrift, Michael 30Shankman, Stewart 0.5

Stanford, Lisa 28Sweeney, John 0

Vaillancourt, David 0Weiden, Peter 20

 Total Hours 416.5

Revised: 03/27/07

Revised: 03/27/07

Appendix HCenter Faculty and Their UIC Academic Appointments

Investigator Primary Department

Secondary Department

Additional Secondary Department

Baslet, Gaston Psychiatry    

Bishop, JeffPharmacy Practice

Psychiatry  

Corcos, Daniel

Movement Sciences Physical

Therapy

Bioengineering, Neurology

DeLeon, Ovidio Psychiatry    

Fall, ChrisAnatomy and Cell

Biology Psychiatry 

Gibbons, Robert Psychiatry Biostatistics  Herbener, Ellen  Psychology Psychiatry  

Hill, Scot Psychiatry    Kassel, Jon Psychology    

Keedy, Sarah Psychiatry    Kraus, Marilyn Psychiatry Neurology  Laatsch, Linda Neurology    Labott, Susan Psychiatry    

Little, Deborah NeurologyAnatomy & Cell Biology

Ophthalmology & Visual Sciences

Macmillian, Carol Neurology Pediatrics  Maki, Pauline Psychiatry Psychology  Marvin, Robert Psychiatry    

Nyenhuis, David Neurology    Pavuluri, Mani Psychiatry    Pedelty, Laura Neurology    

Pliskin, Neil Psychiatry Neurology  Prensky, Eric Psychiatry    

Ragozzino, Michael Psychology    Reilly, James Psychiatry    

Roitman, Michael Psychology    Schneiderhan,

MarkPharmacy Practice

Psychiatry  

Schrift, Michael Psychiatry    Shankman, Stewart Psychology Psychiatry  

Revised: 03/27/07

Stanford, Lisa Psychiatry Psychology  Neurology

Sweeney, John Psychiatry NeurologyPsychology & Bioengineering

Vaillancourt, DavidMovement

ScienceBioengineering Neurology

Weiden, Peter Psychiatry    

Revised: 03/27/07

Appendix I.1 Center for Cognitive MedicineCommittee Structure

Dean of Medicine

John A. Sweeney, PhD, DirectorNeil H. Pliskin, PhD, Co-Director

Neil Pliskin, PhDCo-Chair

Clinical NeuroscienceEducation Committee

Daniel Corcos, PhDCo-Chair

Lisa Stanford, PhD

Michael Schrift, DO

Robert Marvin, MD

Ovidio DeLeon, MD

Susan Labott, PhD

Clinical Research Integration Committee

John Sweeney, PhDChair

Neil Pliskin, PhDCo-chair

Pauline Maki, PhD Co-chair

Jeff Bishop, PharmDCo-chair

Daniel Corcos, PhD

Pauline Maki, PhD

Marilyn Kraus, MDDavid Nyenhuis, PhD

James Reilly, PhD

Kimberly SkinnerEx-Officio

Mani Pavuluri, MD

Peter Weiden, MD

Deborah Little, PhD

Michael Ragozzino, PhD

Chris Fall, PhD

David Nyenhuis, PhD

David Vaillancourt, PhD

Laura Pedelty, MD

Executive Committee

Stephanne Foster-CraneEx-Officio

Peter Weiden, MD

Appendix I.2Center for Cognitive MedicineDepartmental Participation

Dean of Medicine

John A. Sweeney, PhD, DirectorNeil H. Pliskin, PhD, Co-Director

Deborah Little, PhDAssistant Professor of Neurology,

Anatomy & Cell Biology, Ophthalmology & Visual Sciences

and Psychology

Liberal Arts and Sciences

Stewart Shankman, PhDAssistant Professor of

Psychology and Psychiatry

Michael Ragozzino, PhDAssociate Professor of

Psychology

Mani Pavuluri, MD, PhDAssociate Professor of

Child Psychiatry

Michael Schrift, DOAssociate Professor of

Psychiatry

Peter Weiden, MDProfessor of Psychiatry

Lisa Stanford, PhDAssociate Professor of

Psychiatry

Eric Prensky, PhDAssistant Professor of

Psychiatry

Sarah Keedy, PhDAssistant Professor of

Psychiatry

Scot Hill, PhDAssistant Professor of

Psychiatry

Ovidio DeLeon, MDProfessor of Psychiatry

John Sweeney, PhDProfessor of Psychiatry,

Neurology and Psychology

Neil Pliskin, PhDProfessor of Psychiatry

and Neurology

Robert Marvin, MDAssistant Professor of

Psychiatry

James Reilly, PhDAssistant Professor of

Psychiatry

Ellen Herbener, PhDAssistant Professor of

Psychiatry

Robert Gibbons, PhDProfessor of

Biostatistics and Psychiatry

Department of Neurology and Rehabilitation

Medicine

Department of Psychiatry

Susan Labott, PhDAssociate Professor of

Psychiatry

Department ofPsychology

Department ofMovement Sciences

Applied Health Sciences

David Vaillancourt, PhDAssistant Professor of Movement Sciences, Bioengineering and

Neurology

Mark Schneiderhan, PharmD

Assistant Professor of Pharmacy and Psychiatry

Jeffrey Bishop, PharmDAssistant Professor of

Pharmacy and Psychiatry

Department ofPharmacy Practice

Pharmacy

Gaston Baslet, MDAssistant Professor of

Psychiatry

Marilyn Kraus, MDAssociate Professor of

Psychiatry and Neurology

Daniel Corcos, PhD Professor of

Movement Sciences, Neurology,

Physical Therapy and Bioengineering

Medicine

Department of Anatomyand Cell Biology

Chris Fall, PhDAssistant Professor of

Anatomy & Cell Biology and Psychiatry

David Nyenhuis, PhDAssociate Professor of

Neurology

Linda Laatsch, PhDAssociate Professor of Neurology

Mitchell Roitman, PhDAssistant Professor of

Psychology

Carol Macmillan, MDAssociate Professor of

Neurology and Pediatrics

Laura Pedelty, MDAssistant Professor of

Neurology

Pauline Maki, PhDAssociate Professor of

Psychiatry and Psychology

Jon Kassel, PhDAssociate Professor of

Psychology

Pauline Maki, PhDAssociate Professor of

Psychiatry and Psychology

Peter Weiden, MDProfessor of Psychiatry

Liberal Arts and SciencesLiberal Arts and SciencesLiberal Arts and SciencesLiberal Arts and Sciences

Liberal Arts and Sciences

Department ofPsychology

Jon Kassel, PhDProfessor of Psychology

Michael Ragozzino, PhDAssociate Professor of

Psychology

Stewart Shankman, PhDAssistant Professor of

Psychology and Psychiatry

Mitchell Roitman, PhDAssistant Professor of

Psychology

Appendix I.3Center for Cognitive MedicineAcademic Areas of Interest

Mark Schneiderhan, PharmD

James Reilly, PhD

Ellen Herbener, PhD

Scot Hill, PhD

Dean of Medicine

John A. Sweeney, PhD, DirectorNeil Pliskin, PhD, Co-Director

Peter Weiden, MDDirector

Robert Marvin, MD

Psychotic DisordersProgram

Ovidio DeLeon, MD

Sarah Keedy, PhD

NeurobehavioralPrograms

Marilyn Kraus, MD Director

Cognitive Rehabilitation

PediatricPrograms

Mani Pavuluri, MD, PhD

Director

Statistical Methods

Jeff BishopPharmD

Executive Committee

David Vaillancourt, PhD

Deborah Little, PhD

Aging

Pauline Maki, PhD Carol Macmillan, MD

Medical Director

Lisa Stanford, PhD Director, Pediatric Neuropsychology

Robert Gibbons, PhD

Director

Linda Laatsch, PhDDirector

Education Committee Clinical Research Integration Committee

Mike Ragozzino, PhD

Animal Models

Cognitive Neuropsychiatry

Michael Schrift, DO,Medical Director

Gaston Baslet, MD

Traumatic Brain Injury

Neuropsychology

Neil Pliskin, PhD Director

Learning and

NeurodevelopmentClinic

Pediatric Mood Disorders

Daniel Corcos, PhDDirector

Movement Disorders

Pharmacogenetics/Pharmacodynamics

David Nyenhuis, PhD

Chris Fall, PhD

Mitchell Roitman, PhD

John Sweeney, PhD

Research Director

Cognitive Disorders

Laura Pedelty, PhDDirector

Jon Kassel, PhDDirector

PsychologyPrograms

Affective Neuroscience

HealthPsychology

Susan Labott,PhD

Director

Eric Prensky, PhD

Stewart Shankman, PhD

Psychology Programs

HealthPsychology

Affective Neuroscience

Susan Labott, PhDDirector

Stewart Shankman, PhD

Chris Fall, PhD

Jon Kassel, PhD Director

Mike Ragozzino PhD

Mitchell Roitman, PhD

Animal Models

Eric Prensky, PhD

Revised: 03/27/07