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May 13, 2011

Renewable Diesel: Fueling the Future in a

Green Economy Joel Velasco

velasco@amyris.com

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Safe Harbor Summary

This presentation includes forward-looking statements that are subject to many risks and uncertainties. These forward-looking statements, such as statements about Amyris’s short-term and long-term growth strategies, total addressable market expectations, and efforts to develop and commercialize products, can sometimes be identified by use of terms such as “intend,” “expect,” “plan,” “estimate,” “future,” “strive,” and similar words. These statements involve many risks and uncertainties that may cause actual results to differ from what may be expressed or implied in these statements. These risks are discussed in Amyris’s Securities and Exchange Commission filings and reports, including the risks identified under the section captioned “Risk Factors” in its annual report on Form 10-K filed March 14, 2011 and its quarterly report on Form 10-Q filed May 11, 2011. Amyris disclaims any obligation to update information contained in these forward-looking statements whether as a result of new information, future events, or otherwise.

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!  Headquartered in California, Amyris is an integrated renewable products company focused on providing sustainable alternatives to a broad range of petroleum-based products.

!  Through our proprietary technology platform, we convert plant sugars into a variety of hydrocarbon molecules - flexible building blocks that can be used in a variety of markets, including cosmetics, flavors and fragrances, polymers, consumer products, renewable fuels and lubricants.

!  Our innovation is the practical integration of biology with chemistry to create novel solutions to address global, regional and local challenges.

Amyris Leading the next generation of renewable products

RENEWABLE CHEMICALS AND FUELS

ANY BIOMASS FEEDSTOCK INDUSTRIAL SYNTHETIC BIOLOGY PLATFORM

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!  Started in 2004 based on molecular engineering work from University of California - Berkeley Professor Jay Keasling’s laboratory

!  Initially funded in 2005 by a grant from the Gates Foundation to develop a lower cost, consistent supply of artemisinin, key component of a malaria drug !  Every year, malaria kills 1 million people –

mostly children under the age of five in Africa !  Drugs exists but are in short supply and

unaffordable to poorest populations

!  Expanded products to broad suite of petroleum replacements; issued patents covering diesel, jet, polymer and lubricant products

!  Successful public offering in 2010 in the NASDAQ

!  Marketing and distribution channels to deliver products in the United States and other global markets

Building of our Technology Innovation from the lab to commercialization

O

O

O

OO

H

HH

Artemisia annua Annual Wormwood

Amyris engineered yeasts Diesel precursor

Micrograph of fermentation fluids from production of Amyris Diesel

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Synthetic Biology: The Technology of this Century

FARNESENE C-15 (DIESEL)

YEAST CELL ISOPRENOID PATHWAY

ANTI-MALARIAL DRUG

ISOPRENE PINENE C-10 (JET FUEL)

SUGAR SOURCE

Synthetic Biology The Technology of this Century

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Our Vision How Amyris is enabling a bio-based economy

Bio-derived products

+

Jet fuel 2020 est: 124 BGY ($300B)

Hydrocarbon

products

+

Fermentation using Amyris’ engineered yeast

Oil

Traditional Fossil Fuels

Amyris genetically engineered yeast

= Petroleum products

Biomass Sugars

=

Refinery

Diesel 2020 est: 450 BGY ($800B)

Gasoline (Otto Cycle) Others to replace/reduce +20%

Chemicals Polymers, lubes & surfactants

Hyd

ro-p

roce

ssin

g

Cosmetics Squalane & Fragances

Anti-malaria drug non-profit: treat over millions

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Amyris Platform Producing High-Value Products Through Low-Cost Fermentation

High-Throughput Yeast Strain Design and

Testing

Demo Facility Campinas, Brazil

Pilot Plant Emeryville, CA

300 LITER

5,000 LITER

Contract Manufacturing (T&L in Illinois,

Antibioticos in Spain & Biomin in Brazil)

60,000 – 200,000 LITER

Capital Light Production

São Martinho JV (Target Q2 2012)

600,000 LITER

Pilot Plant Campinas, Brazil

300 LITER

Operating

Research Emeryville, CA

2 LITER

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Validated by external labs as a “best-in-class” product, meeting ASTM D975 fuel properties with zero sulfur.

Amyris diesel will be used in blends with conventional fuels; values shown for Amyris diesel is for biomass derived blending component.

+1

Amyris

Today’s Biodiesel

Petroleum diesel

47

58.6

40-55

Cetane Number Energy Density 1000 BTU/gal

118

123

115-142

0 50 100 150 0 20 40 60 -75 -50 -25 0

-9 to-30

Cloud Point degrees Celsius

Temperature below which wax in diesel form a cloudy appearance. Solidified waxes thickens the oil and clogs fuel filters and injectors in engines

Measure of fuel’s ignition delay – higher cetane number has lower ignition delay.

Amount of energy stored per unit volume – directly impacts miles per gallon (km per liter)

Amyris

Today’s Biodiesel

Petroleum diesel

Amyris

Today’s Biodiesel

Petroleum diesel

< – 50

Amyris Renewable Diesel Approved by EPA for 35% Blends

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-1.9% -4.7%

-12%

-0.11%

+2.0%

-15%

-10%

-5%

0%

5%

10%

15% 5% 20% 50% 20% 20%

Cha

nge

vs. B

asel

ine

NOx

-1.5%

-5.7%

-3.1%

-10.1% -12%

-10%

-8%

-6%

-4%

-2%

0% 5% 20% 50% 20% 20%

Cha

nge

vs. B

asel

ine

PM

-6.6% -3.6%

-12%

-20% -21% -25%

-20%

-15%

-10%

-5%

0%

Cha

nge

vs. B

asel

ine

HC

-2.1%

-7.1%

-15% -15%

-11%

-15%

-12%

-9%

-6%

-3%

0%

Cha

nge

vs. B

asel

ine

CO

% FAME in Fed. Diesel*

% Amyris in Federal Diesel*

% Amyris

in CARB Diesel*

* Detroit Diesel Series 60 engine (5 gram NOx) no EGR , tested at SwRI May 2008 ** Source: EPA (http://www.epa.gov/otaq/models/analysis/biodsl/p02001.pdf)

% FAME in Fed. Diesel*

% Amyris in Federal Diesel*

% Amyris

in CARB Diesel*

-0.26%

Amyris Renewable Diesel Significant reductions in NOx, PM, CO, and HC emissions - OEM validated

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!  Derived using diverse, sustainable feedstocks –  Direct sugar to hydrocarbon fermentation

!  Hydrocarbons, not alcohols or esters

–  Can be used in existing engines with no performance trade-offs

–  Can be delivered using existing distribution infrastructure

!  Superior properties –  No sulfur –  Lower particulates, HC, CO and NOx –  Excellent cold flow characteristics –  Comparable energy density –  80%+ lower GHG emissions than fossil fuels

! OEM Validated –  Cummins –  Mercedes Benz –  Volkswagen

Amyris diesel fuel (clear) in front; petroleum diesel (yellow) in the back

Amyris Renewable Diesel No Compromise™ Fuels: Drop-in and Better Performance

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!  Syrups and Juice –  Sorghum Syrup

•  (Ceres, USA) FL and TN –  Cane Syrup

•  Florida-derived

!  Hydrolyzates –  Sorghum Bagasse

•  NREL, USA, FL and TN

Sweet Sorghum

Sugar Cane

Sorghum Bagasse

Amyris Fuels Domestic feedstocks under evaluation with Dept of Energy

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U.S. R&D, Production & Processing Existing facilities in the United States