Regression (NT & NDDs), the importance of timing and of ...Thomas, Knowland, & Karmiloff-Smith,...

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Regression (NT & NDDs), the importance of timing and of cross-syndrome comparisons Annette Karmiloff-Smith Centre for Brain & Cognitive Development Birkbeck-University of London Bethesda workshop - Feb.2016

Transcript of Regression (NT & NDDs), the importance of timing and of ...Thomas, Knowland, & Karmiloff-Smith,...

  • Regression (NT & NDDs), the importance of timing and of cross-syndrome comparisons

    Annette Karmiloff-SmithCentre for Brain & Cognitive Development Birkbeck-University of London

    Bethesda workshop - Feb.2016

  • OutlineNT: Examples of regression/loss of skills in neurotypical development

    - Behavioural regression vs representational progression - Balance – synapse strengthening vs pruning weak connections

    NDD – Williams syndrome: lack of specialisation/localisation of neural functionpossible lack of pruning?

    NDD-ASD: Threshold too high – over-aggressive pruningRegression due to pruning of strong connections,Sequence of regressive behaviours hypothesized: sensory -> motor -> language -> executive function

    Early differences: ASD-sibs, controls and other NDDs

  • Behavioural regression vs representational progression in NT language

    Past tense/plural marking in early language development:

    T-1 Correct: Papa went/Me caught ball/wet feetIsolated representations

    T-2 Behavioural regression: Papa goed/Me catched ball/wet footsT-2 Representational progression: overgeneralisation of –ed past tense/-s plural patterns

    T-3 Correct as at T-1: Papa went/Me caught ball/wet feetRepresentations have now become part of a system of morphological markers

    Question we must ask of ASD regression:Is behaviour before regression sustained by same mental reps as behaviour after the regression?Is child regaining skills, or are the later underlying skills different even if overt behaviour seems the same?

  • NT loss of skills in infancy: face processing

    3-6 month olds: discriminate own-race faces discriminate other-race facesdiscriminate other-species faces

    9-10 month-olds: ability lost for other-race/other speciesdue to pruning of lesser-used connectionsand strengthening of used ones

    12 months: if experience given at 9 months with faces of other-race/other species, then ability = retained

    Pascalis, Scott, Kelly, Shannon, Nicholson, Coleman & Nelson, 2005Kelly, Quin, Slater, Lee, Ge & Pascalis 2007Heron-Delaney, Wirth, & Pascalis, 2011

  • NT loss of skills in infancy: speech processing

    3-6 month olds: discriminate phonemes in native languagediscriminate phonemes in non-native languagesdiscriminate other-species’ cries??

    9-10 month-olds: ability lost for non-native, due to pruning of lesser-used connections and strengthening of used ones

    12 months: if experience given at 9 months with non-native phonemes, ability retained

    Different groups for face/speech. Single domain-general mechanism? Need to research faces/speech tasks in same infants

    Face and speech processing undergo perceptual narrowing in NTBalance: strengthening of used connections + pruning of unused connections Progressive specialisation and localisation of neural function

    Tees & Werker, 1984Nazzi, Jusczyk, & Johnson, 2000Maye, Werker & Gerken, 2002 Best & McRoberts, 2003

  • Specialization and localisation of brainfunction are progressive

    12 months

    Adults

    -- 6 months--- 12 months--- Adults

    6 months

    P400

    N250

    N170

    From de Haan, Pascalis & Johnson, 2002; Halit, de Haan & Johnson, 2005

    See, also, Pascalis, deHaan & Nelson, 2002

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    Human Upright

    Human Inverted

    Monkey Upright

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    5

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Neuroconstructivism · 2009. 9. 30. · Neuroconstructivism Gert Westermann 1, Michael S. C. Thomas 2, and Annette Karmiloff-Smith 2 1 Department of Psychology, Oxford Brookes University,

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