Reducing Opioid Prescribing · 2018-11-27 · Overview Why this occurred ... American Society of...
Transcript of Reducing Opioid Prescribing · 2018-11-27 · Overview Why this occurred ... American Society of...
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Bret Bielawski, DO FACP
Reducing Opioid
Prescribing“Primum non nocere”
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Disclosures
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Objectives
Be able to articulate to a patient the reasons why you are NOT going to prescribe opioids
List the four main standards of care when judiciously prescribing opioids
Be able to articulate why it is time to taper off
opioids
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Overview
Why this occurred
Avoiding Opiates
Four Standards of Care
Time to Reassess
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How did this start?
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“only four cases of reasonably
well documented addiction”
NEJM 1980 302:123
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“We conclude that opioid maintenance therapy can be a safe, salutary and more humane alternative to
the options of surgery or no treatment in those patients with intractable non-malignant pain and
no history of drug abuse.”
Pain 25 (1986) 171-186
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Joint Commission Pain Standard PC.01.02.07
Rational: The identification and treatment of pain is an important component of the plan if care. Patients can expect
that their health care providers will ask
them about whether they have pain. When pain is identified the individual is assessed based on his or her clinical presentation and in accordance with the care, treatment, and services provided by the organization.
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Pain is NOT the “5th Vital Sign”
The “5th Vital Sign”
Lanser P, Gesell S. Pain management: the fifth vital sign.Healthc Benchmarks 2001;8:68–70, 62.
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JACHO Guide
2001
“Some clinicians have inaccurate and exaggerated concerns" about addiction, tolerance and risk of death.”
"This attitude prevails despite the fact there is no evidence that addiction is a significant issue when persons are given opioids for pain control.”
The Joint Commission published a guide sponsored by Purdue Pharma.
www.rwjf.org/en/grants/grant-records/1997/07/supporting-quality-improvement-and-jcaho-standard-setting-for-pa.html
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http://money.cnn.com/2007/05/10/news/companies/oxycontin/index.htm?cnn=yes
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Federation of State Medical Boards
“No disciplinary action will be taken against a practitioner based solely on the quantity and/or frequency of opioids prescribed.”
www.fsmb.org/pdf/2004_grpol_Controlled_Substances.pdf. Accessed April 17, 2013
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https://www.statnews.com/2016/06/27/opioid-addiction-orrin-hatch-ron-wyden/?s_campaign=stat:rss
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What is the largest source of Rx opiates for
non-medical use?
a) Prescribed by > 1 physician
b) Bought from a drug dealer/stranger
c) Given by friend/relative
d) Bought from a friend/relative
e) Stolen from a friend/relative
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Where is the largest source of Rx opiates for
non-medical use?
a) Prescribed by > 1 physician
b) Bought from a drug dealer/stranger
c) Given by friend/relative
d) Bought from a friend/relative
e) Stolen from a friend/relative
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Sources of opioids for non-medical purposes
70%
20%10%
Friend or Relative
Prescribed
Jones CM, Paulozzi LJ, Mack KA. Sources of Prescription Opioid Pain Relievers by Frequency of Past-Year Nonmedical Use: United States, 2008-2011. JAMA Intern Med. 2014
Other
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Who Rx the most opioids in MI ?
A.SurgeryB.Pain managementC.ER/UCD.Primary careE.Oncology
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Who Rx the most opioids in MI ?
A.Surgery (9%)B.Pain management (10%)C.ER/UC (5%)
D.Primary care (64%)
E.Oncology (1%)
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“This is why I’m not going to prescribe narcotics . . .”
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Which of the following is not associated
with opioids?
A. Opioid induced hyperalgesia
B. Hypothalamic hypogonadism
C. Physical dependence
D. Disturbed sleep architecture
E. Improved pain control with higher doses
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Which of the following is not associated
with opioids?
A. Opioid induced hyperalgesia
B. Hypothalamic hypogonadism
C. Physical dependence
D. Disturbed sleep architecture
E. Improved pain control with higher doses
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Opioid Induced Hyperalgesia
Paradoxical increase in pain Diffuse allodynia unrelated to the original pain
source Increasing pain with increasing dosage
Lee, Marion et al. (2011) “A Comprehensive Review of Opioid-Induced Hyperalgesia.” Pain Physician, 14:145-161
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Hypothalamic hypogonadism
Low testosterone and estrogen. Osteoporosis57% long acting and 35% short acting
American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: Part 2—guidance. Pain Physician. 2012 July;15:S67–116.
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Disturbed Sleep Architecture
Opioids decrease total sleep time, sleep efficiency, delta sleep, REM sleep and increase time spent in light sleep.1
Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects. Pain Phys 2008;11:S105‐S120
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Tolerance
A condition in which higher doses of a drug are required to produce the same effect as during initial use.
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Physical Dependence
An adaptive physiological state that occurs with regular drug use and results in a withdrawal syndrome
when drug use is stopped.
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Withdrawal: 4-24 hours
“Flu-like and leaky”• Fever/Sweating
• Rhinorrhea
• Muscle cramps
• N/V/D/Abd cramping
• Insomnia
• Mydriasis
• Piloerection
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Addiction
Compulsive use of a drug and overwhelming involvement with its procurement and use.
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~80% heroin users started with prescription opioids
Jones CM. Heroin use and heroin use risk behaviors among nonmedical users of prescription opioid pain relievers – United States, 2002-2004 and 2008-2010. Drug Alcohol Depend. 2013;132(1-2):95-100.
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What’s the difference?
MorphineHeroin 6-MAM
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Heroin
Hydrocodone
Oxycodone
Morphine
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Safer Alternatives
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CDC Guideline for Prescribing Opioids for Chronic Pain - 2016
1. Use behavioral and physical therapies beforemedication, particularly opioids.
https://stacks.cdc.gov/view/cdc/38440(Accessed 10-2016)
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Safer Alternatives
Heat and cold treatments
Exercise (Home Exercise Program), Handouts
Yoga
Physical and occupational therapy
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Safer Alternatives
Emotional and psychological support
Mindfulness training
Acupuncture
OMM
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World Health Organization
Analgesic Ladder
Acetaminophen or NSAIDs
Short-acting opioid PRN ± non-opioid around the clock ±adjuvant agent
Sustained release opioid or continuous infusion + short-acting opioid PRN ± non-opioid ± adjuvant agent
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Safer Alternatives
Non-opioid medication Compounded agents Lidocaine patches Gabapentin Pregabalin Duloxetine
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Which of the following is the most important
step(s) to take before prescribing opioids?
A. Risk assessmentB. MAPS C. Urine Drug Screen D. Pain Management AgreementE. All the above
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Which of the following is the most important
step(s) to take before prescribing opioids?
A. Risk assessmentB. MAPS C. Urine Drug Screen D. Pain Management AgreementE. All the above
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Standard of Care
Risk assessmentMAPS Urine Drug Screen (UDS)Pain Management Agreement
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Standard of Care
Risk assessmentMAPS Urine Drug Screen (UDS)Pain Management Agreement
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Opioid Risk Tool (ORT)
1. Age: 16-45
2. Hx Substance Abuse Alcohol Illegal Drugs Prescription Drugs
3. Family Hx Substance Abuse Alcohol Illegal Drugs Prescription Drugs
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4. Mental Illness ADD/OCD/Bipolar/Schizophrenia Depression – separate scoring
5. Hx Preadolescent Sexual Abuse
Opioid Risk Tool (ORT)
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opioidrisk.com
Low Risk 0-3
Moderate Risk 4-7
High Risk ≥ 8
Opioid Risk Tool (ORT)
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Standard of Care
Risk assessment
MAPS
Urine Drug Screen (UDS)
Pain Management Agreement
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Who Rx the highest doses (MME) in MI?
A.SurgeryB.Pain managementC.ER/UCD.Primary careE.Oncology
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Who Rx the highest doses (MME) in MI?
A.SurgeryB.Pain managementC.ER/UCD.Primary careE.Oncology
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Primary care is the 1st largest Rx of lorazepam. Who is the 2nd ?
A.SurgeryB.Pain managementC.PsychiatryD.Primary careE.Oncology
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Primary care is the 1st largest Rx of lorazepam. Who is the 2nd ?
A.SurgeryB.Pain managementC.Psychiatry
D.Primary careE.Oncology
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Doctor Shopping and Overdose Death: 2009-2012
< 25 Deaths
1.4-2.3/1003
2.4-3.1
3.2-4.1
4.6-6.0
A Profile of Drug Overdose Deaths Using the Michigan Automated Prescription System (MAPS) Office of Recovery Oriented Systems of Care Staff: Su Min Oh
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Standard of Care
Risk assessment
MAPS
Urine Drug Screen (UDS)
Pain Management Agreement
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Drug Testing
Detect non-prescribed drugs
Detect the absence of drugs
Point Of Care testing (in office)
High rates of false +/-
No toxicologist to consult
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Standard of Care
Risk assessment
MAPS
Urine Drug Screen (UDS)
Pain Management Agreement
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But, wait, there’s more . . .
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Store SECURELY
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Encourage those on opioids to: Store
SECURELY
“Is there a more secure area to keep your pills besides your”: Drawer at work Purse Glove box Medicine Cabinet
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Dispose PROPERLY
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Dispose PROPERLY
Do you really need to save them “just in case”? Give them a list of disposal sites
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How to Dispose of Unused
Medicines
Take drugs out of their original containers and mix them with an undesirable substance, such as used coffee grounds …
www.fda.gov/downloads/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/UnderstandingOver-the-CounterMedicines/ucm107163.pdf (Accessed 5-2015)
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Never SHARE
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Encourage those on opioids to: Never SHARE
FelonyDon’t want to create any more addictions
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What are you going to change?
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Three
classes Patients not on opioids
work hard provide more effective and safer options Patients on opioids
reassess frequently Opioid addiction
Families Against Narcotics
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https://www.npr.org/sections/health-shots/2016/01/11/462390288/anatomy-of-addiction-how-heroin-and-opioids-hijack-the-brain
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Transitioning Off Opioids
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“Plant the seed!”
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First Do No Harm!
“Primum non nocere”