Redemptorist Plaza, Camputhaw Cebu City - SWU...

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Southwestern University - Matias H. Aznar Memorial College of Medicine Inc. Redemptorist Plaza, Camputhaw Cebu City

http://swumhamcollegeofmedicineyahoo.com

VISION

SWU-MHAM College of Medicine is a leading medical institution, anchored in excellence, committed to produce globally competitive medical

professionals, imbued with knowledge in research and community service.

MISSION

Provide state-of-the-art facilities;

Nurture a community of competent medical experts in all fields of specialization;

Strengthen a research- and evidenced-based learning;

To use information technology approach to teaching;

To enhance learning core competencies and skills training;

Strengthen the practice of community-oriented and universally-accepted health care;

To forge linkages/partnership with government and non-government agencies in the service of the community;

To provide opportunities for a medical career to economically challenged but deserving students;

To produce competent, compassionate, and committed physicians;

http://swumhamcollegeofmedicineyahoo.com/

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GOALS

The MHAM College of Medicine Inc, Inc. offers the medical program leading to a degree of Doctor whose graduates are:

Trained in highest scientific and ethical standards of medical education

Responsive to the current health needs of the people in the community and globally

Updated with the latest therapeutic modalities and health related technologies

Proficient in the conduct of globally competitive medical research which is attuned to the prevailing health conditions in the community

In pursuit of lifelong disposition of professional advancement and learning

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CORE VALUES

PROFESSIONALISM

We observe a polite behaviour and courteousness; adhere to a high sense of ethical standards in the performance of our duties and responsibilities in the work

place.

RESPECT

We act with deep admiration, giving due regards and high esteem to everyone.

ONENESS

We stand united in all our endeavours and uphold the good name, honour and integrity of the institution.

LEADERSHIP

We act as role model, do things that will work best in the institution and provide policy directions that are relevant to the needs of the time in order to fulfill our

ultimate

goals

INTEGRITY

We adhere to the highest ethical code of conduct in our dealings with others and exercise our duties and responsibilities with correlative obligation to preserve

human dignity.

FAIRNESS

We are impartial, reasonable, transparent and free from discrimination in the performance of our duties and responsibilities.

EXCELLENCE

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We pursue the highest standard of quality service in all program of engagements and undertakings for the attainment of the Vision and Mission of the institution


Institutional Outcome

Program Outcome Course Outcome

A graduate of SWU-MHAM CM is expected to be a :

Upon completion of the MD program the graduate should be able to :

Upon Completion of Basic medical sciences. (Pharmacology) The student should be able to;

Proficient Physician who adheres to the highest ethical conduct in the care of patients, seasoned with communication and analytical skills

Demonstrate capability in the diagnosis and treatment of health conditions of people without discrimination with respect to their nationality, race, socio-economic status, gender, culture, beliefs and creed. (CHED 1,2,8,9,10) (SWU-MHAM Core Values 2, 6, 7)

Demonstrate competency and

effective communication skills in

discussing and explaining the

following :

The basic principle of

Medical Pharmacology

The standard classification

of drugs based on

intentionally accepted

nomenclature.

The basic principles of the

different pharmacologic

disciplines

The principles of

therapeutics, drug action

and interactions.

(CHED 1,2) SWU MHAM 2,6,7

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Leader who has exemplary moral values which are deeply anchored in his/her religious convictions and work best for the betterment of the community

Leads and manage health care teams in the community through utilization of an interdisciplinary approach, health information dissemination and adherence to ethical, professional, legal, national and international standards in the delivery of health care (CHED 3,5,8,9,10) SWU-MHAM Core Values 1,4,5,6

Effectively and Efficiently work

with other health professionals

especially in Collaborating in

PharmacoTherapeutic teams ,

community awareness forums and

research projects

(CHED 2,3,5,8,9,10)

(SWU MHAM 1,4,5,6)

Manager who has a good working relationship with people coming from different sectors in the community

Initiate planning, organizing, implementation and evaluation of healthcare programs using system- based approach, and observes the principles of social accountability. (CHED 5,6,7,10) (SWU-MHAM Core Values 1, 5)

Initiate Planning and Organizing a

Pharmacology symposium

Research forum

Review Committee for Essential Drugs

Community information awareness regarding the use and abuse of drugs, and alternative medicine .

(CHED 5,6,9,10 (SWU MHAM 1,5)

Researcher who can engage in innovative research activities and utilize research findings in improvement of health care delivery.

Adhere to the ethical standards in the conduct of research; communicate research findings and apply these findings to improve health care delivery. (CHED 2,4,6,8) (SWU-MHAM Core Values 1,5)

Utilizes research in

Investigating the various

endogenous medicinal

plants , their active

compounds, action,

mechanisms and effects

Correlating the concepts

and principles of Rational

Drug use and Evidence

Base pharmaco

therapeutics in a clinical

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Setting

(CHED 4,6,8)(SWU-MHAM 1,5)

Teacher who has deep dedication and passion to transfer knowledge and skills; and include values in the molding of medical professionals.

Engage oneself and inspire others to continue personal and professional development (CHED 7) (SWU MHAM M Core Values 1)

Facilitate a small group

discussion

Convey clear and relevant

information

In written and oral reports

on focused topics , case

studies utilizing different

types of audiovisual to

resources to their faculty

and to their fellow students

To patients regarding a

content and instructions in

a written prescription

(CHED 2) (SWU MHAM 1)

Update oneself by regularly

attending pharmacology and

Toxicology symposium, research

forum, Drug symposium and be

able to apply such knowledge for

his/her professional advancement

in order to educate patients and

deliver quality healthcare.

(CHED 7) (SWU MHAM 1)

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Nationalist who instills to the community and country

Demonstrate love for one’s countrymen, national heritage and culture (CHED 9) (SWU-MHAM Core Values 3)

Demonstrate a love of Filipino

heritage by:

Promoting our natural

plants that have medicinal

potential

Exhibiting an attitude of

service to our community

(CHED 9,10)(SWU-MHAM 3)

Adhere to national, international and legal standards in regulation of drugs (CHED 9,) (SWU-MHAM 3)

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SYLLABUS IN

PHARMACOLOGY AND TOXICOLOGY

MEDICINE -2ND YEAR

I. Course Title: Pharmacology and Toxicology

II. Course Description: This course deals with the drugs and their mechanisms of action discussed at the cellular and

molecular level It also deals with proper identification and fundamental principles of action mechanisms relating to the

different branches such as pharmacognosy, pharmacokinetics, pharmacodynamics, pharmacotherapeutics, posology,

toxicology, pharmacogenetics, teratogenic pharmacology, and pharmacovigilance. Additionally, the students will be

trained to comprehend the subject with the end view of motivating them to explore vast and interesting field of

pharmacology.

III. Unit Credits 16 Units (8 units per semester) 7 hours per week

IV. Venue Audio visual room 2 and 3

V Entry Competencies Medical Students should have prior knowledge in Human Anatomy, Medical Physiology and

Biochemistry

VI Learning Outcomes: Following the Outcome based curriculum, Pharmacology and Toxicology will be geared

Towards making second year medical student achieve the following learning outcome

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VII. Course Objectives :

Students who have completed this course should be able to:

1. Demonstrate competency and effective communication skills in discussing and explaining the following :

1.1 The basic principle of Medical Pharmacology

1.2 The standard classification of drugs based on intentionally accepted nomenclature.

1.3 The basic principles of the different pharmacologic disciplines such as: pharmacokinetics, pharmacodynamics,

Pharmacotherapuetics and toxicology

1.4 The principles of drug action and interactions.

Learning outcomes Level of Emphasis

1. Demonstrate clinical competence Demonstrated

2. Communicate effectively Practiced

3. Lead and manage health care teams Practiced

4. Engage in Research Activities Practiced

5. Collaborate within inter-professional teams Introduced

6. Utilized systems based approached to healthcare Introduced

7. Engage in continuing personal and professional

development

Practiced

8. Adhere to ethical ,professional and legal standards Practiced

9. Demonstrate nationalism, internationalism and dedication

to service

Practiced

10. Practice the principles of social accountability Introduced

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2. Convey clear information

2.1. In written and oral reports on focused topics , case studies utilizing different types of audiovisual to resources to their faculty and to their fellow

students

2.2. To patients regarding a content and instructions in a written prescription

3. Initiate Planning and Organizing a

3.1 Pharmacology symposium

3.2 Research forum

4. Utilizes research in

4.1 Investigating the various endogenous medicinal plants , their active compounds, action, mechanisms and effects

4.2 Correlating the concepts and principles of Rational Drug use and Evidence Base pharmacotherapeutics in a clinical

Setting

5. Effectively and Efficiently work with other health professionals especially in Collaborating in research projects

6. Update oneself by attending

6.1 A pharmacology and Toxicology symposium

6.2 A research forum

6.3 Drug symposium

7. Adhere to national, international and legal standards in regulation of drugs

8. Demonstrate a love of Filipino heritage by:

8.1 Promoting our natural plants that have medicinal potential

8.2 Exhibiting an attitude of service to our community

9. Practice the principles and relevance of RATIONAL DRUG USE in the delivery of health care to the patient and to the community

10. Practiced the principles of social accountability by monitoring and reporting adverse effects and toxicity of drugs

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Unit Learning Outcome Topic Outline TIME

FRAME

TEACHING –

LEARNING

STRATEGIES

Resources Assessment Task

Assessment tool

At the end of the grading period, the

student should be able to:

1.1. Explain the development of

pharmacology as a science.

1.2. Discuss what is pharmacology, the

subdivisions of pharmacology and the

disciplines that interface with it.

UNIT I

INTRODUCTION OF

PHARMACOLOGY

1. History of

pharmacology

- The disciplines of

pharmacology

3.5 hours

-Lectures

-Small group

discussion

Textbook :

-Basic and -Clinical Pharmacology

-quizzes

-oral recitation

-unit examination

- group

participation and

communication

skills

-Short essays

-Posttest MCQ,

-Rating Scale with

rubric

-Embedded testing

incorporated into

assignments

-Minute paper

2.1. Explain and describe the physical

processes underlying drug kinetics.

2.2. Discuss the four mechanisms by

which small molecules (drugs) cross cell

membranes.

2.3. Analyze the process of binding of

drugs to plasma proteins.

2.4. Explain the effect of fats and other

tissues on the accumulation of drugs.

2.5. Discuss the process of drug

absorption according to the:

2.5.1. Major routes of drug

2.Pharmacokinetic of Drugs

a. Routes of administration

b. Different Pharmacokinetic

Processes

-absorption

-protein binding

-distribution

c. Routes of drug

3.5 hrs

-Lectures

-Small group

discussion

Textbook :


-quizzes

-oral recitation

-unit examination

- group

participation and

communication

skills

-Short essays

-Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

12


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

administration.

2.5.2 Explain the different factors

affecting absorption through

gastrointestinal tract and other routes.

2.5.3. Analyze concepts of

bioavailability and bioequivalence.

2.6. Discuss the distribution of drugs in

the body:

2.6.1. Explain the four body fluid

Compartments and the concept of

Bloodbrain-barrier.

2.6.3.Discuss the concept of volume of

distribution.

2.7. Explain the special drug delivery

systems.

2.8. Explain the concept of first-pass

(pre-systemic) metabolism

2.9. Discuss Biliary excretion and

enterohepatic recirculation.

3.0 . Estimate the half life of a drug

based on it’s clearance and volume of

administration

d.Bioavailability

e. bioequivalence

f. Half Life

g.Enterohepatic recycling

h, Kinetics of drug absorption

i..Volume of Distribution

j. Drug clearance

k. Special drug delivery systems.

-Lectures

-Small group

discussion

Textbook :


quizzes

-oral recitation

-unit examination

- group

participation and

communication

skills

-short essy

Quizez on

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

analytical

13


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

distribution

3.1 Solve a case in patients with

impaired renal or liver requiring dosage

adjustment .

Textbook :


problem solving

skills

problem-solving

assessment tools (

4.1. Discuss the process of drug

metabolism according to:

4.1.1. The two kinds of reactions (Phase 1 and Phase 2). 4.1.2 The concept pf stereo-selectivity 4.2. Explain the mechanism by which drugs inhibit the P450 enzymes or increase the activity of microsomal enzymes and oxygenating systems (induction) and identify the drugs that are inducers and inhibitors 4.3. Recognize and list the drugs that are affected by inducers and inhibitors 4.4. Predict the effect on drugs that are affected by an inducers or by an inhibitor 4.4. Present clinical cases of drug

induction , drug inhibition and drug

excretion

3. Biotransformation and Drug

Excretion

a. Type of drug metabolic

reactions

- PHASE 1 reactions

- PHASE 2reactions

b. Drug metabolizing enzyme

system

- Inducers

- Inhibitors

3.5 hours

-Lectures

-Small group

discussion

Textbook :

-Basic and -Clinical

Pharmacology

-quizzes

-oral recitation

-unit examination

- group

participation and

communication

skills

-short essay

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

14


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

4.5. Explain the process of drug and metabolite excretion: 4.5.1. Discuss Renal excretion of drugs and metabolites. 4.6.Correlate clinical cases of drug

overdose with renal clearance

c. Renal excretion of drugs

- Factors affecting the renal

excretion of drugs

-renal clearance of basic drugs

-renal clearance of acidic drugs

5.1. Explain the four protein targets for

drug action receptors, ion-channels,

enzyme and transport proteins.

5.2. Discuss and differentiate among

the four types of receptors according to

location, effectors, and molecular

structure.

5.3.Classify drugs according to it’s

receptor type

5.4.Explain the control of receptor

expression.

5.5. Present clinical diseases linked to

receptor malfunction.

5. Receptors

a.Ligand gated / ion channel receptors b.G- protein coupled receptors c.Tyrosine kinase linked receptors d.Intranuclear / steroid

receptors

e.PPAR receptors

f. Receptor downregulation

g. Receptor upregulation

3.5 hrs

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :

-Basic and -Clinical

Pharmacology

-Netters illustrated

Pharmacology

-quizzes

-oral recitation

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Posttest MCQ

-minute paper

-Essay questions

-Embedded testing

incorporated into

assignments

-Rating Scale with

rubric

15


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

6.1. Review basic genetic concept.

6.2. Explain the mechanism by which

genetic variations may cause adverse

drug reaction and idiosyncratic reactions

6.3. Discuss and give examples of single-

gene pharmacokinetic disorders.

6.4. Discuss the potential benefits of

Pharmacogenetics.

6.5. Explain the potential benefits of

pharmacogenomics

6.5. Evaluate currently available

pharmacogenomic tests and their

potential benefits .

6.4 Review and critique research paper

on pharmacogenomics

6.6. Present a case of genetic variations

6. Clinical Pharmacology

a.Pharmacogenetics

- genetic variations for drug

reactions , idiosyncratic

reactions

-single gene pharmacokinetic

disorders

b. pharmacogenomics, and

personalized medicine

3.5 hours Small group

discussion

-case studies

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :

Rang and Dales

Pharmacology

-Netters Illustrated

Pharmacology

Textbook :

Rang and Dales

Pharmacology

-Netters Illustrated

Pharmacology

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-long exam MCQ

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

16


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

1.1. Review and identify the locations

and types of acetylcholine receptors in

the major organ systems (CNS,

autonomic ganglia, eye, heart, vessels,

bronchi, gut, genitourinary tract,

skeletal muscle, exocrine glands).

1.2. Describe the effects of acetylcholine

on the major organs.

1.3 Classify the different Cholinergic

Agonist

1.3. Relate the different

pharmacokinetic properties of the

various choline esters , cholinesterase

inhibitors and cholinomimetic alkaloids

to their chemical properties and

pharmacokinetic profile.

1.4. Explain in detail the mechanism of

action of cholinomimetic / cholinergic

agonist

1.5 Analyze the pharmacologic

differences of direct acting and indirectly

acting cholinomimetic agents

1.4. Recognize naturally occurring

UNIT II

DRUGS ACTING ON THE

AUTONOMIC NERVOUS SYSTEM

1. Cholinergic agonist /

a. Cholinoceptor Activating

drugs

-direct acting cholinergic

agonist

- choline esters

- naturally occurring

Alkaloids

-indirectly acting

-Choline esterase inhibiting

-reversible

-irreversible

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

-Interactive

Lecture

-Small group

discussion

Textbook :

1. Basic and -Clinical

Pharmacology)

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott

Illustrated Reviews:

Pharmacology

5. Netter’s Illustrated

Pharmacology

Textbook :


Pharmacology

2. Rang and Dale

Pharmacology

-quizzes

-oral recitation

-unit examination

- group

participation and

communication

skills

-short essay

-graded oral

reports

-Unit examination

- group

-Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

17


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

alkaloids and their botanical sources

1.4. Discuss the major clinical uses of

cholinomimetic agonists.

1.5. Differentiate the pharmacodynamic

of direct-acting and indirect-acting

cholinomimetic agents.

1.6. Recognize the major signs and

symptoms of (1) organophosphate

insecticide poisoning and (2) acute

nicotine toxicity.

1.8.Research and Present local cases of

organophosphate /insecticide poisoning

1.7 Formulate a management plan in

the treatment of organophosphate

insecticide poisoning and give the

rationale for such treatment

1.8 Dessiminate information to

communities on

organophosphate/insecticide poisoning

c. Organophosphate poisoning

-insecticides

-agents use in Chemical Warfare

-case studies 3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

participation and

communication

skills

-short essay

assignments

-Minute paper

-Rating Scale with

rubric

18


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

2.1 Discuss the mechanism of action of

antimuscarinics

2.2 Explain effects of atropine on the

major organ system

2.3. Identify the major clinical

indications and contraindications for the

use of muscarinic antagonists

2.4.Recognize naturally occurring

antimuscarinic agents and their

botanical sources

2.4. Classify the different muscarininc

agent promoted for each uses : to

produce mydriasis cycloplegia , to treat

parkinsons, peptic ulcer and asthma

2.6. Describe the signs ,symptoms and

treatmernt of atropine poisoning

2.7 Present a case of poisoning due to

atropine or other naturally occurring

antimuscarinic alkaloid especially in the

Philippine setting

2.8. Formulate a treatment plan in cases

of poisoning of atropine and give the

rationale of the antidote

2. Cholinoceptor Blockers

a. Antimuscarinics

3.5 hours

Interactive

Lecture

-Small group

discussion

-case studies

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-quizzes

-oral recitation

-graded oral

reports

-Unit examination

- participation and

communication

skills

-short essays

-Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

19


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

2.9.Dessimiate information of the

toxicity of naturally occurring

antimuscarinic alkaloids.

2.5. Explain the mechanism of action

and effects of the ganglionic blocking

nicotinic antagonist

2.6 Conduct an information drive of the

ill effects of nicotine.

b. Ganglionic blocking nicotinic

antagonist

3.1. Discuss the transmission process at

the neuromuscular end plate and the

points at which drugs can modify this

process.

3.2. Identify the major nondepolarizing

neuromuscular blockers and one

depolarizing neuromuscular blocker;

compare their pharmacokinetics.

3.3. Compare the difference between

depolarizing and nondepolarizing

blockers from the standpoint of tetanic

and posttetanic twitch strength.

3.4. Describe the method of reversal of

3. Skeletal Muscle Relaxants

- Neuromuscular blocking

agents

-direct acting skeletal muscle

relaxant

-centrally acting skeletal muscle

relaxant

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

20


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

nondepolarizing blockade.

3.5. Explain the mechanism of action of

the major drugs used in the treatment

acute and chronic skeletal muscle

spasticity and describe their

mechanisms.

4.1. List tissues that contain significant numbers of alpha receptors of the ᾳ1, ᾳ2, types. 4.2. List tissues that contain significant numbers of β1 or β2 receptors. 4..3. Describe the major organ system effects of a pure alpha agonist, a pure beta agonist, and a mixed alpha and beta agonist. Give examples of each type of drug. 4..4. Describe a clinical situation in which the effects of an indirect sympathomimetic would differ from those of a direct agonist. 4.5. List the major clinical application of the adrenoceptor agonist. 4.6 . Compare the different sympathomimetics according to: 4.6.1. Mechanism of action

4. Sympathomimetics

-direct acting

sympathomimetic

-indirectly acting

sympathomimetic

-mixed acting

sympathomimetic

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

21


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

4.6.2. Clinical Application 4.6.3. Pharmacokinetics 4.6.4 Toxicities and Drug Interaction 4.7. Present a case of the effect of sympathomimetics of vascular resistance, blood pressure and heart rate.

5.1 Discuss the effects of an alpha

blocker

5.2 Discuss the effects of a beta blocker

5.3 compare the effects of the different

beta blockers

5.4 compare the pharmacokinetics of

the different beta blockers

5.5 describe the clinical indications and

toxicities of alpha and a beta blockers

5.6 Present a case of hypertension using

the different kinds of adrenoceptor

blockers

5. adrenoceptor

blockers

-Alpha blockers

(selective and non-selective)

-Beta blockers (selective and

non-selective)

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-long exam MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

22


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

1.1. Classify the major types of diuretics and relate them to their sites of action. 1.2. Explain two drugs that reduce potassium loss during sodium dieresis. 1.3. Discuss a therapy that will reduce calcium excretion in patients who have recurrent urinary stones. 1.4. Discuss a treatment for severe hypercalcemia in a patient with advance carcinoma. 1.5. Explain a method for reducing urine volume in nephrogenic diabetes insipidus. 1.6. List the major applications and the toxicities of thiazides, loop diuretics, and potassium-sparing diuretics.

UNIT III

CARDIOVASCULAR DRUG

1. Diuretic Drug

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

23


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

2.1. Classify the four major groups of

antihypertensive drugs and give

examples of drugs in each group.

2.2. Explain the compensatory responses

to each of the four major types of

antihypertensive drugs.

2.3. Classify the major sites of action of

sympathoplegic

drugs and give examples of drugs that

act at each site.

2.4. Classify the three mechanism of

action of vasodilator drugs.

2.5. Discuss the differences between the

two types of angiotensin antagonist

2.6. List the major toxicities of the

prototype antihypertensive agents.

2.7. Explain why some combinations of

Antihypertensive drugs are rational and

appropriate and others are not.

2.8. Critic a journal of hypertensive case

reports

2.9. Present a case of hypertension.

2.10. Formulate a drug management in a

2. Drugs used in Hypertension

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

24


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

hypertensive patient

2.11. Attend a seminar on the

management of hypertension

3.1. Discuss the pathophysiology of

effort angina and

vasospastic angina.

3.2. Explain the major determinants of

cardiac oxygen consumotion.

3.3. Discuss the strategies for relief of

angina pain.

3.4. Contrast the therapeutic and

3. Vasodilators and the

Treatment of Angina

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott

-quizzes

-oral recitation

-graded oral

reports

-Unit examination

-participation and

communication

skills

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

25


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

adverse effect of nitrates, beta-blockers,

and calcium channel blockers when used

for angina.

3.5. Explain why the combination of a

nitrate with a beta-blocker or a calcium

channel blocker may be more effective

than either alone.

3.6. Explain why the combination of a

nitrate and sildenafil is potentially

dangerous.

3.7. Contrast the effects of medical

therapy and surgical therapy of angina.

3.8. Attend a drug symposium involving

treatment of angina

3.9. Conduct a community seminar

regarding the cause and prevention of

angina

3.5 hours


Pharmacology

-short essays

4.1. Discuss the strategies and list the

major drug groups used in the treatment

of congestive heart failure.

4.2. Explain the probable mechanism of

action of digitalis.

4.Drugs used in treatment of

congestive heart failure

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

-graded oral

reports

-Unit examination

-participation and

- Posttest MCQ

- Essay questions --

-Embedded testing

incorporated into

26


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

4.3. Explain the nature and mechanism

of digitalis’s toxic effects on the heart.

4.4. List some positive inortropic drugs

that have been invested as digitalis

substitutes.

4.5. Discuss the beneficial effects of

diuretics, vasodilators, ACE inhibitors,

and other drugs that lack positive

inortropic effects in congestive heart

failure.

4.6. Present a case of congestive heart

failure

4.7. Formulate different management

strategies in the management of

congestive heart failure

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott



Pharmacology

communication

skills

-short essays

assignments

-Minute paper

-Rating Scale with

rubric

5.1. Explain the distinguishing features

of the four major classes of

antiarrhythmic drugs and adenosine.

5.2. List two or three of the most

important drugs i each of the four

classes.

5.3. List the major toxicities of those

drugs.

5. Antiarrhythmic Drugs

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

27


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

5.4. Discuss the mechanism of selective

depression by local anesthetic

antiarrhythmic agents.

5.5. Explain how hyperkalemia,

hypokalemia, or an antiarrhythmic drug

can cause an antihythmia


Pharmacology


Pharmacology

-short essay

6.1. Review the proposed role of

lipoproteins in the formation of

atherosclerotic plaques.

6.2. Discuss the dietary management of

hyperlipoproteinemia.

6.3. Classify the four main classes of

drugs used to treat hyperlipidemia and

describe their mechanism of action,

effects upon serum lipid concentration,

and adverse effects.

6.4. Propose a rational drug treatment

regimen based on a set of baseline

serum lipid values.

6.5. Collaborate with professional the

merits of combined drug therapy for

hyperlipedemia.

6.6. Educate patients on hyperlipidemias

6. Drugs used in the

treatment of

Hyperlipidemias

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

-Role playing

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

28


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

7.1.Classify the major classes of

anticlotting drugs and compare their

utility in venous and arterial

thromboses.

7.2. Discuss the four types of

anticoangulants and their mechanisms

of action.

7.3. Explain why the onset of

warfarin’saction is relatively slow.

7.4. Compare the oral anticoangulants,

standard heparin, and low-molecular-

weight heparins in terms of their

pharmacokinetics, mechanisms, and

toxicities.

7.5. Give several examples of warfarin’s

role in pharmacodynamic drug

interactions.

7.6. Diagram the role of activated

platelets at the Site of a damaged blood

vessel wall and show where the major

four classes of antiplatelet drugs act.

7.7. Compare the pharmacokinetics,

clinical uses and toxicity of the major

7. Drugs Used in Coangulation

disorders

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-long exam MCQ

29


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

antiplatelet drugs.

7.8. Classify the different drugs used to

treat Disorders of excessive bleeding.

1.1. Review the major organ system

effects of histamine and serotonin.

1.2. Discuss the pharmacology of the

two generations and three subgroups of

H1 antihistamines; list prototypical

agents for each subgroup.

1.3. Explain the pharmacology of H2

antihistamines; identify the four

members of this group.

1.4. Discuss the action, indication, and

toxicity of sumatripan.

1.5. Discuss one 5-HT2 and one 5-HT3

antagonist and their major applications.

1.6. Anticipate the major organ system

effects of the ergot alkaloids.

1.7. Discuss the major clinical

applications and toxicities of the ergot

drugs.

1.8. Critically appraised relevant

literatures regarding the use of ergot

UNIT IV

AUTOCOIDS AND DRUG WITH

IMPORTANT ACTIONS ON

INFLAMMATION

1. Histamine, Serotonin, and the

Ergot Alkaloids

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

graded oral

reports

-Unit examination

- group

participation and

communication

Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

30


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

alkaloids.

1.9. Formulate an inventory of health

diseases associated with histamine , etc.

and give the plan of management.

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

skills

-short essay

-Minute paper

-Rating Scale with

rubric

2.1. Name an antagonist of angiotensin

at its receptor and at least two drugs

that reduce the formation of angiotensin

II.

2.2. Outline the major effects of

bradykinin and atrial natriuretic peptide.

2.3. Discuss the functions of converting

enzyme(peptidyl dipeptidase, kininase

II).

2.4. Compare two potent

vasoconstrictor peptides based on their

pharmacokinetics.

2.5. Discuss the effects of vasoactive

intestinal peptide, substance P, and

calcitonin gene-related peptide.

2.Vasoactive Peptides 3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

3.1. Review the major effects of PGE2

PGF2ἀ, LTB4, LTC4, and LTD4.

3.2. Discuss the synthesis and the effects

3. Prostaglandins and other

Eicosanoids

3.5 hours

-Interactive

Lecture

-Small group

Textbook :


Pharmacology

graded oral

reports

- Posttest MCQ,

-Essay questions

31


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

of thromboxane and prostacyclin in the

vascular system.

3.3. Categorized the currently available

therapeutic antagonists of leukotrienes

and prostaglandins and their targets

(receptors or enzyme).

3.4. Explain the different effects of

aspirin on prostaglandin synthesis and

on leukotriene synthesis.

discussion

-case studies

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-Unit examination

- group

participation and

communication

skills

-short essay

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

4.1. Review the enzyme responsible for

the synthesis of nitric oxide in tissues.

4.2. Identify the major beneficial and

toxic effects of endogenous nitric oxide.

4.3. Explain two drugs that cause release

of endogenous nitric oxide.

4.4. Discuss two drugs that

spontaneously or enzymatically break

down in the body to release nitric oxide

.

4. Nitric Oxide, Donors , and

Inhibitors

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

5.1. Contrast the functions of COX-1 and

COX-2.

5.2. Discuss the effects of aspirin and

5. Nonsteroidal Anti-

inflammatory Drugs,

Acetaminophen, and Drugs

3.5 hours

-Interactive

Lecture

-Small group

Textbook :


Pharmacology

-graded oral

reports

-Essay questions

32


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

other NSAID on prostaglandin synthesis.

5.3. Contrast the actions and toxicity of

aspirin, the older nonselective NSAIDS

and the COX-2-selective drugs.

5.4. Identify the toxic effects of aspirin.

5.5. Classify the different DMARDs and

compare their mechanism of action and

toxicity with those of the NSAIDs.

5.6. Contrast the treatment of acute and

chronic Gout.

5.7. Discuss the mechanism of action

and toxicity of three different drug

groups used in gout.

5.8. Explain the effects and the major

toxicity of acetaminophen and its

treatment.


literature on NSAID.

5.10. Educate patients and family

regarding prognosis and management of

the different kind of arthritis.

5.11.Promote in the community in

collaboration with LGUs the use of

Used in Gout

discussion

-case studies

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-Unit examination

- group

participation and

communication

skills

-short essay

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-long exam MCQ

33


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

natural plants available for the

treatment of anti-inflammatory

conditions.

1.1. Identify the major types of voltage-

gated and ligand-gated ion channels in

neuronal membranes.

1.2. Categorized the criteria for

accepting a chemical as a

neurotransmitter.

1.3. Discuss the mechanism by which

drugs module synaptic transmission.

1.4. Categorized the major excitatory

and major inhibitory central

eurotransmitters.

1.5. Identify the major receptor

subtypes of CNS neurotransmitters.

UNIT V

DRUGS THAT ACT IN THE

CENTRAL NERVOUS SYSTEM

1. Introduction to CNS

Pharmacology

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

2.1. Categorized the major chemical

classes of sedative-hypnotics.

2.2. Discuss the pharmacodynamics of

benzodiazepines and barbiturates,

including their mechanisms of action.

2.3. Compare the pharmacokinetics of

commonly used benzodiazepines and

2.A. Sedative-Hypnotic Drugs

-Barbiturates

-Benzodiazepines

- “Z” drugs

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

-graded oral

reports

-Unit examination

- group

participation and

communication

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

34


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

barbiturates and discuss how differences

among them affect clinical use.

2.4. Explain the clinical uses and adverse

effects of sedative-hypnotics.

2.5. Compare the distinctive properties

of buspirone, zolpidem, and zaleplon.

2.6. Classify the different anti-anxiety

agents.

2.7. Compare the pharmacokinetic of

the different anti-anxiety agent.

2.8. Critically appraised research

literatures regarding the

benzodiazepines and other drugs used

as hypnotic agents.

2.9. Conduct a research on endogenous

plants that have potential sedative

hypnotic property.

2.B. Anti-anxiety agents

3.5 hours

10 hours

-Interactive

Lecture

-Small group

discussion

-case studies

-Laboratory

researches

Casebook

4.Lippincott


Pharmacology

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

skills

-short essay

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Rating Scale with

rubric

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

3.1. Classify the major drugs used for partial seizures, generalized tonic-clonic seizures, absence and myoclonic seizures, and status epilepticus. 3.2. Explain the mechanisms of

3. Antiseizure / Antiepileptic

agents

3.5 hours

-Interactive

Lecture

-Small group

discussion

Textbook :


Pharmacology

2. Rang and Dales

-quizzes

- graded oral

reports

-Unit examination

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

35


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

antiseizure drug action. 3.3. Discuss the main pharmacokinetics and adverse effects of major antiseizure drugs. 3.4. Identify new antiseizure drugs and their important characteristics. 3.5. Explain the factors that must be considered in designing a dosage regimen for an antiseizure drug.

-case studies Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

- group

participation and

communication

skills

-short essay

assignments

-Minute paper

-Rating Scale with

rubric

4.1. Classify the main inhalation

anesthetic agents and describe their

pharmacodynamics properties.

4.2. Discuss the relationship of the

blood: gas partition coefficient of an

inhalation anesthetic with its speed of

onset of anesthesia and its recovery

time.

4.3. State the factors that influence

inhalation anesthetic biodisposition.

4.4. Discuss the main pharmacokinetic

and pharmacodynamic characteristics of

the intravenous anesthetics.

4. General Anesthetics

-Inhalational general

anesthetics

-Intravenous general

anesthetics

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

- graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

36


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

5.1.Discuss the mechanism of blockade

of the nerve impulses by local

anesthetics

5.2. Discuss the relationship between

pH, pKa, and the speed of onset of local

anesthetics.

5.3. Summarize the factors that

determine the susceptibility of nerve

fibers to blockade.

5.4. List the major toxic effects of the

local anesthetics.

5.5. Explain use-dependent blockade by

local anesthetics.

5. Local Anesthetics

-Esters Local Anesthetics

-Amides Local Anesthetics

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

37


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

6.1. Discuss the neurochemical

imbalance underlying the

symptoms of parkinson’s disease.

6.2. Explain the mechanisms by which

levodopa, dopamine receptor agonists,

selegiline, and muscarinic blocking drugs

alleviate parkinsonism.

6.3. Discuss the therapeutic and toxic

effects of the major antiparkisonism

agents.

6.4. Identify the compounds that inhibit

dopa decarboxylase and catechol-O-

methyltransferase and muscarinic

blocking drugs alleviate parkinsonism.

6.5. Identify the chemical agents and

drug that cause parkinsonism

symptoms.

6.6. Identify the drugs used in

management of tremor, Hungtington’s

disease, drug-induced dyskinesias, and

Wilson’s disease.


research literature of the new

6. Drugs used in Parkinsonism

and other movement Disorders.

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Netter’s illustrated

Pharmacology

-quizzes

--graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

38


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

modalities.

6.8. Attend seminars regarding

Parkinson’s disease and management.

3.5 hours

7.1. Discuss the pharmacodynamics of

older antipsychotic drugs and relate

7. Antipsychotic Drugs and

3.5 hours

-Interactive

Lecture

Textbook :


-quizzes

-oral recitation

- Posttest MCQ,

-Essay questions

39


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

these characteristics to their clinical

uses.

7.2. Compare and identify the main

characteristics and clinical uses of newer

atypical antipsychotic drugs.

7.3. List the major adverse of the

antipsychotic drugs.

7.4. Explain the pharmacokinetics and

pharmacodynamics of lithium.

Lithium

-Small group

discussion

-case studies

Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

8.1. Explain the probable mechanism

and the major properties of tricylic

antidepressants.

8.2. Discuss the toxic effects that occur

during chronic therapy and with an

acute overdose of tricyclic

antidepressants.

8.3. Identify the second-and third-

generation heterocyclic antidepressants

and their distinctive properties.

8.4. Contrast and identify the selective

serotonin reuptake inhibitors and list

their major characteristics.

8. Antidepressants

-Tricyclic Antidepressants

(TCA)

-Heterocyclic Antidepressants

-Monoamine oxidase Inhibitors

-Selective Serotonine

Re-uptake Inhibitors (SSRI)

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

40


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

8.5. Discuss the therapeutic use and

toxic effects Of MOA inhibitors

8.6. Identify the major drug interactions

associated with antidepressant drugs.

8.7. Present a case study of depression

and its treatment.

8.9. Educate family and patient who has

depression regarding the prognosis,

management.

8.10. Formulate health and wellness

plan for patients with depression.

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

9.1.Review the endogenous opioid

peptides.

9.2. List the receptors activated by

opioid analgesics and the endogenous

opioid peptides.

9.3. Categorize the major opioid

agonists according to thier analgesic

9. Opioid Analgesics and

Antagonists

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

-graded oral

reports

-Unit examination

- group

participation and

communication

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

41


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

efficacy.

9.4. Differentiate the effects opioid

receptor antagonists and mixed agonist-

antagonists.

9.5. Discuss the main pharmacodynamic

and pharmacokinetics properties of

agonist opioid analgesics and list their

clinical uses.

9.6. Compare the main adverse effects

of acute and chronic use of opioid

analgesics.

9.7. Discuss the clinical uses of the

opioid receptor antagonists.

9.8. List two opioids used for antitussive

effects and one used for antidiarrheal

effects.

9.9 Explain the different government

requirement sin prescribing a narcotic

-Interactive

Lecture

-Small group

discussion

-case studies

Casebook

4.Lippincott


Pharmacology

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

skills

-short essay

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Rating Scale with

rubric

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

10.1. Discuss the pharmacodynamics

and pharmacokinetics of acute ethanol

10. Alcohols

3.5 hours

-Interactive

Lecture

Textbook :


- quizzes

-graded oral

- Posttest MCQ,

-Essay questions

42


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

ingestion.

10.2. List the toxic effects of chronic

ethanol ingestion.

10.3 Describe the fetal alcohol

syndrome.

10.4. Discuss the treatment of acute and

chronic ethanol over dosage.

10.5. Outline the pharmacotherapy of

(a) the alcohol withdrawal syndrome

and (b) alcoholism.

10.6. Discuss the mechanism of the

toxicity and treatment of acute

poisoning with (a) methanol and (b)

enthylene glycol.

10.7 Conduct community awareness

programs about the ill effects of alcohol

1,5 hrs

-Small group

discussion

-case studies

Health

education in

the

community

Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

Textbooks .

Basic and -Clinical

Pharmacology

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Group

participation And

communication

skills

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

Rating Scale with

Rubric

11.1. Classify and describe the major 11. Drugs of Abuse 3.5 hours -Interactive Textbook : -quizzes - Long exam MCQ

43


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

actions of drugs that are commonly

abused.

11.2. Describe the major signs and

symptoms of overdose with, and

withdrawal from, CNS stimulants.

11.3. Explain the general principles of

the management of overdose of

commonly abused drugs.

11.4. Identify the most likely causes of

death from commonly abused agents.

11.5 Adhere to Legal standards in the

use of substances of abuse

11.5. Collaborate with different health

professional and NGO’s in conducting

campaign and seminars directed

towards educating the youth about drug

abuse

Lecture

-Small group

discussion

-case studies


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

- -graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

1.1. Review the major hypothalamic releasing hormones. 1.2. Discuss the major anterior pituitary hormones and their effects.

UNIT VII

ENDOCRINE DRUGS

-Interactive

Lecture

-Small group

Textbook :


Pharmacology

-quizzes

--graded oral

reports

- Posttest MCQ,

-Essay questions

-Embedded testing

44


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

1.3. Discuss the major posterior pituitary hormones and their effects. 1.4. Describe the major drugs used as substitutes for the natural hypothalamic and pituitary hormones. 1.5. Identify the drugs that are used for treatment of acromegaly and hyperprolactinemia.

1. Hypothalamic and Pituitary

Hormones

3.5 hours

discussion

-case studies

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-Unit examination

- group

participation and

communication

skills

-short essay

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

2.1. Identify the principal drugs used in

the treatment of hypothyroidism.

2.2. Identify the principal drugs used in

the treatment of hyperthyroidism and

compare the onset and duration of their

action.

2.3. Sketch the biochemical pathway for

thyroid Hormone synthesis and release

and indicate the sites of action of

antithyroid drugs.

2.4. Discuss the major toxicities of

thyroxine and the antihtyroid drugs.

2.5. Correlate research findings with the

mechanism of action of anti-thyroid

drugs.

2.Thyroid and Antithyroid Drugs

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

45


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

2.6. Present a case of hyper and hypo

thyroidism and its management.

2.7. Collaborate with LGUs in conducting

community education regarding thyroid

diseases its prevention and

management.

3.1. Discuss the major naturally

occurring glucocorticosteroid and its

actions.

3.2. Compare several synthetic

glucocorticoids and the differences

between these agents and the naturally

occurring hormone.

3.3. Explain the actions of the naturally

occurring mineralocorticoid and one

synthethic agent in this subgroup.

3.4. List the indications for the use of

corticosteroids in adrenal and

nonadrenal disorders.

3. Corticosteroids and

Antagonist

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

--graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

4.1. Discuss the hormonal changes that

occur during the menstrual cycle.

4.2. Identify three estrogens and four

progestins. Describe their pharmacologic

4. Gonadal Hormones and

Inhibitors

-Female Hormone agonist and

3.5 hours

-Interactive

Lecture

-Small group

discussion

Textbook :


Pharmacology

2. Rang and Dales

-quizzes

-graded oral

reports

-Unit examination

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

46


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

effects, clinical uses, and toxicity.

4.3. List the benefits and hazards of oral

contraceptives.

4.4. List the benefits and hazards of

postmenopausal estrogen therapy.

4.5. Discuss the uses of sex hormones

and their antagonists in the treatment of

cancer in women and men.

4.6. Explain the toxic effects of anabolic

steroids used to build muscle mass.

4.7. Define the terms “SERM” and

“mixed agonists.”

4.8. Compare two SERMS and their

unique properties.

antagonist

-Male Hormone agonist and

antagonist


3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

- group

participation and

communication

skills

-short essay

assignments

-Minute paper

-Rating Scale with

rubric

5.1. Review the effects of insulin on the

liver, on muscle, and on adipose tissue.

5.2. Compare the types of insulin

preparations and their durations of

action.

5.3. Explain the major hazards of insulin

therapy.

5.4. Discuss the prototypes and their

5. Pancreatic Hormones,

Antidiabetic Agents, and

Hyperglycemic Drugs.

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott

-quizzes

- graded oral

reports

-Unit examination

- group

participation and

communication

skills

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

47


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

mechanisms of action, toxicities of the

four major classes of oral antidiabetic

agents.

5.5. Give three examples of rational drug

combinations for treatment of type 2

diabetes mellitus.

5.6. Explain the clinical uses of glucagon.

5.7. Review the epidemiology of

diabetes and obesity in the Philippines.

5.8. Attend seminars and drug symposia

regarding diabetes and new modalities

in treatment.


literatures regarding the management

and treatment of diabetes mellitus.

5.10. Conduct community education

regarding the diabetes, prevention and

management options, and prognosis of

the disease.

5.11. Conduct research on endogenous

plant that is useful in the management

of diabetes.


Pharmacology


Pharmacology

6Understanding

Research methods:

An Overview of the

essentials

7. Access to library

and Online library

collections.

-short essay

48


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

6.1. List the agents useful in the

treatment of hypercalcemia.

6.2. Identify the major and minor

regulators of bone mineral homeostasis.

6.3. Discuss the major effects of

parathyroid hormone and vitamin D

derivatives on the intestine, the kidney,

and bone.

6.4. Attend seminars on osteoporosis.

6.5. Conduct community health

education regarding osteoporosis.

6. Drugs that Affect Bone

Mineral Hemeostasis.

3.5 hours

3,5 hours

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Long exam MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

1.1. Discuss the mechanism of

antibacterial action of beta-lactam

antibiotics.

1.2. Explain the mechanisms underlying

the resistance of bacteria to beta-lactam

antibiotics.

1.3. Identify the four important drugs in

each subclass of penicillins and describe

their antibacterial activity and clinical

uses.

1.4. Identify the four subclasses of

cephalosporins and describe their

UNIT VIII

CHEMOTHERAPEUTIC AGENTS

1. Beta-Lactam Antibiotics

and Other Cell Wall Synthesis

Inhibitors

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

49


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

antibacterial activities and clinical uses.

1.5. List the major adverse effects of the

penicillins and the cephalosporins.

1.6. Explain the important features of

aztreonam, imipenem, and meropenem.

1.7. Discuss the clinical uses and

toxicities of vancomycin, fosfomycin,

and bacitracin.

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

2.1. Explain the mechanisms of action of

these inhibitors of bacterial protein

synthesis.

2.2. Explain the mechanisms responsible

for clinical bacterial resistance to these

2. Chloramphenicol,

Tetracyclines, Macrolides,

Clindamycin, Streptogramins,

and Linezolid.

3,5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

50


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

drugs.

2.3. List the major clinical uses of these

drugs.

2.4. Discuss the pharmacokinetics

features of these agents that are most

relevant to their clinical use.

2.5. Identify the main toxic effects of

these drugs.


research literature regarding the use of

antibiotics.

3.5 hours

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Internet sources

6. Published

Researches

7. e-Journals

- group

participation and

communication

skills

-short essay

assignments

-Minute paper

-Rating Scale with

rubric


amino glycosides antibiotics and the

mechanisms by which bacterial

resistance to this class of drugs occurs.

3.2. Identify the major clinical

applications of aminoglycosides and

describe their main toxic effects.

3.3. Discuss the pharmacokinetics of this

drug class, with special reference to the

importance of renal clearance and its

relationship of toxicity.

3. Amino glycosides

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology)

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook (2014)

4.Lippincott


Pharmacology(2014)

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

51


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

4.1. Discuss the mechanism of

antibacterial action of sulfonamides and

trimethoprim on bacterial folic acid

synthesis and the mechanisms involved

in bacterial resistance to the antifolate

drugs.

4.2.Identify the major clinical uses of

sulfonamides and trimethoprim, singly

and in combination, and describe their

pharmacokinetic properties and toxic

effects.

4.3. Discuss the mechanisms of action of

the fluoroquinolone antibiotics and the

mechanisms involved in bacterial

resistance to these agents.

4.4. Identify the major clinical uses of

fluoroquinolones and describe their

pharmacokinetic properties and toxic

effects.

4. Sulfonamides, Trimethoprim,

and Fluoroquinolones.

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

5.1. Explain the special problems

associated with chemotherapy of

mycobacterial infections.

5.2. Discuss the pharmacodynamic and

5. Antimycobacterial Drugs

3.5 hours

-Interactive

Lecture

-Small group

discussion

Textbook :


Pharmacology

2. Rang and Dales

-quizzes

-graded oral

reports

-Unit examination

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

52


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

pharmacokinetic properties of the first-

line drugs used in tuberculosis (isoniazid,

ethambutol, pyrazinamide, rifampin,

and streptomycin).

5.3. Identify the second-line drugs used

in tuberculosis and list their limitations.

5.4. Identify the drugs used in leprosy

and in Atypical mycobacterial diseases

and describe their major toxic effects.

5.5. Critically appraise relevant research

regarding the treatment of tuberculosis

and leprosy.

5.6. Evaluate DOH programs regarding

tuberculosis prevention and treatment.


regarding tuberculosis and leprosy, its

impact in the community and its

prevention and treatment.


3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

6. e- journals

7. Published research

8. Internet sources

- group

participation and

communication

skills

-short essay

assignments

-Minute paper

-Rating Scale with

rubric


the major drugs used for fungal

infections.

6.2. Discuss the clinical uses and

6. Antifungal Agents

3.5 hours

-Interactive

Lecture

-Small group

discussion

Textbook :


Pharmacology

2. Rang and Dales

-quizzes

-graded oral

reports

-Unit examination

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

53


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

pharmacokinetics of amphotericin B,

flucytosine, fluconazole, itraconazole,

ketoconazole, griseofulvin, and

terbinafine.

6.3. Identify the toxic effects of the

major antifungal drugs.

6.4. Identify the main topical antifungal

agents.


3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

- group

participation and

communication

skills

-short essay

assignments

-Minute paper

-Rating Scale with

rubric

7.1. Identify the main steps in viral

replication.


and of resistance of the major

antiherpes drugs.

7.3. Discuss the pharmacokinetic

properties, the clinical uses, and the

toxic effects of the antiherpes drugs.


and Resistance of the major

antiretroviral drugs.

7.5. Discuss the pharmacokinetic

properties, the clinical uses, and the

toxic effects of the antiretroviral drugs.

7. Antiviral Chemotherapy and

Prophylaxis

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

54


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

7.6. Identify the significant antiviral

properties of amanitadine,

neuraminidase, inhibitors, interferons,

and ribavirin.

8.1. Explain the antibacterial actions,

clinical uses and toxicities of

metronidazole, mupirocin, and

polymyxins.

8.2. Compare nitrofurantoin,

methenamine, and nalidixic acid as

urinary antiseptics and describe their

toxic effects.

8.3. Correlate research findings of the

treatment of urinary tract infection with

the mechanism of the disease.

8. Miscellaneous Antimicrobial

Agents and Urinary Antiseptics

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

- -graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

9.1. Analyze the serum drug levels or

bactericidal titers in antimicrobial

chemotherapy.

9.2. Identify the antimicrobial drugs that

require major modifications of dosage

when renal or hepatic function change,

or when dialysis is used.

9.3. Explain the reasons for use of

9. Clinical Use Antimicrobials

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

55


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

antimicrobial drugs in comination and

the probable mechanism involved in

drugs synergy.

9.4. Discuss the principles underlying

valid antimicrobial chemopropylaxis and

give examples of commonly used

surgical and nonsurgical prophylaxis.

9.5. Choose the appropriate drug of

choice in certain infections using the

SANE criteria


Pharmacology


Pharmacology

-short essay

10.1. Discuss the mechanism of drugs

whose targets are enzymes unique to

parasites, ie, not found in host cells.

10.2. Explain the mechanisms of drugs

whose targets are enzymes

indispensable to parasites but not to

their hosts.

10.3 Explain the mechanisms of drugs

whose targets are biomedical functions

common to Host and parasites cells.

10. Basic Principles of

Antiparasitic Chemotherapy

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

11.1 Classify the major of antiprotozoal

drugs

11. Antiprotozoal Drugs

3.5 hours

-Interactive

Textbook :

-quizzes

- Posttest MCQ,

56


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

11.2. Discuss the pharmacodynamic and

pharmacokinetic properties of the major

antimalarial drugs (chloroquine,

mefloquine, quinine, primaquine, and

the antifolate agents).

11.3. Discuss he pharmacodynamic and

pharmacokinetic properties of the major

anebicides (diloxanide, emetine,

iodoquinol, and metronidazole). List

other clinical applications of

metronidazole.

11.4. Identify the drugs useful for

prophylaxis and treatment of

pneumocytosis and toxoplasmosis and

know their toxic effects.

11.5. Identify the major drugs used for

trypanosomiasis and leishmaniasis and

know their toxic effects.

Lecture

-Small group

discussion

-case studies

-Interactive

Lecture

-Small group

discussion

-case studies


Pharmacology)

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology(2014)


Pharmacology

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology


Pharmacology

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

57


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

skills

-short essay

rubric

-long exam MCQ

12.1. Identify the drugs of choice for

treatment of common infections caused

by nematodes, trematodes, and

cestodes.


of the important pharmacokinetic

features, and the major toxic effects of

anthelmintics drugs.

12.3. Differentiate the features of

important anthelmintics.


regarding prevention of anthelmintic

disease.

12. Anthelmintic Drugs

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

58


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

1.1. Compare the primary features of

cell-mediated and humoral immunity.

1.2. Discuss the different

immunosuppressants and describe the

mechanism of action, clinical uses, and

toxicities.

1.3. Discuss the mechanism of action,

clinical uses, and toxicities and

antibodies used as

immunosuppressants.

1.4. Identify the major cytokines and

other immunomodulating agents and

know their clinical applications.

UNIT IX

Immunopharmacology

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

2.1. Discuss the relevance of cell cycle

kinetics to the modes of action and

clinical uses of anticancer drugs.

2.2. Classify the major subclasses of

anticancer drugs, and explain the

mechanisms of action of the main drugs

in each subclass, and describe the

2.Cancer Chemotherapy

3.5 hours

Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

59


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

mechanism by which tumor cells

develop drug resistance.

2.3.Select the drugs used in regimens for

treatment of the more common

neoplastic diseases and describe their

pharmacokinetics and their toxic effects.

2.4. Explain the rationale underlying the

strategies of combination drug

chemotherapy and rescue therapies.

2.5. Observe the administration of

anticancer agents in a clinical setting

2.6. Critique a research paper in the

therapy of different cancer using new

and modern modalities of treatment

2.7. Attend symposium regarding cancer

and its treatment.

2.8. Conduct awareness of the different

kinds of cancer.

-Interactive

Lecture

-Small group

discussion

-case studies

-Conferences

-Symposiums

Casebook

4.Lippincott


Pharmacology

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Symposium

speakers

communication

skills

-short essay

-quizzes

-oral recitation

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Rating Scale with

rubric

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-long exam MCQ

60


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

1.1. Identify the major air pollutants and

their clinical effects.

1.2. Identify the major toxicities of

common solvents and insecticides,

including chlorinated hydrocarbons,

inhibitors of cholinesterase, and

botanicals.

1.3.Identify two important herbicides

and their major toxicities.

1.4. Discuss the toxicologic significance of environmental pollution due to dioxins and polychlorinated biphenyls (PCBs).

UNIT X

TOXICOLOGY

1. Introduction to Toxicology

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology)

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Toxicology

Handbook

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

2.1. Discuss the general mechanism of

metal chelation.

2.2. Identify the clinical useful chelators

and know their indications and their

adverse effects.

2.3. Explain the major clinical features

and treatment of acute and chronic lead

poisoning.

2.4. Discuss the major clinical features

and treatment of arsenic poisoning.

2.5. Explain the major clinical features

2. Heavy Metals

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Toxicology

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

61


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

and treatment of inorganic and organic

mercury poisoning.

2.6. Discuss the major clinical features

and treatment of iron poisoning.

Handbook

3.1. Diagrams the steps in the

management of the poisoned patient,

including the emergency treatment of a

comatose patient.

3.2. Identify toxic syndromes associated

with major drug groups and individual

agents frequently involved in poisoning.

3.3. Explain the methods for

identification of toxic compounds,

including physical symptoms and

laboratory methods.

3.4. Discuss the methods available for

decontamination of poisoned patients

and for increasing the elimination of

toxic compounds.

3.5. Identify the antidotes available for

management of poisoning.

3.6. Solve a clinical case of poisoning.

3. Management of the poisoned

Patient

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Toxicology

Handbook

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

-long exam MCQ

Analytical problem

solving assessment

tool

1.1. Discuss the primary UNIT XI -Interactive Textbook :

62


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

pharmacokinetic mechanisms that that

underlie drug interactions.

1.2. Explain how the pharmacodynamics

characteristics of different drugs

administered concomitantly may lead to

additive, synergistic, or antagonist

effects.

1.3. Identify specific drug interactions

that occur commonly in clinical practice.

1.4. Present a case involving drug-to-

drug interaction.

1.5. Critically appraise relevant research

and journals regarding drug interaction.

SPECIAL TOPICS

1. Drug to Drug Interactions

3.5 hours

Lecture

-Small group

discussion

-case studies


Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Principles of

Pharmacology: the

Pathophysiologic

Basis of Drugs

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

2.1. Review the marketing and

governmental regulations of efficacy and

safety botanical and nutritional

supplements

2.2. Evaluate the medicinal value of

substances that has been demonstrated

in controlled clinical studies.

2.3. Identify the most widely used

botanical products locally and globally,

2. Botanical Medications and

Nutritional Supplements

3.5 hours

-Interactive

Lecture

-Small group

discussion

-case studies

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

Philippine

3.Pharmacotherapy

Casebook

4.Lippincott

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

63


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

and describe their purported medical

uses, adverse effects, and potential for

drug interactions.

2.4. Discuss the proposed medical uses

and adverse effects to

dehydroepiandrosterone and melatonin.

2.5. Conduct research on locally

available natural plants and marine life.


Pharmacology

5. A Beginners Guide

to Medicinal Plants

6. e –journals


-short essay

3.1. Discuss the principles behind the

different alternative medicine.

3.1.1. Homeopathy

3.1.2. Chelation

3.1.3. Ozone

3.1.4. Acupuncture

3.2. Discuss and describe traditional

Chinese medicine.

3.3. Discuss ayuverdic medicine.

3.4. Explain the principle behind

nutritional medicine, electromagnetic

medicine and light therapy.

3.5. List the ten DOH approved herbal

medicine and their approved uses.

3. Alternative Medicine

- Homeopathy

- Chelation

- Ozone

- Acupuncture

-Traditional Chinese Medicine

-Ayuverdic Medicine

-Nutritional Medicine

-Mind and Body Medicine

-Spiritual Medicine

-Herbal Medicine

-Traditional Filipino Medicine

5 hours

5 hours

Interactive

Lecture

-Small group

discussion

-case studies

-Symposiums

on alternative

medicine

Textbook :


Pharmacology

2. Rang and Dales

Pharmacology

3.Pharmacotherapy

Casebook

4.Lippincott


Pharmacology

5. Fundamentals of

Complementary and

Alternative Medicine

6. Resource speakers

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

- Posttest MCQ,

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-Rating Scale with

rubric

64


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

3.6. Explain the evolution of alternative

medicine in the Philippines setting.

3.7. Demonstrate the following :

3.7.1. Qi Gong

3.7.2. Tai Chi

3.7.3. Yoga

3.7.4. Filipino massage (hilot)

3.7.5. Thai massage

3.8. Explain the principle behind Mind

and Body medicine.

3.9. Analyze and explain the connection

between Spirituality and Medicine.

3.10. Critically appraised research

literatures regarding alternative

medicine.

3.11. Conduct research on alternative

medicine.

3.12. Attend seminars on alternative

medicines

3.13. Adhere to ethical and professional

practice of alternative medicine.

3.14. Collaborate with health

professional practicing alternative

5 hours

40 HRS

-Interactive

Lecture

-Small group

discussion

-case studies

-Symposiums

on alternative

medicine

on alternative

medicine

symposiums

7. e-journals


9.Medical Research

Essentials

10. Understanding

Research methods:

An Overview of the

essentials

11. Access to library

and Online library

collections.

12. Symposium

speakers

-quizzes

-graded oral

reports

-Unit examination

- group

participation and

communication

skills

-short essay

Research

-Essay questions

-Embedded testing

incorporated into

assignments

-Minute paper

-long exam MCQ

-Rating Scale with

65


FRAME

TEACHING –

LEARNING

STRATEGIES


Assessment tool

medicine.

3.15. Conduct symposium regarding

alternative medicine.

presentations

rubric

Self reflection

VIII. GRADING SYSTEM :

66

There will be four Bimonthly examinations throughout the school year and two Comprehensive examinations. In each Bimonthly Period a grade will be released which is computed as follows . A) Lecture : Average of quizzes 40% Average of Unit examinations 30% Bi-Monthly exam score 30% B) Laboratory: Quizzes 20% Reporting 25% Group Discussions 25% Oral Examination 30% C) Research : 100% Other activities – conducting symposium 30% Computation of B-Monthly Grade will be as follows : 60% will be taken from the Lecture score ,while the laboratory score comprises 40% Computation of Semestral Grade will be as follows:

67

A) First semester Grade : 80% will be taken from the First and Second Bi-monthly grade, while 20% will be taken from the First semester comprehensive examination . B) Second semester Grade : 80% will be taken from the third and fourth Bimonthly grade , while 20 % will be taken from the Second semester comprehensive examination Computation of Final Grade will be as follows : A) Average of the First and Second semester Grade 70% B) Research Grade 30% ____ Total 100 % No Special Examination will be given if there is no valid reason ( see student manual for reference ) and an excuse letter must be submitted duly signed by the dean . Oral examination will be given to students who missed small or large group discussions . Passing Grade is 70% , students with borderline grade ( 67- 69%) will be given an Oral Examination. Students with grades of 66- 69 will be deliberated. Those with grades of 65 % and below will no longer be deliberated but will be given a grade of 5.0 ( Failed) References

68

Main Textbook Basic and Clinical Pharmacology

By : Katzung, B. G.; Masters, S. B.; Trevor, A. J. (13th edition - 2015)

Other References 1. Goodman and Gilman’s The Pharmacological Basis of Therapeutic 12th edition (2011) By: Brunton, Lawrence; Chabner, Bruce; Knoliman, Bjorn 2. Rang and Dales Pharmacology Philippine Edition (2014) By: Rang, H. P.; Dale, M.M.; Ritter, J.M.; Flower, R.J.; Henderson, G. 3. Pharmacotherapy A Pathophysiologic Approach 9th edition (Feb. 2014) By: Di Prico, Joseph; Talbert, Robert; Yee, Gary; Wells, Barbara 4.Pharmacotherapy Casebook : A Patient- Focused Approach 9th Edition (April 2014)

By: Schwinghammer, Terry; Koehler, Julia

5. Lippincott Illustrated Reviews : Pharmacology 6th Edition (August 2014) By: Walen, Karen 6. Principles of Pharmacology : The Pathophysiologic Basis of Drugs 3rd Edition By: Golan, David; Tashijan, Amen Jr. H.; Armstrong, E.J. 7. Toxicology Handbook (January 2011) By: Murray, Lindsy; Little, Mark 8. Medical Prescription Writing: A Prescription for Clarity (Aug 2014) By: Goodman, Neville ; Edwards

69

9. Netters Illustrated Pharmacology (2014) By: Robert Raffa

10. Rational Use of Drugs (2010) By: WHO International Compilation 11. Fundamentals of Complementary and Alternative Medicine (April 2010) By: Micozzi, Marc 12. A Beginners Guide to Medicinal Plants: Top 10 Medicinal Plants and Herbs; Their Health Benefit and Use (Feb 2015) By: Jones Michael 13. Medical Research Essentials (Dec 2013) By: Estetie, Rania 14. Understanding Research Methods: An Overview the Essential (Nov 2013) By: Patter, Mildred 15. Basic Allied Health Statistics and Analysis (March 2014) By: Koch, Gerda 16. Study Design and Statiscal Analysis: A Practical Guide for Clinicians (Jul 2006) By: Katz, Mitchell 17. Pharmacology Integrated Review (2012) By: Mark Kester

Prepared by : ARLENE M .DIAZ M.D, FPSECP. Ed.D CHAIRMAN

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