R&D trends in Crop Protection - ABIM · 2015-09-17 · Registration Environmental Chemistry...
Transcript of R&D trends in Crop Protection - ABIM · 2015-09-17 · Registration Environmental Chemistry...
ABIM Conference
October 2012 © PhillipsMcDougall1
R&D trends in Crop Protection
Phillips McDougall
Vineyard Business Centre
Saughland
Pathhead
Midlothian
EH37 5XP
Tel : 01875 320611
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Industry background
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Market Performance 2011(Distributor level – average exchange rates - Nominal US$)
Year Crop Protection
Non-Crop Agrochemicals
GMSeed
Conventional Seed
($m) ($m) ($m) ($m)2000 27830 2195 14269
2001 25760 2778 13597
2002 25150 4270 3140 13060
2003 26710 4445 3709 13521
2004 30725 4675 4476 14524
2005 31190 4905 5095 14657
2011 /2010 % +14.9 +7.0
2006 30425 5150 5855 14485
2007 33390 5365 7062 14648
2008 40475 5655 9150 16870
Agrochemicals = $50,305 +13.8%
2009 37860 5860 10570 171852010 38315 5880 12870 17950
Seed= $34,495 +11.9%
2011 44015 6290
+21.9 +4.815685 18810
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R&D in Crop Protection and Production
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Cost of Bringing a New Product to Market
32 41 42
30
4432
10
91118
20 3618
25
54
18
18
32
13
16
24
13
11
25
0
50
100
150
200
250
300
1995 2000 2005-8
Registration
Environmental Chemistry
Toxicology
Field Trials
Chemistry
Tox/Env Chemistry
Biology
Chemistry
$m
Research
72
Research
85
Research
94
Development
67
Development
146
Development
79
Total $152 m.
Total $256 m.
Total $184 m.
Results of Study undertaken for ECPA and CropLife America
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Cost of Bringing a New Product to Market
42
32
11
36
54
32
24
25
0
50
100
150
200
250
300
Agrochemical
$ m
illio
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Total = $256 m.
Registration
Environmental Chemistry
Toxicology
Field Trials
Chemistry
Tox/Env chemistry
Biology
Chemistry
17.613.4
28.3
13.6
28
17.9
17.2
0
50
100
150
200
250
300
Crop Biotech trait
$ m
illio
n
Total = $136 m. Registration & Regulatory Affairs
Regulatory Science
Introgression breeding & testing
Commercial event production
Construct optimisation
Late discovery
Early Discovery
Agrochemical Plant biotechnology trait
Research
Development
Agrochemical costs based on 2009 Crop Life America/ECPA study Plant biotechnology trait costs based on 2011 Crop Life International study
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1995 2000 2005-8
Research Synthesis 52500 139429 140000
Development 4 2 1.3
Registration 1 1 1
No. of Agrochemical Products Processed Leading to a Successful Product Launch
Results of Study undertaken for ECPA and CropLife America
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Activity Stage For an Event introduced between 2008-2012
Mean Number of Units Evaluated
I Early Discovery 6204
II Late Discovery 4005
III Construct Optimisation 511
IV Commercial Event Production & selection
1302
V Introgression Breeding & Wide –Area Testing
2
VI Regulatory Science 1
VII Registration & regulatory Affairs 1
Number of Units Associated with Biotech Trait R&D Process
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1995 2000 2005-8 Number of years between the first synthesis and the first sale of the product
8.3 9.1 9.8
Time from New Product Inception to First Introduction
Results of Study undertaken for ECPA and CropLife America
Canola Corn Cotton Soybean All crops Number of years from discovery of trait to first commercial sale
11.7 12.0 12.7 16.3 13.1
Results of Study undertaken for CropLife International
(1) Agrochemical
(2) Plant biotechnology trait
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2007 2012
Research of New a.i. 32.5%
Research of New a.i.
29.6%
Development of Generics
1.8%
Development of Generics
1.9%
Development of New a.i.
23.3%
Post Launch Development
31.1%
Product Monitoring / Stewardship
11.3%
Development of New a.i.
24.9%
Post Launch Development
31.4%
Product Monitoring / Stewardship
12.2%
Total = $2,328million Total = $2,943 million
Agrochemical Industry R&D Expenditure by Function(Fourteen Reporting Companies Only)
Results of Study undertaken for ECPA and CropLife America
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Company Sales and R&D Expenditure 2011
0
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Sale
s $m
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Agrochemicals Seed and Traits
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Monsanto DuPont Syngenta BASF Dow Bayer
R&D
Expe
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R&D Expenditure of Leading Agrochemical Companies
1000
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2000
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3500
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
US$
mill
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Agrochemical R&D Seed and Trait R&D
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Number of new Active Ingredients Time period
1980/1989 1990/1999 2000/2009 In R&D
Herbicides Cereals 15 12 12 1
Soybean 11 10 1 0
Maize 2 10 9 1
Rice 11 19 15 4
F&V 2 1 0 0
Other 10 5 2 1
Total 51 57 39 7
Insecticides F&V 11 16 16 4
Rice 5 2 3 3
Cotton 9 12 3 0
Others 4 7 5 3
Total 29 37 27 10
Fungicides F&V 13 9 17 4
Cereals 14 16 8 5
Rice 9 5 7 1
Others 0 0 0 0
Total 36 30 32 10
Others 7 3 5 0
Total 123 127 103 27
Average annual rate of introduction 12.3 12.7 10.3 5.4
Product Introductions and R&D by Crop
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6.5
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New Active Ingredient Introductions
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No.of Products
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Agrochemical Product Introductions and R&D Products
Introduced 1995-2010 Currently in R&DBayer 35 6
Syngenta 15 4***
BASF 20 3*
Dow 17 2
Sumitomo 15 1
DuPont 7 3*
Monsanto 2 0
Other Japanese 42 12
Rest 22 2
Total 175 32**
* Some in co-development with other companies
** some licensed products counted twice
*** Syngenta has another 4 unidentified products in early development
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0
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Agrochemical Active Ingredients in Development
a.i.s in development
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Seed Companies: Input Traits - Development
*BASF / Monsanto partnership ** BASF / Embrapa partnership ***Developed through conventional breeding
Maize Soybean Cotton Canola Others
BASF Herbicide Tolerance*
Nematode Resistance*
Disease Resistance
Bayer GlyTol Twinlink insect resistance Roundup Ready Insect Resistant Rice
GlyTol + HPPD Herbicide ToleranceDual Mode Herbicide
ToleranceLiberty Link + Roundup Ready Fungus Resistant Rice
Novel Insect Resistance Roundup Ready 2
Dow Enlist Corn Enlist Soybeans Enlist Cotton
Triple Mode Herbicide Tolerance
DuPontOptimum AcreMax Xtreme Multiple Mode Herbicide Tolerance
Optimum GLY Glyphosate
ToleranceHerbicide Tolerant Rice
Optimum Intrasect + DP4114 Aphid Resistance Liberty Link Insect Resistant Rice
Lepidoptera Resistance III Lepidoptera Resistance
Coleoptera Resistance III Hemiptera Resistance
Asian Soybean Rust Resistance
Monsanto
Dicamba and Glufosinate
Tolerance Genuity Intacta Genuity Bollgard III Roundup Ready 2
Insect protected Roundup Ready
Sugarcane
Genuity Rootworm Resistance III Dicamba ToleranceDicamba and Glufosinate
ToleranceDicamba tolerance Herbicide tolerant wheat
Genuity Corn borer Resistance
IIIRoundup Ready 2 Xtend Lygus Control Roundup Ready + Liberty Link Gemini Virus Resistant Tomato***
FOP Herbicide tolerance2nd Generation Cyst Nematode
Resistance
Reniform Nematode
ResistancePhytophthora Resistant Peppers
Goss's Wilt Resistance*** Asian Rust Resistance*Root Knot Nematode
Resistance
Gray Leaf Spot resistance2nd Generation Phytophthora Root
Rot Resistance
Syngenta Agrisure Viptera 3222 Insect Resistance Insect resistance (COT 102) Insect Resistant Rice
Agrisure Duracade Disease Resistance
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Seed Companies: Output/Agronomic Trait Research
Maize Soybean Cotton Canola OthersBASF Higher yielding* Higher yielding* Drought tolerance* Higher yielding* Higher yielding sugarcane
Drought tolerance* Healthy fatty acids Higher yielding sugarbeet
Improved Nitrogen Amylopectin potatoes
Improved feed Higher yielding wheat*
Stress tolerant wheat*
Bayer Altered oil content Higher yielding Plant made pharmaceuticals
Stress tolerance
Hybrid rice
Dow Healthy oils Stress tolerance
Added Nutrition
DuPontSeed production technology (yield) Higher yielding Higher yielding Hybrid rice
Improved feed Plenish modified oils
Improved processing Increased oils
Improved Nitrogen Improved feed
Drought tolerance
Monsanto Higher yielding* Higher yielding* Drought tolerance* Higher yielding* Higher yielding wheat*
Drought tolerance* SDA omega-3 oil Stress tolerant wheat*
Improved Nitrogen Vistive Gold
Syngenta Improved Nitrogen
Carb Yield
* In collaboration
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Proprietary v Off Patent Market Share - 2011
Patented 23.0% Off - Patent 77.0%
Proprietary 23.0% Proprietary Off Patent 25.3% Generic 51.7%
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Sales $m
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Proprietary v Off Patent Market Share
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45.0
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1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
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Proprietary Off-Patent
Generic
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Company Acquisitions 2011- Present
Company Acquisition
Bayer US seed company Hornbeck Seed, producer of soybean, rice and wheat
Research company SoyTech Seeds Biological crop protection company AgraQuest
BASF US-based biological products company Becker Underwood
Monsanto U.S. based biotechnology company Divergence Bee health company Beeologics Precision Planting
Syngenta Public offer for the Belgian biotechnology company Devgen US-based biotechnology company Pasteuria Bioscience DuPont Professional Products insecticide business for $125 million GreenLeaf Genetics acquired the seed genetics licensing company
JGL Inc
Dow Seed company Northwest Plant Breeding Company
Brand and marketing assets of Prairie Brand Seed
DuPont US-based alfalfa and clover company Cal/West Seeds Danish enzyme and food ingredient company Danisco South African Pannar Seed US seed company Dobler's hybrids
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D Ex
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Agrochemicals Seed and Traits
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expe
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R&D Expenditure – Historical development
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R&D Expenditure 2011 by Industry (Leading companies)
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R&
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Disclaimers
The information contained in this presentation constitutes our best judgement at the
time of publication, but is subject to change. Phillips McDougall do not accept any
liability for any loss, damage or any other accident arising from the use of the
information in this presentation.
The information given in this presentation has been drawn from analyses and reviews
presented in the Phillips McDougall products AgriService, Seed Service, AMIS Globaland AgreWorld.
Phillips McDougall maintain a wide range of databases covering the crop protection and
seed industries, this presentation presents only headline information. Access to these
databases can be gained through subscription or consultancy. Our market research
databases track product sales from global market totals down to brand level sales by
crop and country in both volume, value and area treated terms.
For more information about these products please visit
www.phillipsmcdougall.com
www.agreworld.com