Rangel QI 2012-2013: Antibiotic Stewardship in the Ambulatory Setting COS – May 15, 2013.
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Transcript of Rangel QI 2012-2013: Antibiotic Stewardship in the Ambulatory Setting COS – May 15, 2013.
Rangel QI 2012-2013:Antibiotic Stewardship in the
Ambulatory Setting
COS – May 15, 2013
Background Information• Antibiotic prescribing in the ambulatory setting
occurs >1 in 5 visits• In study of pediatric office visits , antibiotics
prescribed: • 44% of visits for the common cold• 75% of visits for bronchitis• Estimate at least 40-50% of inappropriate antibiotic
use
• While national antibiotic prescribing rates have decreased, more broad spectrum antibiotics are prescribed
• Inappropriate antibiotic use contributes to antibiotic resistance, side effects, and increased cost
Pediatrics. 2012; 130: 23-31.
JAMA 2002; 287(23): 3096-3102.
Background Information
3-24 months
24-48 months
48-<72 months
Background Information
Questions• How well do we adhere to Clinical practice
guidelines for promoting appropriate antimicrobial use?
• How can we improve our practice?• How can we increase the Rangel Community’s
understanding of viral/bacterial infections and the clinically accepted guidelines for therapy?
• Focusing on common pediatric respiratory illnesses:
• Upper Respiratory Infection (URI)• Acute Otitis Media (AOM)• Streptococcal pharyngitis
AIM Statement• AOM
• 1a) for pt’s 3-17yo with uncertain diagnosis or non-severe illness, increase our observation rates from 60% to 80%
• 1b) for pt’s 3-17yo with certain diagnosis and severe illness, increase our prescription of appropriate antibiotic from 73% to 90%
• Streptococcal pharyngitis• 2) Improve the correct prescription (antibiotic, dose,
duration) from 55% to 75%
• Viral URIs• 3) For patients who present for sick visits and leave
without antibiotic prescription, decrease the number who feel antibiotics are necessary from 85% to 65%
Provider cycles/interventions
Pre-intervention provider survey
• Survey Monkey survey of providers assessing knowledge, perceptions and practice of AOM diagnosis & management
• For children < 2 years of age with suspected AOM, how often do you prescribe antibiotics at time of diagnosis?• 67% providers respond that they would always prescribe
abx
• For children > 2 years of age with suspected AOM, how often do you prescribe antibiotics at the time of diagnosis?• 17% providers responded that they would always
prescribe abx
Didactics• Powerpoint presentation to all providers to review
the clinical guidelines for both AOM and Strep pharyngitis
Clinic materials• Created handout materials & posters that
highlighted the clinical guidelines and listed antibiotic options with dose and timing
2004 AAP/AAFP Clinical Practice Guideline: Diagnosis of Acute
Otitis Media
• 3 major criteria for diagnosis of AOM:• acute onset of symptoms• signs of middle ear effusion
• limited or absent mobility• bulging of TM• air-fluid level• otorrhea
• signs and symptoms of middle ear inflammation• distinct erythema of TM• distinct otalgia
Pediatrics 2004; 113(5):1451-1465.
AGE Certain diagnosis Uncertain diagnosis
Birth to <6 months
Amoxicillin 80-90mg/kg, div BID x 10-days
Amoxicillin 80-90 mg/kg, div BID x 10-days
6 months to < 2 years
Amoxicillin 80-90mg/kg, div BID x 10-days
SEVERE illness: Mod to severe otalgia or fever > 102.2 in past 24hrs
HD amoxicillin x 10-days
Non-severe illness: mild otalgia or temp < 102.2
OBSERVE only
> 2 years SEVERE illness: Mod to severe otalgia or fever > 102.2 in past 24hrs
HD amoxicillin x 5-10 days*OBSERVE only
Non-severe illness: mild otalgia or temp < 102.2
OBSERVE onlyOBSERVE only
Do you have a patient with AOM?
**Certain diagnosis includes BOTH inflammation AND effusion
*5-day treatment option if pt > 6 yo AND no h/o AOM in last 3-months
1st line antibiotics:
Amoxicillin 80 mg/kg/d div BID
5-10 days*
Ceftriaxone 50 mg/kg IM/IV Single dose
Type I hypersensitivity- PCN allergy
Azithromycin
10 mg/kg/d x 1d
5 mg/kg/d x 4 d
5 days
Clindamycin 30-40 mg/kg/d
div TID
10 days
2nd line antibiotics: if mild PCN- reaction (no anaphylaxis or urticaria), or failure of 1st line
Augmentin 90 mg (of amox) /kg/d div
BID
10 days
Cefdinir 14 mg/kg qday 10 days
Cefpodoxime
10 mg/kg/d div BID
10 days
Ceftriaxone 50 mg/kg IM/IV 3 doses
Antibiotic options for AOM
*5-day treatment option if pt > 6 yo AND no h/o AOM in last 3-months
New 2013 AAP/AAFP AOM Guidelines
<6 months 6-23 months >24 months
Severe AOMDefined as: *fever ≥39 or,
*moderate or severe otalgia or,
*otalgia for >48 hours
Antibiotics
Non-severe Bilateral AOMDefined as: *mild ear pain lasting less <48 hours or,
* Temp <39
Antibiotics Antibiotics
Observationw/ assured f/u
Non-severe Unilateral AOM Antibiotics Observation
w/ assured f/u
Observationw/ assured f/u
*moderate or severe bulging of TM or new onset otorrhea, or*mild bulging of TM and recent onset (<48 hours) otalgia, or*mild bulging of TM and intense erythema
Do you have a patient with throat pain?
Consider the rapid Strep test, IF AGE > 3 years
AND >=2 of the following:
NO URI symptoms
(cough, conjunctivitis, rhinitis)
Sudden onset of sore throat
Fever
Headache
Nausea, vomiting, abdominal pain
Palatal petechiae
Scarlatiniform rash
Anterior cervical adenitis
Antibiotic options for GAS-pharyngitis:
1st line antibiotics:
Pencillin V Children: 250 mg BID
Adol: 500 mg BID
10 days
Amoxicillin 50 mg/kg/d, max 1G
10 days
Bicillin IM 600K if < 27 kg
1200K if > 27 kg
Single dose
2nd line antibiotics: if PCN- allergic
Azithromycin
12 mg/kg qday 5 days
Cephalexin 40 mg/kg/d div BID
Max 500 mg/dose
10 days
Cefadroxil 30 mg/kg qday
Max 1G
10 days
Clindamycin 21 mg/kg/d div TID 10 days
Clarithromycin
15 mg/kg/d div BID 10 days
QI “Tip of the Week” emails
EMR tools• Acronym expander for both AOM and Strep
pharyngitis for use in the EMR• .aom
EMR tools• Acronym expander for both AOM and Strep
pharyngitis for use in the EMR• .aom• .pharyngitis
Provider Interventions: Results•For children < 2 years of age with suspected AOM, how often do you prescribe antibiotics at time of diagnosis?
Provider Interventions: Results• For children > 2 years of age with suspected AOM,
how often do you prescribe antibiotics at the time of diagnosis?
Provider Interventions: Results• AIM Goal 1a: To increase our observation in pts 3-17yo
with uncertain diagnosis or nonsevere illness from 60% to 80%
Provider Interventions: Results• AIM Goal 1b: To increase our prescription of
appropriate antibiotic for pts 3-17yo with certain diagnosis and severe illness from 73% to 90%
Provider Interventions: Results• AIM Goal 2: Improve the correct prescription
(antibiotic, dose, duration) of strep pharyngitis from 55% to 75%
Provider Interventions: Results• AIM Goal 2: Improve the correct prescription
(antibiotic, dose, duration) of strep pharyngitis from 55% to 75%
Nurse/MA cycles/interventions
Nursing/MA interventions• Posted handouts around clinic and reviewed with
RNs, ex. “how to triage patient with ‘sore throat’”.
Nursing/MA interventions• Didactics on Rapid Strep testing• Change in Rapid Strep testing workflow
Nursing/MA interventions• Didactics on Rapid Strep testing• Change in Rapid Strep testing workflow
Nurse Interventions: Results
Patient cycles/interventions
Pre-intervention Patient Questionnaire: • Paper/pen survey of random group of parents
presenting for visits during a given block• 85% of patients believed that antibiotics are
appropriate for one of the following: ANY FEVER, ANY INFECTION, or ONLY VIRAL INFECTIONS.
• 45% of parents treat their children at home when sick• 45% of parents take their children to the ED when sick
• Parents opt for the ED principally based on severity of illness, but also because they feel they are more likely to be seen by a doctor (rather than an allied health professional) and for convenience.
• 15% of parents call the clinic or walk-in when their child is sick, with 1/3 of these patients opting occasionally to take their children to the ED instead
Patient Interventions• For patients discharged
with viral diagnoses, providers were instructed to supply a viral prescription with written recommendations for care at home.
Patient Interventions• Providers instructed to have patients read back
the most important instructions in the viral prescription to maximize retention and ensure understanding• In a study of critical laboratory values relayed by
telephone to medical providers, physicians had an error rate of 5%, caught and corrected by a program of mandatory read back to laboratory technicians.
Am J Clin Pathol 2004; 121:801-803.
Post-intervention Patient Questionnaire• AIM Goal 3: For patients who present for sick visits and
leave without antibiotic prescription, decrease the number who feel antibiotics are necessary from 85% to 65%
Post-intervention Patient Questionnaire• AIM Goal 3: For patients who present for sick visits and
leave without antibiotic prescription, decrease the number who feel antibiotics are necessary from 85% to 65%
Sustainability within our ACN clinics• Include lecture(s) on diagnosis of, and antibiotic
prescription for, common outpatient presentations: AOM, Strep pharyngitis, CAP, bacterial sinusitis.
• Handout materials above provider offices and RN/MA stations.
• Acronym expander for AOM and Pharyngitis guidelines and other common outpatient walk-in visits.
• Use of viral prescriptions with read back method.
• Ensure availability of pneumatic otoscopy to increase accuracy of AOM diagnosis.
QI as a tool for improvement in Antibiotic Stewardship
Thanks to the entire Rangel Team!• Residents: ElShadey Bekeley, Sandhya Brachio,
Karen Lee-Bride, Alicia Chang, Wee Chua, Kenny McKinley, Laura Perretta, Pelton Phinizy, Lauren Sanlorenzo, Andrew Wherman, Ronny Zviti
• Preceptors: Evelyn Berger-Jenkins, Hetty Cunningham, Christine Krause, Tawana Winkfield-Royster
• NP: Marcia Clarke• MAs: Wendy, Amarilys, Luisa• Nurses: Clara, Michelle, Cindy, Sharman• PFAs: Taina, Betty, Liz• Rangel Parents
References• Hersh, AL, et al.. “Antibiotic Prescribing in Ambulatory Pediatrics in the United States”. Pediatrics
2011; 129(6): 1053-1061.• Di Pentima MC, et al. “Benefits of a Pediatric Antimicrobial Stewardship Program at a Children’s
Hospital”. Pediatrics 2011: 128(6): 1062-1070.• Coco, A, et al. “Management of acute otitis media after publication of the 2004 AAP and AAFP
clinical practice guideline. Pediatrics 2010; 125:214.• Greene SK, et al. “Trends in antibiotic use in Massochusetts children, 2000-2009.” Pediatrics
2012: 3137.• McCaig LF, et al. “Trends in antimicrobial prescribing rates for children and adolescents.” JAMA
2002; 287(23): 3096-3102.• American Academy of Pediatrics and American Academy of Family Physicians – Subcommittee on
Management of Acute Otitis Media. “Diagnosis and Management of Acute Otitis Media”. Pediatrics 2004; 113(5):1451-1465.
• Shulman ST, et al. Infectious Diseases Society of America. “Clinical practice guidelines for the diagnosis and maangement of Group A Streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America.” Clinical infectious diseases 2012; : doi: 10.1093/cid/cis629
• Chai, G, et al. “ Trends of outpatient prescription drug utilization in US children, 2002-2010.” Pediatrics 2012; 130(1): 23-31
• Barenfanger J, et al. “Improving patient safety by repeating (Read-Back) telephone reports of critical information.” Am J Clin Pathol 2004; 121:801-803.