Radiation Research Seeks to Minimize Risks and Broaden and ... · a community of 17...
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Medical diagnosis Radon and decay products Terrestrial radiation and food Cosmic radiation Other < 0.2 mSv/a Dental Skeletal Thorax CT Other CT Angiography/Intervention Skeletal Thorax Other 1.8 mSv/a 1.1 mSv/a 0.7 mSv/a 0.3 mSv/a Sources of Radiation Exposure of the Population Source: BfS Report 2010 37 % 33 % 13 % 7 % 10 % 56 % 18 % 9 % 14 % 3 % Average Exposure of the German Population Effective Total Dose through Medical Treatments Frequency of Medical Examinations Radiation research provides the scientific basis and the methods to protect man and his environment against ionizing radiation risks from natural and anthropogenic sources. Helmholtz Zentrum München covers all impor- tant current areas of radiation research and radiation protection. In the Department of Radiation Sciences, the center combines expertise in radiation protection, on biological-medical radiation effects and their underlying cell-biological and biophysical mechanisms. In addition, the center has competence in research on the behavior of radioactive materials in the environment, in radiation dosimetry and in the further development of radiation applications for diagnostic and therapeutic purposes. The Department of Radiation Sciences unites the competence at Helmholtz Zentrum München in the fields of radiation biology, radiation risk analysis, radiation and environment as well as radiation and medicine. The depart- ment cooperates with excellent partners across the globe and carries out a number of advisory functions in national and international bodies. Radiation research in the Department of Radiation Sciences is characterized by its high degree of coordination and networking, by its use of cutting-edge technologies and by its top-level expertise. Due to its new focus on persona- lized medicine it is a core part of the research at Helmholtz Zentrum München: At the center, researchers investigate the relationships between lifestyle and individual genetic pre-disposition in the pathogenesis of complex diseases. This is a key basis for the development and evaluation of new therapies, diagnostic methods and preventive strategies. The translation of basic research findings into applications is further enabled by the most modern scientific-technical infrastructure and central technology platforms. The center’s intensive cooperations with clinical partners contribute to the rapid transfer of scientific insights into medical practice. Furthermore, Helmholtz Zentrum München is devoted to the education and training of the young generation of scientists. Through special courses and information events, the current status of knowledge about radiation protection is passed on to medical doctors, scientists, technicians as well as to members of the police and fire services. Prof. Dr. Michael Atkinson Spokesperson of the Department of Radiation Sciences Prof. Dr. Günther Wess CEO and President Radiation Research Seeks to Minimize Risks and Broaden and Improve the Medical Spectrum of Radiation Applications As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The head office of the center is located in Neuherberg to the north of Munich. Helmholtz Zentrum München is a member of the Helmholtz Association, a community of 17 scientific-technical and medical-biological research centers with a total of 31,000 staff members. Use in Society → Application Translational Research, Technology Transfer Determine exposure, minimize risks, broaden and improve the medical spectrum of ionizing radiation Radiation Biology and Radiation Risk Radiation and the Environment Medical Applications of Ionizing Radiation Department of Radiation Sciences Leading Science to Health The main focus of research at the Helmholtz Zentrum München is on major common diseases and the interaction of man, genetics and environmental factors. Ionizing Radiation is an environmental factor, but can also play a major role in optimized personalized medicine. Helmholtz Zentrum München covers all current important areas of radiation research and radiation protection: Radiation Biology and Radiation Risk (1), Radiation and the Environment (2) and Medical Applications of Ionizing Radiation (3). With the aid of cooperations (4), translational research and technology transfer (5), the aim of our research is to achieve a benefit for society. Contact persons in the Department of Radiation Sciences Prof. Dr. Michael Atkinson Spokesperson of the Department of Radiation Research Director of the Institute of Radiation Biology (ISB) [email protected] Phone: +49(0)89 3187-2983 Dr. Peter Jacob Acting Director of the Institute of Radiation Protection (ISS) jacob@helmholtz-münchen.de Phone: +49(0)89 3187-4008 Prof. Dr. Christoph Hoeschen Head of the Research Unit of Medical Radiation Physics and Diagnostics (AMSD) [email protected] Phone: +49(0)89 3187-4560 Prof. Dr. Horst Zitzelsberger Head of the Research Unit of Radiation Cytogenetics (ZYTO) [email protected] Phone: +49(0)89 3187-3421 Contact person at Program Planning and Management PD Dr. Christian Langebartels Head Program Planning and Management (PPM) [email protected] Phone: +49(0) 89 3187-3042 Contact persons at Technology Transfer Dr. Wolfgang Nagel Unit Manager Technology Transfer (ART) [email protected] Phone: +49(0) 89 3187-1210 Dr. Sigrid Scheek ascenion GmbH [email protected] Phone: +49(0) 89 3187-2850 Working Model of Helmholtz Zentrum München and Key Contact Persons Imprint Publisher: Helmholtz Zentrum München German Research Center for Environmental Health Ingolstädter Landstraße 1, 85764 Neuherberg, Germany Phone: +49(0)89 3187-0; Fax: +49(0)89 3187-3324 www.helmholtz-muenchen.de Compact: Helmholtz Zentrum München in numbers Research at Helmholtz Zentrum München: 33 institutes and independ- ent research units; 20 technology plat- forms; 2 translational research centers; 13 clinical cooperation groups; 8 junior research groups 1879 staff members: 607 scientists and post-docs; disciplines of the scientists: biology 41 %, chemis- try/biochemistry 14 %, physics/biophys- ics 10 % and medicine 7 %; 430 doctoral students, of these 307 employed at Helm- holtz Zentrum München; 824 technical staff and other employees; 46 train- ees; 95 work-students, interns, tempo- rary employees; 33 % of positions are financed through third-party funds; 77 % of employees in scientific area, 14 % in the technical area, 9 % in the adminis- tration (as of January 31, 2011) Finances: Total budget 173 million euros: 120 million euros from the Federal Government and the Free State of Bavaria; financing ratio 90:10; over 50 million euros in third-party grants (as of January 31, 2011) Cooperations
Transcript of Radiation Research Seeks to Minimize Risks and Broaden and ... · a community of 17...
Medical diagnosis
Radon and decay products
Terrestrial radiation and food
Cosmic radiation
Other < 0.2 mSv/a
Dental
Skeletal
Thorax
CT
Other
CT
Angiography/Intervention
Skeletal
Thorax
Other
1.8 mSv/a
1.1 mSv/a
0.7 mSv/a
0.3 mSv/a
Sources of Radiation Exposure of the Population
Source: BfS Report 2010
37 %
33 %
13 %
7 %
10 %
56 %
18 %
9 %
14 %
3 %
Average Exposure of the German Population
Effective Total Dose through Medical Treatments
Frequency of Medical Examinations
Radiation research provides the scientific basis and the methods to protect man and his environment against ionizing radiation risks from natural and anthropogenic sources. Helmholtz Zentrum München covers all impor-tant current areas of radiation research and radiation protection. In the Department of Radiation Sciences, the center combines expertise in radiation protection, on biological-medical radiation effects and their underlying cell-biological and biophysical mechanisms. In addition, the center has competence in research on the behavior of radioactive materials in the environment, in radiation dosimetry and in the further development of radiation applications for diagnostic and therapeutic purposes.
The Department of Radiation Sciences unites the competence at Helmholtz Zentrum München in the fields of radiation biology, radiation risk analysis, radiation and environment as well as radiation and medicine. The depart-ment cooperates with excellent partners across the globe and carries out a number of advisory functions in national and international bodies.
Radiation research in the Department of Radiation Sciences is characterized by its high degree of coordination and networking, by its use of cutting-edge technologies and by its top-level expertise. Due to its new focus on persona-lized medicine it is a core part of the research at Helmholtz Zentrum München: At the center, researchers investigate the relationships between lifestyle and individual genetic pre-disposition in the pathogenesis of complex diseases. This is a key basis for the development and evaluation of new therapies, diagnostic methods and preventive strategies. The translation of basic research findings into applications is further enabled by the most modern scientific-technical infrastructure and central technology platforms. The center’s intensive cooperations with clinical partners contribute to the rapid transfer of scientific insights into medical practice. Furthermore, Helmholtz Zentrum München is devoted to the education and training of the young generation of scientists. Through special courses and information events, the current status of knowledge about radiation protection is passed on to medical doctors, scientists, technicians as well as to members of the police and fire services.
Prof. Dr. Michael AtkinsonSpokesperson of the Department of Radiation Sciences
Prof. Dr. Günther WessCEO and President
Radiation Research Seeks to Minimize Risks and Broaden and Improve the Medical Spectrum of Radiation Applications
As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The head office of the center is located in Neuherberg to the north of Munich. Helmholtz Zentrum München is a member of the Helmholtz Association, a community of 17 scientific-technical and medical-biological research centers with a total of 31,000 staff members.
Use in Society → Application
Translational Research, Technology Transfer
Determine exposure, minimize risks, broaden and improve the medical spectrum of ionizing radiation
Radiation Biology and Radiation Risk
Radiation and the Environment
Medical Applications of Ionizing Radiation
Department of Radiation Sciences
Leading Science to Health
The main focus of research at the Helmholtz Zentrum München is on major common diseases and the interaction of man, genetics and environmental factors. Ionizing Radiation is an environmental factor, but can also play a major role in optimized personalized medicine. Helmholtz Zentrum München covers all current important areas of radiation research and radiation protection: Radiation Biology and Radiation Risk (1), Radiation and the Environment (2) and Medical Applications of Ionizing Radiation (3). With the aid of cooperations (4), translational research and technology transfer (5), the aim of our research is to achieve a benefit for society.
Contact persons in the Department of Radiation Sciences
Prof. Dr. Michael AtkinsonSpokesperson of the Department of Radiation ResearchDirector of the Institute of Radiation Biology (ISB)[email protected]: +49(0)89 3187-2983
Dr. Peter JacobActing Director of the Institute of Radiation Protection (ISS)jacob@helmholtz-münchen.dePhone: +49(0)89 3187-4008
Prof. Dr. Christoph HoeschenHead of the Research Unit of Medical Radiation Physics and Diagnostics (AMSD)[email protected]: +49(0)89 3187-4560
Prof. Dr. Horst ZitzelsbergerHead of the Research Unit of Radiation Cytogenetics (ZYTO)[email protected]: +49(0)89 3187-3421
Contact person at Program Planning and Management
PD Dr. Christian Langebartels Head Program Planning and Management (PPM)[email protected]: +49(0) 89 3187-3042
Contact persons at Technology Transfer
Dr. Wolfgang NagelUnit Manager Technology Transfer (ART)[email protected]: +49(0) 89 3187-1210
Dr. Sigrid Scheekascenion [email protected]: +49(0) 89 3187-2850
Working Model of Helmholtz Zentrum München and Key Contact Persons
Imprint Publisher: Helmholtz Zentrum MünchenGerman Research Center for Environmental HealthIngolstädter Landstraße 1, 85764 Neuherberg, GermanyPhone: +49(0)89 3187-0; Fax: +49(0)89 3187-3324www.helmholtz-muenchen.de
Compact: Helmholtz Zentrum München in numbers Research at Helmholtz Zent rum München: 33 institutes and independ-ent research units; 20 technology plat-forms; 2 translational research centers; 13 clinical cooperation groups; 8 junior research groups 1879 staff members: 607 scientists and post-docs; disciplines of the scientists: biology 41 %, chemis-try/biochemistry 14 %, physics/biophys-ics 10 % and medicine 7 %; 430 doctoral students, of these 307 employed at Helm-holtz Zentrum München; 824 technical staff and other employees; 46 train-ees; 95 work-students, interns, tempo-rary employees; 33 % of positions are financed through third-party funds; 77 % of employees in scientific area, 14 % in the technical area, 9 % in the adminis-tration (as of January 31, 2011) Finances: Total budget 173 million euros: 120 million euros from the Federal Government and the Free State of Bavaria; financing ratio 90: 10; over 50 million euros in third-party grants (as of January 31, 2011)
Cooperations
Technische Universität München, Ludwig-Maximilians-Universität München, the Federal Office for Radiation Protection (Salzgitter and Neuherberg), German Cancer Research Center (Heidelberg), Charité University Medical Center (Berlin), Universität Mainz, Fraunhofer Institute for Photonic Microsystems and/or Fraunhofer Institute for Electron Beam and Plasma Technology (Dresden), Universität Stockholm, Food and Drug Administration (Silversprings, USA), Duke University (Durham, USA), Environmental Research Station Schneefernerhaus and National Institute for Radio-logical Protection, Peking , ENEA, CEA, SCK-CEN – Belgian Nuclear Research Centre, IAEA – International Atomic Energy Agency (Austria)
Scivis GmbH, Yxlon International GmbH, Siemens AG, Philips Deutschland GmbH, GE Healthcare, IBA Dosim-etry GmbH, Deutsche Lufthansa AG , Saphymo GmbH, SIRION GmbH, Graetz Strahlungsmesstechnik GmbH
_ EpiRadBio: combines epidemiology and radiobiology to study cancer risks in low radiation exposures. EU-funded project, 9.5 million EUR. Coordination: Dr. Peter Jacob
_ GENRISK-T: Genetic risk of radiation-induced thyroid cancer. EU-funded project, 3.0 million EUR. Coordination: Prof. Dr. Michael Atkinson
_ MADEIRA: Minimizing activity and dose with enhanced image quality by radiopharmaceutical administration. EU-funded project, 3.8 million EUR.Coordination: Prof. Dr. Christoph Hoeschen
_ SOUL: Radiation Risk Research in Southern Urals. EU-funded project, 11.4 million EUR. Coordination: Dr. Peter Jacob
_ BMBF-funded projects: Innovative Methods of Biomedical Imaging for the Optimization of the Medical Use of Radiation and Innovative Methods for 3D Imaging. Total 4.8 million EUR. Coordination: Prof. Dr. Christoph Hoeschen
_ BMBF-funded projects on Radiation and Environ-ment: Radionuclides in the Environment and their Transport in Food Chains to and in Humans. 4.9 million EUR. Coordination: Dr. Jochen Tschiersch
Our Partners in Radiation Research
Aim of the DRS: Research to Ensure the Safe Use of Ionizing Radiation in Medical, Technical and Industrial ApplicationsThe Department of Radiation Sciences (DRS) at Helmholtz Zentrum München combines its expertise in radiation research and radiation protection and is developing it further in an interactive way. National and international cooperative projects with excellent partners supplement this network and support the transfer of insights gained in basic research to practical radiation protection. The aim of the Department of Radiation Sciences is to develop innovative methods to determine radiation exposure, to advance medical progress in the field of radiation diagnostics and therapy and, at the same time, to reduce the harm caused by radiation.
Future Perspectives:
Personalized Radiation Therapy_ Identification of new active agents (small molecules)_ Nanoparticles to increase the local effect _ Integrative biology to identify predictive markers of individual radiation sensitivity
_ Online stratification of nuclear medicine
Personalized Benefit-Risk Analysis for Medical Radiation Applications_ Medical benefits and risks_ Dose distribution in organs and tissues_ Risks of long-term consequences, taking age, sex, genetic/familial predisposition, lifestyle and other personal risk factors into consideration
_ Personalized benefit-risk analysis of different therapy methods for diseases with good prognoses
Our Mission and Expertise in Radiation Research
Institute of Radiation Biology (ISB)_ Director: Prof. Dr. Michael Atkinson (Chair of Radiation Biology at TUM)
_ Individual susceptibility: Dr. Michael Rosemann_ Proteomics and cardiovascular effects: Dr. Soile Tapio_ Improvement of radiation therapy: Dr. Simone Mörtl_ Radiation biology of low doses: Prof. Dr. Michael Atkinson
Institute of Radiation Protection (ISS)_ Director: Dr. Peter Jacob (acting)_ Individual dosimetry: Prof. Dr. Werner Rühm_ Experimental radioecology: Dr. Jochen Tschiersch_ Radioecological modeling and retrospective dosimetry: Dr. Jan Christian Kaiser
_ Radiation risk: Dr. Markus Eidemüller_ Radiation biophysics: PD Dr. Stefan Thalhammer_ Education and training: Dr. Werner Kirchinger
Research Unit of Medical Radiation Physics and Diagnostics (AMSD)_ Head: Prof. Dr. Christoph Hoeschen_ Biokinetics and molecular medicine: Dr. Uwe Oeh_ Dose reduction on medical imaging: Dr. Helmut Schlattl_ Virtual human models: Maria Zankl_ Tomographic application: Dr. Oleg Tischenko
Research Unit of Radiation Cytogenetics (ZYTO)_ Head: Prof. Dr. Horst Zitzelsberger_ Mechanisms of radiation carcinogenesis in thyroid and breast cancer: Prof. Dr. H. Zitzelsberger
_ Integrative biology to detect biomarkers in radiation-induced tumors: Dr. Kristian Unger
_ Molecular mechanisms of the radiation sensitivity of tumor cells: Dr. Verena Bauer
Environment, Radioecology, Dosim-etry: Security and Safety Research, Quantification of
Natural Exposures, Dosimetry for Epidemiological Cohorts
Radiation and Risk: Mechanism of Action of Low
Dose Exposures that Damage Health, Modelling of Pathogen-
esis and Analysis of Risks, Manipulation of Radiation Effects,
Markers and Molecular Mechanisms of Radiocarcinogenesis
Medical Applications of Ionizing Ra- diation: Biomarkers for Personalized Radiation
Therapy, Physics Based Optimisation on Radiation
Diagnostics and Therapy, Personalized Risk/Ben-
efit of Analysis for Medical Radiation Application
compactRadiation Research
Selected cooperations with
research bodies
Selected coopera-tions with industry
Selected externally funded projects
under the leader-ship of the DRS
_ Understanding of radiation effects_ PARTRAC for the extrapolation of radiation-biological results to low doses
_ Study of the effect of radiation in biological samples
_ Personalized radiation protection_ Integration of epidemiology and biology for the risk analysis of low doses
_ Elucidation of radiation-induced mechanisms in tumors
_ Extended understanding of radiation effects
_ ICRP voxel models to better estimate the dose
_ Optimized nuclear-medical imaging and dose estimation for patients
_ Standardization of medical imaging systems, new methods (monoener- getic imaging)
_ More dose-efficient x-rays_ Patents and cooperation with industry_ Personalized, molecular imaging and therapy
_ Determination of radiation exposure from natural noble gases and their progenies
_ Improved personal dosimetry_ Radiation exposure during flights: EPCARD with commercial utilization
_ Fast evaluation of radiological emergency situations
_ Analysis of the biological effect of low doses
_ Simulation of the radiation effects from ionization of DNA atoms to the repair of DNA damage
_ Lab-on-a-chip and biosensors_ Genetic susceptibility of radiation-induced cancer
_ Models of carcinogenesis following radiation exposure
_ Radiation-associated biomarkers in tumors
_ Cardiovascular effects of radiation therapy
_ Development of voxel models_ Biokinetic models_ Quality measurements and simulation of optimization concepts
_ New reconstruction methods and imaging geometries
_ Nanoparticles for the increase of absorption and dose coupled to biomarkers
_ Thoron in buildings_ Active detector systems for neutrons, photons and radon
_ Modeling of secondary cosmic radiation
_ Retrospective dosimetry, passive area monitors and geostatistic methods
_ Biosphere models for radio nuclides in ground - water and surface waters
Biological Radiation Effects, Pathogenesis and Risk
Basis
Medical Radiation Biology
Our Approaches in Radiation Research
Optimized Technology in Medical Radiation Applications
Radioecology and Radiation Exposure of the Population
Successes
