ANNUAL REPORT

July 1, 1979 - June 30, 1980DEPARTMENTOF PHYSIOLOGY

UNIVERSITY OF KANSASMEDICAL CENTERCOLLEGEOF HEALTH SCIENCES AND HOSPITAL

Department Rostera. Academic Staff

G. S. Greenwald, Ph.D., Distinguished Professor and ChairmanR. L. Clancy, Ph.D., ProfessorK. L. Goetz, M.D., Ph.D., Adjunct ProfessorD. C. Johnson, Ph.D., Professor (Joint appt. Ob-Gyn)F. E. Samson,Ph.D., Professor (Director of Ralph Smith Center for Mental Retardation)L. P. Sullivan, Ph.D., ProfessorA. M. Thompson,Ph.D., Professor (and Associate DeanGraduate School)N. C. Gonzalez, M.D., Associate ProfessorC. M. Tarr, Ph.D., Associate ProfessorJ. W. Trank, Ph.D., Associate ProfessorJ. L. Voogt, Ph.D., Associate ProfessorD. J. Welling, Ph.D., Adjunct Associate ProfessorP. D. Cheney, Ph.D., Assistant ProfessorH. J. Cooke, Ph.D., Assistant ProfessorS. K. Dey, Ph.D., Adjunct Assistant Professor (Joint appt. Ob-Gyn)H. L. Fernandez, Ph.D., Assistant Professor (Director, Neurosciences Research

Laboratory, VAHospital)P. F. Terranova, Ph.D., Assistant ProfessorH. D. Schultz, Ph.D., Adjunct Instructor

b. Postdoctoral Fellows

Pilar Gomez-Ramos, Ph.D.R. C. Hoversland,Ph.D.Christopher Hubbard, Ph.D.Brett Oxberry, Ph.D.Srinivas K. Saidapur, Ph.D.Harold D. Schultz, Ph.D.Chandrima Shaha, Ph.D.Susan Silavin, Ph.D.Masaomi Takayama, M.D.Kazuyoshi Taya, D.V.M., Ph.D.Yuichi Wada, M.D.

c. Graduate Students Prel ims Candidate forDegree Require-ments Fulfilled

Luis AscanioDennis C. FaterRichard D. McCabeRobert 0 I NeillDaniel A.TerrerosPatricia A. TonkowiczChon HwaTsaiDianne L. VermillionMary S. VomachkaMatthew ZupkaMichael PattersonLorraine RomeRobert Whitman

11/78Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.Ph.D.MS.MS.MS.

11/785/791/79

Notes concerning graduate students:

Dennis Fater attendedthe American Physiological Meetings, NewOrleans,Louisiana, in October and presented a paper entitled "Evidence that the adrenalmedulla is only of minimal importance in certain cardiovascular reflexes".He also attended the Federation of American Society for Experimental BiologyAnaheim, California, in April and presented a paper entitled "Cardiac innervationeliminates the diuretic response elicited by increasing left antral pressurewith a balloon.

Patricia Tonkowicz attended the Society of the Study of Reproduction meetingat Laval University, Quebec, Canada, in August and the Endocrine Society meetings,Washington, D.C., in June.

Chon Hwa Tsai attended the Society of the Study of Reproduction meetingat Laval University, Quebec, Canada, in August and the Endocrine Society meetings,Washington, D.C., in June.

Daniel Terreros attended the Federation of American Society for ExperimentalBiology, Anaheim, California, in April and presented a paper entitled "TransmembranePotential of Cells in Isolated Renal Tubules" with M. Tarr and J. Grantham..

Mary Vomachka attended the American Physiological Society at MichiganState University in August.

COURSES TAUGHT

101 - Elementary Physiology (F), part of a 1,000 hour course for EmergencyCare. Taught by Dr. Voogt and graduate students. Enrollment 16. Dr.Voogt - coordinator.

388 - Human Physiology. Taughts by Drs. Cheney, Greenwald, Samson, Terranova,Terreros, Thompson and Trank. Enrollment 156. Dr. Terranova - coordinator.

705 - Advanced Human Physiology. Taught by Drs. Clancy, Cooke, Gonzalez, Johnson,Sullivan and Tarr. Enrollment 58. Dr. Clancy - coordinator.

770-771 - Medical Physiology. Taught by the staff.Gonzalez and Greenwald - coordinators.

Enrollment 203. Drs.

2

9/10/79

Department Seminars

9/17179

9/24179

10/2/79

10/8179

10/15179

10/22179

10/29/79

11/5179

11/12179

11/19179

11/26179

12/3179

12/10/80

12/17/80

Dr. Caroline S. Pace

Diabetes Research and Training Center

University of Alabama in Birmingham

Dr. Ronald A. JanisThe Medical School

Northwestern University

Dr. Lawrence P. Sullivan

Physiology Department, KUMC

Dr. Frederick Sachs

Department of Pharmacology

State University of N.Y. at Buffalo

Dr. Timothy Rink

Physiology Dept., Cambridge University

Dr. Paul F. Terranova

Physiology Department, KUMC

Dr. Hugo L. Fernandez

Physiology Department, KUMC andDirector, Neuroscience Research

VA Hospital

Dr. Michael D. Bai lie

Chairman, Pediatric Dept., KUMC

Dr. Alan M. Thompson

Physiology Department, KUMC

Dr. Charles Abzug

Department of PhysiologyUniversity of MarylandSchool of Medicine

Dr. Thomas J. Imig

Department of Neurophysiology

University of Wisconsin Medical School

Dr. Norberto C. Gonzalez

Physiology Department, KUMC

Dr. C. Merrill Tarr

Physiology Department, KUMC

Dr. Gilbert Greenwald

Physiology Department, KUMC

Dr. Larry Welling

Pathology Department, KUMC, and

Research Service, VA Hospital

3

The Role of the Plasma Membrane

in Stimulus-Secretion Couplingin Pancreatic Islet Cells

Cyclic Nucleotides and Phospho-

proteins in the Regulation ofSmooth Muscle Tone

Studies of Renal Potassium

Transport

Properties of Single IonicChannels in Tissue Cultured

Muscle Cells

Autonomic Nerve Control of

Cardiac Output

Delayed Ovulation

Nerve-Target Cell Interactions:

Regulation of acetylcholinesterasemolecular forms in skeletal muscle

The Renin-Angiotensin System inthe Newborn

A New Method of Quantifying Regional

Brain Permeability by Autoradiography

Detection of Neuronal Membrane

Conductance Changes in the Hippo-

campal Formation Using Extracellular

Recording Techniques

Cortico-Cortical Connections Related

to Physiological Maps in Cat AuditoryCortex

pH Regulation in Cardiac Cells

Sarcomere Dynamics in Isolated SingleCardiac Cells

Superovulation Induced by Anti-LHSerum

Evidence for Two Systems of Transport

Channels in Cortical CollectingTubules

1/14/80

1/21/80

1/28/80

2/4/80

2/25/80

3/3/80

3/10/80

3/17/80

3/24/80

3/31/80

4/21/80

4/28/80

5/5/80

5/12/80

5/19/80

Dr. Michael Linshaw

Pediatrics Department, KUMC

Dr. Daniel WellingPathology Department, KUMCandPhysiology Department, KUMC

Dr. WiIf ArnoldBiochemistry Department, KUMC

Dr. Helen CookePhysiology Department, KUMC

Dr. Dennis ValenzenoDepartment of PhysiologyEmory University

Dr. Ronald BorchardtDepartment of BiochemistryKU Lawrence Campus

Dr. H. W. Reinhardt

Department of PhysiologyFree University of Berlin

Chon-Hwa TsaiGraduate StudentPhysiology Department, KUMC

Dr. Pierre SoupartDept. of Obstetrics & GynecologyVanderbilt University

Dennis FaterGraduate StudentPhysiology Department, KUMC

Dr. Francis E. CuppagePathology Department, KUMC

Dr. James L. VoogtPhysiology Department, KUMC

Robert O'NeillGraduate StudentPhysiology Department, KUMC

Paul D. CheneyPhysiology Department, KUMC

Mary VomachkaGraduate Student

Physiology Department, KUMC

4

Regulation of Tubular Cell Volume

A Model for Regulation of TubularCell Volume

Biochemistry & Biophysics of theYeast Cell Envelope

Intestinal Transport Properties inthe Mouse Model for Hirschsprung'sDisease

Light, Dye and Membrane Permeability

Recent Advances in BiologicalTransmethylations

Possible Mechanism of AtrialNatriuresis

Control of Steroidogenesis

Fertilization Mechanisms in theHuman

The Influence of Cardiac Receptorson Renal Function

Biological Applications of ElectronProbe Microanalysis

What is so Interesting aboutNocturnal (S)Urges?

Fast Axoplasmic Transport

Transcortical Stretch Reflex:Does it Exist?

Reproduction in the Female DiabeticRat

Publ ications

a. Published during year - July 1, 1979 - June 30, 1980

Cheney, P. D. Response of rubromotoneuronal cells identified by spike-triggeredaveraging of EMGactivity of awake monkeys. Neuroscience Letters 17:137-142, 1980.

Chiras, D. D. and G. S. Greenwald. Analysis of ovarian follicular development andthymidine incorporation in the cyclic golden hamster. Am. J. Anat. 157:209-317.

Cooke, H. J., L. Pfankuche and A. R. Cooke.rabbit jejunum. Am. J. Physiol. 1980

Dey, S.K., D. C. Johnson, and Santos, J. G. (1979) Is histamine production by theblastocyst required for implantation in the rabbit? BioI. Reprod. 21, 1169-1174.

Dey, S. K. and D. C. Johnson (1980) Reevaluation of histamine in implantation. In: Theendometrium. (F. Kimball Ed.) SP Medical and Scientific Books, Spectrum Publications.New York pp 269-283.

Dey, S. K., Chien, S. M., Cox, C. L. and Crist, R. D. (1980). Prostaglandin synthesis inthe rabbit blastocyst. Prostaglandins 19:449-453.

Fernandez, H. L., Duel1, M. J., Festoff, B. W. (1979) Neurotrophic control of 16Sacetylcholinesterase at the vertebrate neuromuscular junction. J. Neurobio1. 10:441-454.

Tryptophan transport by isolated newborn

Fernandez, H. L., Duell, M. J., Festoff, B. W. (1980) Bidirectional axonal transport of16S acetylcholinesterase in rat sciatic nerve. J. Neurobiol. 11:31-39.

Fernandez, H. L., Dorman, R. V., Festoff, B. W. (1979) Neurotrophic control of skeletalmuscle phospholipids. Muscle and Nerve 2:118-123.

Goetz, K. L. A search for evidence 1inking atrial receptors to renal regulatorymechanisms. Chapter 10 in Cardiac Receptors edited by R. Hainsworth, C. Kidd, and R. J.Linden. Cambridge University Press, 1979, pp 213-233.

Gonzalez, N. C., H. G. Weurben and N. Heisler. Intracellular pH regulation of normaland hypertrophic myocardia. J. Appl. Physiol. 47:651-656, 1979.

Greenwald, G. S. Comparative aspects of antral follicular development during themenstrual and estrous cycle. In: Animal Models for Research on Contraception andFertility (Alexander, N., ed.). Harper and Row, Hagerstown, Md. 176-186.

Greenwald, G. S. Analysis of superovulation in the hamster: 1962-1978. Ann. de BioI.Anim., Biochem. Biophys. 19:1483-1488.

Greenwald, G. S. In vivo and in vitro steroidogenesis by the human ovary during themenstrual cycle. In Biology of the Ovary (eds. P. M. Motta and E. S. E. Hafez).Martinus Nijhoff (Pub.), The Hague: pp:244-253.

Johnson, D. C. and S. K. Dey (1980) Role of histamine in implantation: Dexamethasoneinhibits estradiol-induced implantation in the rat. BioI. Reprod. 22:1136-1141.

Nelson, S. R., Howard, R. B., Cross, R. S. and Samson, F. E.: Ketamine-induced changesin the regional glucose utilization in the rat brain. Anesthesiology 52:330-334, 1980.

Saidapur, S. and G. S. Greenwald. Regulation of 178-estradiol synthesis in the proes-trous hamster: role of progesterone and luteinizing hormone. Endocrinology 105:1432-1439.

Schloerb, P. R., L. Sierachi, N. R., Bambenek, J. N. Simone and D. J. Welling. Totalbody water: Prediction from the early arterial disappearance curve of isotopic water.S.G. &o. 148:371-374, 1979.

5

Simone, J. N., D. J. Welling and L. W. Welling. Computer assisted morphometric analysisfor three-dimensional cell shape. Lab. Invest. 41:334-339, 1979.

Sullivan, L. P. Primates in Comparative Physiology of Osmoregulation in Animals, Vol.2. G.M.O. Maloiy Academic Press, London, 1979.

Tarr, M., J. W. Trank, P. Leiffer and N. Shepherd. Sarcomere length-resting tensionrelation in single frog atrial cardiac cells. Circ. Res. 45:554-559, 1979.

Taya, K. and G. S. Greenwald. In vitro and in vivo ovarian steroidogenesis in thelong-term hypophysectomized hamster. Endocrinology 106:1093-1098.

Terranova, P. F., S. K. Saidapur and G. S. Greenwald. In vitro steroidogenesis of newlyformed corpora lutea and the nonluteal ovary in the rat, rabbit, hamster and guinea pig.J. Endocr. 84:101-108.

Terranova, Paul F. Relationship amoung progesterone, androgen and estradiol in corporalutea and nonluteal ovarian compartments of pseudopregnant rats:effects of decidualtissue. Endocrinology 106:785-763, 1980.

Vomachka, A. J. and G. S. Greenwald. The development of gonadotropin and steroidhormone patterns in male and female hamsters from birth to puberty. Endocrinology105:960-966.

Vomachka, A. and G. S. Greenwald. Negative feedback effects of ovarian steroids in thechronically ovariectomized hamster. BioI. Reprod. 22:1127-1135.

Voogt, J. L., Regulation of nocturnal prolactin surges during pregnancy in the rat.Endocrinology 106:1670-1676, 1980.

Welling, L. W. and D. J. Welling. Dimensions of membrane barriers in transepithelialflow pathways. IN: Current Topics in Membranes and Transport, F. Bronner and A.Kleinzeller, Editors, Vol. 13/Cellular Mechanisms of Renal Tubular Ion Transport, E. L.Boulpaep, Guest Editor, Academic Press, 1980.

b. In Press

Carr, L. A. and J. L. Voogt. Catecholamine synthesizing enzymes in the hypothalamusduring the estrous cycle. Brain Research.

Cheney, P. D. and Fetz, E. E. Functional classes of primate corticomotoneuronal cellsand their relation to active force. J. Neurophysiol.

Cooke, H. J., H. Henning, Jr., J. D. Wood and A. R. Cooke. Jejunal transport propertiesof the piebald mouse model for Hirschsprung's disease. Am. J. Physiology.

Dey, S. K. and D. C. Johnson, Histamine formation bymouse preimplantation embryos. J.Reprod. & Fertil.

Dunn, J. D., D. C. Johnson, A. J. Castro and R. Swenson, Twenty-four hour pattern ofprolactin levels in female rats subjected to transection of the mesencephalic raphe orablation of the suprachiasmatic nuclei. Neuroendocrinology.

Fernandez, H. L. and Duell, M. J. (1980) Protease inhibitors reduce effects of denerva-tion on muscle endplate acetylcholinesterase. J. Neurochem.

Fernandez, H. L. and Duell, M. J. (1980) Neurotrophic control of 16s acetylcholines-terase from mammalian skeletal muscle in organ culture. J. Neurobiol.

Festoff, B. W. and Fernandez, H. L. (1980) Plasma and red cell acetylcholinesterase inamyotrophic lateral sclerosis. Muscle and Nerve.

Fetz, E. E. and Cheney, P. D. Post-spike facilitation of forelimb muscle activity byprimate corticomotoneuronal cells. J. Neurophysiol.

6

Huseman, R., A. Grady, D. Welling and J. Grantham.disease in adu1t human kidneys. Kidney Int.

Powers, C. A. and D. C. Johnson, Release of gonadotropin-releasing hormoneby veratrinein a hypothalamic-pituitarycoincubation. Europ. J. Pharmacol.Powers, C. A. and D. C. Johnson, Peptidase regulation of gonadotropin-releasing hormonelevels during in vitro in~ubations of the rat hypothalamus. J. Neurochemistry.

Sullivan, L. P., D. G. Welling and L. A. Rome. Effects of sodium and chloride onpotassium transport by the bullfrog kidney. Am. J. Physiol.

Sundet, W. D., and K. L. Goetz. A window amplitude discriminator which reproduces thewaveforms of accepted action potentials. Med. BioI. Engr. Computing.

Terranova, Paul F. Relationship between the decidual response and ovarian steroido-genesis in the unilaterally ovariectomized pseudopregnant rat. Journal of Endocrin-ology

A macropuncture study of polycystic

Terranova, Paul F. Effects of phenobarbital-induced ovulatory delay on the follicularpopulation and serum levels of steroids and gonadotropins in the hamster: a model foratresia. Biology of Reproduction

Terranova, Paul F. Atresia induced shift of LH-stimulated steroidogenesis in antralfollicles of the cyclic hamster. In Physiologic Cessation of Ovarian Function, eds., N.B. Schwartz and M. Hunzicker-Dunn, N.Y.

Terranova, Paul F. and Greenwald, G. S. Increased ovulation rate in the cyclic guinea-pig after a single injection of an antiserum to LH. Journal of Reprod. Fert.

Thompson, Alan M., Janet L. Thompson and Robert C. Robertson. Effect of acetazolamide on

rate of CO2 uptake in the perfused rat brain" Brain Research.

c. Abstracts

Carr, L. A. and J. L. Voogt. Catecholamine synthesiscycle. APS symposium "Relation Between BrainFunction", p. 16, 1979.

Clancy, R. L. and N. C. Gonzalez.pH. Fed. Proc. 39:514, 1980.

Cooke, H. and J. D. Wood. Transport characteristics of jejunal mucosa in the piebaldmouse model for Hirschsprung's disease. The Physiologist 22:22, 1979.

Dey, S. K. and Johnson, D. C. The role of embryonic histamine in implantation in therabbit. 12th Annual Meeting, The Society for the Study of Reproduction, Quebec City,Canada, 1979.

enzyme activity during the estrousNeurotransmitters and Endocrine

Effect of hypoxia on myocardial and skeletal muscle

Dey, S. K. Histamine formation and embryo development in the mouse. 13th AnnualMeeting, The Society for the Study of Reproduction, Ann Arbor, Michigan, 1980.

Dey, S. K., Abdou, N. I. and Stechschulte, D. J. Modulation of immune response in vitroby the rabbit blastocyst. 8th Rochester Trophoblast Conference, Rochester, New York,1980.

Dorman, R. V., Festoff, B. W. and Fernandez, H. L. (1979) Denervation and phospholipidsof motor endplate regions. Trans. Amer. Soc. Neurochem. 10:45.

Dudley, R. E., Nelson, S. R., Pazdernik, T., Cheney, P. D. and Samson, F. E. Regionalglucose use in rat brain during chlorolose anesthesia. The Pharmacologist 22:271, 1980.

Faraci, F. M., M. A. Klotz, H. W. Shiver, J. A. Orr and J. W. Trank. Characteristics ofthe bulbus cordis mechanoreceptors in the pond turtle. Pseudemys Scripta Elegans.,Kansas Academy of Science, 1980.

7

Fater, D. C., W. D. Sundet, B. C. Wang, and K. L. Goetz. Evidence that the adrenalmedulla is only of minima1 importance in certain cardiovascular reflexes. Physiologist22:36,1979.

Fater, D. C., W. D. Sundet, H. D. Schultz, and K. L. Goetz. Cardiac denervationeliminates the diuretic response elicited by increasing left atrial pressure with aballoon. Fed. Proc. 39:951, 1980.

Fernandez, H. L. and Duell, M. J. (1980) Properties of 16s acetylcholinesterase frommotor nerve and muscle endplates. Trans. Amer. Soc. Neurochem. 11:100.

Festoff, B. W., Duell, M. J. and Fernandez, H. L. (1980) AcHE in human plasma: increasein motor neuron disease. Trans. Amer. Soc.

Goetz, K. L., D. C. Fater, H. D. Schultz, and W. D. Sundet. Diuretic response to leftatrial distension is el iminated after cardiac denervation. Proc. of Int. Union ofPhysiol. Sci.

Goetz, K. L., H. D. Schultz, W. D. Sundet, and D. C. Fater. Cariovascular responses topartial obstruction at various points in the intrathoracic circulation of consciousdogs. Physiologist

Gonzalez, N. C. and R. L. Clancy.Fed. Proc. 39:514, 1980.

Johnson, K., Nelson, S. and Samson, F. E.: Amphetamine and haloperidol alter glucoseuse in rat habenular nuclei. Amer. Soc. Neurochem. Vol. 11(240), 1980.

Rowe, V., Parr, J., Duell, M. and Fernandez, H. L. (1980) Specific AcHE in pineal celland sympathetic neuron co-cultures. Trans. Amer. Soc. Neurochem. 11:257.

Sawyer, S., Cheney, P. D., Martin, R. F. and Fetz, E. E. Facilitation and suppression offorel imb muscle activity from single intracortical microstimul i in behaving monkeys.Neuroscience abstracts 5:298, 1979.

Schultz, H. D., D. C. Fater, W. D. Sundet, and K. L. Goetz. Renal responses to partialobstruction at various points in the intrathoracic circulation of conscious dogs.Physiologist.

Simone, J. N., L. W. Welling, D. J. Welling and J. J. Hill. Computer assisted morpho-metric analysis of cell shape in renal tubules. Fed. Proc. 38:901, 1979.

Sullivan, L. P., D. J. Welling, L. A. Rome, and L. S. Bruhl. Effect of furosemide on Ktransport in the frog kidney. Fed. Proc. 39:1078, 1980.

Tarr, M., J. W. Trank and P. Leiffer. Velocity of shortening in single cardiac cellsunder lightly loaded conditions. Fed. Proc. 39:276, 1980.

Terreros, D. A., M. Tarr, and J. J. Grantham. Transmembrane potentials of cells inisolated renal tubules. Fed. Proc. 39:713, 1980.

Role of CI in the regulation of myocardial cell pH.

Tobias, H., L. Carr, J. Voogt. Effect of estradiol on catecholamine synthetizingenzymes, luteinizing hormone (LH) and prolactin in the ovariectomized rat. Society forNeuroscience, Abstract No. 1569, 1979.

Voogt, J. L. and L. A. Carr. Catecholamine synthesizing enzymes during lactation."Prolactin 1980 and Beyond", Satellite Symposiumof the Sixth International Congress ofEndocrinology, p. 45, 1980.

Welling, L. W., A. P. Evan, D. J. Welling and J. Huser. Contrasting shape and basalinfolding in I ight and dark cells of rabbit cortical collecting tubule. Kidney Int.16:843,1979.

8

Welling, D. J., J. N. Simone and L. W. Welling. Renal cell volume regulation withoutouabain insensitive pumps. Kidney Int. 16:843, 1979.

Welling, L. W., D. J. Welling and A. P. Evan. Evidence for two systems of extracellularchannels in rabbit cortical collecting tubule (CCT). Fed. Proc. 39:334, 1980.

Welling, D. J., J. N. Simone and L. W. Welling. Passive movement of chloride through aheteroporous membrane: An explanation for chloride Nernst disequilibrium in renaltubules. Fed. Proc. 39:285, 1980.

Welling, L. W., D. J. Welling and A. P. Evan. The shape of cells and of two distincttypes of extracellular channels in rabbit cortical collecting ducts. Central StatesElecron Microscopy Society, 1980.

Research Support

P.D. Cheney: Co-investigator with Dr. Fred Samson on U.S. ArmyMedical Research Commandcontract - Action of cholinergic poisons on the central nervous system and effectivenessof potential antidotes, June I, 1979 - May 31, 1980. Total project direct costs$141,701; Indirect costs $36,816; Direct costs (P. D. Cheney) $22,000. Dr. Samson isPrincipal Investigator.

NINCDS, NIH - Neural mechanisms in the control of limb movement, April 1, 1980 - March31, 1981. Direct costs: $57,908. Indirect costs: $7,080.

R. L. Clancy: National Heart, Lung and Blood Institute, NIH - Effect of Hypoxia onCellular Acid Base Regulation, December 1, 1978 - November 3, 1981. Direct costs$25,119; Indirect costs $7,583.

American Heart Association, Kansas Affiliate - Effect of Insulin on Myocardial Cell pH,July 1, 1979 to June 30, 1980. $10,000.

National Science Foundation, Ion Transport: Equipment for Electrolyte Analysis,September 1, 1979 - February 28, 1981. Direct costs $15,025. Indirect costs none.Coinvestigator with Drs. Cooke, Gonzalez and Sullivan.

H. J. Cooke: American Heart Association, Kansas Affiliate - K Transport in the RabbitColon. $10,000.

National Science Foundation, Ion Transport: Equipment for Electrolyte Analysis,September 1, 1979 - February 28, 1981. Direct costs $15,025. Indirect costs none.Coinvestigator with Drs. Clancy, Gonzalez and Sullivan.

S. K. Dey: NIH - Role of histamine in early pregnancy. $109,000 - 3 years.

NIH - Steroid hormones and embryo development. $79,000 - 3 years.

H. L. Fernandez: N.I.H. - Neurotrophic Substances Affecting Adult and EmbryonicMuscles, July 1, 1979 - June 30, 1980. Direct costs $27,844; Direct costs for totalperiod $46,340. First year indirect costs $2,930.

VA Mer i t Rev iew Program - MuscIe Degenerat ion: Inh i bit ion by Proteo Iyt i c EnzymeBlocking Agents, October 1, 1979 - September 30, 1980. Direct costs $47,100; Directcosts for total period $125,100.

KU Research Committee (P.I.) - Neurotrophic substances affecting adult and embryonicmuscles, January 1, 1979 - August 31, 1979. Direct costs $2,500.

9

K . L. Goetz :$43,718.

N.I.H. - "Atrial Receptors", July 1, 1979 - June 30, 1980. Direct costs

Internal Grant Support, St. Luke's Hospital.

N. C. Gonzalez: American Heart Association - CO2 buffer value of hypertrophic myocar-dium, July 1, 1979 - June 30, 1980. Direct costs $19,500.

National Science Foundation - Ion Transport: Equipment for Electrolyte analysis,September 1, 1979 - February 28, 1981. Direct costs $15,025. Indirect costs none.Coinvestigator with Drs. Clancy, Cooke and Sullivan.

G. S. Greenwald: NICHD - FoIl icular and Luteal Regulation in the Mammalian Ovary,January 1, 1980 - December 30, 1984. First year - Direct costs $74,293. Indirect costs$18,656.

U.S.P.H.S. Post Doctoral Fellowship for Dr. Brett Oxberry - $13,000.

U.S.P.H.S. Post Doctoral Fellowship for Dr. Christopher Hubbard - $16,000.

Ford Foundation Training Grant for Research in Reproductive Biology (K.U. EndowmentAssociation), $13,000.

D. C. Johnson: Nat. Inst. Aging. - Aging Effects on Ovarian Tumorigenesis, September29, 1977- September 1, 1980. Direct costs $52,780 (For period September 1, 1979 -September 1, 1980).

F. Eo Samson: NICHHD - Mental Retardation Center CORE Grant (for Ralph L. SmithResearch Center) Total project costs $1,252,715, Direct costs $157,726 for periodJanuary 1, 1979 - December 31, 1979. Direct costs $148,000 for period January 1, 1980 -December 31, 1980.

Ely Lily Co. - Microtubule Involvement in Neuropathies. (carryover from 1979 with IreneBettinger) $4,000.

U. S. Army Medical Research Corrmand- Action of Chol inergic Poisons on the CentralNervous System and Effectiveness of Potential Antidotes, June 1, 1978 - May 31, 1980.Direct costs June 1, 1979 - May 31, 1980 $141,701.

American Cancer Society - Anti-microtubule chemotherapy; relevance of differentialmicrotubule stability, January 1, 1980 - December 31, 1980. Direct costs $48,378.

L. P. Sullivan: National Science Foundation - Study of factors affecting renal potas-sium transport, May 15, 1978 - May 14, 1980 prorated per year. Direct costs $26,159;Indirect costs $11,791.

N.I.H. - Study of Factors Affecting Renal Potassium Transport. May 1, 1980 -April 30,1983. Direct costs $34,750; Indirect costs $14,160 (first year).

National Science Foundation - Ion Transport: Equipment for Electrolyte Analysis.September 1, 1979 - February 28, 1981. Direct costs $15,025; Indirect costs none.Coinvestigator with Drs. Clancy, Cooke and Gonzalez.

American Heart Association, Kansas Affiliate - Vanadium: Effect on and Transport by theFrog Kidney. July 1, 1979- June 30, 1980. Direct costs $9,984; Indirect costs $599.

C. M. Tarr: National Heart and Lung Institute - Contractile Activity of Single CardiacCe11s, April 1,1979 - March 31,1980. Direct costs $29,190 for period; Indirect costs:$12,804. Total period of support April 1, 1979 through March 31, 1982.

10

P. F. Terranova: NICHHD- Aged Antral Follicles and Atresia. September 1, 1979-August31, 1980. Direct costs $30,100; Indirect costs $6,000.

J. W. Trank: NIH - Contractile Activity of Single Cardiac Cell, April 1, 1979 - March31, 1980. Direct costs $29,190 for period. Total period of support April 1, 1979through March 31, 1982.

J. L. Voogt: NIH- Pituitary Hormones and Brain Amines during Reproduction. July 1,1979 - June 30,1980. Direct costs $51,329 for period. Total period of supportSeptember 30, 1977 through August 31, 1980. Indirect costs: $10,059.

D. J. Welling: NIH - Analytic Formulation of Transport in Single Nephrons.1973 - July 31, 1981. Direct costs for period $67,290.

VA Administration Merit Review Award - In Vitro Study of Nephron Transport Mechanism.

NSF - Studies of Factors Affecting Renal Potassium Transport (Coinvestigator - Dr.Sullivan principal investigator.) May 15, 1978 - May 14, 1980 prorated per year.Direct costs $26,159; Indirect costs $11,791.

August 1,

ACTIVITIES OF STAFF

Paul D. Cheney, Ph.D., Associate Professor

November 1-2, 1979 - Attended annual meeting of the Society for Neurological Educationin Atlanta, Ga.

November 2-6, 1979 - Attended annual meeting of the Society for Neuroscience in Atlanta,Ga. and presented a poster entitled "Facilitation and Suppression of Forelimb MuscleActivity from Single Intracortical Microstimuli in Behaving Monkeys".

February 26-28, 1980 - Attended a conference on "Brain Cholinergic System" at AberdeenProving Grounds, Aberdeen, Maryland and presented a paper on liThe Effect of DFP onActivity of Superior Colliculus Neurons".Seminars presented:

April 22, 1980 - Presented a seminar entitled "Organization and Function of PrimateMotor Cortex" to the Pharmacology Department, KUMC.

May 12, 1980 - Presented a departmental seminar entitled "Transcortical Stretch Reflex:Does it exist?"

Teaching Activities:

Medical Physiology10 hours lecture, Neurophysiology10 conferences7 laboratories1 demonstrationResponsible for content of Parkinson's conference.

Physiology 3887 hours lecture

Physiology 822, NeurophysiologyResponsible for 17 of the 22 sessions, 3 hours each, 5 registered

School of Allied Health, Physical Therapy ProgramGave 4 hours of lecture on the muscle spindle apparatus.

students.

11

Richard L. Clancy, Ph.D., Professor

Fall, 1979- Attended Fall Physiology meeting, New Orleans, La.

Spring, 1979 - Attended FASEBmeetings, Anaheim, Calif.Committees:

KUMC Medical Student Affairs, Graduate School Council

Seminars presented:

"Myocardial Acid Base Regulation", Physiology Department, Kansas State University,Manhattan, Kansas.

Teaching Activities:

Medical Physiology11 hours lecture, Cardiovascular

Physiology 705, Advanced Human Physiology, Course Coordinator10 hours lecture

Physiology 830, Cardiovascular Physiology42 hours lecture

Responsible for Student LabsResponsible for departmental graduate students admissions and records.

Supervised medical student Kimo Stine, summer 1979.

Helen J. Cooke, Ph.D., Assistant Professor

October 15-19- Attended American Physiol. meetings, New Orleans, La.

April 13-18 - Attended FASEB meetings, Anaheim, Calif.

Committees:

KUMC Graduate Committee

Cell Physiologist Search Committee

Honors:

American Women in Science

Seminars presented:

November 21, 1979 - Presented a seminar entitled "Pathophysiology of Hirschs-prung1s Disease, Department of Physiology, University of Nevada, Reno, Nevada.

February 4, 1980 - Presented a departmental seminar entitled "Intestinal TransportProperties in the Mouse Model for Hirschsprung's Disease".

Teaching Activities:

Medical Physiology11 hours lecture10 conferences8 labs

Physiology 7058 hours lecture

Physiology 818, Gastroenterology22 lecture hours

Other activities:

November 13-21, 1979 - Visiting professor; lectures to second year medicalstudents, University of Nevada, Reno, Nevada.

March 10-24, 1980- Visiting professor; lectures to first year medical students,Unviersity of Nevada, Reno, Nevada.

Supervised training of graduate student, Richard McCabe

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Sudhansu K. Dey, Ph.D.. Adjunct Assistant Professor

August, 1~7~ - Attended the 12th Annua1Meeting of the Society for the Study of Repro-duction in Quebec City, Canada.

October, 1979 - Attended the Brook Lodge Conference in Kalamazoo, Michigan, andpresented a paper entitled "Reevaluation of Histamine in Implantation".

Seminars presented:November, 1979 - Presented semi nar ent i tIed "Embryo-uterus Interact ion" to theDepartment of OB/GYN, KUMC.June, 1980 - PresentedReproductivePhysiologySeminar (MRRC) entitled "Aspects ofImplantation".

Teaching Activities:

Medical PhysiologyLabs and conferences

Trained one KAWValley Medical Student summer of 1979 - Lori Rush.

Trained one KAWValley Medical Student summer of 1980 - Marquita Jackson

Trained one premedical student summer of 1980 - Sandeet Mukerjee.

Hugo L. Fernandez, Ph.D., Assistant Professor

November 2-6, 1979 - Attended IX Annual Meeting Society for Neurosciences, Atlanta,Georgia.

March 2-9, 1980 - Attended XI Annual Meeting American Society for Neurochemistry,Houston, Texas.Committees:

KCVAMC,Research and Development Committee, Regular Member, FY-80.KCVAMC,R & D Space Subcommittee Member, FY-80.

Honors:Elected Regular Member, New York Academy of Science, 5/1/80.Chaired session on "Plasticity: Degeneration and Regeneration",Meeting, American Society Neurochem., March 2-8, 1980.Appointed to Graduate Faculty, KUMC,1980.

Refereed:

XI Annual

Neurobiology Review Board Member for Research Division, Catholic University ofChile (8 proposals reviewed, 1979-1980).

Ad-Hoc Advisory Consultant NINCDS, evaluation and site visit, "SpecializedResearch Center for Neuromuscular Diseases", at Baylor College of Medicine,Houston, 8/2-5/79.

Rev i ewed 3 papers for "Acta Phys i 01. Lat-Amer", 1979-1980.

Other Activities:

Appointed Director of Neuroscience Research Laboratory, VAMC, 10/1/79.

Collaborated in organization of program for scientific presentations, XI AnnualMeeting Amer. Soc. Neurochemistry (Program Committee Chairman, Dr. F. Samson,1980).

Collaborated in preparation of application to establish an "Office for Regenera-tion Research", at the KCVAMC,June, 1980.

13

September 18, 1979 - VAMC Neurobiology Journal Club Seminar, "Trophic Functions ofVertebrate Neurons".

October 22, 1979 - Presented a departmenta 1 semi nar ent it 1ed "Nerve-target Ce11 Inter-actions".

June, 1980 - Presented a seminar entitled "Regulationvertebrate neuromuscular junction" at the SeminarUniversity of Maryland, Department of Anatomy.

Teaching Activites:Medical Physiology

8 lectures7 laboratory sessions11 conferences2 lecture review sessions2 problem-exercise sessions1 conference pre-briefing session.

of 16S-acetylcholinesterase at theSeries on Neurotrophic Effects,

Kenneth L. Goetz, M.D., Ph.D., Adjunct Professor

October 14-19, 1979 - Attended fall meetings of American Physiology Society, NewOrleans, La.

October 17-21, 1979 - Attended Baroreceptors and Hypertension meeting, Oxford Univer-sity, England.

April 14-18, 1980 - Attended FASABmeetings, Anaheim, Calif.Committees:

Chairman, Human Investigation Committee, St. Luke's Hospital.Member, Education and Research Committee, Medical Curriculum Committee, Ad hocCommittee on Conditioning Center.

Refereed:Ad hoc reviewer for American Journal of Physiology

September 25, 1979 - Presented seminar entitled liThe Gauer-Henry Reflex" at the Univer-sity of Dusseldorf, Germany.

November 2, 1979 - Presented seminar entitled "Balloons, pericardial pouches, anddenervated hearts: another look at cardiac reflexes" at the University of Missouri,Columbia, Mo.

November 6, 1979 - Presented a seminar entitled "Hypertension" at St. Luke's Hospital,Department of Anesthesiology.

Teaching Activities:Medical Physiology - 4 lecturesCV grad course - 2 lectures

Supervised predoctoral training of Dennis C. Fater

Supervised postdoctoral training of Harold D. Schultz, Ph.D.

Norberto C. Gonzalez, M.D., Associate Professor

April 13-18, 1980 - Attended FASEBmeetings, Anaheim, California.

Commi ttees:Ad hoc member of the Cardiovascular Study Section, NIHGuest referee for NSF grants

14

Guest referee of Respiration Physiology

Judge in the 1980 KUMCStudent Research Day.Seminars presented:

November 26, 1979 - Presented a departmental seminar entitled "pH Regulation in CardiacCells".

June 23, 1980 - Lectured on acid base regulation in mammalian tissues at the Max PlanckInstitute for Experimental Medicine, Gottingen, Germany.

Teaching Activites:

Medical Physiology - Respiratory Physiology11 hours lecture

20 hours (approx.) study sessions and demonstrations.

conference and laboratory instructor in the course.

Physiology 705 - Respiratory Physiology section6 hours lecture

Other Activities:

March 6-7, 1980- Travelled to Dodge City, Ks., to talk to civic groups on behalf ofthe American Heart Association.

June 10 - August 10, 1980 - Visiting scientist at the Department of Physiology,Max Planck Institute for Experimental Medicine, Gottingen, Germany.

June-August, 1980 - Fellowship from the Alexander von Humboldt Foundation, Bonn, W.

Germany.

Gilbert S. Greenwald, Ph.D., Distinguished Professor and Chairman

August, 1979 - Attended the meeting of the Society for the Study of Reproduction,

Quebec, Canada and took part in panel on the granting situation.

April 13-18, 1980 - Attended meeting of the Federation of American Societies for Experi-mental Biology, Anaheim, Calif.

Committees - KUMC:

Interinstitutional Executive Committee (Wichita and Kansas City)Promotions and Tenure Committee

Chairman, Subcommittee on Joint Appointments

Chairman, Election Committee, Medical Faculty Senate

Member, Search Committee for Chairman of AnatomyChairman, Search Committee for Dean of Allied Health

Member, Medical Image Committee

Committees - External:

Organizing Committee, NIH Workshop on the Ovary, Ann Arbor, Mi., August, 1980.Ad hoc member,ReproductiveBiologyStudy Section,NIH - June, 1980Ad hoc reviewof applications(4) for National Science Foundation.

Reviewed Papers for:

Endocrinology, Biology of Reproduction, Journal of Reproduction and Ferti Iity,

Fertility and Sterility, Life Sciences, Gamete Research, Proc. Soc. Exp. BioI.

Seminars Presented:

Department of Physiology, University of Kansas, Lawrence

Department of Physiology, University of Kansas Medical Center

Department of Anatomy, University of Oregon Medical SchoolOregon Regional Primate Center, Beaverton, Oregon

Department of Zoology, University of California, Berkeley

15

Department of Hormone Research, University of California Medical School, SanFrancisco

Department of Bio1ogical Sciences, Northwestern University, Evanston, 11. (2lectures).Speaker, KUMCWorkshop on Grantsmanship, Fall, 1979.

Teaching activities:Medical Physiology - Endocrinology

5 hours lecture3 conference sessionsClass coordinator

Physiology 388 - G.I. Physiology4 hours lecture

Physiology 8066 hours 1ecture

Postdoctoral Fellows:Christopher Hubbard, Ph.D.Brett Oxberry, Ph.DSrinivas K. Saidapur, Ph.D.Chandrima Shaha, Ph.D.Susan Silavin, Ph.D.Kazuyoshi Taya, D.V.M., Ph.D.Yuichi Wada, M.D.

College Student (summer):Scott Eveloff

Donald C. Johnson, Ph.D., Profesor of Obstetrics and Gynecology and Physiology

August, 1979 - Attended Society for Study of Reproduction meetings in Quebec, Canada,

March, 1980 - Attended Society for Gynecologic Investigation, Denver, Colorado.

Refereed:Proc. Soc. Exper. BioI.Biology of ReproductionEndoc r ino 1ogyNeuroendocrinologyAndrology

and Med.

Seminars presented:May 12, 1980 - "Role of Histamine in Implantation", Department of Anatomy, Univer-sity of Oregon, Portland, Oregon.May 13, 1980 - "Regulation of Ovarian Steroidogenesis", Department of Ob/Gyn,University of Oregon, Portland, Oregon.

Teaching activities:Medical Physiology - Endocrinology

5 hours 1ectu re11 conferences5 lab sessions

Physiology 806Course Coordinator8 lectures

Physiology 705 - Advanced Human Physiology8 lectures

Physiology 825 - Biology of Sex

16

16 conferences and seminars

Pre and post-doctoral students trained:C. A. Powers, Ph.D. candidate in PharmacologyC. H. Tsai, Ph.D. candidate in PhysiologyM. Vomachka, Ph.D. candidate in PhysiologyR. C. Hoversland, Ph.D., postdoctorate fellow (NIH) joined June 1, 1980.

Fred E. Samson, Ph.D., Professor

July 1-31, 1979 - Neurosciences Research Program (MIT), Boston, Ma.

October 15-27, 1979 - Institute for Cell Research, Valencia, Spain; UniversidadAutonoma, Madrid, Cajal Institute, Madrid. Research consultation lectures onaxoplasmic transport, microtubules, brain functional mapping.

November 3-5, 1979 - Mental Retardation Research Center Directors Meeting, Cincinnati,Ohio. Presentat ion on bra i n reg iona I funct iona I mappi ng and inter-Center researchcollaboration, University of Cincinnati.

January 28-29, 1980 - Consultation with U.S. Army Medical Research and DevelopmentCommand, Aberdeen, Md.

Feb. 27-28, 1980 - Conference on Research at University of Kansas on anticholinesterasetoxins. Aberdeen, Md.

March 2-6, 1980 - Annual Meeting of American Society Neurochemistry, Houston, Tx.Program Chairman; also responsible for organizing and publishing the program/abstractvolume for the meeting. Co-author with K. Johnson and S. Nelson on paper "Amphetamineand haloperidol after glucose use in rat habenular nuclei".

May 12-13, 1980 - Mental Retardation Research Directors Meeting, San Francisco, Calif.

June 29-30, 1980 - Neurosciences Research Program, MIT, Boston, Ma. Work session on"Excitatory neurotoxins: selectivity, specificity, and mechanisms of action".

Committees - Internal:Director, Ralph L. Smith Research CenterPast-President, Sigma Xi, Kansas City Club (on Sigma Xi Counci I) 1978-79 andChapter Status CommitteePh.D. Thesis Committee:

Bernard Schneider, Department of PharmacologyRobert O'Neill, Department of PhysiologyWayne Daughtry, Department of Pharmacology

KUMCChairman of Committee, Institute for Cell Research (Valencia, Spain)Scrivener-Scribe, Department of PhysiologyTenure and Promotions Statement for Department of Physiology. Chairman, pro tern.

Committees - External:Chairman, University of Chicago Alumni Fund, Greater Kansas City AreaChairman, Program Committee, American Society Neurochemistry (1980 Meeting,Houston, Texas).Chairman, Planning Committee for encouraging research collaboration between MentalRetardation Research Centers.

Honors:Appointed to University of Chicago National Alumni Fund BoardStanding ovation at the 11th Annual Meeting of the American Society for Neuro-chemi stry in Houston; des igned the sc ient if i c program and the program/abstract(volume).

17

Seminars presented:

October15-27,1979- Lectures given at Universidad Autonoma,Madrid, on axoplasmictransport, microtubules, brain regional function mapping.January 24, 1980 - Kiwanis Club, Lawrence, Ks on "Health and Disease in the1980's".February 27, 1980 - Lecture on brain regional functional mapping to U. S. ArmyMedical Research and Development Command, Aberdeen, MD.

Reviewed:

Neurosciences Research Program Bulletin (ad hoc)Proc. National Academy of Sciences

Occasionally from journals in neurobiology

National Science Foundation - Neurobiology Division - grant reviews

Teaching Activities:Medical Physiology

4 lecture hours

Physiology 3884 lectures

Physiology 80012 two hour conferences

Physiology 850 (Research)15 hours

Physiology 782Participated in every session of this class.

Sponsor:

Scientific sponsor for the Career Development Awards of

Wayne Moore, M.D., Ph.D., Pediatrics and MRRC, and

Vernon Rowe, M.D., Neurology and MRRC.

Trainees:

Robert OINeil1 - Graduate student, Department of PhysiologyPilar Gomez-Ramos, Ph.D. - NIH International Post-Doctoral Fellowship; September,1979 - September, 1980 (Autonoma University, Madrid)Masaomi Takayama, M.D. - Post-doctoral, February - May, 1980 (Tokyo MedicalCollege)

Lawrence P. Sullivan, Ph.D., Professor

November 18-20, 1979 - Attended meeting of American

February 20-22, 1980 - Attended meeting of Great

American Heart Association, St. Louis, Mo.

April 16-18, 1980 - Attended FASEB meeting, Anaheim, California and presented a paperand chaired session on Renal Transport.

Seminars presented:September 24, 1979 - Presented a departmental seminar entitled "Studies of RenalPotassium Transport".December 11, 1979 - Presented a seminar to Department of Pharmacology entitled"Studies of Potassium Transport by the Kidney".

January 8, 1980 - Gave talk for local divisions of the American Heart Association,Coffeyville, Kansas.

February 7, 1980 - Gave talk for local divisions of the American Heart Association,Marion, Kansas.

Society of Nephrology, Boston, Mass.

Plains Regional Research Committee,

18

Committees:

Member, Facu1ty Promotion and Tenure Committee, KUMCMember, Renal Dialysis & Transplantation CommitteeConsultant on physiology curriculum, University of Illinois at Urbana-Champaign/Member, Research Committee for Great Plains Region, American Heart AssociationResearch Publicity Director, member of Board of Directors and member ResearchCommittee, Kansas Affiliate, American Heart Association.Member Board of Directors, Kaw Valley Division, American Heart Association.

Reviewed:Reviewed manuscripts on ad hoc basis for American Journal of Physiology and Toxi-cology and Applied PhysiologyReviewed grant applications on ad hoc basis for National Institutes of Health.

Teaching activities:Medical Physiology

10 hours lecture8 - 2 hour problem sessionsIn charge of lab and conference groups

Physiology 7058 hours lecture

Physiology 8062 lectures

Medical Pharmacology2 hours lecture on Diuretic Agents

Review for National Board Exams2 hours lecture

Trainees:Dr. Harold Wilkinson, Assistant Professor, Millikin University. June 1 - August15, 1979, National Science Foundation Program for research training of smallcollege faculty.Ravi Bajaj - 2nd year medical student, Summer Research training, June 1 - August15, 1980.

Merrill Tarr, Ph.D., Associate Professor

April 13-18, 1980 - Attended FASEBMeeting,

December 3, 1979 - Presented departmentalIsolated Single Cardiac Cells".

Commi ttees:Special program subcommittee of the Academic Committee

Refereed:Refereed papers for Circulation Research (Member of Editorial Board)

Teaching Activities:Medical Physiology

12 hours lecture3 hours review sessionsconference and laboratory

Physiology 7058 hours lecture

Anaheim, California, and presented a paper.

seminar entitled "Sarcomere Dynamics in

Other activities:October, 1979 - Member of site visit team from National Institutes of Health toUCLA.

19

Students in training:

Daniel A. Terreros, Graduate student, Physiology Department.

Paul F. Terranova, Ph.D., Assistant Professor

October 15, 1979 - Presented a departmental seminar entitled "Delayed Ovulation".

Fall, 1979 - Presented a seminar entitled "Delayed Ovulation" to the Department ofAnatomy/Physiology, Kansas State University Veterinary School.Refereed:

1-2 manuscripts/month - Biology of ReproductionNSF grants

Teaching activities:

Medical Physiology8 hours lectureconference and lab

Physiology 3885 hours lectureCourse Coordinator

Physiology 7821 hour Advanced Topics

Students trained:William Carlile, Medical StudentScott Sherwood, Medical StudentLuis Ascanio, Graduate Student, Physiology DepartmentBarb Krumme, Senior nursing student-KUMCCharles Lunn, Junior undergraduate Pittsburg State UniversityStudent Fellowship

- Kaw Valley Medical

Alan M. Thompson, Ph.D., Professor and Associate Dean for Graduate Studies

August, 1979 - Attended Symposium on Blood-brain barrier in Galveston, Texas.

November, 1979 - Attended the Council of Graduate Schools in Chicago, Illinois.

November 5, 1979 - Presented a departmental seminar entitled "A New Method of Quanti-fying Regional Brain Permeability by Autoradiography".

Committees:

Vice-Chancellors' Committee of Deans

KUMCGraduate Council

KUMCGraduate Committee

Other committees connected with Graduate School responsibilites

Refereed:Journal of Neurochemistry (occasionally)

Teaching activities:

Medical Physiology6 hours lecturelab and conference

Physiology 388

20

6 hours lecture

One hour lecture - Graduate course on Autoradiographic Methods and Results.

Three hours lecture on Physiology of Aging in Graduate Nursing course.

John W. Trank, Ph.D., Associate Professor

April 13-18, 1979 - Attended FASEB meetings, Anaheim, California.

Committees:

KUMC:

Curriculum, Development and Education Committee

Electronics Shop Supervisory Committee

Biomedical Engineering Search Committee

University:

Biomedical Engineering Curriculum, joint committee KUMC-Lawrence Engineeringschool

Regional Committees:

American Heart Association - Kansas Affiliate, Board of Directors

Kaw Valley Tricounty Division - Kansas Affiliate, American Heart Association,Board of Directors

Community Programs Committee - Kansas Affiliate, American Heart Association

Biomedical Engineering Technician Advisory Committee, Johnson County JuniorCollege

Teaching Activities:

Medical Physiology

9 hours lecture - Hemodynamicsand50 hours conference and laboratory

Physiology 3887 hours lecture

Optics & Vision

Physiology 82730 hours lecture

Physiology 83036 hours lecture and conference

Critical Care Nursing (School of Nursing)10 hours lecture

Electrical Engineering 2303 hours lecture

Students trained:

Frank Faraci, Graduate Student, KU Lawrence campus

James L. Voogt, Ph.D., Associate Professor

August 22-24, 1979 - Attended American Physiological Society Specialty Meeting, Mich-igan State University

February 10-16, 1980 - Attended Sixth International Congress of Endocrinology,

Melbourne, Australia.

21

February 18 & 19, 1980Adelaide, Australia, andDuring Lactationll.

June 18-20, 1980 - AttendedD.C.April 28, 1980 - Presented department seminar entitled IIWhat is so interesting aboutnocturnal (s)urges111.

Reproductive Physiology Seminar:

Committee:Departmental Library CommitteeKUMCRecreation Opportunities Committee

Refereed:Numerous articles for Endocrinology, Neuroendocrinology, and ScienceNSF grants

Teaching activities:Medical Physiology

6 hours lecture7 labs11 conferencesResponsible for Endocrinology Section

Physiology 1016 hours lecture3 labsCourse Director

Physiology 8065 hours lecture

Students trained:Martin Bartolac - medical student (summer, 1979)Scott Teeter - medical student (summer, 1980)Patricia Tonkowicz - Graduate student, Physiology Department (Sept. 1, 1979-present).

- Attended Satell ite Symposium Prolactin 1980 and Beyond,presented paper entitled "Catecholamine Synthesizing Enzymes

Sixty-Second Annual Endocrine Society Meeting, Washington,

Neuroendocrine control of ovulation.

Daniel J. Welling, Ph.D., Associate Professor

November, 1979 - Attended American Society of Nephrology meetings, Boston, Massachu-setts.

April, 1980 - Attended FASEBmeetings, Anaheim, California.

January 21, 1980 - Presented a departmental seminar entitled IIA Model for Regulation ofTubular Cell Volumell.

May, 1980 - Presented a seminar entitled liCeI I Volume Regulation in Renal Tubulesll,Physiology Department, Yale University, New Haven, Connecticut.

Refereed:American Journal of PhysiologyKidney InternationNIH Grants

Students trained:J. Morgenegg - Predoctoral student, Physics Department, Virginia PolytechnicInstitute and State University, Blacksburg, Virginia.

22

Chairman's Report

11m sure it comes as no suprise that the nationa1 reputation of any university

affi1iated department or scho01 is based on its research accomp1ishments. Based on

this criterion, our department and KUMC, in genera1, are improving but obvious1yhave a 10ng way to go before their academic stature is recognized. This is not to

detract from the importance of teach ing; in that category our department is

extreme1y conscientious and compares favorab1y with any physi010gy department inthe country. It just recognizes the facts of academic 1ife: that research is the

key e1ement in university reputations.

From research accomp1ishments f10ws the associated benefits of service on the

nationa1 1eve1: study section assignments, offices in scientific societies,

editoria1 boards of prestigious journa1s, guest seminars, invitations to meetings,etc. I be1ieve we have this potentia1; otherwise I never wou1d have been inter-

ested in the chairmanship. In fact, I view this as my main responsibi1ity: to

provide as much encouragement and nagging, if necessary, to have the Physi010gy

Department at KUMC recognized as one of the top departments in the country.

This can on1y be accomp1ished by sustained hard work on the part of every

facu1ty member. Our objectives shou1d inc1ude:

1. A minimum of two papers - pub1ished or in press - each year.

2. Grant support on the nationa1 1eve1 for every facu1ty member. The size of the

grant is of 1imited concern. It is important to be continua11y productive -

which pays off in continued grant support.

3. An increase in the number of post-doctora1 fellows which will result

especially from the academic reputation of the staff and wi11 feedback onitems 1 and 2.

4. Greater representation of the department in service functions on the nationa1

1eve1: study sections, editoria1 boards, etc.

This isnlt a pipe dream. These are tangib1e goa1s, within our grasp. Ibe1ieve welre on the move but the principa1 goa1 of academic exce11ence viaresearch must constant1y be kept in mind.

To get off the soap box and back to the present: The two positions vacant the

past year have been fi11ed with the arriva1 on August 1, 1980, of Dr. Thomas Imigand Dr. Dennis Va1enzeno on September 1, 1980. We1come to the fami1y~ Dr. He1en

Cooke res igned on June 1, 1980, and a search is on for her rep1acement. I amconfident this position wi11 be fi11ed by the next annua1 report.

A11 in a11, this has been a good year for the department but we must strive to

make each year better than the one before.

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