• In the United States alone nearly 40% of the adults are obese and this number is continuing to grow causing more serious health issues.• The initial goal is to reduce body weight by

10% percent in 6 months.

Qsymia•May help some obese adults or some overweight adults who also have weight-related medical problems lose weight and keep the weight off.

Those who should try Qsymia

• Qsymia is commonly described as assistance to a reduced-calorie diet and increased physical activity to reduce body weight.

• The overweight group are those that also have a weight related symptom such as hypertension, type 2 diabetes or dyslipidemia(high blood cholesterol).

BMI(Body Mass Index)• The Body mass index is to measure the body of fat based on

height and weight, it is not just your weight so do not let the numbers confuse you.

• Qsymia is a unique combination of Phentermine and extended-release Topiramate.

The Mechanism of Qsymia

The Mechanism of Qsymia

• The Phentermine which is an ingredient in Qsymia is released immediately and is thought to reduce appetite and enhance satiety which is feeling too full.• The Topiramate is an anticonvulsant which

means it has been reported to have mood stabilizing properties. Anticonvulsants are used to treat bipolar disorder, epilepsy, and neuropathic pains.

Adverse Reactions

• For patients treated with Qsymia the most common reactions are paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth.• Parathesia is a sensation described as

burning, tingling or pin pricks on certain areas.• Dysgeusia is a distorted sense of taste.

Reasons not to give medication

• Qsymia should not be taken if you are pregnant or may become pregnant, have glaucoma, hyperthyroidism, or any patient that has recently been given a new medication within 14 days with monoamine oxidase inhibitors.• The should not take Qsymia if they also

have a hypersensitivity to sympathomimetic amines, topiramate, or any other inactive ingredients.

Warnings and Precautions

• The following are pre-existing conditions or symptoms that may result from using Qsymia. If any occur the dosage should be decreased, discontinued, or not prescribed to the patient.

____________________________________• Patients using Antidiabetic Medications

should not use this drug because it increases the risk of hypoglycemia.

Warnings and Precautions

• Fetal toxicity- can cause fetal harm during the first trimester leading to risk of oral clefts.• Females should have a negative pregnancy

test(not pregnant) before treatment and use of effective contraception during use of Qsymia.• If a patient becomes pregnant while use of

Qsymia then the treatment should be discontinued.

Warnings and Precautions

• Qsymia can cause an increase in resting heart rate. Regular measurement of resting heart rate is recommended.• Patients with unstable cardiac or

cerebrovascular disease are recommended NOT to take the drug.• Patients should notify a healthcare

provider of any feelings relating to a racing heartbeat while on the treatment and the dose should be reduced.

Warnings and Precautions

• The Topiramate in Qsymia can increase the risk of suicidal thoughts or behavior in patients taking these drugs for any purpose. If this occurs Qsymia treatment should be discontinued.•Qsymia can cause mood disorders,

depression, anxiety, and insomnia.

Warnings and Precautions

• Those with glaucoma can receive a decreased visual acuity and/or eye pain. Symptoms typically occur within one month of treatment.• Creatinine may increase in the blood and if

so the treatment should be discontinued.• There may be cognitive dysfunction such

as memory loss or difficulty with speech. Patients are cautioned about operating hazardous machinery.

Warnings and Precautions

•Metabolic Acidosis• Potential risk of hypotension in patients

treated with Antihypertensive medications• Potential seizures with abrupt withdrawal

of Qsymia• Patients with Renal Impairment• Patients with Hepatic Impairment

Warnings and Precautions

• Patients with Kidney Stones• Hypokalemia• Drug abuse and dependence- The

Phentermine component has known potential for abuse.• Use of drugs or alcohol during the

ingestion of Qsymia may cause CNS depression or other centrally mediated effects of these agents.

Limitations

• The effect of Qsymia on cardiovascular morbidity and mortality has not been established, the safety and effectiveness of Qsymia in combination with other products intended for weight loss, including prescription and over the counter drugs, and herbal preparation have not been established.