PAIN MODELS

TIMELINES

STUDY SITES

DRUG DEVELOPMENT COSTS

PAIN MANAGEMENTCLINICAL TRIALS THE WORLD OVER,

HAVE ONE NAME - QPS

CURRENT CHALLENGESThe current gap between basic science research and the

development of new analgesics presents a serious challenge for

the future of pain medicine. In addition to technical constraints

like the inability of animal pain models to simulate

multidimensional clinical pain conditions, it also involves

alarmingly rising drug development costs and timelines. The

uncertainty of a site’s ability to meet study obligations further

compromises planning efforts while inconsistent recruitment

across sites leads to study delays.

QPS is an independent, global player in the field of

contract research, with facilities in the USA, the

Netherlands, Austria, India, China and Taiwan engaging

more than 900 qualified and experienced professionals. Our

unique management models, new technologies, and creative

study approaches can combat the increasing timelines and

costs of your clinical trials. Our unparalleled competence in

drug metabolism and pharmacokinetics, toxicology,

bioanalysis, translational medicine, and early stage and phase

II – IV clinical research can reduce your time-to-market and

minimize your costs. QPS will plan your clinical study from start

to finish, putting the right team and protocol in place to make

certain your trial runs smoothly.

WHYCHOOSE

QPS?Knowledge and

Experience = Expertise

PAIN MANAGEMENT –A GLOBAL FOOTPRINT More than 1.5 billion people worldwide suffer from

chronic pain.

Approximately 3 - 4.5% of the global population suffers from neuropathic pain, with incidence rate increasing with age.

Worldwide, 37% of low back pain was attributed to occupation, with two-fold variation across regions.

Work-related low back pain was estimated to cause 818,000 disability-adjusted life years lost annually.

DEDICATED FRAMEWORK OF INTEGRATED PAIN RESEARCH SERVICES

Recently, QPS has extended its service portfolio by adding

more pain research facilities and expertise. For phase I and

IIa investigations of both nociceptive and neuropathic pain,

the Quantitative Sensory Testing Battery (QST) and the Third

Molar Extraction Model (M3) are available. In the QST

battery, cold/heat and mechanical/pressure thresholds are

measured in healthy volunteers to investigate pain/flare and

primary/secondary hyperalgesia. The M3 model is

performed in collaboration with the Department of Orofacial

Surgery of the University Medical Center Groningen in the

Netherlands, a large facility that provides easy subject

recruitment and high recruitment rates. Both pain and

anti‐inflammatory biomarkers can be measured on request.

Especially the combination of both pain models in the same

person who needs M3 surgery twice on different sites offers

the opportunity to investigate a nociceptive and

anti‐hyperalgesic effect simultaneously. QPS manages a

network of pain clinicians in both university and

non‐university hospitals through which we may either

mediate or conduct phase IIb and III pain studies. Via its

dedicated framework of integrated pain research services,

QPS offers a full range of outsourcing solutions from ‘first in

human’ to ‘first in patient’ (proof of concept) to late stage

pain studies.

EXTENSIVE EXPERIENCE IN COMBINATION WITH STATE OF THE ART FACILITIES

Over the past two decades, QPS has performed thousands

of preclinical and clinical studies for local and international

pharmaceutical and biotechnology companies, covering

numerous disease therapies. QPS provides one of the

largest capacities in bioanalysis for small molecules and

biologics, as well as specialized biomarker assay

capabilities. Our early stage clinical research facilities

comprise more than 400 phase I beds. Over the past 15

years, QPS phase I sites have collectively completed more

than a thousand clinical trials often including data

management, biostatistics, PK/PD evaluation and medical

writing as well.

TAIWAN

USA

INDIA

NETHERLANDS

54

40

92

240PHASE I BEDSAROUND THE GLOBE

SPEEDY PATIENT RECRUITMENT QPS ensures speedy patient recruitment through powerful

associations with efficient study sites across Europe, USA and

Asia, innovative patient recruitment strategies, and close links

with academia, SMOs, and specialist networks. We maintain a

large worldwide database of investigators to ensure high

enrollment rates of patients selected according to strict

eligibility criteria. A specialized QPS team works 24/7 to offer

solutions that increase patient enrollment rates.

EXPERIENCED INVESTIGATORS QPS works closely with our principal investigators to ensure

that your studies are recruited on time and with qualified

subjects. The strong relationships we forge with the

investigators who conduct your clinical trials promote the

performance of quality studies. We take pride in the fact that

the skills of the most experienced investigators are applied to

every clinical trial QPS conducts.

Corporate OfficeDelaware Technology Park, 3 Innovation Way, Suite 240, Newark, DE 19711

Email: info@qps.com TEL: + 1 302 369 5601 FAX: + 1 302 369 5602

2012 QPS Holdings. All Rights Reserved

www.qps.com

REFERENCES:-1. Mao J. Current challenges in translational pain research. Trends Pharmacol Sci. 2012 Sep 5.

2. AAPM Facts and Figures on Pain. The American Academy of Pain Medicine. Available at http://www.painmed.org/patientcenter/facts_on_pain.aspx. Accessed on 1/11/2012.

3. Punett L et al. Estimating the global burden of low back pain attributable to combined occupational exposures. American Journal of Industrial Medicine.

QPS FOR YOUR NEXT PAIN MANAGEMENTCLINICAL TRIAL

Whether you need clinical trials of small molecules, biologics,

or other medications, QPS has the experience and resources

to handle your trials and get your product to market. Choose

QPS for your next pain management trial! Should you want to

discuss your questions in more detail with one of our experts,

please contact us directly at: info@qps.com