Q1 Uptake of the products of digestion (small intestine) Absorption.
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Transcript of Q1 Uptake of the products of digestion (small intestine) Absorption.
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Q1 Uptake of the products of
digestion (small intestine)
Absorption
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Q2 Breaking down large
molecules into smaller ones
Digestion
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Q3 2 types of digestion
Chemical
Mechanical
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Q4Where does ingestion
occur
Mouth
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Q5Using the products of
digestion in cells?
assimilation
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Biological Molecules
AS Biology
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Biological Molecules
80% of the mass of living organisms is water.
13% is composed of organic (carbon-based) MACROMOLECULES, of which there are 4 groups CARBOHYDRATES PROTEINS LIPIDS (FATS) NUCLEIC ACID
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Carbon
• Carbon-containing molecules=organic molecules
• Carbohydrates, proteins and lipids all contain carbon
• Carbon atoms can form 4 chemical bonds with other carbons or different atoms
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Polymers & monomersWhat are polymers?
What are monomers?
Long chained molecules consisting of repeating units
The repeating unit that join together to form polymers
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Macromolecules
Carbon chains can be straight
Carbon chains can be branched
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CARBOHYDRATES
• This type of molecule contains only the elements:
»C
»H
»O
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CARBOHYDRATES
Divided into 3 main types;1.Monosaccharides
Single sugars
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Monosaccharides – single sugars
Examples
Alpha Glucose6 carbons
Fructose6 carbons
Galactose6 carbons
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Glucose – C6H12O6
• Glucose is the best known monosaccharide, having the general formula C6H12O6.
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Alpha Glucose
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CARBOHYDRATES
Divided into 3 main types;1.Monosaccharides = single sugars
2.Disaccharides
sugars containing 2 monosaccharide residues
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Disaccharides– 2 monosaccharide residues joined
together Examples
sucrose
Alpha Glucose
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Making Chains• Disaccharides are
formed when two monosaccharides join together.
• The reaction involves the formation of a water molecule, & so is called a condensation reaction.
• The type of bond formed is called a glycosidic bond.
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The bonds between the individual monomers in disaccharides and polysaccharides can be broken by hydrolysis, which is the reversal of condensation reactions.
A hydrolysis reaction does not occur by putting a carbohydrate in water – an enzyme is required. In the case of starch, this enzyme is amylase.
Breaking Chains
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Disaccharides (to learn)
• There are 3 common disaccharides:
– Maltose: glucose + glucose– Sucrose: glucose + fructose– Lactose: glucose + galactose
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Draw how the disaccharides: maltose and lactose are formed
• For each identify the water molecule that is produced
• Draw out the complete disaccharide & identify the glycosidic bond
galactose
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CARBOHYDRATES
Divided into 3 main types;1.Monosaccharides = single sugars
2.Disaccharides = sugars containing 2 monosaccharide residues
3.Polysaccharides =
very large molecules that contain many monosaccharide residues
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Making Longer Chains
• Polysaccharides are long chains of many monosaccharides joined together by glycosidic bonds.
• There are three important polysaccharides:
• Starch• Glycogen• Cellulose
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Polysaccharides – many monosaccharide residues joined
together Examples
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Carbohydrates
Sugars
Monosaccharides
(monomers)
Disaccharides
(dimers)
Polysaccharides
(polymers)
Glucose
Fructose
Galactose
Maltose
Sucrose
Lactose
Starch
Glycogen
Cellulose
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Carbohydrate digestion
Polysaccharide
disaccharide
monosaccharide
insoluble
soluble
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Carbohydrate digestion example Starch
Polysaccharide
DisaccharideMaltose
monosaccharide
Starch
Alpha glucose
Salivary amylase & pancreatic amylase
Maltase in intestinal epithelium (cells lining small intestine)
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• Starch is the plant storage polysaccharide. It is insoluble and forms starch granules inside many plant cells. It’s insolubility means it does not affect the water potential of cells.
• It is not a pure substance, but a mixture of two structures (both alpha glucose polymers though)
• Amylose
• Amylopectin
Starch
Amylopectin can be broken down more easily because it has “more ends”
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Glycogen is similar in structure to amylopectin. It is made by animals as their storage polysaccharide, being found mainly in muscle and the liver. Its branched structure means it can be mobilised (broken down to glucose) very quickly.
Glycogen
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Cellulose is only found in plants where it is the main constituent of cell walls.
Cellulose is made from beta glucose arranged in long parallel chains. The chains are held together in a bundle by hydrogen bonds, forming microfibrils which are very strong.
The beta glycosidic bond cannot be broken down by amylase, but requires a specific cellulase enzyme. Only bacteria contain this enzyme, so herbivores like cows & termites have bacteria in their guts. Humans cannot digest cellulose – it is what we call fibre or roughage.
Cellulose
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ProteinsProteins are the most complex and diverse group of bioligical compounds. They have an astonishing range of different functions:
structure e.g. collagen (bone, cartilage, tendon), keratin (hair), actin (muscle)
Enzymes e.g. amylase, catalase, pepsin (>10000)
Transport e.g. haemoglobin (oxygen), transferrin (iron)
Pumps e.g. sodium-potassium pumps in cell membranes
Hormones e.g. insulin, glucagon, adrenalin
Antibodies
Blood clotting
And many more
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ProteinsProteins are made of amino acids which have a central carbon atom with three different chemical groups attached:
Carboxylic acid group
Amino group
R-group
Alpha carbon
Amino acids are so called because they have both amino groups (-NH2) and acidic groups (-COOH).
Amino acids are made of the five elements C H O N S
There are 20 different R-groups and so 20 different amino acids. This means that there are many, many different proteins with differing numbers and combinations of amino acids
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Proteins- making and breaking
Joining amino acids involves, again, a condensation reaction. The bond formed is called a peptide bond
Two amino acids form a dipeptide, many amino acids form a polypeptide. In a polypeptide, one end is still the amino group and the other end the acidic group.
The same type of reaction, hydrolysis, is again involved in breaking down (or hydrolysing) proteins. This can be achieved in the presence of protease enzyme or by boiling with dilute acid.
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Protein structure
Polypeptides are just a string of amino acids, but they fold up to form the complex structures of working proteins. To help understand protein structure it is broken down into four levels – but be aware that these are not real sequential stages in protein formation
PRIMARY STRUCTURE
SECONDARY STRUCTURE
TERTIARY STRUCTURE
QUARTERNARY STRUCTURE
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Protein: primary structure
This is just the sequence of amino acids in the polypeptide chain, so is not really a structure at all
Gly – Pro – His – Leu – Tyr – Ser – Trp – Asp - Lys
This can also be shown using the three letter abbreviations for each amino acid:
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Protein: secondary structure
This is the folding that then occurs, being held together by hydrogen bonds between the amino and carboxyl groups.
The two main types of secondary structure are the alpha helix and the beta pleat.
In the alpha helix the polypeptide chain is wound round to form a helix that is held together by many hydrogen bonds. In the beta pleat, the polypeptide chain zig-zags back and forward, once again held together by hydrogen bonds
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Protein: tertiary structure
This is the three dimensional structure formed by the folding up of the whole chain, with every proteins properties and functions being related to this. E.g. the unique shape of an enzymes active site is due to its tertiary structure. Three kinds of bond hold this structure together:
Hydrogen bonds,which are relatively weak
Ionic bonds between the R-groups, which are quite strong
Sulphur bridges between the sulphur containing amino acids, which are strong
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Protein: quarternary structure
This structure is found only in those proteins that contain more than one polypeptide chain, and simply means how the different chains are arranged together e.g. haemoglobin
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Globular or Fibrous?
The final 3-D shape of a protein can be described as globular or fibrous
GLOBULAR: most proteins, soluble, have biochemical roles e.g. enzymes, receptors, hormones
FIBROUS: look like “ropes”, are insoluble and have structural functions e.g. Collagen, keratin
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Biochemical test for proteins, carbohydrates (sugars, starch),
and lipids
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Lipids
You can test for the presence of lipids by using the EMULSION TEST.1.Add alcohol to the sample of
food.Shake to dissolve any lipid.
2. Two layers of liquid will form. Pour the top layer of & add water.
3. A cloudy white EMULSION shows the presence of a lipid
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Starch
The presence of starch can be teated using the iodine test.
Starch + iodine blue-black colour
With other polysaccharides, iodine remains yellow-brown
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SugarsSugars can be identified with blue Benedict’s solution. However there are two types of sugar:
Reducing Sugars – these carry out reduction reactions and include all monosaccharides and most disaccharides.
When heated with Benedict’s, the colour changes from blue to green to orange/red
Non-reducng sugars (mainly sucrose in fact) do not react with Benedict’s unless first hydrolysed by heating with acid first. As Before adding Benedict’s, you must neutralise the acid with an alkali
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ProteinsProteins can be identified with blue Biuret Reagent (copper sulphate and sodium hydroxide).
Blue Biuret reagent turns lilac in the presence of protein