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httpswwwnbclosangelescomnewslocalucla-study-finds-antidepressant-drug-may-help-fight-cancer2615002 15

$38900 $24000 $51000

-15

$40275

UCLA

UCLA Study Finds Antidepressant Drug May Help Fight CancerldquoWhats especially exciting is that this is a very well-studied and safe class of drug so repurposing it for cancer isnt as challenging as developing a

completely new drug would berdquo

By City News Service bull Published June 10 2021 bull Updated on June 10 2021 at 1117 pm

Results of a study released Thursday by UCLA suggests that a class of drug commonly prescribed to treat

depression might have another health benefit by helping the immune system attack cancer

The class of drug called monoamine oxidase inhibitors (MAOI) work by boosting levels of serotonin the brains

ldquohappiness hormonerdquo according to researchers

ldquoMAOIs had not been linked to the immune systems response to cancer beforerdquo said Lili Yang senior author of the

study and a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA

ldquoWhats especially exciting is that this is a very well-studied and safe class of drug so repurposing it for cancer isnt

as challenging as developing a completely new drug would berdquo

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The findings are reported in two papers which are published in the journals Science Immunology and Nature

Communications

Recent advances in understanding how the human immune system naturally seeks out and destroys cancer cells

as well as how tumors try to evade that response has led to new cancer immunotherapies -- drugs that boost the

immune systems activity to try to fight cancer

ldquoIn an effort to develop new cancer immunotherapies Yang and her colleagues compared immune cells from

melanoma tumors in mice to immune cells from cancer-free animals Immune cells that had infiltrated tumors had

much higher activity of a gene called monoamine oxidase A or MAOA MAOAs corresponding protein called MAO-

A controls levels of serotonin and is targeted by MAOI drugsrdquo

ldquoFor a long time people have theorized about the cross-talk between the nervous system and the immune system

and the similarities between the twordquo said Yang who is also a UCLA associate professor of microbiology

immunology and molecular genetics and a member of the UCLA Jonsson Comprehensive Cancer Center

ldquoSo it was exciting to find that MAOA was so active in these tumor-infiltrating immune cellsrdquo

Copyright CNS - City News Service

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