Purinsynthese
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Transcript of Purinsynthese
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Purinsynthese
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O
OHHO
C
O O OP P
OOOOP O
5-Phosphoribosyl-1-pyrophosphat(PRPP)
GlutamatGlutamin
COO--OOC CH2 CH2 C
H
+NH3O
OHHO
CP ONH2
O OP
OO
OP
OO
O
5-Phosphoribosyl-1-amin
W. Storch D. Doenecke
![Page 3: Purinsynthese](https://reader036.fdocuments.us/reader036/viewer/2022082517/56812b12550346895d8f04a4/html5/thumbnails/3.jpg)
Glutamat
O
OHHO
CP O NH2
COO-
H
CH +NH3
Phosphoribosylamin
Glycin
NH
+NH3
C
O
CH2
O OHP
OO
C
O
H THF
THF
C
O
H NH
Glutamin
C
O
CH2
NH
COO--OOC CH2 CH2 C
H
+NH3
![Page 4: Purinsynthese](https://reader036.fdocuments.us/reader036/viewer/2022082517/56812b12550346895d8f04a4/html5/thumbnails/4.jpg)
N
NH2
N
C
CH
HC
N
NH2
N
C
C
HC
C
O
O
O OHP
OO
NH
N
NH
C
CH2
C
O
H
C
CH
H
C
O
O
HO
N
HN
N
C
CH
HC
C
O
O
O
OHHO
CP O
O OHP
OO
Bicarbonat
CH3N
C
CH2
C
H
OHO
OO
+
AspartatN
NH2
N
C
C
HC
C
O
CHN
C
CH2
C
H
OHO
OO
C
C
CH
C
H
OHO
OO
N
NH2
N
C
C
HC
C
O
NH2
Fumarat
O OHP
OO
THF
N
N
N
C
C
HC
C
O
NH
CH
H2O
Inosinat (IMP)
COTHF
H
N
N
N
C
C
HC
C
O
NH2
H CO
H
![Page 5: Purinsynthese](https://reader036.fdocuments.us/reader036/viewer/2022082517/56812b12550346895d8f04a4/html5/thumbnails/5.jpg)
Adenylat (AMP)
C
C
CH
C
H
OHO
OO
N
N
N
C
C
HC
C
N
CH
N
N
N
C
C
HC
C
O
NH
CH
O
OHHO
CP O
CH3N
C
CH2
C
H
OHO
OO
+
Aspartat
Fumarat
Inosinat (IMP)
CHN
C
CH2
C
H
OHO
OOH
NH2
OP
OO
O
![Page 6: Purinsynthese](https://reader036.fdocuments.us/reader036/viewer/2022082517/56812b12550346895d8f04a4/html5/thumbnails/6.jpg)
NH2
NADH+H+
N
N
N
C
C
HC
C
O
NH
CH
O
OHHO
CP O
Inosinat (IMP)
N
HN
N
C
C
HC
C
O
NH
C
O
Glutamin
COO--OOC CH2 CH2 C
H
+NH3
Glutamat
N
N
C
C
HC
C
O
HN N
C
H
Guanylat (GMP)