Pub. annotated bibliography 3
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Fall Semester 2012-13 Annotated Bibliography 3 Roll Book.# 6 Name Juan Enrique Maldonado Weng Date: November 2nd, 20012 Annotated Bibliography 3: Na K, Tae S, Song J and Kim Y. 2009. Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients. Official Journal of Korean Neuropsychiatric Association, [Internet]; [Cited 2012 November 22]. DOI 10.4306/pi. 2009:6:306-312 Available at: http://synapse.koreamed.org/Synapse/Data/PDFData/0162PI/pi-6-306.pdf These Korean investigators attempt to find the relationship between Borna Disease Virus (BDV) and schizophrenia. It is believed that BDV is a cause for the schizophrenic conditions. With the utilization of a new technique that has not been previously used for this type of study, rRT-PCR (real- time Reverse Transcriptase Polymerase Chain Reaction), the researchers look for answers. This process tracks BDV antibodies or RNA in the peripheral blood mononuclear cells (PBMC) of the human body. For the study, sixty healthy patients were recruited for the control and 198 psychiatric patients were recruited for the experimental. The experimental group was composed of sixty patients with schizophrenia and 138 with other major psychiatric conditions. Within the rRT-PCR method, all the patients tested negative for BDV. These results are not conclusive due to many uncertainties in the methodology such as the success rate, their handling of the procedure, and the researcher's experience with the procedure. Even though this method is shown to have low possibilities of contamination, this is the first known utilization of the procedure. The researchers might be inexperienced with the resulting reactions of the virus. Another example of an uncertainty is the lack of comparison and continuation of the
Transcript of Pub. annotated bibliography 3
Fall Semester 2012-13
Annotated Bibliography 3Roll Book.# 6 Name Juan Enrique Maldonado Weng
Date: November 2nd, 20012
Annotated Bibliography 3:Na K, Tae S, Song J and Kim Y. 2009. Failure to Detect Borna Disease Virus Antibody andRNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients. Official Journal of Korean Neuropsychiatric Association, [Internet]; [Cited 2012 November 22]. DOI 10.4306/pi. 2009:6:306-312 Available at: http://synapse.koreamed.org/Synapse/Data/PDFData/0162PI/pi-6-306.pdf
These Korean investigators attempt to find the relationship between Borna Disease Virus (BDV) and schizophrenia. It is believed that BDV is a cause for the schizophrenic conditions. With the utilization of a new technique that has not been previously used for this type of study, rRT-PCR (real-time Reverse Transcriptase Polymerase Chain Reaction), the researchers look for answers. This process tracks BDV antibodies or RNA in the peripheral blood mononuclear cells (PBMC) of the human body. For the study, sixty healthy patients were recruited for the control and 198 psychiatric patients were recruited for the experimental. The experimental group was composed of sixty patients with schizophrenia and 138 with other major psychiatric conditions. Within the rRT-PCR method, all the patients tested negative for BDV. These results are not conclusive due to many uncertainties in the methodology such as the success rate, their handling of the procedure, and the researcher's experience with the procedure. Even though this method is shown to have low possibilities of contamination, this is the first known utilization of the procedure. The researchers might be inexperienced with the resulting reactions of the virus. Another example of an uncertainty is the lack of comparison and continuation of the experiment. The researchers did not validate the results from other tests nor did they publish their results of their other tests. This experiment shows that to find answers, it is necessary to require new and more adequate methods to trace the virus in patients. When that can be accomplished, a new origin of the schizophrenic condition may be found.
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