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were calculated separately for incident MIs occurring in 1998-2001 and 2002-2005, andobtained from multivariable Cox regression models that adjusted for age, indigenous status,comorbidities, prior revascularisation, and revascularisation within 30 days of MI. Changesin the hazard ratio between the two periods were tested using a period x diabetic statusinteraction term.Results: There were 13,874 30-day survivors post incident MI from 1998-2005 (23.9%diabetics), with 2,657 deaths within 5 years (38.2% diabetics), of which 50.9% were CVDdeaths (36.9% diabetics). Unadjusted 5-year all-cause mortality was higher in diabeticsthan non-diabetics in women (36.0% vs 20.0%) and men (27.7% vs 13.9%) overall. Whenrestricted to CVD deaths only, unadjusted 5-year mortality was also higher in diabetics(women 19.8% vs 10.6%; men 14.5% vs 7.5%). The adjusted hazard ratio comparing all-cause mortality in diabetics with non-diabetics was greater in 2002-2005 in men (HR 1.5,95% CI 1.3, 1.8) compared with 1998-2001 (HR 1.3, 95% CI 1.1, 1.5) and similarly inwomen (HR 1.6, 95% CI 1.3, 1.9 versus HR 1.3, 95% CI 1.1, 1.6), although differencesbetween the periods were not significant (interaction p-value men 0.11, women 0.55).There was no significant difference in the hazard ratios for 5-year CVD mortality betweenthe two periods.Conclusion: The excess mortality in diabetics compared with non-diabetics following MIdid not diminish during the study period. This indicates a need for more aggressive sec-ondary prevention for diabetic patients who survive a first MI.Disclosure of Interest: None Declared

PT162

Prediction of Major Adverse Cardiac Events of Patients With Acute CoronarySyndrome In Hospital Using Timi Risk Score And Timi Risk Index

Mohammad A. Ehsan1, Manzoor Mahmood*2, Md A. Salim2, Jahanara Arzu2, M. M. Rahman21Cardiology, Sylhet MAG Osmani Medical College, Sylhet, 2Cardiology, Bangabandhu SheikhMujib Medical University, Dhaka, Bangladesh

Introduction: Patient with acute coronary syndrome (ACS) has considerable variabilityin outcome and mortality risk.The Thrombolysis in Myocardial Infarction (TIMI) riskscore and TIMI risk index (TRI) for unstable angina (UA)/non STelevation myocardialinfarction (NSTEMI) and ST elevation myocardial infarction (STEMI) were a conve-nient bedside clinical risk score for predicting 30 days mortality at presentationwith ACS.Objectives: This study was done to predict and validate major adverse cardiac events(MACE) in patients of ACS thus it will help us to quantify risk, observe the prognostic valueand to guide appropriate therapy by using TIMI risk score and TRI.Methods: This prospective study was carried out in the department of cardiology,Bangabandhu Sheikh Mujib Medical University, Dhaka from April 2011 to March2012. Data were collected from 279 patients attending cardiac emergency departmentwith the presentation of ACS. History, physical examination, ECG and cardiac markerswere done. TIMI risk score and TRI were calculated in each patient. The MACE(recurrent myocardial infarction, urgent revascularization and all-cause mortality) weremeasured for next 30 days in hospital and out-patient department by follow up. Afterfollow up Cox univariate and multivariate regression analysis were used to evaluate theinfluence of potential risk factors on duration of event free survival, and likelihoodratio tests to assess the outcome.Results: In patients with UA/NSTEMI, MACE were 0%, 4.2%, 6.9%, 12.5%, 13.6% and33.3% with TIMI score 0,1, 2, 3, 4, 5, 6 and 7 respectively. In patients with STEMIgroup, MACE were 0%, 0%, 0%, 0%, 7.1%, 9.5%, 10%, 17.6%, 19% and 38.5% withTIMI score 0, 1, 2, 3, 4, 5, 6, 7, 8 and more than 8 respectively. Death from TRI group 1,2, 3, 4 and 5 were 0%, 0%, 3.7%, 12.9% and 19.2% respectively in UA/NSTEMI group.In STEMI group death of TRI group 1, 2, 3, 4 and 5 were 0%, 4.7%, 12.5%, 17.1%and24.1% respectively.Conclusion: Increasing TIMI risk score was associated with increased risk of MACE. Thesescore were a valid tool for risk assessment.Disclosure of Interest: None Declared

PT163

Gender differences of coronary intervention for patients with acute coronarysyndrome admitted at a major metropolitan hospital in Melbourne, Australia

Linda Worrall-Carter1, Andrew I. MacIsaac2, Elizabeth Scruth3, Muhammad Aziz Rahman*11St Vincent’s Centre for Nursing Research (SVCNR) & The Cardiovascular Research Centre(CvRC), Faculty of Health Sciences, Australian Catholic University, 2Department of Cardiology,St Vincent’s Hospital, Melbourne, Australia, 3Kaiser Permanente (NCAL) Regional Quality andRegulatory Services, California, United States

Introduction: Literature suggests an ongoing gender disparity in the use of coronaryangiography and subsequent interventions among patients with acute coronary syndrome(ACS). Many studies describe women with ACS as being older, with more co-morbiditiesthan men resulting in less coronary interventions.Objectives: To investigate the factors underlying the gender differences for coronaryangiogram and revascularization for patients admitted with ACS at a major metropolitanhospital in Melbourne during 2009-12.Methods: Patients, having the primary diagnosis of ACS in the database and admitted forthe first time, were selected for analyses. ICD-10 was used for coding of ACS and co-morbidities. ACS was classified as unstable angina (UA), ST-segment elevation myocardialinfarction (STEMI) and non-STEMI. For each category, gender differences were analysedon demographics, coronary angiogram, angioplasty, coronary artery bypass grafting(CABG), risk factors and co-morbidities.

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Results: A total of 2096 patients were included, 624 (30%) were women. Mean age(SD) of the patients was 64.3(13.4) years. Half of them (51%) were diagnosed asNSTEMI, 23% as STEMI and 25% as UA. Women diagnosed with NSTEMI were 24%less likely to have an angiogram than men (60% vs. 67%, p<0.05, odds ratio 0.76,95%CI 0.58-0.99). Compared to men, women were less likely to have angioplasty ifdiagnosed with STEMI (57% vs. 72%, p<0.01, odds ratio 0.50, 95%CI 0.33-0.76) anddiagnosed with NSTEMI (32% vs. 39%, p<0.05, odds ratio 0.75, 95%CI 0.57-0.98).Women were also less likely to have CABG than men if diagnosed with UA (10% vs.21%, p<0.01, odds ratio 0.41, 95%CI 0.23-0.72) and diagnosed with NSTEMI (9% vs.16%, p<0.01, odds ratio 0.51, 95%CI 0.33-0.78). Women of 35-59 years were lesslikely to have coronary interventions, however, the likelihood of this increased if theywere above 70 years of age. There was no gender difference for severe co-morbidities.Current smoking was the only significant risk factor for gender difference and menwere more likely to smoke than women.

Conclusion: Younger women were less likely to receive coronary intervention interms of diagnosis and treatment compared to men. Future research investigatingsymptom presentation of younger women as well as exploring perceptions of healthcare workers including cardiologists for decisions on coronary intervention couldexplain the reasons of gender disparity and subsequent gaps in treatment adherenceguideline.Disclosure of Interest: None Declared

PT164

Alcohol consumption and acute myocardial infarction in patients with previousrevascularization

Predrag Mitrovic*1, Branislav Stefanovic1, Mina Radovanovic1, Nebojsa Radovanovic1,Gordana Matic1, Dubravka Rajic1, Tanja Jozic1, Ana Novakovic1, Ida Subotic1,Zorana Vasiljevic11Cardiology Clinic, CLINICAL CENTER OF SERBIA, Faculty of Medicine, University ofBelgrade, Belgrade, Serbia

Introduction: It is well known that the risk of myocardial infarction is lower among light-to-moderate alcohol consumers compared with abstainers.Objectives: The prognosis of patients (pts) after coronary artery bypass surgery (CABS)has been noted in many studies, but there were no studies which analyzed prognosis oflight-to-moderate alcohol consumers with acute myocardial infarction (AMI) after priorCABS.Methods: The effect of light-to-moderate alcohol consumption was assessed in 324pts with AMI after prior CABS (post bypass group) and control group of 538 ptswith AMI and without prior CABS, who were followed from April 1988 to April2013.Results: At baseline post bypass group was slightly younger (p¼0.0402), with more men(p¼0.445) and with more pts with previous angina (p¼0.0440) and previous AMI(p¼0.0389). Control group of pts had more hypertensives (p¼0.0318) and hyperlipidemia(p¼0.0205) . Other baselines characteristics were similar in both groups of patients. In-dexes of infarct size were lower in post bypass group (p¼0.0104). In-hospital mortality wassimilar (p¼0.4012). After adjustment for cardiovascular risk factors by logistic regression,alcohol consumption displayed a protective effect against myocardial infarction in controlgroup of patients, but not in bypass group of pts.Conclusion: The effect of light-to-moderate alcohol consumption is associated withdecreasing risk of myocardial infarction in pts with AMI and without prior CABS, but notin pts with AMI and with prior CABS. This effect of light-to-moderate alcohol consumptionis probably because of decreasing of cholesterol, triglycerides and fibrinogen, as well asincreasing of diastolic and systolic blood pressure.Disclosure of Interest: None Declared

PT165

Prediction of short and intermediate-term mortality in patients with acute coronarysyndrome: Validation of the lab index in patients from the Gulf-RACE-2 registry

Tarek Kashour*1, Khalid Alhabib1, Hussam Alfaleh1, Ahmed Hersi1, Anhar Ullah2,Alawi Alsheikhali3, Jassim Al Suwaidi4, Haitham Amin5, Ahmed Al-motarreb6,Ahmed Al-Motarreb6, Wael Almahmeed31Cardiology, King Saud University, 2Security Forces Hospital, Riyadh, Saudi Arabia,3Cardiology, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates, 4Cardiology,Hamad Medical corporation, Doha, Qatar, 5Cardiology, Mohammed bin Khalifa Cardiac center,Manama, Bahrain, 6Cardiology, Sana’s University, Sana’a, Yemen

Introduction: Lab index is a simple score that incorporates hemoglobin and creatinineclearance, was developed and validated in two large STEMI trials (InTIME II- TIMI 17 and

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