Psychosis in DementiaPsychosis in DementiaConclusionsConclusions

Psychosis in dementia is distressful and disturbing to patients and

Is similar across the spectrum of the dementia

Is common

Can be identified

Is persistent

Psychosis in DementiaPsychosis in DementiaMethodsMethods

Janssen has 2 databases of 1603 patients:Data contains information from 2 studies: Mild to moderate AD, community-dwelling Severe AD, nursing home residents

The placebo data from these trials describes a natural history of psychosis in AD (n=285); (n=162)

What was done with the data:

Experts correlated scale-items and item-scores with their clinical experience to identify characteristics of AD patients with psychosisDelusions/hallucinations subscales: NPI of 4 or greater or BEHAVE-AD of 2 or greater

Mild to Moderate AD, community dwelling (n=285)

Severe AD, nursing home (n=162)

Women = 62%

Mean age = 77 years

Mean MMSE = 18

100% had AD

Women = 67%

Mean age = 83 years

Mean MMSE = 7

Psychosis in DementiaPsychosis in DementiaDemographics Demographics

84% had AD

Psychosis in DementiaPsychosis in DementiaCommunity Based & Nursing Home Residents with Alzheimer’s DiseaseCommunity Based & Nursing Home Residents with Alzheimer’s Disease

~7 in 10 nursing home residents had psychosis during the study

~2 in 10 community dwelling AD patients had psychosis during the study

Psychosis in DementiaPsychosis in DementiaResultsResults

Community Dwelling (n=285)

Nursing Home (n=162)

12% had psychosis at baseline

2/3 had symptoms that persisted for at least 1 month 1/3 had symptoms that persisted for at least 5 months

12% developed a psychosis

64% had psychosis at baseline

>2/3 had symptoms that persisted for at least 2 weeks

1/2 had symptoms that persisted for at least 4 weeks 17% developed a psychosis

Psychosis in DementiaPsychosis in DementiaConclusionsConclusions

Psychosis in dementia is distressful and disturbing to patients and

Is similar across the spectrum of the dementia

Is common

Can be identified

Is persistent