The tau of PSP

Neurofibrillary tangles

Tufted astrocytes

(Oligodendroglial)Coiled bodies

Basal ganglia

Subthalamic nucleus

Globus pallidus

Atrophy of superior colliculus

Superior colliculus

Substantia nigra

Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T.

Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.

Grade 3

Grade 3

Dentate nucleus:Grumose degeneration

PSP-tau scores

Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau

burden and distribution distinguishes progressive supranuclear palsy-parkinsonism

from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.

Distribution of tau pathology in PSP-tau score >7

Pink = Grade 1Purple = Grade 2Red = Grade 3

Brown = Grade 4

Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau

burden and distribution distinguishes progressive supranuclear palsy-parkinsonism

from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.

Mid-Frontal Hippocampus