Psoriasis/Psoriatic Arthritis Immunopathologic Mechanisms (PsAIM) CentersRepresentitivesSpecialty...
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Transcript of Psoriasis/Psoriatic Arthritis Immunopathologic Mechanisms (PsAIM) CentersRepresentitivesSpecialty...
Psoriasis/Psoriatic Arthritis Immunopathologic Mechanisms (PsAIM)
Centers Representitives Specialty UCSDA. Kavanaugh Rheum D.Boyle Rheum
Gent D. Baeten Rheum Amsterdam P.P. Tak Rheum
J.D. Bos/M.A de Rie Derm Leuven K.de Vlam Rheum
R. Lories RheumSeattle (P.Mease) RheumGlasgow I. McInnes RheumDublin D. Veale Rheum
O.FitzGerald Rheum(B.Bresnihan) Rheum
Newcastle D. Kane RheumRochester C. Ritchlin Rheum
Psoriasis/Psoriatic Arthritis Immunopathologic Mechanisms (PsAIM)
Aims(1) Ps/PsA sample collections.
-Inventory of what is available for study.
(2) Primary study-To assess/validate immunohistologic change in skin and synovial tissue as a surrogate marker in PsA.-Need to agree how we go about this. Have we enough samples?-Can we use tissues stained in different centres or should they all be done in one centre? -What markers should we look at first?
Psoriasis/Psoriatic Arthritis Immunopathologic Mechanisms (PsAIM)
(3) Is there an opportunity here to ask some additional questions? e.g.
-As PsA is a more asymmetric disease, is the synovial involvement less uniform?
-Are clinically uninvolved joints in PsA immunohistologically abnormal as in RA?
-Is there an opportunity here to ask some additional questions?
-Are there SM changes that are specific to PsA? Doug Veale has suggested that the vascularity is distinct at macroscopic level, are there distinct vascular markers at cellular level?
Psoriasis/Psoriatic Arthritis Immunopathologic Mechanisms (PsAIM)
-Are there parallels between skin and SM in response to treatment at immunohistologic level?
-Do different subsets of PsA have different immunohistologic features?
-Can we study mechanisms driving new bone formation using immmunohistology?
-Can we gain a better understanding of the importance of adaptive vs innate immune responses in PsA joints and skin?
-Study the joints and skin of Ps patients without MSK symptoms to gain insight into the early events in PsA.
Inventory: DublinDisease No. Sm Skin Rx Times OCT P Snap Syn
PsA 40 + - 1 + + + 9
PsA 8 + + Il1ra 2 + + + 8
PsA 12 + MTX 2 + +
Ps 15 + Infl 3 + +
AS 11 + - 1 + + + 5
USpA 27 + - 1 + +
Inventory: Gent
Disease No. Sm Skin Rx Times OCT P Snap Syn
PsA 36 + - 1 + + +
PsA 14 + TNF 3 + + +
USpA + + + +
AS + + + +
Inventory: Amsterdam
Disease No. Sm Skin Rx Times OCT P Snap Syn
PsA 10 + + Alef 1 + +
PsA 10 + + Infl 2 + +
PsA 10 + + ? 2 + +
Inventory: Glasgow
Disease No. Sm Skin Rx Times OCT P Snap Syn
PsA NIH + + - 1 + +
PsA ++ + TNF 2 + +
Inventory: Rochester
Disease No. Sm Skin Rx Times OCT P Snap Syn
PsA 12 + - 1 + +
Ps 6-8 + - 1 + +