PRP & Regenerative Medicine Symposium

10 TH ANNUAL

June 7-8, 2019McCormick Place

Chicago, IL

www.tobiconference.com

PLATELET RICH PLASMA

1. Welcome & IntroductionSteven Sampson, DO, The Orthohealing Center, Los Angeles, CA

2. PRP in Sports Medicine: The Evidence and What I DoBrian Cole, MD, Rush University Medical Center, Department of Orthopedics and Departmentof Anatomy and Cell Biology, Chicago, IL

3. The Evolving Biologic Landscape for Foot and Ankle InjuriesMaCalus V. Hogan, MD, MBA, University of Pittsburgh School of Medicine, Department ofOrthopedic Surgery, Pittsburgh, PA

4. Evaluation of Biologic Activity of PRP & Correlation with Clinical Outcomes in Knee OABrian C. Halpern, MD, Hospital for Special Surgery, New York, NY

5. Leucocyte-rich Platelet-rich Plasma (LR-PRP) Treatment of Gluteal Tendinopathy: A DoubleBlind Randomized Controlled Trial with 2 Year Follow UpJane Fitzpatrick, PhD, MB.BS, FACSEP, University of Western Australia Crawley WA, Australia

6. Effects of Aspirin on Growth Factor Release from Leukocyte-Rich Platelet-Rich Plasma inHealthy Men - Prathap Jayaram, MD, Director Regenerative Sports Medicine,Baylor College ofMedicine, Houston, TX

7. PRP Humanitarian Effort in Tanzania: A Win-Win - Christopher J. Visco, MD, Columbia UniversityMedical Center, Department of Rehabilitation and Regenerative Medicine, New York, NY

8. Q&A PLATELET RICH PLASMA

BONE MARROW ASPIRATE CONCENTRATE

9. BMC Results: Randomized Controlled Trials for Knee OA, Rotator Cuff and ACL Tears/Will FDA Go All Health Canada On Us? - Christopher J. Centeno, MD, Centeno-SchultzClinic, Broomfield, CO

Day One – June 7 - TOBI 2019 Symposium

BONE MARROW ASPIRATE CONCENTRATE

10. Bone Marrow Aspirate Concentrate for Meniscus and Cartilage: From Processing to ClinicalIndications and Outcomes - Jorge Chahla, MD, Rush University Medical Center, Departmentof Orthopaedic Surgery, Chicago, IL

11. New Biologic Formulations to Treat Muscle and Tendon Disorders - Jason Dragoo, MD,Stanford University School of Medicine, Department of Orthopedic Surgery, Redwood City, CA

12. Novel Insights Using Bone Marrow Concentrate vs Aspirate: Cellular Formulations and RedBlood Cell Effects on the Local Microenvironment - Peter Everts, PhD, Gulf Coast Biologics,Scientific Research & Educational Department, Fort Myers, FL

13. Emory Sports Medicine Updates on Knee OA: BMC Harvest Techniques, BMAC vs MFAT, andOngoing Multi-Center Trial - Kenneth R. Mautner, MD, Emory School of Medicine, Departmentof Physical Medicine and Rehabilitation and the Department of Orthopedic Surgery, Atlanta, GA

14. Q&A BONE MARROW ASPIRATE CONCENTRATE

LIPOASPIRATE

15. Adipose Tissue in Orthopaedics: Overview and National Status - C. Thomas Vangsness, Jr.,MD, Keck School of Medicine of USC, Department of Orthopaedic Surgery, Los Angeles, CA

16. Evaluation of the Safety and Exploratory Efficacy of PSC-01, an Autologous AdiposeStromal Vascular Fraction Cell Product For Knee osteoarthritis - Christopher Rogers, MD,San Diego Orthobiologics Medical Group, Carlsbad, CA

17. The Unique Role for Adipose Tissue in Shoulder Disorders: Osteoarthritis and Rotator CuffPathology - Joanne Borg-Stein, MD, Harvard Medical School, Department of Physical Medicineand Rehabilitation, Boston, MA

18. Morbidity & Mortality Case Report: Learning from a Lipoaspirate Adverse EventColonel - Sean Mulvaney, MD, Department of Defense, Fort Meade, MD

Day One – June 7 - TOBI 2019 Symposium

LIPOASPIRATE

19. PANEL: PRP, BMC, LIPOASPIRATE, AMNIOTIC CELLS: WHICH DO I CHOOSE? MODERATOR: Danielle Aufiero, MD, Orthohealing Center, Los Angeles, CA Joanne Borg-Stein, MD, Harvard Medical School, Department of Physical Medicine and Rehabilitation, Boston, MA Jason Dragoo, MD, Stanford University School of Medicine, Department of Orthopedic Surgery, Redwood City, CA Jack Farr, MD, Knee Restoration Center of Indiana, Greenwood, IN Kenneth R. Mautner, MD, Emory School of Medicine, Department of Physical Medicine and Rehabilitation and the Department of Orthopedic Surgery, Atlanta, GA Alberto J. Panero, DO, SAC Regenerative Orthopedics, Sacramento, CA Brian Shiple, DO, The Center for Sports Medicine, Springfield, PA

FUNCTIONAL MEDICINE & BIOLOGIC RESEARCH

20. Effects of Age, Environment and Activity on Muscle Stem Cell Functioning & Masterful Care of the Aging Athlete - Vonda Wright, MD, Chief – Northside Hospital Sports Medicine & Orthopaedic Network, Atlanta, GA

21. A Purple Heart Recipient’s Personal Story: How Regenerative Medicine Can Transform Lives Michael Smyre & Paras Mehta, MD, Director of Whole Health for Veterans Affairs, Charlotte, NC

22. Stem Cell Therapy to Combat the Opioid Epidemic and Reverse Opioid Tolerance Jianguo Cheng, MD, PhD, FIPP, Cleveland Clinic Lerner Research Institute, Department of Pain Management, Cleveland, OH

23. Healing Heroes: Orthobiologics in the US Military. Ongoing Musculoskeletal Grant DoD Projects - Gerard A. Malanga, MD, New Jersey Sports Medicine, Cedar Knolls, NJ

Day One – June 7 - TOBI 2019 Symposium

Day Two – June 8 - TOBI 2019 Symposium

BASIC SCIENCE / PRE-CINICAL

1. The Proteomic Profile of PRP, A New ParadigmAllan Mishra, MD, Stanford University Medical Center, Menlo Park, CA

2. More with Less: When Growth Factors Meet Fibrin Eduardo Anitua, MD, Eduardo Anitua Foundation, Vitoria, Spain

3. Are Amniotic Fluid Products “Stem Cell” Therapies? Analysis for Mesenchymal Stem Cells with Bone Marrow ComparisonAlberto J. Panero, DO, SAC Regenerative Orthopedics, Sacramento, CA

4. All-Autologous Fibrin Glue: The Clot Thickens - Lisa Fortier, DVM, PhD, Cornell University College of Veterinary Medicine, Department of Clinical Sciences, Ithaca, NY

4. Cord Blood Cells Poorly Disguised as Stem Cells - Lisa Fortier, DVM, PhD, CornellUniversity College of Veterinary Medicine, Department of Clinical Sciences, Ithaca, NY

5. Use of Platelet-Rich Plasma Lysate Improves Bacterial Load and Outcomes ofStaphylococcus Aureus Infectious Arthritis in Horses - Lauren Schnabel, DVM, PhD,NCSU College of Veterinary Medicine, Department of Clinical Sciences, Raleigh, NC

6. Should We Continue to Use the Term “Stem Cell”? What We Should be Focusing onin the Next 5 Years, 10 Years?Arnold Caplan, PhD, Case Western Reserve University, Department of Biology, Cleveland, OH

ORTHOPEDIC SURGERY & BIOLOGICS

7. Meniscus Management: Appropriate Indications and Navigating the Spectrum of OptionsBert Mandelbaum, MD, Cedars-Sinai Kerlan-Jobe Institute, Los Angeles, CA

8. Hip Preservation: Osteotomies, cutting edge arthroscopic techniques and Biologics forDysplasia and Early OA - Omer Mei-Dan, MD, University of Colorado School of Medicine,Department of Orthopedics, Denver, CO

ORTHOPEDIC SURGERY & BIOLOGICS

9. Avoiding Knee Arthroplasty in the Young Patient: Osteotomy and Biologic TherapiesMikel Sánchez Álvarez, MD, Arthroscopic Surgery Unit, Vittoria-Gasteiz, Spain

10. Pro Athlete Return to Play Algorithms: Pre, PRP, and Post Care – Joint, Tendon, MuscleCase Studies - Gonzalo Samitier, MD, PhD, FEBOT, Instituto Cugat, Barcelona, Spain

11. Managing Hip Chondral Lesions. Intraosseous (IO) Hip Infiltrations with PRP: 1 YearOutcome Results - Nicolás Fiz, MD, Arthroscopic Surgery Unit, Vitoria-Gasteiz, Spain

12. Q&A: ORTHOPEDIC SURGERY & BIOLOGICS

SPINE & EMERGING SCIENCES

13. Novel Stem Cell Treatment to Reduce Pain and Mobility Issues Caused by DegenerativeDisc Disease - David Copenhaver, MD, MPH University of California at Davis, Department ofAnesthesiology & Pain Management, Davis, CA

14. First Ever Spine Biologics Guidelines. Research Update: Intra-discal PRP vs BMC vsPlacebo, Randomized Controlled TrialAnnu Navani, MD, Comprehensive Spine and Sports Center, Campbell, CA

15. Randomized Controlled Trial: Amniotic Suspension vs Hyaluronic Acid and Normal SalineIntraarticular Injections for Improvement of Osteoarthritis SymptomsJack Farr, MD, Knee Restoration Center of Indiana, Greenwood, IN

16. Update on Orthobiologic Research at Mayo Clinic Including Gene Therapy forOsteoarthritis - Jacob L. Sellon, MD, Mayo Clinic, Department of Sports Medicine andDepartment of Physical Medicine and Rehabilitation, Rochester, MN

17. Q&A: SPINE & EMERGING SCIENCES

Day Two – June 8 - TOBI 2019 Symposium

REGULATORY

18. Will PRP and Autologous Cell Therapies Ever be Approved and Covered by Insurance?Navigating the Risks and Opportunities in Orthopaedic Regenerative MedicineScott Bruder, MD, PhD, Bruder Consulting International, LLC New York, NY

19. TOWN HALL Q&A: What Can and Can’t I Do with Practicing Cell Medicine?Scott Bruder, MD, PhD, Bruder Consulting International, LLC New York, NYAmy Dow, JD, Epstein, Becker & Green Law, Chicago, IL

PROTOCOLS & CME REVIEW

20. Protocols: TOBI 2019 TakeawaysNicholas R. Beatty, DO, Regenerative Sportscare Institute, New York, NY

21. CME Review: Claim TOBI 2019 CreditsNicholas R. Beatty, DO, Regenerative Sportscare Institute, New York, NY

Day Two – June 8 - TOBI 2019 Symposium