Amino Acids, Peptides, and Proteins.. Classification of Amino Acids.
Proteins. Slide 2 of 19 Proteins Polymers composed of amino acids Protein = Polypeptide (polymer) ...
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Transcript of Proteins. Slide 2 of 19 Proteins Polymers composed of amino acids Protein = Polypeptide (polymer) ...
![Page 1: Proteins. Slide 2 of 19 Proteins Polymers composed of amino acids Protein = Polypeptide (polymer) Monomer = Amino acids Peptide bonds Amino.](https://reader035.fdocuments.us/reader035/viewer/2022062517/56649f215503460f94c399dc/html5/thumbnails/1.jpg)
Proteins
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Proteins
Polymers composed of amino acids
Protein = Polypeptide (polymer) Monomer = Amino acids
Peptide bonds
Amino acid Amine Group (NH2)
Basic Carboxylic Acid Group (COOH)
Acidic
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Protein Functions
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4 Levels of Protein Structure
Primary level Sequence of amino acids Polar covalent bonds link the amino acids Only level that doesn’t use hydrogen bonds
Secondary Hydrogen bonding between amino acid side groups The sequence of amino acids converts into 1 of 2 forms
α-helix β-pleated sheets
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1’ and 2’ Levels Protein Structure
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1’ & 2’ Animations
05_21aPrimaryStructure.swf
05_21bSecondaryStructure.swf
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3’ & 4’ Structure
Tertiary 3D shape of a polypeptide Many types of bonds/interactions between side groups Disulfide bridges are most significant here
Quaternary 2 or more polypeptides (subunits) of a protein Not found in all proteins Same bonds/interactions as tertiary level
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Tertiary & Quaternary Levels
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3’ & 4’ Animations
05_21cTertiaryStructure.swf
05_21dQuaternaryStructure.swf
Animation-03-01.swf
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Protein Denaturation
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Protein Denaturation
Denaturation Protein unravels and loses its native conformation
Structure & Function Change in the protein’s structure = loss of function
Denaturation occurs: Organic solvent Any chemical that disrupts the tertiary structure Heat (excessive)
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Chaperonins
Proteins that assist the proper folding of other proteins
Provide stable, insulated environment for polypeptide to achieve the correct conformation
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Protein Questions
Name all of the bonds in primary protein structure?
What bonds hold together secondary structure?
What about tertiary level? Quaternary?
Which level of protein structure is NOT found in all proteins?
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Protein Questions (Page 2)
What is the name of a protein’s monomer?
What is the name of a protein’s polymeric form?
What are the 2 functional groups on an Amino Acid?