VERONASilos di Ponente del Polo di Santa Marta · University of Verona

PROTEINE 2018

MAY 28 - 30, 2018

ENDORSEMENTS

May 28, 2018

14:00 Participants Registration

Session I · Protein Interactions and DynamicsChairs: Rita Casadio, M. Eugenia Schininà

15:00 Annalisa Pastore, The Francis Crick Institute, London (UK) The intricate network of interactions in iron-sulfur cluster biogenesis

15:40 Margherita Ruoppolo, Università degli Studi di Napoli Federico II Altered intracellular pathways in inherited disorders of vitamin B12 metabolism

16:10 Luca Federici, Università degli Studi Gabriele D’Annunzio, Chieti-Pescara Exploring nucleophosmin interactions for the treatment of acute myeloid leukemia

16:40 Coffee break

17:10 Pier Luigi Martelli, Alma Mater Studiorum Università degli Studi di Bologna Predicting protein-protein interaction sites with computational approaches

17:40 Alessandra Astegno, Università degli Studi di Verona Plant calmodulin-like proteins: calcium binding and target interactions

18:00 SELECTED ORAL COMMUNICATIONS

Giovanni Bisello, Verona Pathogenic variants of human Aromatic L-Amino Acid Decarboxylase:

evidences of misfolding in functionally active variants

Emanuela Leonardi, Padova TANC2 a possible dynamic regulator of CDKL5 protein levels

19:00 Welcome Cocktail at Santa Marta

May 29, 2018

8:30 Registration Desk opening

Session II · Amyloids and Intrinsically-Disordered ProteinsChairs: Vittorio Bellotti, Silvio Tosatto

9:00 Tuomas Knowles, University of Cambridge (UK) Kinetics of protein aggregation

9:40 Stefano Gianni, Sapienza Università di Roma Understanding the mechanism of binding induced folding of intrinsically

disordered proteins

10:10 Coffee break

S C I E N T I F I C P R O G R A M

10:30 Fabrizio Chiti, Università degli Studi di Firenze The amyloidogenic and Aβ scavenger states of transthyretin studied with high

resolution intrinsic fluorescence and FRET

11:00 Alessandra Corazza, Università degli Studi di Udine An NMR approach to structure and dynamics of human transthyretin

11:30 Damiano Piovesan, Università degli Studi di Padova Computational resources for the study of intrinsically disordered proteins

12:00 SELECTED ORAL COMMUNICATIONS

Stefano Ricagno, Milano Conformational dynamics in crystals reveal the molecular bases for D76N Beta-2 microglobulin aggregation propensity

Stefania Brocca, Milano How to design an (in)soluble protein tag: some insights from synthetic intrinsically disordered proteins

12:30 Lunch

Session III · Biocatalysis: mechanisms and applicationsChairs: Marco Moracci, Loredano Pollegioni

15:00 Gideon J. Davies, University of York (UK) Lytic Polysaccharide Monooxygenases: new players in biomass breakdown

15:40 Gianfranco Gilardi, Università degli Studi di Torino Exploitation of monooxygenases in biocatalysis

16:10 Mario Cappiello, Università di Pisa Intra-site differential inhibition of enzymes: the case of aldose reductase

16:40 Coffee break

17:10 Andrea Strazzulli, Università degli Studi di Napoli Federico II Chemoenzymatic synthesis of α-N-glycoconjugates of biomedical interest

17:40 SELECTED ORAL COMMUNICATIONS

Elena Rosini, Varese Lignin valorization: the Lig system

Francesco Marchesani, Parma Insights On S-Nitrosylation In Human Serine Racemase

18:10 Andrea Pigozzo, ALFATEST, Roma Innovative approaches to accelerate affinity and kinetics characterization in biologics development and drug discovery

20:00 Social Dinner at Villa Lebrecht

S C I E N T I F I C P R O G R A M

S C I E N T I F I C P R O G R A M

May 30, 2018 8:30 Registration Desk opening

Session IV · Frontiers in Structural BiologyChairs: Martino Bolognesi, Menico Rizzi

9:00 Alessandro Vannini, The Institute of Cancer Research, London (UK) Unveiling (Class III) Gene Transcription through Integrated Structural Biology

9:40 Marco Nardini, Università degli Studi di Milano NF WHY? Structural studies on transcription factors

10:10 Coffee break

10:30 Riccardo Miggiano, Università degli Studi del Piemonte Orientale, Novara Nucleotide Excision Repair and direct DNA damage reversal in Mycobacterium

tuberculosis: a structural perspective

11:00 Silvia Onesti, ELETTRA Sincrotrone Trieste Structural insights in eukaryotic and archaeal DNA replication

11:30 Fulvia Bono, University of Exeter (UK) Structure-function studies of mRNA localisation

12:00 SELECTED ORAL COMMUNICATIONS

Paola Baiocco, Roma Humanized archaeal ferritin as a tool for cell targeted delivery

Samanta Raboni, Parma Engineering Methionine g−Lyase from Citrobacter freundii for anticancer

activity

12:30 End of the Conference

G E N E R A L I N F O R M A T I O N

SCIENTIFIC COMMITTEEMartino Bolognesi, Università degli Studi di MilanoRita Casadio, Università degli Studi di BolognaPaola Dominici, Università degli Studi di VeronaAndrea Mozzarelli, Università degli Studi di ParmaLoredano Pollegioni, Università degli Studi dell’InsubriaMenico Rizzi, Università degli Studi del Piemonte Orientale Maria Eugenia Schininà, Sapienza Università di Roma Carla Voltattorni, Università degli Studi di VeronaGiuseppe Zanotti, Università degli Studi di Padova

LOCAL COMMITTEEAlessandra AstegnoMariarita BertoldiDaniele Dell’OrcoPaola DominiciAlejandro GiorgettiGiovanni GotteSofia MariottoCarla Voltattorni

VENUESilos di Ponente del Polo di Santa Marta, University of VeronaVia Cantarane, 24 - 37129 Verona (Italy)

ORGANIZING SECRETARIAT COGEST M. & C. srlVicolo San Silvestro 6, 37122 Verona (Italy)Tel: +39 045-597940 · Fax: +39 045-597265 · Email: stella@cogest.info

REGISTRATION FEES (Registration fees are expressed in EURO)

Category Registration fees

SIB Member fee* € 300,00 + VAT 22% (€ 366,00 vat incl.)

NON Member fee* € 370,00 + VAT 22% (€ 451,40 vat incl.)

Student/young researcher fee* (under 35 years) € 250,00 + VAT 22% (€ 305,00 vat incl.)

Daily fee** € 160,00 + VAT 22% (€ 195,20 vat incl.)

Dinner fee ONLY for Accompanying person € 60,00 + VAT 22% (€ 66,00 vat incl.)

(*) Registration includes: Conference kit, coffee breaks, lunch and Welcome cocktail.The Social dinner is offered by the Conference Organizers, please be so kind to inform us if you suffer from any food allergy or intolerance when you fill in the registration form available online.

(**) Registration includes: Conference kit, coffee break, lunch according to the program.

G E N E R A L I N F O R M A T I O N

ONLINE REGISTRATIONRegistration for the Conference is available, please click here and check the website for any further information.After registration please remember to send your payment receipt to the Organizing Secretariat (email: alessandra@cogest.info). Registration will be considered confirmed only upon payment received.

PAYMENTAll fees can be paid by credit card or by bank transfer. Please remember to send a copy of your payment to the Organizing Secretariat (email: alessandra@cogest.info). COGEST M. & C. will send you an official receipt for the payment and further organizing information.

PAYMENT BY CREDIT CARDPlease note that payment by credit card is available only for Visa and Mastercard users.If you prefer to pay charges by American Express / Diners credit card please contact the Organizing Secretariat (email: alessandra@cogest.info)

PAYMENT BY BANK TRANSFERBank transfer to COGEST M. & C.IBAN IT49H0200811705000005233961BIC SWIFT UNCRITM1M03BANK UNICREDIT BANCAAGENCY Piazza Bra 26/e, Verona, Italy

INFORMATION ABOUT V.A.T. (Value Added Tax) FOR INVOICING PROCEDURESPlease be informed that:EU or NON-EU Institutions or Companies are due to pay registration fee VAT excludedEU or NON-EU private citizens are due to pay registration fee VAT included

Public institutions registering their employees must request for VAT exemption. Once the invoice is issued any change involving a credit note or a new invoice with different heading will be charged e 30,00+VAT. If the organization does not pay by the beginning of the Conference, payment has to be made by the participant, who will receive an invoice addressed to the institution.

CANCELLATION / REFUND POLICYNotification of cancellation Before 4th of May 2018 will be refunded 100% of the total amount paidFrom 5th of May to 11th of May 2018 will be refunded 50% of the total amount paidAfter 11th of May 2018 no refund is foreseenRegistration fees less a e 40,00 of administrative charge will be refunded after the Conference. However, it is possible to transfer registration from one person to another one.

GUIDELINES & ABSTRACT SUBMISSION Guidelines and information about abstract submission are available on the website, please click here or check the abstract page.

ACKNOWLEDGEMENTSfor the contribution of a generous unrestricted grant

G E N E R A L I N F O R M A T I O N

SOCIAL PROGRAMMonday 28th of May h. 19:30Welcome Cocktail at Santa Marta (walking distance from the Conference venue)h. 20:30 End of the cocktail

Tuesday 29th of May h. 20:00Social Dinner at Villa Lebrecht (transfer directly at the end of the working session)h. 19:00 The pick up point for transfer is S. Paolo Church wich is located closer to the

Conference venue (5 minutes by walk). The Organizing Secretariat will help the attendees to reach the pick up point for the transfer

h. 23:00 End of the dinner and transfer back to the city center, Pradaval area closer to Corso Porta Nuova/Piazza Bra

www.proteineverona2018.org