Protein structure
description
Transcript of Protein structure
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Protein Engineering
BIT317 Class 2438
Lecture 12Protein Structure
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Motifs (supersecondary structures) in proteins
Greek keyBeta hairpin
Beta-omega-betaRossman fold
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All Alpha proteins
Three helix bundle
Globin fold (8 helices)
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All Beta Sheet Proteins
Beta Barrel(ion channels) Beta Propellor
(light harvesting complexes)
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Alpha / beta structures
Rossman Fold(beta-alpha-beta-alpha-beta)TIM Barrel (alpha/beta)8
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Alpha + beta structures
Ferridoxin Fold DNA Clamp
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Non-covalent interactions in proteins
Intramolecular interactions Hydrogen bonding Ion pair interactions (salt bridges) Cation-pi interactions Pi-pi interactions Hydrophobic interactions
Intermolecular interactions Solvation / hydration
Specific examples for the above should be learnt as discussed in the class
Non-covalent interactions in proteins