Propelling the MCBK Community: Workgroup Launch · • Broad perspective on CBK • Framework •...
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Propelling the MCBK Community: Workgroup Launch December 19, 2018, 12-1 EST • All lines are muted upon entry • Pose your questions via the chat pod • Click on the “Send-to” drop-down and select EVERYONE, then submit your question • Continue the conversation on Twitter: #MobilizeCBK 1
Transcript of Propelling the MCBK Community: Workgroup Launch · • Broad perspective on CBK • Framework •...
Propelling the MCBK Community: Workgroup Launch
December 19, 2018, 12-1 EST
• All lines are muted upon entry
• Pose your questions via the chat pod• Click on the “Send-to” drop-down and select EVERYONE,
then submit your question
• Continue the conversation on Twitter: #MobilizeCBK
1
Propelling the MCBK Community:Workgroup Launch
#MobilizeCBK
Rachel Richesson, PhD, MPH Duke University
MCBK Co-Chair and Moderator
Bob Greenes, MD, PhDArizona State University
Chris Shaffer, MSUniversity of California San Francisco
Blackford Middleton, MD, MPH, MScApervita, Inc.
Jerry Perry, MLSUniversity of Arizona
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Structure for Today • Getting Here
• Computable Biomedical Knowledge (CBK) – What?
• Mobilizing CBK – Why?
• The Growing MCBK Community – How!
• MCBK Workgroup Presentations • #1 - Standards for MCBK | Bob Greenes
• #2 - Technical Infrastructure for MCBK | Chris Shaffer
• #3 - Policy and Coordination to Ensure Quality & Trust | Blackford Middleton
• #4 - Sustainability for Mobilization and Inclusion | Jerry Perry
• Questions and Answers 3
Present: Human readable in words & pictures
Future: Computable (machine-executable) in code
Library Holdings: Books and Journals
Library Holdings: Will add Digital Knowledge Objects
Two Complementary Ways to Represent Knowledge
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Human Readable: Article
Extraction
Computable: CodeEncodable: Model
Programming
Envisioning An Extended Publication Pipeline
LibraryExpanded Library
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Approach to Knowledge FAIRness: Machine-Executable Knowledge Objects
Articles
Knowledge Objects
Description
Interface
Computer-processableKnowledge‘Payload’
Guidelines
Learning Health Sciences
Local Analytical
Results
*FAIR: Findable | Accessible | Interoperable | Reusable
Use Cases for Computable Knowledge: CDS & Beyond
• Clinical: Present advice to inform decisions of providers & patients; evaluate treatments and measure performance for health organizations
• Research: Enhance scientific data & patient records, computable phenotypes, analytic “packages”
• Public Health: Event detection; deploy rapid response actions to threats; support behavior change and chronic disease management
• Education: Learning analytics, training for big data or ubiquitous knowledge environments
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MCBK - Inaugural Public MeetingJuly 10-11, 2018
Lister Hill National Center for Biomedical Communications
National Library of Medicine
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Outcomes of July Meeting• Advance MCBK agenda, primarily through the 4 theme-
based workgroups
• Develop supportive infrastructure (website, communication and outreach plans)
• Create webinar series
• Plan for 2nd public meeting for summer 2019
• Interim “governance”• Meeting Planning Committee Steering Committee• University of Michigan interim home/resource hub
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MCBK Workgroup Co-Chairs
Sustainability for Mobilization and InclusionChris Dymek, Ed.D. Jerry Perry, MLS
Policy & Coordination to Ensure Quality & TrustBlackford Middleton, MD, MPH, MSc Jody Platt, PhD, MPH
Technical Infrastructure for MCBK Leslie McIntosh, PhD, MPH Chris Shaffer, MS
Standards for MCBK Bob Greenes, MD, PhD TBD
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Standards for MCBK
Bob GreenesCo-Chair
Arizona State University
Allen FlynnMCBK Liaison
University of Michigan
Goals
• Standardize descriptions for characterizing CBK• Identify axes for metadata,
• e.g., relating to domain, type of knowledge, derivation, user anticipated, and other context-situation attributes
• Develop a spanning set of use cases for CBK and knowledge-sharing scenarios
• Standardize knowledge representation for each type of knowledge
• Recruit key stakeholders to Workgroup• Identify priority use cases for reusable knowledge
• Constituency committed to working on it• Demonstrated need / commitment to use it
• E.g. Reducing physician burden
• Develop candidate metadata axes• Coordinate with HL7, OMG, and other initiatives to
leverage and contribute to ongoing relevant work• Develop candidate KRs• Iterate
Processes
Evolution of Workgroup • Broad perspective on CBK
• Framework• Metadata• Representation formalism• Packaging
• Embodiment of FAIR principles• Need for input of diverse community
• To decide on priorities and direction • To establish leadership team with appropriate
breadth, experience• Familiar with ongoing standards efforts• Have sufficient time/energy to commit
Standards for MCBK: Questions?
Technical Infrastructure for MCBK
Chris ShafferCo-Chair
University of CaliforniaSan Francisco
Leslie McIntoshCo-Chair
Research Data Alliance
Peter BoisvertMCBK Liaison
University of Michigan
MCBK Infrastructure: Charge
● Identify the landscape of infrastructure stakeholders● Describe the framework components necessary to
move computable biomedical knowledge from generation into practice by facilitating the testing, versioning, use, evaluation, scalability, interoperability, and dissemination of CBK
● Develop use cases connecting stakeholders to framework components
● Act as a clearinghouse for news and events of interest to infrastructure stakeholders and the overall MCBK community
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MCBK Stakeholders are the generators, managers, and consumers of CBK
● Clinical researcher who uses CBK● Clinical providers● Biomedical informatics leader who runs EHR and
leads a Learning Health System● Consumers / patients● Patient organizations (e.g. Michael J. Fox
Foundation)● Insurance companies● Security / IT / Compliance
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Engaging with Complementary Efforts
● RDA ● GA4GH ● Chan Zuckerberg ● BioHub
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Technical Infrastructure for MCBK: Questions?
Policy and Coordination to Ensure Quality and Trust
Blackford MiddletonCo-Chair
Apervita, Inc.
Jody PlattCo-Chair and MCBK Liaison
University of Michigan
Policy and Coordination to Ensure Quality and Trust
Summary from July, 2018 Meeting: What would we need to ensure quality and trust in CBK?
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Components: ValidityAuthorship/ Review/ Publication criteriaEvidenceCurrency (up-to-date)Audit CredentialingSoftwareInteroperability
Characteristics:TransparencyReliabilityReproducibilityConsistencyProvenanceAccessibilityRelevancy
Challenges: GovernanceAdjudication of knowledge/ PrioritizationAligning incentives (Buy-in, acceptability)Validity/ Validation
Characters: Users (patients, providers, payors, communities)EngineersVendorsSystem administratorsDisseminatorsContent area expertsAuthorsRelationships between actors
Policy and Coordination to Ensure Quality and Trust
Preliminary Charter• Identify and address gaps in policy and issues that
would impact the quality of the data and knowledge, or its trustworthiness.
• Coordinate efforts to apply, evaluate, and build upon the Trust Framework to ensure that all stakeholders can participate as trusted and trustworthy agents.
• Action-focused • Ensuring robust and unbiased methods to support
• (1) transparency• (2) FAIRness, and • (3) currency, validity, and provenance of CBK
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Policy and Coordination to Ensure Quality and Trust
Next Steps• Understand the current CBK landscape as it relates to
trust, governance of CBK, policies for CBK• Define attributes for CBK “product information labels”
that would promote transparency and trust• Develop and test model governance structures• Work with and support the MCBK community and
work groups
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Policy and Coordination to Ensure Quality and Trust: Questions?
Sustainability for Mobilization and Inclusion
Jerry PerryCo-Chair
University of Arizona
Chris DymekCo-Chair
AHRQ
Josh RubinMCBK Liaison
University of Michigan
Sustainability for Mobilization and Inclusion
Summary from July, 2018 Meeting
Day 1:● Get energized to promote the movement for CBK
○ Need to articulate the value proposition for CBK
● Broke into 4 groups to think about how to stratify stakeholders and strategies for moving CBK forward
● Groups considered included:○ Knowledge creators○ Knowledge hosts, disseminators, and developers○ Knowledge consumers
Day 2:● Drafted a value proposition, strategy and initial tactical plans for
engaging with the groups targeted during day 128
Sustainability for Mobilization and Inclusion
Preliminary Charter:
• Seek to mobilize diverse stakeholders in an ongoing and active engagement around the value proposition of computable biomedical knowledge (CBK)
• Will focus on communications and engagement with stakeholdersas a necessary prerequisite in order to establish an equitable and FAIR* CBK ecosystem
• Seek engagement through diverse and active communication channels with stakeholders from CBK:
• “creator” communities, including professional societies, accrediting bodies, entrepreneurs and businesses;
• “hosting and dissemination” communities, including publishers, libraries and commercial brokerages;
• “consumer” communities, including healthcare providers and clinical care delivery systems, and healthcare provider and consumer advocacy organizations; and,
• funding communities, including Federal, charitable, philanthropic, association-based, and for-benefit entities that support innovation and equity in healthcare
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Sustainability for Mobilization and Inclusion
Next Steps:• Socialize this draft charter with workgroup
members• Revise based on workgroup feedback
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Sustainability for Mobilizationand Inclusion:
Questions?
Q & A
• Pose your questions via the chat pod• Click on the “Send-to” drop-down and select EVERYONE,
then submit your question• The moderator may unmute selected participants• Unanswered questions will be distributed post-webinar• Join a workgroup! http://bit.ly/MCBKweb2• Continue the conversation on Twitter: #MobilizeCBK
www.MobilizeCBK.org32
Get involved!
• Website – www.MobilizeCBK.org• General Email –
• Join a workgroup – complete the survey or email us!http://bit.ly/MCBKweb2
• Promote and attend webinars
• Plan to attend next MCBK meeting July 18-19, 2019
#MobilizeCBK 33
Q & A
• Pose your questions via the chat pod• Click on the “Send-to” drop-down and select EVERYONE,
then submit your question• The moderator may unmute selected participants• Unanswered questions will be distributed post-webinar• Join a workgroup! http://bit.ly/MCBKweb2• Continue the conversation on Twitter: #MobilizeCBK
www.MobilizeCBK.org34
