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![Page 1: Promoting high quality, cost effective drug therapy throughout the Military Health System The Basics for a Successful MTF P&T Meeting Prepared by the DoD.](https://reader038.fdocuments.us/reader038/viewer/2022110206/56649cdb5503460f949a64ff/html5/thumbnails/1.jpg)
Promoting high quality, cost effective drug therapy throughout the Military Health System
The Basics for a Successful MTF P&T Meeting
Prepared by the DoD Pharmacoeconomic Center
![Page 2: Promoting high quality, cost effective drug therapy throughout the Military Health System The Basics for a Successful MTF P&T Meeting Prepared by the DoD.](https://reader038.fdocuments.us/reader038/viewer/2022110206/56649cdb5503460f949a64ff/html5/thumbnails/2.jpg)
DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Introduction
• LCDR Joseph B. Lawrence– PEC Navy Pharmacist Consultant
• Purpose of discussion– Basic tools and strategies for P&T
– Mock agenda for a MTF P&T
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Topics of Discussion
• Purpose of P&T
• Organization and operation
• Functions and scope
• Assembling a quality meeting agenda
• Information resources for MTF specific data and research
• Medication use evaluation
• Drug class review.
• Reports
• JCAHO and other surveys
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Purposes
• Policy development– Evaluation, selection and therapeutic use of drugs
and related devices
• Education– Programs for drug related matter for medical team
• Goal– ensure medications are used safely and
appropriately
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Organization and Operation
• Composition: physicians, pharmacists, nurses, administrators, QA coordinators, others
• Physician chairperson
• Pharmacist recorder
• Meet regularly
• Invite ad hoc members and specialist as needed
• Sufficient time to review meeting materials
• Recommendation presented to medical staff
• Liaison with other organization committees concerned with drug use
• Actions routinely communicated
• Conflict of interest policy
• Attentive to ASHP, AHA, JCAHO, DOD, ect…
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
P&T Committee
• Organization– Chairperson
• Respected member of medical staff
• Familiar with and advocate for progressive pharmacy
• Effective ally for pharmacy with medical staff and hospital administration
– Secretary• Director of Pharmacy
• Sets agenda with chairperson
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Functions and Scope
• Evaluative, education and advisory capacity to the med staff
• Develop a formulary of drugs for the organization
• Programs/procedures to help ensure the safe and effective drug therapy
• Programs/procedures to ensure cost-effective drug therapy
• Educational programs for medical team
• Participate in QA activities regarding medication
• Monitor/evaluate ADR
• DUE
• Advise pharmacy in effective drug distribution and control
• Disseminate information of actions to health-care staff
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
P&T Agenda
• Delivered via member preference (email, hard copy, etc)• Delivered with adequate time to review before meeting (1 week)• Informative enclosures
– Eg: drug monographs, adverse drug reaction reports, and policy changes
• Date/time/location of the meeting• Review of old business
– Medical staff notification– Minute routing comments– Pharmacy budget– Standing issues
• New business– Requests for change in formulary– Drug/product complaint– Drug recalls– Narcotic overlap– ADR– Planning for next meeting
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
P&T Committee
• Organization– Follow-up
• Actions should be conveyed to all health-care professionals
• Recommendations are to be passed on to the appropriate committee
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Formulary
– Definition: a continually revised compilation of pharmaceuticals that reflects the clinical judgment of the medical staff
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Formulary system management– Definition: method where the medical staff
working through the P&T committee, evaluates, appraises, and selects from the numerous available drug products those considered most useful in patient care
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Formulary system management– Theory: a well designed formulary can guide
physicians to prescribe the safest and most effective agents for treatment of a particular condition.
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Objectives– Decrease drug cost
– Assure high quality care
– Provide information on drug products
– Provide information on organizational policies/procedures
– Development of institution specific guidelines/protocols
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Purpose for ongoing management– Removal/addition of drugs from/to the market
– Changes in hospital policies/procedures
– New clinical information available• Clinical trials
• Guidelines
• Safety
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Advantages
– Ensure quality and appropriateness of drug use
– Educational for staff regarding most effective agents
– Economic benefits
• Disadvantages– Only reduces cost
– Compromises patient care
– Limits physician prescribing authority
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Principles– Drug product selection
• Comparison of all aspects of an agent to that of similar medications.
• Should be based on scientific evidence
• Consider effectiveness, safety and cost
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Formulary Management
• Principles– Formulary Maintenance
• Addition/deletion– Newly approved agents
– New information available (i.e. safety, efficacy)
– Tracking use of nonformulary agents
• Single drug review– Compare single drug to other drugs that are similar
– Focus is on a single drug
• Therapeutic class review– Compares/contrasts all the agents in a single class
– Focus is not on a single drug
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
• Development of a drug monograph
– Purpose: to evaluate various medications to ensure that patients receive drugs that are safe,therapeutically effective and cost effective
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
• Development of a drug monograph– Preparation
• Identify drug to evaluate
• Determine if there are similar agents on formulary
• Obtain background information– Clinical and safety information
– Indications
– Cost
– Clinical trials
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
• Development of a drug monograph– Components
• Summary page
• Introduction
• Pharmacology
• Pharmacokinetics
• Clinical efficacy
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
• Development of a drug monograph– Components (cont)
• Adverse effects
• Drug Interactions
• Cost and dosage
• Conclusion/Recommendations
• References
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
• Points to consider – addition to formulary– Clinical effectiveness, safety, and cost
– Comparison to similar agents
– Comparison to standard therapies
– Advantages/disadvantages
– Niche
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
• Therapeutic Interchange
– Definition: interchange of various TE drug products by pharmacists under pre-defined arrangements with the prescriber
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
• Therapeutic interchange– Elements for successful implementation
• P&T approval
• Scientific/clinical evidence
• Medical staff education
• Mechanism to implement interchange
• Maintenance
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Drug Product Selection
– Therapeutic interchange process• Substitute generic for brand
• Give individual agents in place of combination product
• Switch from intravenous to oral antibiotics
• Change to different agent in same class
• Interchange may be automatic or may require notification
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Therapeutic Interchange
• Advantages– Reduced inventory
– MTF saves money
– Encourages compliance with formulary
• Disadvantages– Confusing to patients
– Patients may think that drugs are NOT equally effective
– Preferred product may change based on contracts
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Information resources
• Local dataCHCS
CIS
Pharmacy automation system (ScriptPro, Pyxis, ect)
Prime Vendor
PDTS
• DoD level data
• PDTS
• M2
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Utilizing CHCS data
Obtaining CHCS data
Capturing CHCS data in Kea™
Importing columnar reports into Excel™
Importing delimited reports into Excel™
Sorting data in Excel™
Using Access queries to clean up data
Miscellaneous tactics to clean up data before exportation including Word™ and Monarch™
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29DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Obtaining CHCS data
• Do it yourself– Canned reports (dur, cost)
– Ad hoc report
• Request from CHCS administration– Delimited with “^”
– Specify columns
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30DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Capturing CHCS data in Kea™
• Print report to “spool”– Command policy (i.e., after 2200)
– Big report take longer
• Print spooled report (PSR) – don’t print yet!
• Set Kea to “capture incoming data”
• Select file location and name
• Set Kea to “end capture”
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31DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Importing text reports into Excel™
• Open Excel• File, Open, (change file type to .txt)
• Import text wizard– Columns
– Delimited
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Sorting data in Excel™Generic Name AHFS Description # RX Avg Qty per Rx Avg DS Total $ Utilizers
SIMVASTATIN HMG-COA REDUCTASE INHIBITORS 4912 83.94 80 $221,617.65 4343CLOPIDOGREL BISULFATE MISCELLANEOUS THERAPEUTIC AGENTS 709 81.34 80 $161,008.46 615FLUTICASONE/SALMETEROL SYMPATHOMIMETIC (ADRENERGIC) AGENTS 830 128.67 64 $142,101.09 678
ALENDRONATE SODIUM MISCELLANEOUS THERAPEUTIC AGENTS 1144 13.81 72 $127,977.42 1011RABEPRAZOLE SODIUM PROTON-PUMP INHIBITORS 1965 87.54 77 $110,281.04 1722
GABAPENTIN MISCELLANEOUS ANTICONVULSANTS 548 169.34 56 $101,221.12 410MONTELUKAST SODIUM MISCELLANEOUS THERAPEUTIC AGENTS 744 66.48 64 $82,180.50 620ESTROGENS,CONJUGATED ESTROGENS 1261 85.69 75 $67,273.60 1102
SERTRALINE HCL ANTIDEPRESSANTS 698 67.89 63 $67,003.02 553ROSIGLITAZONE MALEATE THIAZOLIDINEDIONES 489 92.27 75 $64,118.43 409
FEXOFENADINE HCL SECOND GENERATION ANTIHISTAMINES 740 92.4 59 $63,657.53 685AMLODIPINE BESYLATE DIHYDROPYRIDINES 879 84.7 79 $62,009.03 750
BLOOD SUGAR DIAGNOSTIC DIABETES MELLITUS 1338 155.53 46 $61,530.61 1043IRBESARTAN ANGIOTENSIN II RECEPTOR ANTAGONISTS 611 84.91 81 $56,863.22 522
VENLAFAXINE HCL ANTIDEPRESSANTS 451 80.77 61 $52,575.20 326ZOLPIDEM TARTRATE MISC. ANXIOLYTICS, SEDATIVES & HYPNOTICS 754 28.95 27 $44,548.55 466
FLUTICASONE PROPIONATE ANTI-INFLAMMATORY AGENTS (EENT) 1605 28.86 54 $42,440.70 1380MELOXICAM NONSTEROIDAL ANTI-INFLAMMATORY AGENTS 709 67.14 58 $41,935.31 632
RAMIPRIL ANGIOTENSIN-CONVERTING ENZYME INHIBITORS 662 88.54 77 $41,006.34 552LANSOPRAZOLE PROTON-PUMP INHIBITORS 754 78.27 70 $37,646.15 649
ESTROGEN,CON/M-PROGEST ACET ESTROGENS 158 74.43 73 $37,142.26 139BUPROPION HCL ANTIDEPRESSANTS 377 97.02 47 $36,553.85 288
INSULIN GLARGINE,HUM.REC.ANLOG INSULINS 346 29.19 43 $35,332.51 250MEDICAL SUPPLIES DEVICES 1354 170.75 46 $30,333.90 947
EZETIMIBE MISCELLANEOUS ANTILIPEMIC AGENTS 259 76.9 73 $27,967.99 226CITALOPRAM HYDROBROMIDE ANTIDEPRESSANTS 353 55.94 64 $26,995.95 281
TERBINAFINE HCL ALLYLAMINES 112 42.64 41 $24,819.27 83AMLODIPINE BESYLATE/BENAZEPRIL DIHYDROPYRIDINES 221 86.4 77 $24,693.04 191
RALOXIFENE HCL ESTROGEN AGONIST-ANTAGONISTS 198 82.17 81 $24,189.81 183LISINOPRIL ANGIOTENSIN-CONVERTING ENZYME INHIBITORS 2656 91.04 80 $23,824.91 2290
METFORMIN HCL BIGUANIDES 1454 187.63 77 $23,730.35 1212ALBUTEROL SULFATE/IPRATROPIUM SYMPATHOMIMETIC (ADRENERGIC) AGENTS 390 35.92 52 $23,529.57 317
TOLTERODINE TARTRATE GENITOURINARY SMOOTH MUSCLE RELAXANTS 237 74.68 72 $23,490.90 210AZITHROMYCIN MACROLIDES 779 8.18 9 $20,360.54 735
SUMATRIPTAN SUCCINATE MISC. CENTRAL NERVOUS SYSTEM AGENTS 236 13.92 26 $19,077.60 163METHYLPHENIDATE HCL ANOREXIGENICS;RESPIR.,CEREBRAL STIMULANT 280 63.98 47 $18,216.34 169
GLYBURIDE/METFORMIN HCL SULFONYLUREAS 390 221.95 78 $17,897.66 319CLONIDINE HCL CENTRAL ALPHA-AGONISTS 406 105.22 71 $17,709.98 326DILTIAZEM HCL MISC. CALCIUM-CHANNEL BLOCKING AGENTS 727 88.12 80 $17,513.96 619
AMOX TR/POTASSIUM CLAVULANATE PENICILLINS 469 53.28 11 $16,580.31 430OLOPATADINE HCL ANTIALLERGIC AGENTS 256 7.81 40 $15,583.44 216
LATANOPROST MISCELLANEOUS EENT DRUGS 393 4.69 55 $15,372.95 283FLUTICASONE PROPIONATE ADRENALS 215 20.38 46 $15,343.73 178
GLIPIZIDE SULFONYLUREAS 671 131.44 77 $15,171.19 547PAROXETINE HCL ANTIDEPRESSANTS 330 64.76 65 $14,212.90 267
NIFEDIPINE DIHYDROPYRIDINES 455 90.6 83 $14,112.43 402OLANZAPINE ANTIPSYCHOTIC AGENTS 43 77.09 52 $13,332.15 26CETIRIZINE HCL SECOND GENERATION ANTIHISTAMINES 476 183.85 35 $13,215.22 347
QUETIAPINE FUMARATE ANTIPSYCHOTIC AGENTS 116 84.88 42 $12,544.25 66RISPERIDONE ANTIPSYCHOTIC AGENTS 58 92.79 42 $12,526.56 36
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Obtaining DoD level data
• PDTS– PDTS request: http://www.pec.ha.osd.mil
– PDTS training
• M2– Command authorized user
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
• Outline the steps in developing this process improvement using the FOCUS-PDCA model
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Example P&T Process improvement
• Wanted to improve error reporting, including the reporting of near miss errors.
• MTF filled an average of 33,000 prescriptions per month between Oct 02 and Jul 03
• During this time period an average 4.1 errors/month were documented.
• No near miss errors were documented
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Definition of a Medication Error
"A Medication Error is any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the health care professional, patient, or consumer. Such events may be related to professional practice, health care products, procedures, and systems, including prescribing; order communications; product labeling, packaging, and nomenclature; compounding; dispensing; distribution; administration; education; monitoring; and use."*
Source: The National Coordinating Council for Medication Error Reporting and Prevention
(NCC MERP), 1995.
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Types of errorNo Error A Circumstances or events that have the capacity to cause error.
Error, No Harm
B An error occurred but the error did not reach the patient (An "error of omission" does reach the patient).
C An error occurred that reached the patient but did not cause patient harm.
D An error occurred that reached the patient and required monitoring to confirm that it resulted in no harm to the patient and/or required intervention to preclude harm.
Error, Harm
E An error occurred that may have contributed to or resulted in temporary harm to the patient and required intervention.
F An error occurred that may have contributed to or resulted in temporary harm to the patient and required initial or prolonged hospitalization.
G An error occurred that may have contributed to or resulted in permanent patient harm.
H An error occurred that required intervention necessary to sustain life.
Error, Death
I An error occurred that may have contributed to or resulted in the patient's death.
Near Miss
Miss
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
P&T Process
• Studied current process
• Identified areas of needless complexity or redundancy
• Looked at outcomes and the best way the process should work
• Considered factors such as cost restraints, expandability and maintainability
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
P&T Discoveries
• Current process for reporting errors was too time consuming
– All reports were documented on a written report
– Routed through chain of command
• Felt many people didn’t document errors due to fear of repercussions from chain of command and/or didn’t want to bother with the hassle of filling out a “report”
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
P&T Collaboration
• Team assembled from pharmacy personal, Risk Management, Performance Improvement and PIPA.
• Goal was to improve process for reporting errors by eliminating fear of reporting and making it easier to report errors.
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Plan the Process Improvement
• New process was instituted for reporting errors.
• Points of contacts identified at all pharmacies to facilite the reporting of errors into MedMarx
• New forms created
• Staff trained
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
Do the Improvement, Collect Data, Analyze
• Med errors measured pre and post
• Pharmacy staff entered errors into MedMarx
• Problems encountered:
– Required continuous awareness training
– Staff deployment and turnover
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
MTF Medication Errors
0
20
40
60
80
100
120
140
Feb-02
Apr-02
Jun-02
Aug-02
Oct-02
Dec-02
Feb-03
Apr-03
Jun-03
Aug-03
Oct-03
Dec-03
Feb-04
Apr-04
Jun-04
Aug-04
Oct-04
Dec-04
Near miss
Miss
Near missBenchmark
Start of FOCUS PDCA
New Process Implemented
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
0
500
1000
1500
2000
2500
3000
3500
Feb-02
Apr-02
Jun-02
Aug-02
Oct-02
Dec-02
Feb-03
Apr-03
Jun-03
Aug-03
Oct-03
Dec-03
Feb-04
Apr-04
Jun-04
Aug-04
Oct-04
Dec-04
Miss
Near Miss
Near MissBenchmark
Ninety-One MedMarx Ambulatory Care Facilities (All minus MTF)
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DoD Pharmacoeconomic Centerwww.pec.ha.osd.mil
0
200
400
600
800
1000
1200
Feb-04
Mar-04
Apr-04
May-04
Jun-04
Jul-04
Aug-04
Sep-04
Oct-04
Nov-04
Dec-04
Jan-05NHCC Data
National Data (91 AmbulatoryCare Facilities, Minus NHCC)
All Errors reported from Ambulatory Care Facilities in MedMarx
MTF