7/23/2019 Prokinin Tablet & Susp Patient Information Leaflet

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rokinin

omperid one Table ts and Suspens ion

Composition:

Prokinln Tablets: Each tablet contains to mg Domperidone.

Proklnln suspension: Each 5m1contains 5 mg Domperidone.

Properties:

Domperidone is a dopamine-receptor blocking agent. Its action

on the dopamine-receptors in the chemo-emetic trigger zone

produces an anti-emetic effect. It does not cross the blood-brain

barrier to any appreciable degree.

Domperidone increases the duration 01 antral and duodenal

CQl)tractiQ Uo increase gastric emptying,. but it does not alter

g as tr ic s ec re tio n s a nd h as n o ef fe ct o n in tr ac ra nial p res su re o r in

the cardiovascular system.

Domperidone is rapidly absorbed, with peak plasma

concentration at approximately 1 hour after oral administration,

the bioavailability is low (approximately 15%) due to first pass

hepatic

and

intestinal metabolism, it is 91-93 bound to plasma

proteins, the plasma half life after a single oral dose is 7-9 hours

in healthy patients but it is prolonged in patients with sever renal

insufficiency.

Indications:

A) The dyspeptJc symptom complex that is often assooateo With

delayed gastric emptying, gastro-oesophageal reflux and

oesophagitis:

epigastric sense of fullness, early satiety, feel ing of abdominal

distension, upper abdominal pain;

bloating, eructation, flatulence;

n au sea an d vom i t in g

heartburn with or without regurgitations of gastric contents in

the mouth.

b) Nausea and vomiting of functional, organIC_ Infectious or

dietetic origin or .induced b radiotherapy therapy_ A

SPOCllIIC'lnOica . is nausea . dopa.

agonists, as used in Parkinson's tflSea5e (such as L- dopa and

brornocriptine).

Contraindications:

Proklnin is contraindicated for patients with known

hypersensitivity to any of tts components.

Dompendone should not be used whenever stimulation of gastric

motilijy is to be avoided or could be harmful, ego In case of

gastro-intestinal haemorrhage, obstruction or perforation.

Domperidone is contraindicated.Ja.patients wilb a prolactin-

releasing pitui tary tumor (prolactinoma).

Precautions:

Domperidone given to animals at doses up ID 160 mgI