Program Update to the Scientific Guidance Panel; March 16 ... · •Cover letter •Fact sheet with...
Transcript of Program Update to the Scientific Guidance Panel; March 16 ... · •Cover letter •Fact sheet with...
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Program Update
Rupali Das, MD, MPH Lead, Biomonitoring California
California Department of Public Health
Biomonitoring California Scientific Guidance Panel Meeting March 16, 2012 – Oakland, CA
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Program Updates 1. Staffing 2. Projects:
– Maternal and Infant Environmental Exposure Project – Firefighter Occupational Exposures Project – Biomonitoring Exposures Study
3. Additional Activities 4. Upcoming Activities
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Staff Changes
• Results Return Coordinator – Duyen Kauffman • Research Scientist II – Wei Zou • Research Scientist Supervisor I – Ryszard Gajek • Sample Management Specialist – Alanna Viegas • Associate Toxicologist – Laurel Plummer
• Environmental Laboratory Scientist – unfilled
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Maternal and Infant Environmental Exposure Project (MIEEP)
4 Chemicals in Our Bodies Project
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MIEEP
• Collaboration with UCSF and UC Berkeley • Convenience sample from SFGH • 92 mothers enrolled; 65 mother-infant pairs • Current status:
– Sample analyses ongoing – Preparation of first set of results return materials
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MIEEP Analyses Analyte Status
Metals in blood (cadmium, lead, mercury) Complete
Perfluorinated compounds (PFCs) Complete
Polybrominated diphenyl ethers (PBDEs) Complete
Polychlorinated biphenyls (PCBs) Complete
Organochlorine pesticides (OCPs) Complete
Selected brominated flame retardants (BFRs) Complete (subset)
Phthalates Under review
Pyrethroid and Organophosphate (OP) metabolites Under review
Bisphenol A (BPA) and triclosan Under review
Metals in urine In progress
Hydroxy polycyclic aromatic hydrocarbons (OH-PAHs) In progress
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Recruitment Collection Data Results
Recruit, enroll, and consent participants
Collect maternal urine
Analyze 1st set of chemicals
Translate materials into Spanish
Preliminary interview
Interview participant
Analyze 2nd set of chemicals
Return 1st set of results
Distribute exposure questionnaire
Collect take-home questionnaire
Abstract medical records
Return 2nd set of results
Collect maternal blood
Enter questionnaires & medical records
Analyze participant understanding
Collect umbilical cord blood
Analyze data
Previous MIEEP Status
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Recruitment Collection Data Results
Recruit, enroll, and consent participants
Collect maternal urine
Analyze 1st set of chemicals
Translate materials into Spanish
Preliminary interview
Interview participant
Analyze 2nd set of chemicals
Return 1st set of results
Distribute exposure questionnaire
Collect take-home questionnaire
Abstract medical records
Return 2nd set of results
Collect maternal blood
Enter questionnaires & medical records
Analyze participant understanding
Collect umbilical cord blood
Analyze data
Current MIEEP Status
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MIEEP Results Return Evaluation
• Collaboration with Rachel Morello-Frosch • Two phases of participant interviews
– Assess understanding of first set of results to inform future results return efforts (State funding)
– Final assessment after all results have been returned (non-CDC grant funding)
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Mercury Consumer Alert
10 http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM294876.pdf
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Biomonitoring Exposures Study (BEST)
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Pilot BEST
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• Collaboration with Kaiser Permanente Northern California, Division of Research
• Stratified random sample of adult KPNC members from California’s Central Valley
• Pilot goal:100 participants • Current status:
– Recruitment, sample collection
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Recruitment Collection Data Results
Recruit participants from random sample
Collect blood and urine
Enter data Return results (2 sets)
Schedule home visit
Collect exposure assessment questionnaire
Analyze samples Evaluation survey
Consent & enroll participant at visit
Abstract information from medical records
Previous BEST Status
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Recruitment Collection Data Results
Recruit participants from random sample
Collect blood and urine
Enter data Return results (2 sets)
Schedule home visit
Collect exposure assessment questionnaire
Analyze samples for blood metals
Evaluation survey
Consent & enroll participant at visit
Abstract information from medical record
Analyze urine and serum samples
Current BEST Status
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Expanded BEST
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• Goal: enroll additional 200 participants by 2013
• English- and Spanish- speaking participants – All materials developed in
both languages
• Materials under IRB review
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Expanded BEST
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• Changes to study design – Electronic consent and questionnaire developed
and accessible through a secure web login – Samples collected at KPNC through their lab
orders system
• Modifications increase efficiency – Expedited participant enrollment at reduced cost
to Program – Increased ease for participants
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Firefighter Occupational Exposures (FOX)
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FOX Project
• Collaboration with UC Irvine and Orange County Fire Authority (OCFA)
• Convenience sample of 101 OCFA Firefighters • Current status:
– Returned first set of results (blood metals & PFCs) – Completed collection of firehouse environment checklists – Ongoing laboratory data analyses
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Recruitment Collection Data Results
Recruit participants
Collect blood and urine
Data entry Return 1st set of results
Enroll participants at wellness exam
Collect exposure assessment questionnaire
Analyze 1st set of chemicals
Return 2nd set of results
Abstract information from medical record
Analyze 2nd set of chemicals
Evaluation survey
Collect environmental samples
Evaluation and review of data
Collect information on firehouses
Analyze & review environmental sample data
Previous FOX Status
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Recruitment Collection Data Results
Recruit participants
Collect blood and urine
Data entry Return 1st set of results
Enroll participants at wellness exam
Collect exposure assessment questionnaire
Analyze 1st set of chemicals
Return 2nd set of results
Abstract information from medical record
Analyze 2nd set of chemicals
Evaluation survey
Collect environmental samples
Evaluation and review of data
Collect information on firehouses
Analyze & review environmental sample data
Current FOX Status
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FOX Sample Results Packet Contents
• Cover letter • Fact sheet with project goals • Mock chemical results for each
metal and PFCs as a group: – Laboratory test results page – Frequently asked questions (FAQ’s) – Graph
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FOX Fact Sheet
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Mock Test Results: Lead
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Brief description
Test result & Comparison
Narrative
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Mock Test Results: Perfluorochemicals (PFCs)
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FAQs: Mercury
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FAQ’s: PFCs
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Graphs of Mock Test Results
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QUESTIONS?
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Additional Program Activities
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Additional Activities
• Distribute survey on environmental health priorities to California Local Health Officers and Directors of Environmental Health
• Data summary report due July 2012 • CDC Year 3 progress report and proposal for
Year 4 activities due March 30, 2012
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Request for Information (RFI)
• Issued December 2011 • Criteria for selection include
– California study population – Higher likelihood of potential exposure or health effect – Specimens collected in 2005 or later – Adequate sample volumes; collection, storage protocols
• Submission period closed February 2012; submissions are under review
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Thank you for your contributions!
Josephine Alvaran
Frank Barley
Paramjit Behniwal
Reber Brown
Shirley Cao
Sungyeol Choi
Robin Christensen
Sabrina Crispo-Smith
Rupali Das
Dina Dobraca
Amy Dunn
Ruifang Fan
Laura Fenster
Jeff Fowles
Ryszard Gajek
Qi Gavin
Phillip Gonzaga
Tan Guo
Weihong Guo
Suhash Harwani
Sara Hoover
Duyen Kaufman
Farla Kaufman
Gail Krowech
Michael Lipsett
Nancy Lopez
Amiko Mayeno
Sandy McNeel
June-Soo Park
Myrto Petreas
Sissy Petropoulou
Laurel Plummer
Indranil Sen
Jianwen She
Beverly Shen
Darcy Tarrant
Alanna Viegas
Jed Waldman
Dongli Wang
Miaomiao Wang
Yunzhu Wang
Berna Watson
Todd Whitehead
Rana Zahedi
Lauren Zeise
32 Staff listed are funded by a variety of sources, including TSCA and other state funds, and the CDC cooperative agreement.
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Acknowledgments • SGP members
– Asa Bradman – Dwight Culver – Marion Kavanaugh-Lynch – Ulrike Luderer – Thomas McKone – Gina Solomon – Julia Quint – Michael Wilson
• Orange County Fire Authority – Marty Driscoll – Tom Moon – Peter Condy
• UC San Francisco: – Carrie Dickenson – Jackie Schwartz – Tracey Woodruff
• UC Berkeley: – Rachel Morello-Frosch – Holly Brown-Williams
• UC Irvine – Leslie Israel – Idalia Reynoso – Hannah Nguyen – Cristy Fan
• Kaiser RPGEH – Stephen VanDenEeden – Amethyst Leimpeter
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QUESTIONS?
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